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P35869

- AHR_HUMAN

UniProt

P35869 - AHR_HUMAN

Protein

Aryl hydrocarbon receptor

Gene

AHR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.2 Publications

    GO - Molecular functioni

    1. DNA binding Source: DFLAT
    2. E-box binding Source: UniProtKB
    3. enhancer binding Source: MGI
    4. Hsp90 protein binding Source: BHF-UCL
    5. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
    6. protein binding Source: IntAct
    7. protein dimerization activity Source: DFLAT
    8. protein heterodimerization activity Source: DFLAT
    9. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    10. sequence-specific DNA binding Source: Ensembl
    11. sequence-specific DNA binding transcription factor activity Source: MGI
    12. signal transducer activity Source: InterPro
    13. transcription factor binding Source: BHF-UCL
    14. transcription regulatory region DNA binding Source: DFLAT

    GO - Biological processi

    1. apoptotic process Source: UniProtKB
    2. blood vessel development Source: DFLAT
    3. cell cycle Source: UniProtKB
    4. circadian regulation of gene expression Source: UniProtKB
    5. intracellular receptor signaling pathway Source: GOC
    6. negative regulation of transcription, DNA-templated Source: UniProtKB
    7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: Ensembl
    9. positive regulation of transcription, DNA-templated Source: UniProtKB
    10. prostate gland development Source: Ensembl
    11. regulation of B cell proliferation Source: DFLAT
    12. regulation of gene expression Source: DFLAT
    13. regulation of transcription, DNA-templated Source: UniProtKB
    14. regulation of transcription from RNA polymerase II promoter Source: DFLAT
    15. response to stress Source: UniProtKB
    16. response to xenobiotic stimulus Source: UniProtKB
    17. transcription from RNA polymerase II promoter Source: UniProtKB
    18. xenobiotic metabolic process Source: DFLAT

    Keywords - Molecular functioni

    Activator, Receptor, Repressor

    Keywords - Biological processi

    Biological rhythms, Cell cycle, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP35869.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aryl hydrocarbon receptor
    Short name:
    Ah receptor
    Short name:
    AhR
    Alternative name(s):
    Class E basic helix-loop-helix protein 76
    Short name:
    bHLHe76
    Gene namesi
    Name:AHR
    Synonyms:BHLHE76
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:348. AHR.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: DFLAT
    2. cytosolic aryl hydrocarbon receptor complex Source: DFLAT
    3. nucleus Source: UniProtKB
    4. transcription factor complex Source: DFLAT

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi381 – 3811V → A: Increases specific ligand binding. 1 Publication
    Mutagenesisi381 – 3811V → D: Abolishes specific ligand binding. 1 Publication
    Mutagenesisi381 – 3811V → L or G: No effect on specific ligand binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA24641.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 1010By similarityPRO_0000013450
    Chaini11 – 848838Aryl hydrocarbon receptorPRO_0000013451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP35869.
    PaxDbiP35869.
    PRIDEiP35869.

    PTM databases

    PhosphoSiteiP35869.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.2 Publications

    Inductioni

    Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).1 Publication

    Gene expression databases

    BgeeiP35869.
    CleanExiHS_AHR.
    GenevestigatoriP35869.

    Organism-specific databases

    HPAiCAB005072.
    HPA029722.
    HPA029723.

    Interactioni

    Subunit structurei

    Binds MYBBP1A By similarity. Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. Interacts with ARNTL/BMAL1.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARNTP275405EBI-80780,EBI-80809
    EBNA3P129775EBI-80780,EBI-993115From a different organism.
    NCOA7Q8NI082EBI-80780,EBI-80799
    NCOR2Q9Y6182EBI-80780,EBI-80830

    Protein-protein interaction databases

    BioGridi106699. 37 interactions.
    DIPiDIP-946N.
    IntActiP35869. 11 interactions.
    MINTiMINT-6597538.
    STRINGi9606.ENSP00000242057.

    Structurei

    3D structure databases

    DisProtiDP00381.
    ProteinModelPortaliP35869.
    SMRiP35869. Positions 31-383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 8054bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini111 – 18171PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 34268PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini348 – 38639PACAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi600 – 64041Gln-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG253623.
    HOGENOMiHOG000252935.
    HOVERGENiHBG007313.
    InParanoidiP35869.
    KOiK09093.
    OMAiQQLCQKM.
    OrthoDBiEOG793BBM.
    PhylomeDBiP35869.
    TreeFamiTF352074.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR013655. PAS_fold_3.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    PF08447. PAS_3. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35869-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL    50
    ASLLPFPQDV INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN 100
    CRAANFREGL NLQEGEFLLQ ALNGFVLVVT TDALVFYASS TIQDYLGFQQ 150
    SDVIHQSVYE LIHTEDRAEF QRQLHWALNP SQCTESGQGI EEATGLPQTV 200
    VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ GKLKYLHGQK 250
    KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC 300
    DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV 350
    FRLLTKNNRW TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT 400
    KLPFMFTTGE AVLYEATNPF PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS 450
    LNPSSLLAAM MQQDESIYLY PASSTSSTAP FENNFFNESM NECRNWQDNT 500
    APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY SIMKNLGIDF 550
    EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ 600
    QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM 650
    FENWNSNQFV PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF 700
    ISCNQPVLPQ HSKCTELDYP MGSFEPSPYP TTSSLEDFVT CLQLPENQKH 750
    GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH THVGQMQYNP VLPGQQAFLN 800
    KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP DLTSSGFL 848
    Length:848
    Mass (Da):96,147
    Last modified:July 15, 1998 - v2
    Checksum:i1BFE022871B7B028
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911E → EG in AAA92082. (PubMed:16696038)Curated
    Sequence conflicti340 – 3412MI → SD(PubMed:7515333)Curated
    Sequence conflicti807 – 84842LNETY…SSGFL → FK in BAA03857. (PubMed:8393992)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti517 – 5171P → S.1 Publication
    Corresponds to variant rs72552768 [ dbSNP | Ensembl ].
    VAR_015516
    Natural varianti554 – 5541R → K.3 Publications
    Corresponds to variant rs2066853 [ dbSNP | Ensembl ].
    VAR_009281
    Natural varianti570 – 5701V → I.2 Publications
    Corresponds to variant rs4986826 [ dbSNP | Ensembl ].
    VAR_009282
    Natural varianti786 – 7861M → V.1 Publication
    Corresponds to variant rs72552769 [ dbSNP | Ensembl ].
    VAR_015517

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16354 mRNA. Translation: BAA03857.1.
    L19872 mRNA. Translation: AAA16210.1.
    AC003075 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24281.1.
    CH471073 Genomic DNA. Translation: EAW93686.1.
    BC069390 mRNA. Translation: AAH69390.1.
    BC070080 mRNA. Translation: AAH70080.1.
    U28063
    , U27656, U27657, U28060, U28061, U28062 Genomic DNA. Translation: AAA92082.1.
    U28064 Genomic DNA. Translation: AAA92083.1.
    U28066, U28065 Genomic DNA. Translation: AAA92084.1.
    D38044 Genomic DNA. Translation: BAA07235.1.
    CCDSiCCDS5366.1.
    PIRiS59514.
    RefSeqiNP_001612.1. NM_001621.4.
    UniGeneiHs.171189.

    Genome annotation databases

    EnsembliENST00000242057; ENSP00000242057; ENSG00000106546.
    ENST00000463496; ENSP00000436466; ENSG00000106546.
    GeneIDi196.
    KEGGihsa:196.
    UCSCiuc011jxz.1. human.

    Polymorphism databases

    DMDMi3041653.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16354 mRNA. Translation: BAA03857.1 .
    L19872 mRNA. Translation: AAA16210.1 .
    AC003075 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24281.1 .
    CH471073 Genomic DNA. Translation: EAW93686.1 .
    BC069390 mRNA. Translation: AAH69390.1 .
    BC070080 mRNA. Translation: AAH70080.1 .
    U28063
    , U27656 , U27657 , U28060 , U28061 , U28062 Genomic DNA. Translation: AAA92082.1 .
    U28064 Genomic DNA. Translation: AAA92083.1 .
    U28066 , U28065 Genomic DNA. Translation: AAA92084.1 .
    D38044 Genomic DNA. Translation: BAA07235.1 .
    CCDSi CCDS5366.1.
    PIRi S59514.
    RefSeqi NP_001612.1. NM_001621.4.
    UniGenei Hs.171189.

    3D structure databases

    DisProti DP00381.
    ProteinModelPortali P35869.
    SMRi P35869. Positions 31-383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106699. 37 interactions.
    DIPi DIP-946N.
    IntActi P35869. 11 interactions.
    MINTi MINT-6597538.
    STRINGi 9606.ENSP00000242057.

    Chemistry

    BindingDBi P35869.
    ChEMBLi CHEMBL3201.

    PTM databases

    PhosphoSitei P35869.

    Polymorphism databases

    DMDMi 3041653.

    Proteomic databases

    MaxQBi P35869.
    PaxDbi P35869.
    PRIDEi P35869.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000242057 ; ENSP00000242057 ; ENSG00000106546 .
    ENST00000463496 ; ENSP00000436466 ; ENSG00000106546 .
    GeneIDi 196.
    KEGGi hsa:196.
    UCSCi uc011jxz.1. human.

    Organism-specific databases

    CTDi 196.
    GeneCardsi GC07P017304.
    HGNCi HGNC:348. AHR.
    HPAi CAB005072.
    HPA029722.
    HPA029723.
    MIMi 600253. gene.
    neXtProti NX_P35869.
    PharmGKBi PA24641.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253623.
    HOGENOMi HOG000252935.
    HOVERGENi HBG007313.
    InParanoidi P35869.
    KOi K09093.
    OMAi QQLCQKM.
    OrthoDBi EOG793BBM.
    PhylomeDBi P35869.
    TreeFami TF352074.

    Enzyme and pathway databases

    SignaLinki P35869.

    Miscellaneous databases

    ChiTaRSi AHR. human.
    GeneWikii Aryl_hydrocarbon_receptor.
    GenomeRNAii 196.
    NextBioi 786.
    PROi P35869.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35869.
    CleanExi HS_AHR.
    Genevestigatori P35869.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR013655. PAS_fold_3.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    PF08447. PAS_3. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 2 hits.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human Ah receptor cDNA: analysis for highly conserved sequences."
      Itoh S., Kamataki T.
      Nucleic Acids Res. 21:3578-3578(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Cloning and expression of a human Ah receptor cDNA."
      Dolwick K.M., Schmidt J.V., Carver L.A., Swanson H.I., Bradfield C.A.
      Mol. Pharmacol. 44:911-917(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21."
      Ema M., Matsushita N., Sogawa K., Ariyama T., Inazawa J., Nemoto T., Ota M., Oshimura M., Fujii-Kuriyama Y.
      J. Biochem. 116:845-851(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    8. "Complete structural characterisation of the human aryl hydrocarbon receptor gene."
      Bennett P., Ramsden D.B., Williams A.C.
      Clin. Mol. Pathol. 49:M12-M16(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-235; 388-461 AND 764-848.
    9. "Interindividual difference in expression of human Ah receptor and related P450 genes."
      Hayashi S., Watanabe J., Nakachi K., Eguchi H., Gotoh O., Kawajiri K.
      Carcinogenesis 15:801-806(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 236-341, TISSUE SPECIFICITY.
    10. "Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors."
      Ema M., Ohe N., Suzuki M., Mimura J., Sogawa K., Ikawa S., Fujii-Kuriyama Y.
      J. Biol. Chem. 269:27337-27343(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF VAL-381.
    11. "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex."
      Nguyen T.A., Hoivik D., Lee J.-E., Safe S.
      Arch. Biochem. Biophys. 367:250-257(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    12. "Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1)."
      Wolff S., Harper P.A., Wong J.M.Y., Mostert V., Wang Y., Abel J.
      Mol. Pharmacol. 59:716-724(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    13. "Role of the aryl hydrocarbon receptor in cell cycle regulation."
      Puga A., Xia Y., Elferink C.
      Chem. Biol. Interact. 141:117-130(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON ROLE IN CELL CYCLE.
    14. "Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor."
      Antenos M., Casper R.F., Brown T.J.
      J. Biol. Chem. 277:44028-44034(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NEDD8.
    15. "The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein."
      Dunham E.E., Stevens E.A., Glover E., Bradfield C.A.
      Mol. Pharmacol. 70:8-15(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IVNS1ABP.
    16. Cited for: REVIEW ON VARIANTS.
    17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Polymorphisms of human Ah receptor gene are not involved in lung cancer."
      Kawajiri K., Watanabe J., Eguchi H., Nakachi K., Kiyohara C., Hayashi S.
      Pharmacogenetics 5:151-158(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LYS-554.
    19. "Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms."
      Smart J., Daly A.K.
      Pharmacogenetics 10:11-24(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LYS-554 AND ILE-570.
    20. "Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer."
      Cauchi S., Stucker I., Solas C., Laurent-Puig P., Cenee S., Hemon D., Jacquet M., Kremers P., Beaune P., Massaad-Massade L.
      Carcinogenesis 22:1819-1824(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LYS-554 AND VAL-786.
    21. "Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction."
      Wong J.M.Y., Okey A.B., Harper P.A.
      Biochem. Biophys. Res. Commun. 288:990-996(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-517 AND ILE-570.

    Entry informationi

    Entry nameiAHR_HUMAN
    AccessioniPrimary (citable) accession number: P35869
    Secondary accession number(s): A4D130
    , Q13728, Q13803, Q13804
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 154 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3