P35832 (PTP99_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase 99A
EC=3.1.3.48

Alternative name(s):
Receptor-linked protein-tyrosine phosphatase 99A
Short name=DPTP99A

Gene names

Name:	Ptp99A
ORF Names:	CG2005

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a key role in signal transduction and growth control. May have a role in the establishment of the intersegmental and segmental nerves. Ref.1
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Selectively expressed in a subset of axons and pioneer neurons (including aCC and RP2) in the embryo. Ref.1 Ref.2 Ref.3
Developmental stage	Start of expression coincides with the onset of axonogenesis. Ref.1
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. Contains 3 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defasciculation of motor neuron axon Inferred from genetic interaction PubMed 8598046. Source: FlyBase motor neuron axon guidance Inferred from genetic interaction PubMed 11178866PubMed 8598046. Source: FlyBase
Cellular_component	axon Inferred from direct assay PubMed 18237413. Source: FlyBase integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 20462449. Source: FlyBase
Molecular_function	transmembrane receptor protein tyrosine phosphatase activity Inferred from sequence or structural similarity Ref.1. Source: FlyBase
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: P35832-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P35832-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1050-1119: Missing.

Isoform C (identifier: P35832-3)

The sequence of this isoform differs from the canonical sequence as follows:
     238-238: R → REFNYVFIWGLFGVKG
     1050-1119: Missing.

Note: No experimental confirmation available.

Isoform D (identifier: P35832-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1050-1058: GNVPQHVIL → AQQRQMLKT
     1059-1301: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 1301	1273	Tyrosine-protein phosphatase 99A		PRO_0000025429
Regions
	Topological domain	29 – 394	366	Extracellular Potential
	Transmembrane	395 – 415	21	Helical; Potential
	Topological domain	416 – 1301	886	Cytoplasmic Potential
	Domain	66 – 165	100	Fibronectin type-III 1
	Domain	171 – 265	95	Fibronectin type-III 2
	Domain	271 – 365	95	Fibronectin type-III 3
	Domain	476 – 741	266	Tyrosine-protein phosphatase 1
	Domain	764 – 1016	253	Tyrosine-protein phosphatase 2
	Compositional bias	34 – 67	34	Ser-rich
	Compositional bias	1054 – 1091	38	Gln-rich
	Compositional bias	1124 – 1128	5	Poly-Ser
	Compositional bias	1228 – 1252	25	Gln-rich
Sites
	Active site	682	1	Phosphocysteine intermediate By similarity
Amino acid modifications
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	176	1	N-linked (GlcNAc...) Potential
	Glycosylation	212	1	N-linked (GlcNAc...) Potential
	Glycosylation	278	1	N-linked (GlcNAc...) Potential
	Glycosylation	322	1	N-linked (GlcNAc...) Potential
	Glycosylation	336	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	238	1	R → REFNYVFIWGLFGVKG in isoform C.		VSP_015261
	Alternative sequence	1050 – 1119	70	Missing in isoform A and isoform C.		VSP_005142
	Alternative sequence	1050 – 1058	9	GNVPQHVIL → AQQRQMLKT in isoform D.		VSP_015262
	Alternative sequence	1059 – 1301	243	Missing in isoform D.		VSP_015263
Experimental info
	Sequence conflict	46	1	V → A in AAF56891. Ref.4
	Sequence conflict	46	1	V → A in AAN14172. Ref.4
	Sequence conflict	46	1	V → A in AAS65222. Ref.4
	Sequence conflict	46	1	V → A in AAX53004. Ref.4
	Sequence conflict	68	1	F → S in AAF56891. Ref.4
	Sequence conflict	68	1	F → S in AAN14172. Ref.4
	Sequence conflict	68	1	F → S in AAS65222. Ref.4
	Sequence conflict	68	1	F → S in AAX53004. Ref.4
	Sequence conflict	83	1	S → T in AAF56891. Ref.4
	Sequence conflict	83	1	S → T in AAN14172. Ref.4
	Sequence conflict	83	1	S → T in AAS65222. Ref.4
	Sequence conflict	83	1	S → T in AAX53004. Ref.4
	Sequence conflict	108	1	A → E in AAF56891. Ref.4
	Sequence conflict	108	1	A → E in AAN14172. Ref.4
	Sequence conflict	108	1	A → E in AAS65222. Ref.4
	Sequence conflict	108	1	A → E in AAX53004. Ref.4
	Sequence conflict	116	1	A → V in AAF56891. Ref.4
	Sequence conflict	116	1	A → V in AAN14172. Ref.4
	Sequence conflict	116	1	A → V in AAS65222. Ref.4
	Sequence conflict	116	1	A → V in AAX53004. Ref.4
	Sequence conflict	586	1	R → P in AAA28483. Ref.3
	Sequence conflict	1133	1	T → P in AAF56891. Ref.4
	Sequence conflict	1133	1	T → P in AAN14172. Ref.4
	Sequence conflict	1133	1	T → P in AAS65222. Ref.4
	Sequence conflict	1167 – 1176	10	ASPVTPATAS → GSPAT in AAF56891. Ref.4
	Sequence conflict	1167 – 1176	10	ASPVTPATAS → GSPAT in AAN14172. Ref.4
	Sequence conflict	1167 – 1176	10	ASPVTPATAS → GSPAT in AAS65222. Ref.4
	Sequence conflict	1205	1	N → H Ref.1
	Sequence conflict	1205	1	N → H Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified August 30, 2005. Version 2. Checksum: AB1FB7A8F5D7D30F	FASTA	1,301	145,396
	10 20 30 40 50 60 MPRPQHHALL RAMLKLLLFA SIAEHCATAL PTNSSNSPSS PSPFTVASLP PTTASSSSSP 70 80 90 100 110 120 AVISTSSFDR NLADLVNPEA ETSGSGWESL ETEFNLATTV DSSTQKTAKE PVLGTAATSI 130 140 150 160 170 180 EQQDQPPDVP ATTLAFANAF PVPVAGEMGN GNGNYNDATP PYAAVDDNYV PSKPQNLTIL 190 200 210 220 230 240 DVSANSITMS WHPPKNQNGA IAGYHVFHIH DNQTGVEIVK NSRNSVETLI HFELQNLRPY 250 260 270 280 290 300 TDYRVIVKAF TTKNEGEPSD QIAQRTDVGG PSAPAIVNLT CHSQESITIR WRRPYEFYNT 310 320 330 340 350 360 IDFYIIKTRL AGQDTHRDIR INASAKELET AMILQNLTTN SYYEVKVAAA TFSVINPKKI 370 380 390 400 410 420 VLGKFSESRI IQLQPNCEKL QPLLRQSHND YNLAVLVGII FSCFGIILII MAFFLWSRKC 430 440 450 460 470 480 FHAAYYYLDD PPHHPNAPQV DWEVPVKIGD EIRAAVPVNE FAKHVASLHA DGDIGFSREY 490 500 510 520 530 540 EAIQNECISD DLPCEHSQHP ENKRKNRYLN ITAYDHSRVH LHPTPGQKKN LDYINANFID 550 560 570 580 590 600 GYQKGHAFIG TQGPLPDTFD CFWRMIWEQR VAIIVMITNL VERGRRKCDM YWPKDGVETY 610 620 630 640 650 660 GVIQVKLIEE EVMSTYTVRT LQIKHLKLKK KKQCNTEKLV YQYHYTNWPD HGTPDHPLPV 670 680 690 700 710 720 LNFVKKSSAA NPAEAGPIVV HCSAGVGRTG TYIVLDAMLK QIQQKNIVNV FGFLRHIRAQ 730 740 750 760 770 780 RNFLVQTEEQ YIFLHDALVE AIASGETNLM AEQVEELKNC TPYLEQQYKN IIQFQPKDIH 790 800 810 820 830 840 IASAMKQVNS IKNRGAIFPI EGSRVHLTPK PGEDGSDYIN ASWLHGFRRL RDFIVTQHPM 850 860 870 880 890 900 AHTIKDFWQM VWDHNAQTVV LLSSLDDINF AQFWPDEATP IESDHYRVKF LNKTNKSDYV 910 920 930 940 950 960 SRDFVIQSIQ DDYELTVKML HCPSWPEMSN PNSIYDFIVD VHERCNDYRN GPIVIVDRYG 970 980 990 1000 1010 1020 GAQACTFCAI SSLAIEMEYC STANVYQYAK LYHNKRPGVW TSSEDIRVIY NILSFLPGNL 1030 1040 1050 1060 1070 1080 NLLKRTALRT EFEDVTTATP DLYSKICSNG NVPQHVILQQ QQLHMLQLQQ QHLETQQQQQ 1090 1100 1110 1120 1130 1140 QQQQQQQQQQ QTALNETVST PSTDTNPSLL PILSLLPPTV APLSSSSSTT PPTPSTPTPQ 1150 1160 1170 1180 1190 1200 PPQTIQLSSH SPSDLSHQIS STVANAASPV TPATASASAG ATPTTPMTPT VPPTIPTIPS 1210 1220 1230 1240 1250 1260 LASQNSLTLT NANFHTVTNN AADLMEHQQQ QMLALMQQQT QLQQQYNTHP QQHHNNVGDL 1270 1280 1290 1300 LMNNADNSPT ASPTITNNNH ITNNNVTSAA ATDAQNLDIV G
	Isoform A [UniParc]. Checksum: DD38E6D4A8505FD2	FASTA	1,231	137,399
	10 20 30 40 50 60 MPRPQHHALL RAMLKLLLFA SIAEHCATAL PTNSSNSPSS PSPFTVASLP PTTASSSSSP 70 80 90 100 110 120 AVISTSSFDR NLADLVNPEA ETSGSGWESL ETEFNLATTV DSSTQKTAKE PVLGTAATSI 130 140 150 160 170 180 EQQDQPPDVP ATTLAFANAF PVPVAGEMGN GNGNYNDATP PYAAVDDNYV PSKPQNLTIL 190 200 210 220 230 240 DVSANSITMS WHPPKNQNGA IAGYHVFHIH DNQTGVEIVK NSRNSVETLI HFELQNLRPY 250 260 270 280 290 300 TDYRVIVKAF TTKNEGEPSD QIAQRTDVGG PSAPAIVNLT CHSQESITIR WRRPYEFYNT 310 320 330 340 350 360 IDFYIIKTRL AGQDTHRDIR INASAKELET AMILQNLTTN SYYEVKVAAA TFSVINPKKI 370 380 390 400 410 420 VLGKFSESRI IQLQPNCEKL QPLLRQSHND YNLAVLVGII FSCFGIILII MAFFLWSRKC 430 440 450 460 470 480 FHAAYYYLDD PPHHPNAPQV DWEVPVKIGD EIRAAVPVNE FAKHVASLHA DGDIGFSREY 490 500 510 520 530 540 EAIQNECISD DLPCEHSQHP ENKRKNRYLN ITAYDHSRVH LHPTPGQKKN LDYINANFID 550 560 570 580 590 600 GYQKGHAFIG TQGPLPDTFD CFWRMIWEQR VAIIVMITNL VERGRRKCDM YWPKDGVETY 610 620 630 640 650 660 GVIQVKLIEE EVMSTYTVRT LQIKHLKLKK KKQCNTEKLV YQYHYTNWPD HGTPDHPLPV 670 680 690 700 710 720 LNFVKKSSAA NPAEAGPIVV HCSAGVGRTG TYIVLDAMLK QIQQKNIVNV FGFLRHIRAQ 730 740 750 760 770 780 RNFLVQTEEQ YIFLHDALVE AIASGETNLM AEQVEELKNC TPYLEQQYKN IIQFQPKDIH 790 800 810 820 830 840 IASAMKQVNS IKNRGAIFPI EGSRVHLTPK PGEDGSDYIN ASWLHGFRRL RDFIVTQHPM 850 860 870 880 890 900 AHTIKDFWQM VWDHNAQTVV LLSSLDDINF AQFWPDEATP IESDHYRVKF LNKTNKSDYV 910 920 930 940 950 960 SRDFVIQSIQ DDYELTVKML HCPSWPEMSN PNSIYDFIVD VHERCNDYRN GPIVIVDRYG 970 980 990 1000 1010 1020 GAQACTFCAI SSLAIEMEYC STANVYQYAK LYHNKRPGVW TSSEDIRVIY NILSFLPGNL 1030 1040 1050 1060 1070 1080 NLLKRTALRT EFEDVTTATP DLYSKICSNV APLSSSSSTT PPTPSTPTPQ PPQTIQLSSH 1090 1100 1110 1120 1130 1140 SPSDLSHQIS STVANAASPV TPATASASAG ATPTTPMTPT VPPTIPTIPS LASQNSLTLT 1150 1160 1170 1180 1190 1200 NANFHTVTNN AADLMEHQQQ QMLALMQQQT QLQQQYNTHP QQHHNNVGDL LMNNADNSPT 1210 1220 1230 ASPTITNNNH ITNNNVTSAA ATDAQNLDIV G
	Isoform C [UniParc]. Checksum: 0517A4F8753FF168	FASTA	1,246	139,157
	10 20 30 40 50 60 MPRPQHHALL RAMLKLLLFA SIAEHCATAL PTNSSNSPSS PSPFTVASLP PTTASSSSSP 70 80 90 100 110 120 AVISTSSFDR NLADLVNPEA ETSGSGWESL ETEFNLATTV DSSTQKTAKE PVLGTAATSI 130 140 150 160 170 180 EQQDQPPDVP ATTLAFANAF PVPVAGEMGN GNGNYNDATP PYAAVDDNYV PSKPQNLTIL 190 200 210 220 230 240 DVSANSITMS WHPPKNQNGA IAGYHVFHIH DNQTGVEIVK NSRNSVETLI HFELQNLREF 250 260 270 280 290 300 NYVFIWGLFG VKGPYTDYRV IVKAFTTKNE GEPSDQIAQR TDVGGPSAPA IVNLTCHSQE 310 320 330 340 350 360 SITIRWRRPY EFYNTIDFYI IKTRLAGQDT HRDIRINASA KELETAMILQ NLTTNSYYEV 370 380 390 400 410 420 KVAAATFSVI NPKKIVLGKF SESRIIQLQP NCEKLQPLLR QSHNDYNLAV LVGIIFSCFG 430 440 450 460 470 480 IILIIMAFFL WSRKCFHAAY YYLDDPPHHP NAPQVDWEVP VKIGDEIRAA VPVNEFAKHV 490 500 510 520 530 540 ASLHADGDIG FSREYEAIQN ECISDDLPCE HSQHPENKRK NRYLNITAYD HSRVHLHPTP 550 560 570 580 590 600 GQKKNLDYIN ANFIDGYQKG HAFIGTQGPL PDTFDCFWRM IWEQRVAIIV MITNLVERGR 610 620 630 640 650 660 RKCDMYWPKD GVETYGVIQV KLIEEEVMST YTVRTLQIKH LKLKKKKQCN TEKLVYQYHY 670 680 690 700 710 720 TNWPDHGTPD HPLPVLNFVK KSSAANPAEA GPIVVHCSAG VGRTGTYIVL DAMLKQIQQK 730 740 750 760 770 780 NIVNVFGFLR HIRAQRNFLV QTEEQYIFLH DALVEAIASG ETNLMAEQVE ELKNCTPYLE 790 800 810 820 830 840 QQYKNIIQFQ PKDIHIASAM KQVNSIKNRG AIFPIEGSRV HLTPKPGEDG SDYINASWLH 850 860 870 880 890 900 GFRRLRDFIV TQHPMAHTIK DFWQMVWDHN AQTVVLLSSL DDINFAQFWP DEATPIESDH 910 920 930 940 950 960 YRVKFLNKTN KSDYVSRDFV IQSIQDDYEL TVKMLHCPSW PEMSNPNSIY DFIVDVHERC 970 980 990 1000 1010 1020 NDYRNGPIVI VDRYGGAQAC TFCAISSLAI EMEYCSTANV YQYAKLYHNK RPGVWTSSED 1030 1040 1050 1060 1070 1080 IRVIYNILSF LPGNLNLLKR TALRTEFEDV TTATPDLYSK ICSNVAPLSS SSSTTPPTPS 1090 1100 1110 1120 1130 1140 TPTPQPPQTI QLSSHSPSDL SHQISSTVAN AASPVTPATA SASAGATPTT PMTPTVPPTI 1150 1160 1170 1180 1190 1200 PTIPSLASQN SLTLTNANFH TVTNNAADLM EHQQQQMLAL MQQQTQLQQQ YNTHPQQHHN 1210 1220 1230 1240 NVGDLLMNNA DNSPTASPTI TNNNHITNNN VTSAAATDAQ NLDIVG
	Isoform D [UniParc]. Checksum: 211DA48DE1DD067C	FASTA	1,058	119,563
	10 20 30 40 50 60 MPRPQHHALL RAMLKLLLFA SIAEHCATAL PTNSSNSPSS PSPFTVASLP PTTASSSSSP 70 80 90 100 110 120 AVISTSSFDR NLADLVNPEA ETSGSGWESL ETEFNLATTV DSSTQKTAKE PVLGTAATSI 130 140 150 160 170 180 EQQDQPPDVP ATTLAFANAF PVPVAGEMGN GNGNYNDATP PYAAVDDNYV PSKPQNLTIL 190 200 210 220 230 240 DVSANSITMS WHPPKNQNGA IAGYHVFHIH DNQTGVEIVK NSRNSVETLI HFELQNLRPY 250 260 270 280 290 300 TDYRVIVKAF TTKNEGEPSD QIAQRTDVGG PSAPAIVNLT CHSQESITIR WRRPYEFYNT 310 320 330 340 350 360 IDFYIIKTRL AGQDTHRDIR INASAKELET AMILQNLTTN SYYEVKVAAA TFSVINPKKI 370 380 390 400 410 420 VLGKFSESRI IQLQPNCEKL QPLLRQSHND YNLAVLVGII FSCFGIILII MAFFLWSRKC 430 440 450 460 470 480 FHAAYYYLDD PPHHPNAPQV DWEVPVKIGD EIRAAVPVNE FAKHVASLHA DGDIGFSREY 490 500 510 520 530 540 EAIQNECISD DLPCEHSQHP ENKRKNRYLN ITAYDHSRVH LHPTPGQKKN LDYINANFID 550 560 570 580 590 600 GYQKGHAFIG TQGPLPDTFD CFWRMIWEQR VAIIVMITNL VERGRRKCDM YWPKDGVETY 610 620 630 640 650 660 GVIQVKLIEE EVMSTYTVRT LQIKHLKLKK KKQCNTEKLV YQYHYTNWPD HGTPDHPLPV 670 680 690 700 710 720 LNFVKKSSAA NPAEAGPIVV HCSAGVGRTG TYIVLDAMLK QIQQKNIVNV FGFLRHIRAQ 730 740 750 760 770 780 RNFLVQTEEQ YIFLHDALVE AIASGETNLM AEQVEELKNC TPYLEQQYKN IIQFQPKDIH 790 800 810 820 830 840 IASAMKQVNS IKNRGAIFPI EGSRVHLTPK PGEDGSDYIN ASWLHGFRRL RDFIVTQHPM 850 860 870 880 890 900 AHTIKDFWQM VWDHNAQTVV LLSSLDDINF AQFWPDEATP IESDHYRVKF LNKTNKSDYV 910 920 930 940 950 960 SRDFVIQSIQ DDYELTVKML HCPSWPEMSN PNSIYDFIVD VHERCNDYRN GPIVIVDRYG 970 980 990 1000 1010 1020 GAQACTFCAI SSLAIEMEYC STANVYQYAK LYHNKRPGVW TSSEDIRVIY NILSFLPGNL 1030 1040 1050 NLLKRTALRT EFEDVTTATP DLYSKICSNA QQRQMLKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS." Yang X., Seow K.T., Bahri S.M., Oon S.H., Chia W. Cell 67:661-673(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo." Tian S.-S., Tsoulfas P., Zinn K. Cell 67:675-685(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY. Tissue: Embryo.
[3]	"Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster." Hariharan I.K., Chuang P.-T., Rubin G.M. Proc. Natl. Acad. Sci. U.S.A. 88:11266-11270(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), TISSUE SPECIFICITY. Tissue: Eye imaginal disk.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M80464 mRNA. Translation: AAA28486.1. M80539 mRNA. Translation: AAA28485.1. M81795 mRNA. Translation: AAA28483.1. AE014297 Genomic DNA. Translation: AAF56891.3. AE014297 Genomic DNA. Translation: AAN14172.1. AE014297 Genomic DNA. Translation: AAS65222.1. AE014297 Genomic DNA. Translation: AAX53004.1.
PIR	A41622.
RefSeq	NP_476816.1. NM_057468.3. NP_733288.1. NM_170409.3. NP_996302.1. NM_206579.3.
UniGene	Dm.4029.
3D structure databases
ProteinModelPortal	P35832.
SMR	P35832. Positions 127-157, 269-375, 455-1013.
ModBase	Search...
Proteomic databases
PaxDb	P35832.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	43469.
KEGG	dme:Dmel_CG11516.
Organism-specific databases
CTD	43469.
FlyBase	FBgn0004369. Ptp99A.
Phylogenomic databases
eggNOG	COG5599.
HOGENOM	HOG000148805.
InParanoid	P35832.
KO	K01104.
OrthoDB	EOG4R7SRK.
Gene expression databases
Bgee	P35832.
GermOnline	CG2005. Drosophila melanogaster.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00041. fn3. 1 hit. PF00102. Y_phosphatase. 2 hits. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 2 hits. SM00194. PTPc. 2 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. 2 hits. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	Ptp99A. drosophila.
GenomeRNAi	43469.
NextBio	834086.

Entry information

Entry name

PTP99_DROME

Accession

Primary (citable) accession number: P35832
Secondary accession number(s): Q59DT5 , Q7KRW3, Q8IMK9, Q9VAL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project