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P35842 (PPAB_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acid phosphatase PHO11

EC=3.1.3.2
Alternative name(s):
P56
Gene names
Name:PHO11
Ordered Locus Names:YAR071W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Induction

S.cerevisiae has 2 types of acid phosphatase: one is constitutive and the other is repressible by inorganic phosphate.

Post-translational modification

Glycosylated during secretion across the membrane.

Miscellaneous

Present with 1460 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 By similarity
Chain18 – 467450Acid phosphatase PHO11
PRO_0000023956

Sites

Active site751Nucleophile By similarity
Active site3381Proton donor By similarity

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential
Glycosylation3561N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential
Glycosylation4451N-linked (GlcNAc...) Potential
Glycosylation4611N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict171A → L in AAA73479. Ref.1
Sequence conflict82 – 832VS → AR in AAA73479. Ref.1
Sequence conflict1501R → H in AAA73479. Ref.1
Sequence conflict3541K → Q in AAA73479. Ref.1
Sequence conflict4231D → G in AAA73479. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P35842 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: AECDC1C046B326C3

FASTA46752,758
        10         20         30         40         50         60 
MLKSAVYSIL AASLVNAGTI PLGKLSDIDK IGTQTEIFPF LGGSGPYYSF PGDYGISRDL 

        70         80         90        100        110        120 
PESCEMKQVQ MVGRHGERYP TVSKAKSIMT TWYKLSNYTG QFSGALSFLN DDYEFFIRDT 

       130        140        150        160        170        180 
KNLEMETTLA NSVNVLNPYT GEMNAKRHAR DFLAQYGYMV ENQTSFAVFT SNSNRCHDTA 

       190        200        210        220        230        240 
QYFIDGLGDK FNISLQTISE AESAGANTLS AHHSCPAWDD DVNDDILKKY DTKYLSGIAK 

       250        260        270        280        290        300 
RLNKENKGLN LTSSDANTFF AWCAYEINAR GYSDICNIFT KDELVRFSYG QDLETYYQTG 

       310        320        330        340        350        360 
PGYDVVRSVG ANLFNASVKL LKESEVQDQK VWLSFTHDTD ILNYLTTIGI IDDKNNLTAE 

       370        380        390        400        410        420 
HVPFMENTFH RSWYVPQGAR VYTEKFQCSN DTYVRYVIND AVVPIETCST GPGFSCEIND 

       430        440        450        460 
FYDYAEKRVA GTDFLKVCNV SSVSNSTELT FFWDWNTKHY NDTLLKQ 

« Hide

References

« Hide 'large scale' references
[1]"The primary structure of acid phosphatase gene PHO11 in S. cerevisiae and comparison with other gene families."
Chen J.Y., Gong Y.I., Ao S.Z.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 21:437-444(1989)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 52 Kbp CDC15-FLO1-PHO11-YAR074 region."
Bussey H., Keng T., Storms R.K., Vo D., Zhong W., Fortin N., Barton A.B., Kaback D.B., Clark M.W.
Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19789 Genomic DNA. Translation: AAA73479.1.
L28920 Genomic DNA. Translation: AAC09508.1.
BK006935 Genomic DNA. Translation: DAA07011.1.
PIRS53476.
RefSeqNP_009434.1. NM_001178239.1.

3D structure databases

ProteinModelPortalP35842.
SMRP35842. Positions 37-457.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31819. 8 interactions.
DIPDIP-4589N.
IntActP35842. 1 interaction.
MINTMINT-536024.
STRING4932.YAR071W.

Proteomic databases

MaxQBP35842.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAR071W; YAR071W; YAR071W.
GeneID851299.
KEGGsce:YAR071W.

Organism-specific databases

CYGDYAR071w.
SGDS000000094. PHO11.

Phylogenomic databases

GeneTreeENSGT00510000050349.
HOGENOMHOG000189191.
KOK01078.
OrthoDBEOG7TQV9N.

Enzyme and pathway databases

BioCycYEAST:YAR071W-MONOMER.

Gene expression databases

GenevestigatorP35842.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMSSF53254. SSF53254. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968307.

Entry information

Entry namePPAB_YEAST
AccessionPrimary (citable) accession number: P35842
Secondary accession number(s): D6VPP1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families