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Protein

Insulin-like growth factor-binding protein complex acid labile subunit

Gene

Igfals

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role in regulating the access of circulating IGFs to the tissues.

GO - Molecular functioni

  • insulin-like growth factor binding Source: RGD
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cell adhesion Source: UniProtKB-KW
  • signal transduction Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein complex acid labile subunit
Short name:
ALS
Gene namesi
Name:Igfals
Synonyms:Als
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68429. Igfals.

Subcellular locationi

GO - Cellular componenti

  • insulin-like growth factor ternary complex Source: RGD
  • intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000002069824 – 603Insulin-like growth factor-binding protein complex acid labile subunitAdd BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Glycosylationi578N-linked (GlcNAc...)Sequence analysis1
Glycosylationi586N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35859.
PRIDEiP35859.

Expressioni

Tissue specificityi

Brain, kidney, lung, heart, spleen, muscle and liver.

Interactioni

Subunit structurei

Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.

GO - Molecular functioni

  • insulin-like growth factor binding Source: RGD
  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020233.

Structurei

3D structure databases

ProteinModelPortaliP35859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 74LRRNTAdd BLAST43
Repeati75 – 96LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati123 – 144LRR 3Add BLAST22
Repeati147 – 168LRR 4Add BLAST22
Repeati171 – 192LRR 5Add BLAST22
Repeati195 – 216LRR 6Add BLAST22
Repeati219 – 240LRR 7Add BLAST22
Repeati243 – 264LRR 8Add BLAST22
Repeati267 – 288LRR 9Add BLAST22
Repeati291 – 312LRR 10Add BLAST22
Repeati315 – 336LRR 11Add BLAST22
Repeati339 – 360LRR 12Add BLAST22
Repeati363 – 384LRR 13Add BLAST22
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Repeati435 – 456LRR 16Add BLAST22
Repeati459 – 480LRR 17Add BLAST22
Repeati483 – 504LRR 18Add BLAST22
Repeati507 – 528LRR 19Add BLAST22
Domaini535 – 603LRRCTAdd BLAST69

Sequence similaritiesi

Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000033909.
HOVERGENiHBG000327.
InParanoidiP35859.
KOiK17256.
PhylomeDBiP35859.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 19 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRTGGPAL VVLLAFWVAL GPCHLQGTDP GASADAEGPQ CPVACTCSHD
60 70 80 90 100
DYTDELSVFC SSKNLTHLPD DIPVSTRALW LDGNNLSSIP SAAFQNLSSL
110 120 130 140 150
DFLNLQGSWL RSLEPQALLG LQNLYYLHLE RNRLRNLAVG LFTHTPSLAS
160 170 180 190 200
LSLSSNLLGR LEEGLFQGLS HLWDLNLGWN SLVVLPDTVF QGLGNLHELV
210 220 230 240 250
LAGNKLTYLQ PALFCGLGEL RELDLSRNAL RSVKANVFVH LPRLQKLYLD
260 270 280 290 300
RNLITAVAPG AFLGMKALRW LDLSHNRVAG LMEDTFPGLL GLHVLRLAHN
310 320 330 340 350
AIASLRPRTF KDLHFLEELQ LGHNRIRQLG ERTFEGLGQL EVLTLNDNQI
360 370 380 390 400
TEVRVGAFSG LFNVAVMNLS GNCLRSLPER VFQGLDKLHS LHLEHSCLGH
410 420 430 440 450
VRLHTFAGLS GLRRLFLRDN SISSIEEQSL AGLSELLELD LTTNRLTHLP
460 470 480 490 500
RQLFQGLGHL EYLLLSYNQL TTLSAEVLGP LQRAFWLDIS HNHLETLAEG
510 520 530 540 550
LFSSLGRVRY LSLRNNSLQT FSPQPGLERL WLDANPWDCS CPLKALRDFA
560 570 580 590 600
LQNPGVVPRF VQTVCEGDDC QPVYTYNNIT CAGPANVSGL DLRDVSETHF

VHC
Length:603
Mass (Da):66,812
Last modified:June 1, 1994 - v1
Checksum:iDCD7637D94A5037C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46785 mRNA. Translation: AAB23770.2.
PIRiJC1282.
RefSeqiNP_445781.2. NM_053329.2.
UniGeneiRn.7327.

Genome annotation databases

GeneIDi79438.
KEGGirno:79438.
UCSCiRGD:68429. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46785 mRNA. Translation: AAB23770.2.
PIRiJC1282.
RefSeqiNP_445781.2. NM_053329.2.
UniGeneiRn.7327.

3D structure databases

ProteinModelPortaliP35859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020233.

Proteomic databases

PaxDbiP35859.
PRIDEiP35859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79438.
KEGGirno:79438.
UCSCiRGD:68429. rat.

Organism-specific databases

CTDi3483.
RGDi68429. Igfals.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000033909.
HOVERGENiHBG000327.
InParanoidiP35859.
KOiK17256.
PhylomeDBiP35859.

Miscellaneous databases

PROiP35859.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 19 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiALS_RAT
AccessioniPrimary (citable) accession number: P35859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 5, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.