Reviewed, UniProtKB/Swiss-Prot P35810 (GYRA_FIBSU)

Names and origin

Protein names

Recommended name:
    DNA gyrase subunit A
    EC=5.99.1.3

Gene names

Name:

gyrA

Organism

Fibrobacter succinogenes (Bacteroides succinogenes)

Taxonomic identifier

833 [NCBI]

Taxonomic lineage

Bacteria › Fibrobacteres › Fibrobacterales › Fibrobacteraceae › Fibrobacter

Protein attributes

Sequence length	195 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA.
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer.
Sequence similarities	Belongs to the topoisomerase gyrA/parC subunit family.

Ontologies

Keywords
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Isomerase Topoisomerase
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 195	›195	DNA gyrase subunit A		PRO_0000145234
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P35810-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: C0BA2F6DA3C9CC23	FASTA	195	21,010
	10 20 30 40 50 60 DLLMIATKNG QAVTFPISCF RAMGRGTHGV KGITLAEGDE VISLLWLKAG NKILTITEKG 70 80 90 100 110 120 YGKRSEPGSY RVTRRGSKGV RNLNVTDKIG AAVFVESVAD DYDLIITSKD GQVIRIKAAD 130 140 150 160 170 180 IRLTGRNAQG VKAITLRDGD VVKDATALPS VEDIEQDSAD AKETFDKVKG VEVDDDSVVK 190 DDAEKQEIGP TETEE

References

[1]

"The xynC gene from Fibrobacter succinogenes S85 codes for a xylanase with two similar catalytic domains." Paradis F.W., Zhu H., Krell P.J., Phillips J.P., Forsberg C.W. J. Bacteriol. 175:7666-7672(1993) [PubMed: 8244936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S85 / ATCC 19169.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U01037 Genomic DNA. Translation: AAA21849.1.
PIR	A53295.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.99.1.3. 15235.
Family and domain databases
InterPro	IPR006691. GyrA/parC_pinwhl. [Graphical view]
Pfam	PF03989. DNA_gyraseA_C. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GYRA_FIBSU

Accession

Primary (citable) accession number: P35810

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)