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Protein

Folate receptor alpha

Gene

Folr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101FolateBy similarity1
Binding sitei105FolateBy similarity1
Binding sitei194FolateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • anterior neural tube closure Source: BHF-UCL
  • axon regeneration Source: BHF-UCL
  • cardiac neural crest cell migration involved in outflow tract morphogenesis Source: BHF-UCL
  • cellular response to folic acid Source: MGI
  • folate import across plasma membrane Source: InterPro
  • folic acid metabolic process Source: MGI
  • folic acid transport Source: UniProtKB
  • heart looping Source: BHF-UCL
  • neural crest cell migration involved in heart formation Source: BHF-UCL
  • pharyngeal arch artery morphogenesis Source: BHF-UCL
  • posttranslational protein targeting to endoplasmic reticulum membrane Source: MGI
  • regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  • response to axon injury Source: BHF-UCL

Keywordsi

Molecular functionReceptor
Biological processTransport
LigandFolate-binding

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6807878 COPI-mediated anterograde transport

Protein family/group databases

MoonProtiP35846

Names & Taxonomyi

Protein namesi
Recommended name:
Folate receptor alpha
Short name:
FR-alpha
Alternative name(s):
Folate receptor 1
Folate-binding protein 1
Gene namesi
Name:Folr1
Synonyms:Fbp1, Folbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95568 Folr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality at about 10.5 dpc, due to gross developmental defects, including defects of neural tube closure, craniofacial defects and defects in heart development. Embryos can be rescued by maternal folate supplementation.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000880425 – 232Folate receptor alphaAdd BLAST208
PropeptideiPRO_0000008805233 – 255Removed in mature formBy similarityAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 63By similarity
Disulfide bondi55 ↔ 103By similarity
Disulfide bondi64 ↔ 107By similarity
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 173By similarity
Disulfide bondi94 ↔ 144By similarity
Disulfide bondi133 ↔ 207By similarity
Disulfide bondi137 ↔ 187By similarity
Disulfide bondi150 ↔ 167By similarity
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi232GPI-anchor amidated serineBy similarity1

Post-translational modificationi

The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP35846
PeptideAtlasiP35846
PRIDEiP35846

Expressioni

Tissue specificityi

Detected in kidney proximal tubules (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000001827
CleanExiMM_FBP1
MM_FOLR1
ExpressionAtlasiP35846 baseline and differential
GenevisibleiP35846 MM

Interactioni

Protein-protein interaction databases

IntActiP35846, 1 interactor
MINTiP35846
STRINGi10090.ENSMUSP00000001882

Structurei

3D structure databases

ProteinModelPortaliP35846
SMRiP35846
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 126Folate bindingBy similarity5
Regioni155 – 160Folate bindingBy similarity6

Sequence similaritiesi

Belongs to the folate receptor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFP Eukaryota
ENOG4111IU4 LUCA
GeneTreeiENSGT00390000010470
HOGENOMiHOG000006539
HOVERGENiHBG039612
InParanoidiP35846
KOiK13649
OMAiWNWTSGF
OrthoDBiEOG091G0GIA
TreeFamiTF328532

Family and domain databases

InterProiView protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032935 FOLR1
PANTHERiPTHR10517 PTHR10517, 1 hit
PTHR10517:SF15 PTHR10517:SF15, 1 hit
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLMTVQLL LLVMWMAECA QSRATRARTE LLNVCMDAKH HKEKPGPEDN
60 70 80 90 100
LHDQCSPWKT NSCCSTNTSQ EAHKDISYLY RFNWNHCGTM TSECKRHFIQ
110 120 130 140 150
DTCLYECSPN LGPWIQQVDQ SWRKERILDV PLCKEDCQQW WEDCQSSFTC
160 170 180 190 200
KSNWHKGWNW SSGHNECPVG ASCHPFTFYF PTSAALCEEI WSHSYKLSNY
210 220 230 240 250
SRGSGRCIQM WFDPAQGNPN EEVARFYAEA MSGAGFHGTW PLLCSLSLVL

LWVIS
Length:255
Mass (Da):29,449
Last modified:December 11, 2013 - v2
Checksum:iA12ACA978BC8E134
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236F → L in AAA37595 (PubMed:1894617).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64782 mRNA Translation: AAA37595.1
AF096319 mRNA Translation: AAD19353.1
AC167240 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL16530.1
CH466531 Genomic DNA Translation: EDL16532.1
CH466531 Genomic DNA Translation: EDL16533.1
CH466531 Genomic DNA Translation: EDL16534.1
CH466531 Genomic DNA Translation: EDL16535.1
CH466531 Genomic DNA Translation: EDL16536.1
CH466531 Genomic DNA Translation: EDL16537.1
CH466531 Genomic DNA Translation: EDL16538.1
BC138781 mRNA Translation: AAI38782.1
BC138795 mRNA Translation: AAI38796.1
BC145414 mRNA Translation: AAI45415.1
M97700 Genomic DNA Translation: AAA37596.1
M97701 Genomic DNA Translation: AAA37598.1
CCDSiCCDS21517.1
PIRiA40969
RefSeqiNP_001239481.1, NM_001252552.1
NP_001239482.1, NM_001252553.1
NP_001239483.1, NM_001252554.1
NP_032060.2, NM_008034.3
XP_006507423.1, XM_006507360.3
XP_006507424.1, XM_006507361.2
XP_006507426.1, XM_006507363.3
XP_006507427.1, XM_006507364.2
XP_006507428.1, XM_006507365.3
XP_006507429.1, XM_006507366.2
XP_006507430.1, XM_006507367.3
XP_006507431.1, XM_006507368.3
XP_006507432.1, XM_006507369.3
XP_006507433.1, XM_006507370.3
UniGeneiMm.2135
Mm.490265

Genome annotation databases

EnsembliENSMUST00000106981; ENSMUSP00000102594; ENSMUSG00000001827
ENSMUST00000106982; ENSMUSP00000102595; ENSMUSG00000001827
ENSMUST00000106983; ENSMUSP00000102596; ENSMUSG00000001827
ENSMUST00000106985; ENSMUSP00000102598; ENSMUSG00000001827
ENSMUST00000106986; ENSMUSP00000102599; ENSMUSG00000001827
GeneIDi14275
KEGGimmu:14275
UCSCiuc009ipm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFOLR1_MOUSE
AccessioniPrimary (citable) accession number: P35846
Secondary accession number(s): Q9R222
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 11, 2013
Last modified: June 20, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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