P35846 (FOLR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Folate receptor alpha
Short name=FR-alpha

Alternative name(s):
Folate receptor 1
Folate-binding protein 1

Gene names

Name:	Folr1
Synonyms:	Fbp1, Folbp1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Post-translational modification	Eight disulfide bonds are present Probable.
Sequence similarities	Belongs to the folate receptor family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
Ligand	Folate-binding
Molecular function	Receptor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	folic acid metabolic process Inferred from mutant phenotype PubMed 12854656. Source: MGI posttranslational protein targeting to membrane Traceable author statement PubMed 11111049. Source: MGI
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Traceable author statement PubMed 11111049. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	folic acid binding Traceable author statement PubMed 11111049. Source: MGI folic acid transporter activity Traceable author statement PubMed 11111049. Source: MGI receptor activity Traceable author statement PubMed 11111049. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 232	208	Folate receptor alpha		PRO_0000008804
	Propeptide	233 – 255	23	Removed in mature form By similarity		PRO_0000008805
Amino acid modifications
	Lipidation	232	1	GPI-anchor amidated serine By similarity
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Glycosylation	199	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P35846 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: A12ACA9AE6A8E134	FASTA	255	29,415
	10 20 30 40 50 60 MAHLMTVQLL LLVMWMAECA QSRATRARTE LLNVCMDAKH HKEKPGPEDN LHDQCSPWKT 70 80 90 100 110 120 NSCCSTNTSQ EAHKDISYLY RFNWNHCGTM TSECKRHFIQ DTCLYECSPN LGPWIQQVDQ 130 140 150 160 170 180 SWRKERILDV PLCKEDCQQW WEDCQSSFTC KSNWHKGWNW SSGHNECPVG ASCHPFTFYF 190 200 210 220 230 240 PTSAALCEEI WSHSYKLSNY SRGSGRCIQM WFDPAQGNPN EEVARFYAEA MSGAGLHGTW 250 PLLCSLSLVL LWVIS

References

[1]	"Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement." Brigle K.E., Westin E.H., Houghton M.T., Goldman I.D. J. Biol. Chem. 266:17243-17249(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Insertion of an intracisternal A particle within the 5'-regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression." Brigle K.E., Westin E.H., Houghton M.T., Goldman I.D. J. Biol. Chem. 267:22351-22355(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64782 mRNA. Translation: AAA37595.1. M97700 Genomic DNA. Translation: AAA37596.1. M97701 Genomic DNA. Translation: AAA37598.1.
IPI	IPI00123114.
PIR	A40969.
UniGene	Mm.2135. Mm.490265.
3D structure databases
ModBase	Search...
Proteomic databases
PaxDb	P35846.
PRIDE	P35846.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000123321; ENSMUSP00000114167; ENSMUSG00000001827.
Organism-specific databases
MGI	MGI:95568. Folr1.
Phylogenomic databases
eggNOG	NOG26606.
GeneTree	ENSGT00390000010470.
HOGENOM	HOG000006539.
HOVERGEN	HBG039612.
InParanoid	P35846.
OrthoDB	EOG4HDSV6.
Gene expression databases
ArrayExpress	P35846.
Bgee	P35846.
CleanEx	MM_FBP1. MM_FOLR1.
Genevestigator	P35846.
GermOnline	ENSMUSG00000001827. Mus musculus.
Family and domain databases
InterPro	IPR004269. Folate_rcpt. IPR018143. Folate_rcpt-like. [Graphical view]
PANTHER	PTHR10517. PTHR10517. 1 hit.
Pfam	PF03024. Folate_rec. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

FOLR1_MOUSE

Accession

Primary (citable) accession number: P35846

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program