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Protein

Protein HES1

Gene

HES1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in ergosterol synthesis.

GO - Molecular functioni

  • lipid binding Source: SGD
  • oxysterol binding Source: SGD
  • sterol transporter activity Source: SGD

GO - Biological processi

  • endocytosis Source: SGD
  • exocytosis Source: SGD
  • maintenance of cell polarity Source: SGD
  • piecemeal microautophagy of nucleus Source: SGD
  • sterol biosynthetic process Source: UniProtKB-KW
  • sterol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-33733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HES1
Alternative name(s):
Oxysterol-binding protein homolog 5
Gene namesi
Name:HES1
Synonyms:OSH5
Ordered Locus Names:YOR237W
ORF Names:O5234
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR237W.
SGDiS000005763. HES1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Protein HES1PRO_0000100385Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi34629. 22 interactions.

Structurei

3D structure databases

ProteinModelPortaliP35843.
SMRiP35843. Positions 2-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

HOGENOMiHOG000197950.
InParanoidiP35843.
OMAiFIIENEA.
OrthoDBiEOG092C2RAT.

Family and domain databases

InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQHASSSSW TSFLKSISSF NGDLSSLSAP PFILSPTSLT EFSQYWAEHP
60 70 80 90 100
ALFLEPSLID GENYKDHCPF DPNVESKEVA QMLAVVRWFI STLRSQYCSR
110 120 130 140 150
SESMGSEKKP LNPFLGEVFV GKWKNDEHPE FGETVLLSEQ VSHHPPMTAF
160 170 180 190 200
SIFNEKNDVS VQGYNQIKTG FTKTLTLTVK PYGHVILKIK DETYLITTPP
210 220 230 240 250
LHIEGILVAS PFVELGGRSF IQSSNGMLCV IEFSGRGYFT GKKNSFKARI
260 270 280 290 300
YRSPQEHSHK ENALYLISGQ WSGVSTIIKK DSQVSHQFYD SSETPTEHLL
310 320 330 340 350
VKPIEEQHPL ESRRAWKDVA EAIRQGNISM IKKTKEELEN KQRALREQER
360 370 380 390 400
VKGVEWQRRW FKQVDYMNEN TSNDVEKASE DDAFRKLASK LQLSVKNVPS
410 420 430
GTLIGGKDDK KDVSTALHWR FDKNLWMREN EITI
Length:434
Mass (Da):49,505
Last modified:June 1, 1994 - v1
Checksum:i8D7D71C860A91097
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03914 Unassigned DNA. Translation: AAA17737.1.
Z75145 Genomic DNA. Translation: CAA99458.1.
BK006948 Genomic DNA. Translation: DAA11006.1.
PIRiS42677.
RefSeqiNP_014880.3. NM_001183656.3.

Genome annotation databases

EnsemblFungiiYOR237W; YOR237W; YOR237W.
GeneIDi854412.
KEGGisce:YOR237W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03914 Unassigned DNA. Translation: AAA17737.1.
Z75145 Genomic DNA. Translation: CAA99458.1.
BK006948 Genomic DNA. Translation: DAA11006.1.
PIRiS42677.
RefSeqiNP_014880.3. NM_001183656.3.

3D structure databases

ProteinModelPortaliP35843.
SMRiP35843. Positions 2-434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34629. 22 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR237W; YOR237W; YOR237W.
GeneIDi854412.
KEGGisce:YOR237W.

Organism-specific databases

EuPathDBiFungiDB:YOR237W.
SGDiS000005763. HES1.

Phylogenomic databases

HOGENOMiHOG000197950.
InParanoidiP35843.
OMAiFIIENEA.
OrthoDBiEOG092C2RAT.

Enzyme and pathway databases

BioCyciYEAST:G3O-33733-MONOMER.

Miscellaneous databases

PROiP35843.

Family and domain databases

InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHES1_YEAST
AccessioniPrimary (citable) accession number: P35843
Secondary accession number(s): D6W2U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1690 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.