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P35822

- PTPRK_MOUSE

UniProt

P35822 - PTPRK_MOUSE

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Protein
Receptor-type tyrosine-protein phosphatase kappa
Gene
Ptprk, Ptpk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1068 – 10681Substrate By similarity
Active sitei1100 – 11001Phosphocysteine intermediate By similarity
Binding sitei1144 – 11441Substrate By similarity
Active sitei1394 – 13941Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  1. cell migration Source: Ensembl
  2. cellular response to UV Source: Ensembl
  3. cellular response to reactive oxygen species Source: Ensembl
  4. focal adhesion assembly Source: Ensembl
  5. negative regulation of cell cycle Source: Ensembl
  6. negative regulation of cell migration Source: Ensembl
  7. negative regulation of keratinocyte proliferation Source: Ensembl
  8. negative regulation of transcription, DNA-templated Source: Ensembl
  9. neuron projection development Source: Ensembl
  10. peptidyl-tyrosine dephosphorylation Source: GOC
  11. protein dephosphorylation Source: MGI
  12. protein localization to cell surface Source: Ensembl
  13. transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase kappa (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase kappa
Short name:
R-PTP-kappa
Gene namesi
Name:Ptprk
Synonyms:Ptpk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:103310. Ptprk.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 752727Extracellular Reviewed prediction
Add
BLAST
Transmembranei753 – 77422Helical; Reviewed prediction
Add
BLAST
Topological domaini775 – 1457683Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. cell surface Source: Ensembl
  3. cell-cell junction Source: Ensembl
  4. dendrite Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. leading edge membrane Source: Ensembl
  7. neuronal cell body Source: MGI
  8. photoreceptor outer segment Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 14571432Receptor-type tyrosine-protein phosphatase kappa
PRO_0000025447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi139 – 1391N-linked (GlcNAc...)1 Publication
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi215 ↔ 269 Reviewed prediction
Glycosylationi415 – 4151N-linked (GlcNAc...)1 Publication
Glycosylationi423 – 4231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi435 – 4351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi461 – 4611N-linked (GlcNAc...)1 Publication
Glycosylationi551 – 5511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi585 – 5851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi589 – 5891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi606 – 6061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi689 – 6891N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

This protein undergoes proteolytic processing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP35822.
PaxDbiP35822.
PRIDEiP35822.

PTM databases

PhosphoSiteiP35822.

Miscellaneous databases

PMAP-CutDBP35822.

Expressioni

Tissue specificityi

High levels in liver and kidney. Lower levels in lung, brain and heart. Not seen in spleen and testis.

Developmental stagei

Developmentally regulated with highest expression found in developing areas or in areas capable of developmental plasticity.

Gene expression databases

ArrayExpressiP35822.
BgeeiP35822.
CleanExiMM_PTPRK.
GenevestigatoriP35822.

Interactioni

Protein-protein interaction databases

IntActiP35822. 1 interaction.
MINTiMINT-4109163.

Structurei

3D structure databases

ProteinModelPortaliP35822.
SMRiP35822. Positions 32-595, 876-1456.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 193164MAM
Add
BLAST
Domaini195 – 28086Ig-like C2-type
Add
BLAST
Domaini293 – 38896Fibronectin type-III 1
Add
BLAST
Domaini391 – 48797Fibronectin type-III 2
Add
BLAST
Domaini490 – 594105Fibronectin type-III 3
Add
BLAST
Domaini595 – 68894Fibronectin type-III 4
Add
BLAST
Domaini899 – 1159261Tyrosine-protein phosphatase 1
Add
BLAST
Domaini1191 – 1453263Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1100 – 11067Substrate binding By similarity

Sequence similaritiesi

Contains 1 MAM domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00640000091300.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.
InParanoidiP35822.
KOiK06776.
OMAiYRDGYQR.
OrthoDBiEOG70KGNP.
PhylomeDBiP35822.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35822-1 [UniParc]FASTAAdd to Basket

« Hide

MDVAAAALPA FVALWLLYPW PLLGSALGQF SAGGCTFDDG PGACDYHQDL     50
YDDFEWVHVS AQEPHYLPPE MPQGSYMVVD SSNHDPGEKA RLQLPTMKEN 100
DTHCIDFSYL LYSQKGLNPG TLNILVRVNK GPLANPIWNV TGFTGRDWLR 150
AELAVSTFWP NEYQVIFEAE VSGGRSGYIA IDDIQVLSYP CDKSPHFLRL 200
GDVEVNAGQN ATFQCIATGR DAVHNKLWLQ RRNGEDIPVA QTKNINHRRF 250
AASFRLQEVT KTDQDLYRCV TQSERGSGVS NFAQLIVREP PRPIAPPQLL 300
GVGPTYLLIQ LNANSIIGDG PIILKEVEYR MTSGSWTETH AVNAPTYKLW 350
HLDPDTEYEI RVLLTRPGEG GTGLPGPPLI TRTKCAEPMR TPKTLKIAEI 400
QARRIAVDWE SLGYNITRCH TFNVTICYHY FRGHNESRAD CLDMDPKAPQ 450
HVVNHLPPYT NVSLKMILTN PEGRKESEET IIQTDEDVPG PVPVKSLQGT 500
SFENKIFLNW KEPLEPNGII TQYEVSYSSI RSFDPAVPVA GPPQTVSNLW 550
NSTHHVFMHL HPGTTYQFFI RASTVKGFGP ATAINVTTNI SAPSLPDYEG 600
VDASLNETAT TITVLLRPAQ AKGAPISAYQ IVVEQLHPHR TKREAGAMEC 650
YQVPVTYQNA LSGGAPYYFA AELPPGNLPE PAPFTVGDNR TYKGFWNPPL 700
APRKGYNIYF QAMSSVEKET KTQCVRIATK AAATEEPEVI PDPAKQTDRV 750
VKIAGISAGI LVFILLLLVV IVIVKKSKLA KKRKDAMGNT RQEMTHMVNA 800
MDRSYADQST LHAEDPLSLT FMDQHNFSPR LPNDPLVPTA VLDENHSATA 850
ESSRLLDVPR YLCEGTESPY QTGQLHPAIR VADLLQHINL MKTSDSYGFK 900
EEYESFFEGQ SASWDVAKKD QNRAKNRYGN IIAYDHSRVI LQPVEDDPSS 950
DYINANYIDI WLYRDGYQRP SHYIATQGPV HETVYDFWRM VWQEQSACIV 1000
MVTNLVEVGR VKCYKYWPDD TEVYGDFKVT CVEMEPLAEY VVRTFTLERR 1050
GYNEIREVKQ FHFTGWPDHG VPYHATGLLS FIRRVKLSNP PSAGPIVVHC 1100
SAGAGRTGCY IVIDIMLDMA EREGVVDIYN CVKALRSRRI NMVQTEEQYI 1150
FIHDAILEAC LCGETAIPVC EFKAAYFDMI RIDSQTNSSH LKDEFQTLNS 1200
VTPRLQAEDC SIACLPRNHD KNRFMDMLPP DRCLPFLITI DGESSNYINA 1250
ALMDSYRQPA AFIVTQYPLP NTVKDFWRLV YDYGCTSIVM LNEVDLSQGC 1300
PQYWPEEGML RYGPIQVECM SCSMDCDVIN RIFRICNLTR PQEGYLMVQQ 1350
FQYLGWASHR EVPGSKRSFL KLILQVEKWQ EECEEGEGRT IIHCLNGGGR 1400
SGMFCAIGIV VEMVKRQNVV DVFHAVKTLR NSKPNMVEAP EQYRFCYDVA 1450
LEYLESS 1457
Length:1,457
Mass (Da):164,186
Last modified:June 1, 1994 - v1
Checksum:i19D4B99B7ECE8605
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10106 mRNA. Translation: AAA40021.1.
CCDSiCCDS35874.1.
PIRiA48066.
RefSeqiNP_033009.1. NM_008983.2.
UniGeneiMm.332303.

Genome annotation databases

EnsembliENSMUST00000166468; ENSMUSP00000126279; ENSMUSG00000019889.
GeneIDi19272.
KEGGimmu:19272.
UCSCiuc007esk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10106 mRNA. Translation: AAA40021.1 .
CCDSi CCDS35874.1.
PIRi A48066.
RefSeqi NP_033009.1. NM_008983.2.
UniGenei Mm.332303.

3D structure databases

ProteinModelPortali P35822.
SMRi P35822. Positions 32-595, 876-1456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P35822. 1 interaction.
MINTi MINT-4109163.

PTM databases

PhosphoSitei P35822.

Proteomic databases

MaxQBi P35822.
PaxDbi P35822.
PRIDEi P35822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000166468 ; ENSMUSP00000126279 ; ENSMUSG00000019889 .
GeneIDi 19272.
KEGGi mmu:19272.
UCSCi uc007esk.1. mouse.

Organism-specific databases

CTDi 5796.
MGIi MGI:103310. Ptprk.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00640000091300.
HOGENOMi HOG000049029.
HOVERGENi HBG062785.
InParanoidi P35822.
KOi K06776.
OMAi YRDGYQR.
OrthoDBi EOG70KGNP.
PhylomeDBi P35822.
TreeFami TF312900.

Miscellaneous databases

ChiTaRSi PTPRK. mouse.
NextBioi 296162.
PMAP-CutDB P35822.
PROi P35822.
SOURCEi Search...

Gene expression databases

ArrayExpressi P35822.
Bgeei P35822.
CleanExi MM_PTPRK.
Genevestigatori P35822.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region."
    Jiang Y.P., Wang H., D'Eustachio P., Musacchio J.M., Schlessinger J., Sap J.
    Mol. Cell. Biol. 13:2942-2951(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: RI.
    Tissue: Brain.
  2. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-139; ASN-415 AND ASN-461.

Entry informationi

Entry nameiPTPRK_MOUSE
AccessioniPrimary (citable) accession number: P35822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi