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P35789

- ZNF93_HUMAN

UniProt

P35789 - ZNF93_HUMAN

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Protein

Zinc finger protein 93

Gene

ZNF93

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 93
Alternative name(s):
Zinc finger protein 505
Zinc finger protein HTF34
Gene namesi
Name:ZNF93
Synonyms:ZNF505
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13169. ZNF93.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Zinc finger protein 93PRO_0000047402Add
BLAST

Proteomic databases

PRIDEiP35789.

PTM databases

PhosphoSiteiP35789.

Expressioni

Developmental stagei

Expressed early during embryonic development.

Gene expression databases

BgeeiP35789.
CleanExiHS_ZNF93.
ExpressionAtlasiP35789. baseline and differential.
GenevestigatoriP35789.

Interactioni

Protein-protein interaction databases

BioGridi123631. 2 interactions.
STRINGi9606.ENSP00000342002.

Structurei

3D structure databases

ProteinModelPortaliP35789.
SMRiP35789. Positions 143-620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00550000074383.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP35789.
KOiK09228.
OMAiNAFCFSS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP35789.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P35789-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP
60 70 80 90 100
DLIAHLEQGK KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL
110 120 130 140 150
RRYEKRGHGN LQLIKRCESV DECKVHTGGY NGLNQCSTTT QSKVFQCDKY
160 170 180 190 200
GKVFHKFSNS NRHNIRHTEK KPFKCIECGK AFNQFSTLIT HKKIHTGEKP
210 220 230 240 250
YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA SSTLSKHEII
260 270 280 290 300
HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL
310 320 330 340 350
TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF
360 370 380 390 400
IASSTLSRHE FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE
410 420 430 440 450
ECGKAFKYSS TLSSHKRSHT GEKPYKCEEC GKAFVASSTL SKHEIIHTGK
460 470 480 490 500
KPYKCEECGK AFNQSSSLTK HKKIHTGEKP YKCEECGKAF NQSSSLTKHK
510 520 530 540 550
KIHTGEKPYK CEECGKAFNQ SSTLIKHKKI HTREKPYKCE ECGKAFHLST
560 570 580 590 600
HLTTHKILHT GEKPYRCREC GKAFNHSATL SSHKKIHSGE KPYECDKCGK
610 620
AFISPSSLSR HEIIHTGEKP
Length:620
Mass (Da):70,971
Last modified:January 10, 2006 - v4
Checksum:i722A49B2EA82801A
GO
Isoform 2 (identifier: P35789-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-418: Missing.

Note: No experimental confirmation available.

Show »
Length:592
Mass (Da):67,799
Checksum:i6718FB94ED926F46
GO
Isoform 3 (identifier: P35789-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-582: Missing.

Note: No experimental confirmation available.

Show »
Length:536
Mass (Da):61,323
Checksum:iD9515EAF8AE19FD1
GO

Sequence cautioni

The sequence BAB14093.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751S → SGP in AAA83548. (PubMed:2023909)Curated
Sequence conflicti89 – 891Q → H in AAA83548. (PubMed:2023909)Curated
Sequence conflicti119 – 1191S → R in AAA83548. (PubMed:2023909)Curated
Sequence conflicti136 – 1361C → S in AAA83548. (PubMed:2023909)Curated
Sequence conflicti153 – 1531V → D in AAA83548. (PubMed:2023909)Curated
Sequence conflicti337 – 3371G → E in BAC04764. (PubMed:14702039)Curated
Sequence conflicti597 – 5971K → E in BAC04764. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti93 – 931D → Y.1 Publication
Corresponds to variant rs12151060 [ dbSNP | Ensembl ].
VAR_052768

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei391 – 41828Missing in isoform 2. 1 PublicationVSP_016988Add
BLAST
Alternative sequencei499 – 58284Missing in isoform 3. 1 PublicationVSP_016989Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022550 mRNA. Translation: BAB14093.1. Different initiation.
AK096342 mRNA. Translation: BAC04764.1.
AC007204 Genomic DNA. Translation: AAD22981.1. Sequence problems.
AC011477 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84866.1.
BC136718 mRNA. Translation: AAI36719.1.
BC136719 mRNA. Translation: AAI36720.1.
M61873 Genomic DNA. Translation: AAA83548.1.
CCDSiCCDS32973.1. [P35789-1]
PIRiH39384.
RefSeqiNP_112495.2. NM_031218.3. [P35789-1]
UniGeneiHs.301059.
Hs.723768.

Genome annotation databases

EnsembliENST00000343769; ENSP00000342002; ENSG00000184635. [P35789-1]
GeneIDi81931.
KEGGihsa:81931.
UCSCiuc002non.3. human. [P35789-1]

Polymorphism databases

DMDMi85681872.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022550 mRNA. Translation: BAB14093.1 . Different initiation.
AK096342 mRNA. Translation: BAC04764.1 .
AC007204 Genomic DNA. Translation: AAD22981.1 . Sequence problems.
AC011477 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84866.1 .
BC136718 mRNA. Translation: AAI36719.1 .
BC136719 mRNA. Translation: AAI36720.1 .
M61873 Genomic DNA. Translation: AAA83548.1 .
CCDSi CCDS32973.1. [P35789-1 ]
PIRi H39384.
RefSeqi NP_112495.2. NM_031218.3. [P35789-1 ]
UniGenei Hs.301059.
Hs.723768.

3D structure databases

ProteinModelPortali P35789.
SMRi P35789. Positions 143-620.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123631. 2 interactions.
STRINGi 9606.ENSP00000342002.

PTM databases

PhosphoSitei P35789.

Polymorphism databases

DMDMi 85681872.

Proteomic databases

PRIDEi P35789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343769 ; ENSP00000342002 ; ENSG00000184635 . [P35789-1 ]
GeneIDi 81931.
KEGGi hsa:81931.
UCSCi uc002non.3. human. [P35789-1 ]

Organism-specific databases

CTDi 81931.
GeneCardsi GC19P020012.
HGNCi HGNC:13169. ZNF93.
MIMi 603975. gene.
neXtProti NX_P35789.
PharmGKBi PA37741.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00550000074383.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P35789.
KOi K09228.
OMAi NAFCFSS.
OrthoDBi EOG7KSX7Q.
PhylomeDBi P35789.
TreeFami TF342117.

Miscellaneous databases

ChiTaRSi ZNF93. human.
GenomeRNAii 81931.
NextBioi 72275.
PROi P35789.
SOURCEi Search...

Gene expression databases

Bgeei P35789.
CleanExi HS_ZNF93.
ExpressionAtlasi P35789. baseline and differential.
Genevestigatori P35789.

Family and domain databases

Gene3Di 3.30.160.60. 17 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-620 (ISOFORM 3), VARIANT TYR-93.
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.
  5. "The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
    Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-195.

Entry informationi

Entry nameiZNF93_HUMAN
AccessioniPrimary (citable) accession number: P35789
Secondary accession number(s): A6NMY2
, B9EGT2, Q8N8Q4, Q9H9X5, Q9Y2N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3