##gff-version 3 P35900 UniProtKB Chain 1 424 . . . ID=PRO_0000063675;Note=Keratin%2C type I cytoskeletal 20 P35900 UniProtKB Domain 70 381 . . . Note=IF rod;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01188 P35900 UniProtKB Region 1 69 . . . Note=Head P35900 UniProtKB Region 70 105 . . . Note=Coil 1A P35900 UniProtKB Region 106 123 . . . Note=Linker 1 P35900 UniProtKB Region 124 215 . . . Note=Coil 1B P35900 UniProtKB Region 216 238 . . . Note=Linker 12 P35900 UniProtKB Region 239 377 . . . Note=Coil 2 P35900 UniProtKB Region 378 424 . . . Note=Tail P35900 UniProtKB Site 228 229 . . . Note=Cleavage%3B by caspases;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16608857;Dbxref=PMID:16608857 P35900 UniProtKB Modified residue 13 13 . . . Note=Phosphoserine%3B by MAPKAPK2%2C MAPKAPK3 and PKC;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16608857;Dbxref=PMID:16608857 P35900 UniProtKB Natural variant 4 4 . . . ID=VAR_036367;Note=In a colorectal cancer sample%3B somatic mutation. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 P35900 UniProtKB Natural variant 129 129 . . . ID=VAR_024489;Note=S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs7212483,PMID:14702039 P35900 UniProtKB Natural variant 214 214 . . . ID=VAR_064726;Note=Found in a renal cell carcinoma sample%3B somatic mutation. G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21248752;Dbxref=PMID:21248752 P35900 UniProtKB Mutagenesis 13 13 . . . Note=Promotes keratin filament disassembly. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16608857;Dbxref=PMID:16608857 P35900 UniProtKB Mutagenesis 14 14 . . . Note=No effect on keratin filament organization. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16608857;Dbxref=PMID:16608857 P35900 UniProtKB Mutagenesis 80 80 . . . Note=Leads to collapsed filaments. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12857878;Dbxref=PMID:12857878 P35900 UniProtKB Sequence conflict 161 161 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P35900 UniProtKB Sequence conflict 349 349 . . . Note=Q->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P35900 UniProtKB Sequence conflict 398 398 . . . Note=R->T;Ontology_term=ECO:0000305;evidence=ECO:0000305