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P35844 (KES1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein KES1
Alternative name(s):
Oxysterol-binding protein homolog 4
Gene names
Name:KES1
Synonyms:OSH4
Ordered Locus Names:YPL145C
ORF Names:LPI3C, P2614
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in ergosterol synthesis.

Miscellaneous

Present with 32200 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the OSBP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Protein KES1
PRO_0000100386

Amino acid modifications

Modified residue3371Phosphothreonine Ref.8
Modified residue3701Phosphothreonine Ref.8
Modified residue3831Phosphothreonine Ref.8
Modified residue3891Phosphoserine Ref.8

Experimental info

Sequence conflict3551I → T in AAS56373. Ref.5

Secondary structure

1 .......................................................................................... 434
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35844 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 360E4A46ABE2D87B

FASTA43449,492
        10         20         30         40         50         60 
MSQYASSSSW TSFLKSIASF NGDLSSLSAP PFILSPISLT EFSQYWAEHP ELFLEPSFIN 

        70         80         90        100        110        120 
DDNYKEHCLI DPEVESPELA RMLAVTKWFI STLKSQYCSR NESLGSEKKP LNPFLGELFV 

       130        140        150        160        170        180 
GKWENKEHPE FGETVLLSEQ VSHHPPVTAF SIFNDKNKVK LQGYNQIKAS FTKSLMLTVK 

       190        200        210        220        230        240 
QFGHTMLDIK DESYLVTPPP LHIEGILVAS PFVELEGKSY IQSSTGLLCV IEFSGRGYFS 

       250        260        270        280        290        300 
GKKNSFKARI YKDSKDSKDK EKALYTISGQ WSGSSKIIKA NKKEESRLFY DAARIPAEHL 

       310        320        330        340        350        360 
NVKPLEEQHP LESRKAWYDV AGAIKLGDFN LIAKTKTELE ETQRELRKEE EAKGISWQRR 

       370        380        390        400        410        420 
WFKDFDYSVT PEEGALVPEK DDTFLKLASA LNLSTKNAPS GTLVGDKEDR KEDLSSIHWR 

       430 
FQRELWDEEK EIVL

« Hide

References

« Hide 'large scale' references
[1]"A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein."
Jiang B., Brown J.L., Sheraton J., Fortin N., Bussey H.
Yeast 10:341-353(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The sequence of 55 kb on the left arm of yeast chromosome XVI identifies a small nuclear RNA, a new putative protein kinase and two new putative regulators."
Purnelle B., Coster F., Goffeau A.
Yeast 12:1483-1492(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Overlapping functions of the yeast oxysterol-binding protein homologues."
Beh C.T., Cool L., Phillips J., Rine J.
Genetics 157:1117-1140(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: GENETIC ANALYSIS.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-337; THR-370; THR-383 AND SER-389, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U03913 Unassigned DNA. Translation: AAA17736.1.
U43703 Genomic DNA. Translation: AAB68217.1.
X96770 Genomic DNA. Translation: CAA65548.1.
Z73501 Genomic DNA. Translation: CAA97849.1.
AY558047 Genomic DNA. Translation: AAS56373.1.
BK006949 Genomic DNA. Translation: DAA11290.1.
PIRS42676.
RefSeqNP_015180.1. NM_001183959.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZHTX-ray1.90A2-434[»]
1ZHWX-ray1.70A2-434[»]
1ZHXX-ray1.50A2-434[»]
1ZHYX-ray1.60A2-434[»]
1ZHZX-ray1.90A2-434[»]
1ZI7X-ray2.50A/B/C30-434[»]
3SPWX-ray2.60A/B1-434[»]
ProteinModelPortalP35844.
SMRP35844. Positions 2-434.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2867N.
IntActP35844. 10 interactions.
MINTMINT-1678684.
STRING4932.YPL145C.

Proteomic databases

PaxDbP35844.
PeptideAtlasP35844.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPL145C; YPL145C; YPL145C.
GeneID855958.
KEGGsce:YPL145C.

Organism-specific databases

CYGDYPL145c.
SGDS000006066. KES1.

Phylogenomic databases

eggNOGNOG262374.
GeneTreeENSGT00550000075838.
HOGENOMHOG000197950.
OMAFLGKWED.
OrthoDBEOG4BVW3T.

Gene expression databases

GenevestigatorP35844.
GermOnlineYPL145C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERPTHR10972. PTHR10972. 1 hit.
PfamPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEPS01013. OSBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP35844.
NextBio980753.

Entry information

Entry nameKES1_YEAST
AccessionPrimary (citable) accession number: P35844
Secondary accession number(s): D6W3M4, E9P8U8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 3, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents