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P35868

- SYR_CORGL

UniProt

P35868 - SYR_CORGL

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Protein
Arginine--tRNA ligase
Gene
argS, Cgl1179, cg1333
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. arginine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:Cgl1179, cg1333
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Arginine--tRNA ligaseUniRule annotation
PRO_0000151554Add
BLAST

Expressioni

Inductioni

Up-regulated by arginine and repressed by lysine.1 Publication

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi196627.cg1333.

Structurei

3D structure databases

ProteinModelPortaliP35868.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi130 – 14011"HIGH" regionUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
KOiK01887.
OMAiQQEVFRS.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35868-1 [UniParc]FASTAAdd to Basket

« Hide

MTPADLATLI KETAVEVLTS RELDTSVLPE QVVVERPRNP EHGDYATNIA    50
LQVAKKVGQN PRDLATWLAE ALAADDAIDS AEIAGPGFLN IRLAAAAQGE 100
IVAKILAQGE TFGNSDHLSH LDVNLEFVSA NPTGPIHLGG TRWAAVGDSL 150
GRVLEASGAK VTREYYFNDH GRQIDRFALS LLAAAKGEPT PEDGYGGEYI 200
KEIAEAIVEK HPEALALEPA ATQELFRAEG VEMMFEHIKS SLHEFGTDFD 250
VYYHENSLFE SGAVDKAVQV LKDNGNLYEN EGAWWLRSTE FGDDKDRVVI 300
KSDGDAAYIA GDIAYVADKF SRGHNLNIYM LGADHHGYIA RLKAAAAALG 350
YKPEGVEVLI GQMVNLLRDG KAVRMSKRAG TVVTLDDLVE AIGIDAARYS 400
LIRSSVDSSL DIDLGLWESQ SSDNPVYYVQ YGHARLCSIA RKAETLGVTE 450
EGADLSLLTH DREGDLIRTL GEFPAVVKAA ADLREPHRIA RYAEELAGTF 500
HRFYDSCHIL PKVDEDTAPI HTARLALAAA TRQTLANALH LVGVSAPEKM 550
Length:550
Mass (Da):59,723
Last modified:February 1, 1996 - v2
Checksum:i3AF724BDEE8DC4C1
GO

Sequence cautioni

The sequence CAA38537.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti355 – 3551G → D in CAA79710. 1 Publication
Sequence conflicti412 – 4121I → M in CAA79710. 1 Publication
Sequence conflicti513 – 5131V → A in CAA79710. 1 Publication
Sequence conflicti540 – 5401H → R in CAA79710. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54740 Genomic DNA. Translation: CAA38537.1. Different initiation.
Z21501 Genomic DNA. Translation: CAA79710.1.
BA000036 Genomic DNA. Translation: BAB98572.1.
BX927151 Genomic DNA. Translation: CAF19883.1.
PIRiA49936.
S12227.
RefSeqiNP_600405.1. NC_003450.3.
YP_225469.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98572; BAB98572; BAB98572.
CAF19883; CAF19883; cg1333.
GeneIDi1019162.
KEGGicgb:cg1333.
cgl:NCgl1132.
PATRICi21494404. VBICorGlu203724_1158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54740 Genomic DNA. Translation: CAA38537.1 . Different initiation.
Z21501 Genomic DNA. Translation: CAA79710.1 .
BA000036 Genomic DNA. Translation: BAB98572.1 .
BX927151 Genomic DNA. Translation: CAF19883.1 .
PIRi A49936.
S12227.
RefSeqi NP_600405.1. NC_003450.3.
YP_225469.1. NC_006958.1.

3D structure databases

ProteinModelPortali P35868.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98572 ; BAB98572 ; BAB98572 .
CAF19883 ; CAF19883 ; cg1333 .
GeneIDi 1019162.
KEGGi cgb:cg1333.
cgl:NCgl1132.
PATRICi 21494404. VBICorGlu203724_1158.

Phylogenomic databases

eggNOGi COG0018.
KOi K01887.
OMAi QQEVFRS.
OrthoDBi EOG6JB13C.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and organization of the upstream region of the Corynebacterium glutamicum lysA gene."
    Marcel T., Archer J.A.C., Mengin-Lecreulx D., Sinskey A.J.
    Mol. Microbiol. 4:1819-1830(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13059 / LMG 3658 / NCIB 10332 / AS019 / 613.
  2. "A gene encoding arginyl-tRNA synthetase is located in the upstream region of the lysA gene in Brevibacterium lactofermentum: regulation of argS-lysA cluster expression by arginine."
    Oguiza J.A., Malumbres M., Eriani G., Pisabarro A., Mateos L.M., Martin F., Martin J.F.
    J. Bacteriol. 175:7356-7362(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: ATCC 13869 / DSMZ 1412 / NCIMB 9567.
  3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  5. "Corynebacterium glutamicum arginyl-tRNA synthetase."
    Sharp P.M., Mitchell K.J.
    Mol. Microbiol. 8:200-200(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSYR_CORGL
AccessioniPrimary (citable) accession number: P35868
Secondary accession number(s): P41253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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