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Protein

Insulin-like growth factor-binding protein complex acid labile subunit

Gene

Igfals

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have an important role in regulating the access of circulating IGFs to the tissues.

GO - Molecular functioni

  • insulin-like growth factor binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cell adhesion Source: UniProtKB-KW
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to epidermal growth factor stimulus Source: RGD
  • cellular response to growth hormone stimulus Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • response to nutrient levels Source: RGD

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein complex acid labile subunit
Short name:
ALS
Gene namesi
Name:Igfals
Synonyms:Als
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi68429 Igfals

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000002069824 – 603Insulin-like growth factor-binding protein complex acid labile subunitAdd BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35859
PRIDEiP35859

Expressioni

Tissue specificityi

Brain, kidney, lung, heart, spleen, muscle and liver.

Interactioni

Subunit structurei

Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.

GO - Molecular functioni

  • insulin-like growth factor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020233

Structurei

3D structure databases

ProteinModelPortaliP35859
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 74LRRNTAdd BLAST43
Repeati75 – 96LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati123 – 144LRR 3Add BLAST22
Repeati147 – 168LRR 4Add BLAST22
Repeati171 – 192LRR 5Add BLAST22
Repeati195 – 216LRR 6Add BLAST22
Repeati219 – 240LRR 7Add BLAST22
Repeati243 – 264LRR 8Add BLAST22
Repeati267 – 288LRR 9Add BLAST22
Repeati291 – 312LRR 10Add BLAST22
Repeati315 – 336LRR 11Add BLAST22
Repeati339 – 360LRR 12Add BLAST22
Repeati363 – 384LRR 13Add BLAST22
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Repeati435 – 456LRR 16Add BLAST22
Repeati459 – 480LRR 17Add BLAST22
Repeati483 – 504LRR 18Add BLAST22
Repeati507 – 528LRR 19Add BLAST22
Domaini535 – 603LRRCTAdd BLAST69

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000033909
HOVERGENiHBG000327
InParanoidiP35859
KOiK17256
PhylomeDBiP35859

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 19 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRTGGPAL VVLLAFWVAL GPCHLQGTDP GASADAEGPQ CPVACTCSHD
60 70 80 90 100
DYTDELSVFC SSKNLTHLPD DIPVSTRALW LDGNNLSSIP SAAFQNLSSL
110 120 130 140 150
DFLNLQGSWL RSLEPQALLG LQNLYYLHLE RNRLRNLAVG LFTHTPSLAS
160 170 180 190 200
LSLSSNLLGR LEEGLFQGLS HLWDLNLGWN SLVVLPDTVF QGLGNLHELV
210 220 230 240 250
LAGNKLTYLQ PALFCGLGEL RELDLSRNAL RSVKANVFVH LPRLQKLYLD
260 270 280 290 300
RNLITAVAPG AFLGMKALRW LDLSHNRVAG LMEDTFPGLL GLHVLRLAHN
310 320 330 340 350
AIASLRPRTF KDLHFLEELQ LGHNRIRQLG ERTFEGLGQL EVLTLNDNQI
360 370 380 390 400
TEVRVGAFSG LFNVAVMNLS GNCLRSLPER VFQGLDKLHS LHLEHSCLGH
410 420 430 440 450
VRLHTFAGLS GLRRLFLRDN SISSIEEQSL AGLSELLELD LTTNRLTHLP
460 470 480 490 500
RQLFQGLGHL EYLLLSYNQL TTLSAEVLGP LQRAFWLDIS HNHLETLAEG
510 520 530 540 550
LFSSLGRVRY LSLRNNSLQT FSPQPGLERL WLDANPWDCS CPLKALRDFA
560 570 580 590 600
LQNPGVVPRF VQTVCEGDDC QPVYTYNNIT CAGPANVSGL DLRDVSETHF

VHC
Length:603
Mass (Da):66,812
Last modified:June 1, 1994 - v1
Checksum:iDCD7637D94A5037C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46785 mRNA Translation: AAB23770.2
PIRiJC1282
RefSeqiNP_445781.2, NM_053329.2
UniGeneiRn.7327

Genome annotation databases

GeneIDi79438
KEGGirno:79438
UCSCiRGD:68429 rat

Entry informationi

Entry nameiALS_RAT
AccessioniPrimary (citable) accession number: P35859
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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