P35841 (DCRA_DESVH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemoreceptor protein A

Gene names

Name:	dcrA
Ordered Locus Names:	DVU_3182

Organism

Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) [Reference proteome] [HAMAP]

Taxonomic identifier

882 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio vulgaris

Protein attributes

Sequence length	669 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Subcellular location	Cell membrane; Single-pass membrane protein; Periplasmic side Potential.
Sequence similarities	Contains 1 HAMP domain. Contains 1 methyl-accepting transducer domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transducer
PTM	Methylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphorelay sensor kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 669	669	Chemoreceptor protein A		PRO_0000110564
Regions
	Transmembrane	11 – 31	21	Helical; Potential
	Domain	209 – 261	53	HAMP
	Domain	330 – 382	53	PAC
	Domain	397 – 633	237	Methyl-accepting transducer
Experimental info
	Sequence conflict	248	1	N → K in AAA23379. Ref.1
	Sequence conflict	456 – 460	5	LANGE → CQWR in AAA23379. Ref.1
	Sequence conflict	536	1	V → L in AAA23379. Ref.1
	Sequence conflict	638 – 649	12	GIQRR…EAGDA → ASRDGCGKQAMP in AAA23379. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P35841 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: BB3079D58F3FF9A5	FASTA	669	72,984
	10 20 30 40 50 60 MSTQRSLGTK VMLLVSGISL FVYLILAVLT SYWQRQSALT LIDSGAVRAS ELLLDAIADP 70 80 90 100 110 120 MSKGNDTGTT EKFDAIARRY ADIRAYMTDF RGNITYSTSK DVLRRDLADV VQAPALLDKF 130 140 150 160 170 180 NAALKTDSRE EQLATIDGMA FYATIRSIPN APECHHCHGR SQPILGTLVM LQDVTPAMSE 190 200 210 220 230 240 LRLHQYETVG LSVGGLLLLV GVLSLFMRRA VISRVQRIAA VSGQIEQGDY SVSFEHDGND 250 260 270 280 290 300 ELTRLNANLA SMVTTIRDQM QYNRSVLEGI IVPLAVVDAR NRIEFINQPM CTIVSTACHE 310 320 330 340 350 360 YSGKDFSAFM QQGGVEEDIT ATVLKGGNNQ QGNISYRRDD GTVFPLHYEV SPLRDDRGAV 370 380 390 400 410 420 NGAIAVIIDL TQEEEARRRI EEQRINLLRV ADEVTGVAET LVRAAEALVT RMGELERDAT 430 440 450 460 470 480 EAASETTQVA TAMEEMNVTV TEVARNASST AEMADLANGE AQSGGTEMAN TVRETRQVAQ 490 500 510 520 530 540 RTEDLAESLH ELARRADNIG RVIEVINEIA DQTNLLALNA AIEAARAGDA GRGFAVVADE 550 560 570 580 590 600 VRKLAEKTMV ATREVEQAIA AIQQGSNDAV EVMTETRQQV EVTAGKAEDT GKVLSGIVGR 610 620 630 640 650 660 AESIADMVRN IATASEQQSS TSDEINRNVT RINDLTEGIQ RRVREAGDAI RQVEGMAQRL EALVDGFRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of dcrA, a Desulfovibrio vulgaris Hildenborough chemoreceptor gene, and its expression in Escherichia coli." Dolla A., Fu R., Brumlik M.J., Voordouw G. J. Bacteriol. 174:1726-1733(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough." Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T., Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M., Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Fouts D.E. , Haft D.H., Selengut J., Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D., Voordouw G., Fraser C.M. Nat. Biotechnol. 22:554-559(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M81168 Genomic DNA. Translation: AAA23379.1. AE017285 Genomic DNA. Translation: AAS97652.1.
PIR	A42275.
RefSeq	YP_012392.1. NC_002937.3.
3D structure databases
ProteinModelPortal	P35841.
ModBase	Search...
Protein-protein interaction databases
STRING	882.DVU3182.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS97652; AAS97652; DVU_3182.
GeneID	2793832.
KEGG	dvu:DVU3182.
PATRIC	32065906. VBIDesVul119526_2887.
Phylogenomic databases
eggNOG	COG0840.
KO	K03406.
OMA	NEPACHH.
ProtClustDB	CLSK706222.
Enzyme and pathway databases
BioCyc	DVUL882:GJIL-3265-MONOMER.
Family and domain databases
InterPro	IPR004090. Chemotax_Me-accpt_rcpt. IPR003660. HAMP_linker_domain. IPR004089. MCPsignal_dom. IPR001610. PAC. IPR000014. PAS. IPR000700. PAS-assoc_C. [Graphical view]
Pfam	PF00672. HAMP. 1 hit. PF00015. MCPsignal. 1 hit. [Graphical view]
PRINTS	PR00260. CHEMTRNSDUCR.
SMART	SM00304. HAMP. 2 hits. SM00283. MA. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit. PS50885. HAMP. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCRA_DESVH

Accession

Primary (citable) accession number: P35841

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	May 24, 2004
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program