Reviewed,
UniProtKB/Swiss-Prot P35853 (PUR1_LACCA)
Last modified
June 16, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Amidophosphoribosyltransferase Short name=ATase EC=2.4.2.14 Alternative name(s): Glutamine phosphoribosylpyrophosphate amidotransferase Short name=GPATase | ||
| Gene names |
| ||
| Organism | Lactobacillus casei | ||
| Taxonomic identifier | 1582 [NCBI] | ||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus |
Protein attributes
| Sequence length | 194 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. |
| Cofactor | Binds 1 magnesium ion per subunit Potential. Binds 1 4Fe-4S cluster per subunit Potential. |
| Pathway | |
| Sequence similarities | In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. Contains 1 glutamine amidotransferase type-2 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Domain | Glutamine amidotransferase |
| Ligand | 4Fe-4S Iron Iron-sulfur Magnesium Metal-binding |
| Molecular function | Glycosyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW purine base biosynthetic processInferred from electronic annotation. Source: InterPro purine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW amidophosphoribosyltransferase activityInferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Propeptide | 1 – 11 | 11 | By similarity | PRO_0000029253 | |||||
| Chain | 12 – ›194 | ›183 | Amidophosphoribosyltransferase | PRO_0000029254 | |||||
Regions | |||||||||
| Domain | 12 – ›194 | ›183 | Glutamine amidotransferase type-2 | ||||||
Sites | |||||||||
| Active site | 12 | 1 | For GATase activity By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 194 | 1 | |||||||
Sequences
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References
| [1] | "Isolation and complete sequence of the purL gene encoding FGAM synthase II in Lactobacillus casei." Gu Z.-M., Martindale D.W., Lee B.H. Gene 119:123-126(1992) [PubMed: 1398079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | Erratum Gu Z.-M., Martindale D.W., Lee B.H. Gene 133:147-147(1993) [PubMed: 8224889] [Abstract] |
Cross-references
Sequence databases | |
|---|---|
| M85265 Genomic DNA. Translation: AAC36948.1. | |
| PIR | PC1136. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AO0 based on UniProtKB P00497. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.4.2.14. 610. |
Family and domain databases | |
| InterPro | IPR005854. Amd_phspho_trans. IPR000583. GATase_2. IPR017932. GATase_II. IPR002375. Pr/py_Pribosyl_transf_CS. [Graphical view] |
| PANTHER | PTHR11907. Amd_phspho_trans. 1 hit. |
| Pfam | PF00310. GATase_2. 1 hit. [Graphical view] |
| PROSITE | PS51278. GATASE_TYPE_2. 1 hit. PS00103. PUR_PYR_PR_TRANSFER. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PUR1_LACCA | ||||||||
| Accession | Primary (citable) accession number: P35853 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


