Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tail needle protein gp26

Gene

26

Organism
Salmonella phage P22 (Bacteriophage P22)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell-perforating component and plug protein of the phage tail machine. Host cell membrane perforation allows viral DNA ejection. Together with gp4 and gp10, gp26 is required for stabilization of the condensed DNA within the capsid by plugging the hole through which the DNA enters.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei200Needle distal tip1

GO - Biological processi

Keywordsi

Molecular functionViral short tail ejection system
Biological processPore-mediated penetration of viral genome into host cell, Viral genome ejection through host cell envelope, Viral penetration into host cytoplasm, Virus entry into host cell

Protein family/group databases

TCDBi1.K.4.1.1. the phage p22 cell envelope-penetrating needle (p22-cen) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tail needle protein gp26
Alternative name(s):
Head completion protein
Packaged DNA stabilization protein
Tail accessory factor gp26
Gene namesi
Name:26
OrganismiSalmonella phage P22 (Bacteriophage P22)
Taxonomic identifieri10754 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeP22virus
Virus hostiSalmonella typhimurium [TaxID: 90371]
Proteomesi
  • UP000001796 Componenti: Genome
  • UP000007960 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Viral tail protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by hostCurated
ChainiPRO_00000777672 – 233Tail needle protein gp26Add BLAST232

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Elongated coiled-coil homotrimer (240A x 25A). Interacts with gp10.2 Publications

Protein-protein interaction databases

DIPiDIP-60502N.

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 7Combined sources4
Beta strandi19 – 22Combined sources4
Turni24 – 26Combined sources3
Helixi29 – 139Combined sources111
Beta strandi142 – 144Combined sources3
Beta strandi155 – 159Combined sources5
Beta strandi161 – 163Combined sources3
Beta strandi166 – 169Combined sources4
Beta strandi179 – 181Combined sources3
Helixi202 – 229Combined sources28
Beta strandi230 – 232Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2POHX-ray2.10A/B/C/D/E/F1-233[»]
3C9IX-ray1.95A/B/C/D/E/F1-233[»]
4LINX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L1-233[»]
4ZKPX-ray2.10A/B1-233[»]
4ZKUX-ray2.50A/B1-233[»]
4ZXQX-ray2.75A/B/C/D/E/F1-140[»]
ProteinModelPortaliP35837.
SMRiP35837.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35837.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati77 – 84Trimerization octad repeat 18
Repeati98 – 105Trimerization octad repeat 28
Repeati112 – 119Trimerization octad repeat 38
Repeati133 – 140Trimerization octad repeat 48
Repeati205 – 212Trimerization octad repeat 58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 27Interaction with gp10Add BLAST26
Regioni28 – 140Fibrous coreAdd BLAST113
Regioni141 – 170Beta-helixAdd BLAST30
Regioni171 – 233LazoAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi216 – 220Basic cluster5

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

OrthoDBiVOG0900012H.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPSLNNPV VIQATRLDAS ILPRNVFSKS YLLYVIAQGT DVGAIAGKAN
60 70 80 90 100
EAGQGAYDAQ VKNDEQDVEL ADHEARIKQL RIDVDDHESR ITANTKAITA
110 120 130 140 150
LNVRVTTAEG EIASLQTNVS ALDGRVTTAE NNISALQADY VSKTATTSQS
160 170 180 190 200
LASPLNVTTS YSVGGKKVLG ARQTGWTAAT GTANKGVFDA DLTFAVSDTY
210 220 230
TQSEIQAIAN ALITERRRTK ALEDALRAHG LID
Length:233
Mass (Da):24,734
Last modified:January 23, 2007 - v2
Checksum:iB4564B274B5564D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169L → V in AAM81393 (PubMed:12562822).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14810 Genomic DNA. Translation: AAA32271.1.
AF217253 Genomic DNA. Translation: AAF75051.1.
AF527608 Genomic DNA. Translation: AAM81393.1.
PIRiS34956.

Similar proteinsi

Entry informationi

Entry nameiNEEDL_BPP22
AccessioniPrimary (citable) accession number: P35837
Secondary accession number(s): Q8LTG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome