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P35901

- RECA_MYCLE

UniProt

P35901 - RECA_MYCLE

Protein

Protein RecA

Gene

recA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA-dependent ATPase activity Source: InterPro
    3. endonuclease activity Source: InterPro
    4. single-stranded DNA binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. intein-mediated protein splicing Source: InterPro
    4. SOS response Source: UniProtKB-KW

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein RecA
    Alternative name(s):
    Recombinase A
    Cleaved into the following chain:
    Gene namesi
    Name:recA
    Ordered Locus Names:ML0987
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0987.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Protein RecA, 1st partPRO_0000030260Add
    BLAST
    Chaini206 – 570365Mle RecA inteinPRO_0000030261Add
    BLAST
    Chaini571 – 711141Protein RecA, 2nd partPRO_0000030262Add
    BLAST

    Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

    Keywords - PTMi

    Autocatalytic cleavage, Protein splicing

    Proteomic databases

    PRIDEiP35901.

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0987.

    Structurei

    3D structure databases

    ProteinModelPortaliP35901.
    SMRiP35901. Positions 3-211, 538-696.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini320 – 420101DOD-type homing endonucleaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RecA family.Curated

    Phylogenomic databases

    eggNOGiCOG1372.
    HOGENOMiHOG000089956.
    KOiK03553.
    OMAiDQGTQDV.
    OrthoDBiEOG6ZKXNZ.

    Family and domain databases

    Gene3Di2.170.16.10. 2 hits.
    3.10.28.10. 1 hit.
    3.30.250.10. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPiMF_00268. RecA.
    InterProiIPR003593. AAA+_ATPase.
    IPR013765. DNA_recomb/repair_RecA.
    IPR020584. DNA_recomb/repair_RecA_CS.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR027434. Homing_endonucl.
    IPR004042. Intein_endonuc.
    IPR006141. Intein_splice_site.
    IPR004860. LAGLIDADG_2.
    IPR027417. P-loop_NTPase.
    IPR020588. RecA_ATP-bd.
    IPR023400. RecA_C.
    IPR020587. RecA_monomer-monomer_interface.
    [Graphical view]
    PANTHERiPTHR22942:SF1. PTHR22942:SF1. 1 hit.
    PfamiPF03161. LAGLIDADG_2. 1 hit.
    PF00154. RecA. 2 hits.
    [Graphical view]
    PRINTSiPR00142. RECA.
    SMARTiSM00382. AAA. 1 hit.
    SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view]
    SUPFAMiSSF51294. SSF51294. 2 hits.
    SSF52540. SSF52540. 2 hits.
    SSF54752. SSF54752. 1 hit.
    SSF55608. SSF55608. 1 hit.
    TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    TIGR02012. tigrfam_recA. 1 hit.
    PROSITEiPS50818. INTEIN_C_TER. 1 hit.
    PS50819. INTEIN_ENDONUCLEASE. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    PS00321. RECA_1. 1 hit.
    PS50162. RECA_2. 1 hit.
    PS50163. RECA_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35901-1 [UniParc]FASTAAdd to Basket

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    MAQVPDREKA LELAMAQIEK NYGKGSVMRL GDEMCQPISV IPTGSIALDV    50
    ALGIGGLPRG RIVEIYGPES SGKTTVALHA VANAQAVGGV AAFIDAEHAL 100
    EPEYAKKLGV DTDSLLVSQP DTGEQALEIA DMLIRSGALD IVVIDSVAAL 150
    VPRAELEGEM GDSYVGLQAR LMSQALRKMT GALSNSGTTA IFINQLREKI 200
    GVMFGCMNYS TRVTLADGST EKIGKIVNNK MDVRVLSYDP VTDRIVPRKV 250
    VNWFNNGPAE QFLQFTVEKS GSNGKSQFAA TPNHLIRTPG GWTEAGNLIA 300
    GDRVLAVEPH MLSDQQFQVV LGSLMGDGNL SPNLCDRNGV RFRLLGYGCK 350
    QVEYLQWKKA LMGNIRHTVR ENSMGASFID FTPLPELVEL QRAVYLGDGK 400
    KFLSEEYLKA LTPLVLAIWY MDDGSFTVGS KRVQERTAGG SGRIEICVDA 450
    MTEGTRVRLR DYLCDTHGLD VRLREVGSAG KAVLVFSTAA TAKFQSLIAP 500
    YVAPSMEYKL LPQFRGRGSV TPQFVEPTQQ LVPARVLDVH VKLSTRSMNR 550
    FDIEVEGNHN YFVDGVMVHN SPETTTGGKA LKFYASVRMD VRRIETLKDG 600
    VDAVGNRTRV KIVKNKVSPP FKQAEFDILY GKGISREGSL IDMGVEQGFV 650
    RKSGSWFTYE GEQLGQGKEN ARNFLLENAD VANEIEKKIK EKLGIGAVVT 700
    DDDILPTPVD F 711
    Length:711
    Mass (Da):77,638
    Last modified:June 1, 1994 - v1
    Checksum:i4D6A5B8B2A115C0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73822 Genomic DNA. Translation: CAA52040.1.
    U00019 Genomic DNA. Translation: AAA17277.1.
    AL583920 Genomic DNA. Translation: CAC31368.1.
    PIRiS37025.
    RefSeqiNP_301732.1. NC_002677.1.
    WP_010908056.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31368; CAC31368; CAC31368.
    GeneIDi910009.
    KEGGimle:ML0987.
    PATRICi18053688. VBIMycLep78757_1789.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73822 Genomic DNA. Translation: CAA52040.1 .
    U00019 Genomic DNA. Translation: AAA17277.1 .
    AL583920 Genomic DNA. Translation: CAC31368.1 .
    PIRi S37025.
    RefSeqi NP_301732.1. NC_002677.1.
    WP_010908056.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P35901.
    SMRi P35901. Positions 3-211, 538-696.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0987.

    Proteomic databases

    PRIDEi P35901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31368 ; CAC31368 ; CAC31368 .
    GeneIDi 910009.
    KEGGi mle:ML0987.
    PATRICi 18053688. VBIMycLep78757_1789.

    Organism-specific databases

    Lepromai ML0987.

    Phylogenomic databases

    eggNOGi COG1372.
    HOGENOMi HOG000089956.
    KOi K03553.
    OMAi DQGTQDV.
    OrthoDBi EOG6ZKXNZ.

    Family and domain databases

    Gene3Di 2.170.16.10. 2 hits.
    3.10.28.10. 1 hit.
    3.30.250.10. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPi MF_00268. RecA.
    InterProi IPR003593. AAA+_ATPase.
    IPR013765. DNA_recomb/repair_RecA.
    IPR020584. DNA_recomb/repair_RecA_CS.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR027434. Homing_endonucl.
    IPR004042. Intein_endonuc.
    IPR006141. Intein_splice_site.
    IPR004860. LAGLIDADG_2.
    IPR027417. P-loop_NTPase.
    IPR020588. RecA_ATP-bd.
    IPR023400. RecA_C.
    IPR020587. RecA_monomer-monomer_interface.
    [Graphical view ]
    PANTHERi PTHR22942:SF1. PTHR22942:SF1. 1 hit.
    Pfami PF03161. LAGLIDADG_2. 1 hit.
    PF00154. RecA. 2 hits.
    [Graphical view ]
    PRINTSi PR00142. RECA.
    SMARTi SM00382. AAA. 1 hit.
    SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51294. SSF51294. 2 hits.
    SSF52540. SSF52540. 2 hits.
    SSF54752. SSF54752. 1 hit.
    SSF55608. SSF55608. 1 hit.
    TIGRFAMsi TIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    TIGR02012. tigrfam_recA. 1 hit.
    PROSITEi PS50818. INTEIN_C_TER. 1 hit.
    PS50819. INTEIN_ENDONUCLEASE. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    PS00321. RECA_1. 1 hit.
    PS50162. RECA_2. 1 hit.
    PS50163. RECA_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence of selection for protein introns in the recAs of pathogenic mycobacteria."
      Davis E.O., Thangaraj H.S., Brooks P.C., Colston M.J.
      EMBO J. 13:699-703(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Smith D.R., Robison K.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiRECA_MYCLE
    AccessioniPrimary (citable) accession number: P35901
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3