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Protein

Type II secretion system protein D

Gene

xcpQ

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.By similarity

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein transporter activity Source: InterPro

GO - Biological processi

  • protein secretion by the type II secretion system Source: PseudoCAP

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3161-MONOMER

Protein family/group databases

TCDBi1.B.22.1.2 the outer bacterial membrane secretin (secretin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Type II secretion system protein D
Short name:
T2SS protein D
Alternative name(s):
General secretion pathway protein D
Gene namesi
Name:xcpQ
Ordered Locus Names:PA3105
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3105

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: UniProtKB-SubCell
  • type II protein secretion system complex Source: PseudoCAP

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001310435 – 658Type II secretion system protein DAdd BLAST624

Proteomic databases

PaxDbiP35818
PRIDEiP35818

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-16224942,EBI-16224942

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-60809N
STRINGi208964.PA3105

Structurei

Secondary structure

1658
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 44Combined sources3
Beta strandi52 – 61Combined sources10
Helixi62 – 73Combined sources12
Beta strandi77 – 79Combined sources3
Beta strandi86 – 96Combined sources11
Helixi97 – 110Combined sources14
Beta strandi113 – 117Combined sources5
Beta strandi119 – 126Combined sources8
Beta strandi145 – 150Combined sources6
Beta strandi152 – 154Combined sources3
Helixi156 – 163Combined sources8
Helixi164 – 166Combined sources3
Beta strandi171 – 176Combined sources6
Helixi177 – 179Combined sources3
Beta strandi181 – 186Combined sources6
Helixi188 – 202Combined sources15
Beta strandi209 – 213Combined sources5
Beta strandi215 – 217Combined sources3
Helixi219 – 231Combined sources13
Beta strandi235 – 237Combined sources3
Beta strandi242 – 246Combined sources5
Helixi247 – 249Combined sources3
Beta strandi251 – 257Combined sources7
Helixi258 – 271Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E9JX-ray2.03A/B35-277[»]
4EC5X-ray2.20A/B35-277[»]
5WLNelectron microscopy3.57A/B/C/D/E/F/G/H/I/J/K/L/M/N/O35-658[»]
ProteinModelPortaliP35818
SMRiP35818
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP D family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105GVR Bacteria
COG1450 LUCA
HOGENOMiHOG000253751
InParanoidiP35818
KOiK02453
OMAiYAVVEMD
PhylomeDBiP35818

Family and domain databases

Gene3Di3.30.1370.120, 3 hits
InterProiView protein in InterPro
IPR001775 GspD/PilQ
IPR005644 NolW-like
IPR038591 NolW-like_sf
IPR004846 T2SS/T3SS
IPR013356 T2SS_GspD
IPR004845 T2SS_GspD_CS
PfamiView protein in Pfam
PF00263 Secretin, 1 hit
PF03958 Secretin_N, 3 hits
PRINTSiPR00811 BCTERIALGSPD
TIGRFAMsiTIGR02517 type_II_gspD, 1 hit
PROSITEiView protein in PROSITE
PS00875 T2SP_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPLLRALF APSSRSYVPA VLLSLALGIQ AAHAENSGGN AFVPAGNQQE
60 70 80 90 100
AHWTINLKDA DIREFIDQIS EITGETFVVD PRVKGQVSVV SKAQLSLSEV
110 120 130 140 150
YQLFLSVMST HGFTVVAQGD QARIVPNAEA KTEAGGGQSA PDRLETRVIQ
160 170 180 190 200
VQQSPVSELI PLIRPLVPQY GHLAAVPSAN ALIISDRSAN IARIEDVIRQ
210 220 230 240 250
LDQKGSHDYS VINLRYGWVM DAAEVLNNAM SRGQAKGAAG AQVIADARTN
260 270 280 290 300
RLIILGPPQA RAKLVQLAQS LDTPTARSAN TRVIRLRHND AKTLAETLGQ
310 320 330 340 350
ISEGMKNNGG QGGEQTGGGR PSNILIRADE STNALVLLAD PDTVNALEDI
360 370 380 390 400
VRQLDVPRAQ VLVEAAIVEI SGDIQDAVGV QWAINKGGMG GTKTNFANTG
410 420 430 440 450
LSIGTLLQSL ESNKAPESIP DGAIVGIGSS SFGALVTALS ANTKSNLLST
460 470 480 490 500
PSLLTLDNQK AEILVGQNVP FQTGSYTTNS EGSSNPFTTV ERKDIGVSLK
510 520 530 540 550
VTPHINDGAA LRLEIEQEIS ALLPNAQQRN NTDLITSKRS IKSTILAENG
560 570 580 590 600
QVIVIGGLIQ DDVSQAESKV PLLGDIPLLG RLFRSTKDTH TKRNLMVFLR
610 620 630 640 650
PTVVRDSAGL AALSGKKYSD IRVIDGTRGP EGRPSILPTN ANQLFDGQAV

DLRELMTE
Length:658
Mass (Da):69,953
Last modified:June 1, 1994 - v1
Checksum:iEC2F81FD1A185D50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68594 Genomic DNA Translation: CAA48582.1
AE004091 Genomic DNA Translation: AAG06493.1
PIRiS39653
RefSeqiNP_251795.1, NC_002516.2
WP_003113934.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG06493; AAG06493; PA3105
GeneIDi880114
KEGGipae:PA3105
PATRICifig|208964.12.peg.3257

Similar proteinsi

Entry informationi

Entry nameiGSPD_PSEAE
AccessioniPrimary (citable) accession number: P35818
Secondary accession number(s): Q9HZB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health