P35808 (AKH2_SCHGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Adipokinetic prohormone type 2 Cleaved into the following 2 chains: Adipokinetic hormone 2 Alternative name(s): Adipokinetic hormone II Short name=AKH-II Adipokinetic hormone precursor-related peptide beta chain Short name=APRP-beta
Organism	Schistocerca gregaria (Desert locust)
Taxonomic identifier	7010 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Orthopteroidea › Orthoptera › Caelifera › Acridomorpha › Acridoidea › Acrididae › Cyrtacanthacridinae › Schistocerca

Protein attributes

Sequence length	39 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This hormone, released from cells in the corpora cardiaca after the beginning of flight, causes release of diglycerides from the fat body and then stimulates the flight muscles to use these diglycerides as an energy source.
Subunit structure	Adipokinetic hormone precursor-related peptide (APRP) can form three type of disulfide-bond dimers: p1 (alpha-alpha), p2 (alpha-beta), and p3 (beta-beta).
Subcellular location	Secreted.
Sequence similarities	Belongs to the AKH/HRTH/RPCH family.

Ontologies

Keywords
Biological process	Flight
Cellular component	Secreted
Molecular function	Hormone Neuropeptide
PTM	Amidation Cleavage on pair of basic residues Disulfide bond Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	flight behavior Inferred from electronic annotation. Source: UniProtKB-KW neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 39	39	Adipokinetic prohormone type 2		PRO_0000000920
	Peptide	1 – 8	8	Adipokinetic hormone 2 Ref.2		PRO_0000000921
	Peptide	12 – 39	28	Adipokinetic hormone precursor-related peptide beta chain		PRO_0000000922
Amino acid modifications
	Modified residue	1	1	Pyrrolidone carboxylic acid
	Modified residue	8	1	Tryptophan amide
	Disulfide bond	37		Interchain

Sequences

	Sequence		Length	Mass (Da)
	P35808-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: DB80C45CE57310C3	FASTA	39	4,371
	10 20 30 QLNFSTGWGR RYADPNADPM AFLTKLIQIE ARKLSGCSN

References

[1]	"Regulation of neuropeptide stoichiometry in neurosecretory cells." Hekimi S., Fischer-Lougheed J., O'Shea M. J. Neurosci. 11:3246-3256(1991) [PubMed: 1941082] [Abstract] Cited for: PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING.
[2]	"Primary structures of locust adipokinetic hormones II." Siegert K., Morgan P., Mordue W. Biol. Chem. Hoppe-Seyler 366:723-727(1985) [PubMed: 4063072] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-8.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR010475. Adipokinetic_2. IPR002047. Adipokinetic_hormone_CS. [Graphical view]
Pfam	PF06377. Adipokin_hormo. 1 hit. [Graphical view]
PROSITE	PS00256. AKH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AKH2_SCHGR

Accession

Primary (citable) accession number: P35808
Secondary accession number(s): P08378

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	June 1, 1994
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)