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Protein

Granulocyte colony-stimulating factor

Gene

CSF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-BTA-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte colony-stimulating factor
Short name:
G-CSF
Gene namesi
Name:CSF3
Synonyms:GCSF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 195174Granulocyte colony-stimulating factorPRO_0000015568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 63
Disulfide bondi85 ↔ 95
Glycosylationi154 – 1541O-linked (GalNAc...)By similarity

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35833.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021462.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028610.

Structurei

Secondary structure

1
195
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi32 – 6029Combined sources
Helixi65 – 695Combined sources
Helixi72 – 754Combined sources
Helixi83 – 853Combined sources
Turni87 – 893Combined sources
Helixi92 – 11221Combined sources
Turni113 – 1153Combined sources
Turni118 – 1203Combined sources
Helixi121 – 14525Combined sources
Helixi164 – 19128Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BGCX-ray1.70A22-195[»]
ProteinModelPortaliP35833.
SMRiP35833. Positions 29-193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35833.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
GeneTreeiENSGT00390000017328.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.
InParanoidiP35833.
KOiK05423.
OMAiLWHSALW.
OrthoDBiEOG091G0NDU.
TreeFamiTF337698.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PfamiPF16647. GCSF. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLMVLQLLL WHSALWTVHE ATPLGPARSL PQSFLLKCLE QVRKIQADGA
60 70 80 90 100
ELQERLCAAH KLCHPEELML LRHSLGIPQA PLSSCSSQSL QLTSCLNQLH
110 120 130 140 150
GGLFLYQGLL QALAGISPEL APTLDTLQLD VTDFATNIWL QMEDLGAAPA
160 170 180 190
VQPTQGAMPT FTSAFQRRAG GVLVASQLHR FLELAYRGLR YLAEP
Length:195
Mass (Da):21,431
Last modified:April 27, 2001 - v2
Checksum:i8C06119E4ADFBA73
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 942TS → RG (PubMed:7504736).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092533 mRNA. Translation: AAD16102.1.
RefSeqiNP_776453.1. NM_174028.1.
UniGeneiBt.4660.

Genome annotation databases

EnsembliENSBTAT00000028610; ENSBTAP00000028610; ENSBTAG00000021462.
GeneIDi281096.
KEGGibta:281096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092533 mRNA. Translation: AAD16102.1.
RefSeqiNP_776453.1. NM_174028.1.
UniGeneiBt.4660.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BGCX-ray1.70A22-195[»]
ProteinModelPortaliP35833.
SMRiP35833. Positions 29-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028610.

Proteomic databases

PaxDbiP35833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028610; ENSBTAP00000028610; ENSBTAG00000021462.
GeneIDi281096.
KEGGibta:281096.

Organism-specific databases

CTDi1440.

Phylogenomic databases

eggNOGiENOG410IIM2. Eukaryota.
ENOG4111DA4. LUCA.
GeneTreeiENSGT00390000017328.
HOGENOMiHOG000015371.
HOVERGENiHBG005411.
InParanoidiP35833.
KOiK05423.
OMAiLWHSALW.
OrthoDBiEOG091G0NDU.
TreeFamiTF337698.

Enzyme and pathway databases

ReactomeiR-BTA-449147. Signaling by Interleukins.

Miscellaneous databases

EvolutionaryTraceiP35833.

Gene expression databases

BgeeiENSBTAG00000021462.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR030474. IL-6/GCSF/MGF.
IPR030473. IL6/GCSF/MGF_CS.
[Graphical view]
PfamiPF16647. GCSF. 1 hit.
[Graphical view]
PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
PRINTSiPR00433. IL6GCSFMGF.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSF3_BOVIN
AccessioniPrimary (citable) accession number: P35833
Secondary accession number(s): Q9TV89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.