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Protein

Insulin-like growth factor-binding protein complex acid labile subunit

Gene

Igfals

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role in regulating the access of circulating IGFs to the tissues.

GO - Molecular functioni

  • insulin-like growth factor binding Source: RGD
  • protein C-terminus binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cell adhesion Source: UniProtKB-KW
  • signal transduction Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein complex acid labile subunit
Short name:
ALS
Gene namesi
Name:Igfals
Synonyms:Als
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68429. Igfals.

Subcellular locationi

GO - Cellular componenti

  • insulin-like growth factor ternary complex Source: RGD
  • intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 603580Insulin-like growth factor-binding protein complex acid labile subunitPRO_0000020698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence analysis
Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence analysis
Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35859.
PRIDEiP35859.

Expressioni

Tissue specificityi

Brain, kidney, lung, heart, spleen, muscle and liver.

Interactioni

Subunit structurei

Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.

GO - Molecular functioni

  • insulin-like growth factor binding Source: RGD
  • protein C-terminus binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020233.

Structurei

3D structure databases

ProteinModelPortaliP35859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 7443LRRNTAdd
BLAST
Repeati75 – 9622LRR 1Add
BLAST
Repeati99 – 12022LRR 2Add
BLAST
Repeati123 – 14422LRR 3Add
BLAST
Repeati147 – 16822LRR 4Add
BLAST
Repeati171 – 19222LRR 5Add
BLAST
Repeati195 – 21622LRR 6Add
BLAST
Repeati219 – 24022LRR 7Add
BLAST
Repeati243 – 26422LRR 8Add
BLAST
Repeati267 – 28822LRR 9Add
BLAST
Repeati291 – 31222LRR 10Add
BLAST
Repeati315 – 33622LRR 11Add
BLAST
Repeati339 – 36022LRR 12Add
BLAST
Repeati363 – 38422LRR 13Add
BLAST
Repeati387 – 40822LRR 14Add
BLAST
Repeati411 – 43222LRR 15Add
BLAST
Repeati435 – 45622LRR 16Add
BLAST
Repeati459 – 48022LRR 17Add
BLAST
Repeati483 – 50422LRR 18Add
BLAST
Repeati507 – 52822LRR 19Add
BLAST
Domaini535 – 60369LRRCTAdd
BLAST

Sequence similaritiesi

Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000033909.
HOVERGENiHBG000327.
InParanoidiP35859.
KOiK17256.
PhylomeDBiP35859.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 19 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRTGGPAL VVLLAFWVAL GPCHLQGTDP GASADAEGPQ CPVACTCSHD
60 70 80 90 100
DYTDELSVFC SSKNLTHLPD DIPVSTRALW LDGNNLSSIP SAAFQNLSSL
110 120 130 140 150
DFLNLQGSWL RSLEPQALLG LQNLYYLHLE RNRLRNLAVG LFTHTPSLAS
160 170 180 190 200
LSLSSNLLGR LEEGLFQGLS HLWDLNLGWN SLVVLPDTVF QGLGNLHELV
210 220 230 240 250
LAGNKLTYLQ PALFCGLGEL RELDLSRNAL RSVKANVFVH LPRLQKLYLD
260 270 280 290 300
RNLITAVAPG AFLGMKALRW LDLSHNRVAG LMEDTFPGLL GLHVLRLAHN
310 320 330 340 350
AIASLRPRTF KDLHFLEELQ LGHNRIRQLG ERTFEGLGQL EVLTLNDNQI
360 370 380 390 400
TEVRVGAFSG LFNVAVMNLS GNCLRSLPER VFQGLDKLHS LHLEHSCLGH
410 420 430 440 450
VRLHTFAGLS GLRRLFLRDN SISSIEEQSL AGLSELLELD LTTNRLTHLP
460 470 480 490 500
RQLFQGLGHL EYLLLSYNQL TTLSAEVLGP LQRAFWLDIS HNHLETLAEG
510 520 530 540 550
LFSSLGRVRY LSLRNNSLQT FSPQPGLERL WLDANPWDCS CPLKALRDFA
560 570 580 590 600
LQNPGVVPRF VQTVCEGDDC QPVYTYNNIT CAGPANVSGL DLRDVSETHF

VHC
Length:603
Mass (Da):66,812
Last modified:June 1, 1994 - v1
Checksum:iDCD7637D94A5037C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46785 mRNA. Translation: AAB23770.2.
PIRiJC1282.
RefSeqiNP_445781.2. NM_053329.2.
UniGeneiRn.7327.

Genome annotation databases

GeneIDi79438.
KEGGirno:79438.
UCSCiRGD:68429. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S46785 mRNA. Translation: AAB23770.2.
PIRiJC1282.
RefSeqiNP_445781.2. NM_053329.2.
UniGeneiRn.7327.

3D structure databases

ProteinModelPortaliP35859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020233.

Proteomic databases

PaxDbiP35859.
PRIDEiP35859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79438.
KEGGirno:79438.
UCSCiRGD:68429. rat.

Organism-specific databases

CTDi3483.
RGDi68429. Igfals.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000033909.
HOVERGENiHBG000327.
InParanoidiP35859.
KOiK17256.
PhylomeDBiP35859.

Miscellaneous databases

NextBioi614812.
PROiP35859.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 19 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the acid-labile subunit of the rat insulin-like growth factor binding protein complex."
    Dai J., Baxter R.C.
    Biochem. Biophys. Res. Commun. 188:304-309(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Purification and characterization of the acid-labile subunit of rat serum insulin-like growth factor binding protein complex."
    Baxter R.C., Dai J.
    Endocrinology 134:848-852(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-44, CHARACTERIZATION.
    Strain: Wistar.
    Tissue: Serum.

Entry informationi

Entry nameiALS_RAT
AccessioniPrimary (citable) accession number: P35859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.