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Protein

Granulocyte colony-stimulating factor

Gene

CSF3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte colony-stimulating factor
Short name:
G-CSF
Gene namesi
Name:CSF3
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000587591 – 175Granulocyte colony-stimulating factorAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 43
Disulfide bondi65 ↔ 75
Glycosylationi134O-linked (GalNAc...)By similarity1

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35834.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000023945.

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 39Combined sources28
Helixi45 – 55Combined sources11
Helixi63 – 65Combined sources3
Turni67 – 69Combined sources3
Helixi72 – 92Combined sources21
Turni93 – 95Combined sources3
Turni98 – 100Combined sources3
Helixi101 – 125Combined sources25
Helixi144 – 171Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BGDX-ray2.30A1-175[»]
1BGEX-ray2.20A/B1-175[»]
ProteinModelPortaliP35834.
SMRiP35834.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35834.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.
InParanoidiP35834.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PfamiPF16647. GCSF. 1 hit.
[Graphical view]
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLGPTGPL PQSFLLKCLE QMRKVQADGT ALQETLCATH QLCHPEELVL
60 70 80 90 100
LGHALGIPQP PLSSCSSQAL QLMGCLRQLH SGLFLYQGLL QALAGISPEL
110 120 130 140 150
APTLDTLQLD TTDFAINIWQ QMEDLGMAPA VPPTQGTMPA FTSAFQRRAG
160 170
GVLVASNLQS FLELAYRALR HFAKP
Length:175
Mass (Da):18,858
Last modified:June 1, 1994 - v1
Checksum:i28C26B24990C6DB3
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BGDX-ray2.30A1-175[»]
1BGEX-ray2.20A/B1-175[»]
ProteinModelPortaliP35834.
SMRiP35834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000023945.

Proteomic databases

PaxDbiP35834.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.
InParanoidiP35834.

Miscellaneous databases

EvolutionaryTraceiP35834.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PfamiPF16647. GCSF. 1 hit.
[Graphical view]
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSF3_CANLF
AccessioniPrimary (citable) accession number: P35834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.