P35789 (ZNF93_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 93

Alternative name(s):
Zinc finger protein 505
Zinc finger protein HTF34

Gene names

Name:	ZNF93
Synonyms:	ZNF505

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	620 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Developmental stage	Expressed early during embryonic development.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 17 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence BAB14093.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement Ref.5. Source: UniProtKB zinc ion binding Non-traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35789-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35789-2)

The sequence of this isoform differs from the canonical sequence as follows:
     391-418: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P35789-3)

The sequence of this isoform differs from the canonical sequence as follows:
     499-582: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 620	620	Zinc finger protein 93		PRO_0000047402
Regions
	Domain	4 – 75	72	KRAB
	Zinc finger	145 – 167	23	C2H2-type 1; degenerate
	Zinc finger	173 – 195	23	C2H2-type 2
	Zinc finger	201 – 223	23	C2H2-type 3
	Zinc finger	229 – 251	23	C2H2-type 4
	Zinc finger	257 – 279	23	C2H2-type 5
	Zinc finger	285 – 307	23	C2H2-type 6
	Zinc finger	313 – 335	23	C2H2-type 7
	Zinc finger	341 – 363	23	C2H2-type 8
	Zinc finger	369 – 391	23	C2H2-type 9
	Zinc finger	397 – 419	23	C2H2-type 10
	Zinc finger	425 – 447	23	C2H2-type 11
	Zinc finger	453 – 475	23	C2H2-type 12
	Zinc finger	481 – 503	23	C2H2-type 13
	Zinc finger	509 – 531	23	C2H2-type 14
	Zinc finger	537 – 559	23	C2H2-type 15
	Zinc finger	565 – 587	23	C2H2-type 16
	Zinc finger	593 – 615	23	C2H2-type 17
Natural variations
	Alternative sequence	391 – 418	28	Missing in isoform 2.		VSP_016988
	Alternative sequence	499 – 582	84	Missing in isoform 3.		VSP_016989
	Natural variant	93	1	D → Y. Ref.1 Corresponds to variant rs12151060 [ dbSNP | Ensembl ].		VAR_052768
Experimental info
	Sequence conflict	75	1	S → SGP in AAA83548. Ref.5
	Sequence conflict	89	1	Q → H in AAA83548. Ref.5
	Sequence conflict	119	1	S → R in AAA83548. Ref.5
	Sequence conflict	136	1	C → S in AAA83548. Ref.5
	Sequence conflict	153	1	V → D in AAA83548. Ref.5
	Sequence conflict	337	1	G → E in BAC04764. Ref.1
	Sequence conflict	597	1	K → E in BAC04764. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 4. Checksum: 722A49B2EA82801A	FASTA	620	70,971
	10 20 30 40 50 60 MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP DLIAHLEQGK 70 80 90 100 110 120 KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL RRYEKRGHGN LQLIKRCESV 130 140 150 160 170 180 DECKVHTGGY NGLNQCSTTT QSKVFQCDKY GKVFHKFSNS NRHNIRHTEK KPFKCIECGK 190 200 210 220 230 240 AFNQFSTLIT HKKIHTGEKP YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA 250 260 270 280 290 300 SSTLSKHEII HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL 310 320 330 340 350 360 TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF IASSTLSRHE 370 380 390 400 410 420 FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE ECGKAFKYSS TLSSHKRSHT 430 440 450 460 470 480 GEKPYKCEEC GKAFVASSTL SKHEIIHTGK KPYKCEECGK AFNQSSSLTK HKKIHTGEKP 490 500 510 520 530 540 YKCEECGKAF NQSSSLTKHK KIHTGEKPYK CEECGKAFNQ SSTLIKHKKI HTREKPYKCE 550 560 570 580 590 600 ECGKAFHLST HLTTHKILHT GEKPYRCREC GKAFNHSATL SSHKKIHSGE KPYECDKCGK 610 620 AFISPSSLSR HEIIHTGEKP
	Isoform 2 [UniParc]. Checksum: 6718FB94ED926F46	FASTA	592	67,799
	10 20 30 40 50 60 MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP DLIAHLEQGK 70 80 90 100 110 120 KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL RRYEKRGHGN LQLIKRCESV 130 140 150 160 170 180 DECKVHTGGY NGLNQCSTTT QSKVFQCDKY GKVFHKFSNS NRHNIRHTEK KPFKCIECGK 190 200 210 220 230 240 AFNQFSTLIT HKKIHTGEKP YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA 250 260 270 280 290 300 SSTLSKHEII HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL 310 320 330 340 350 360 TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF IASSTLSRHE 370 380 390 400 410 420 FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE ECGKAFVASS TLSKHEIIHT 430 440 450 460 470 480 GKKPYKCEEC GKAFNQSSSL TKHKKIHTGE KPYKCEECGK AFNQSSSLTK HKKIHTGEKP 490 500 510 520 530 540 YKCEECGKAF NQSSTLIKHK KIHTREKPYK CEECGKAFHL STHLTTHKIL HTGEKPYRCR 550 560 570 580 590 ECGKAFNHSA TLSSHKKIHS GEKPYECDKC GKAFISPSSL SRHEIIHTGE KP
	Isoform 3 [UniParc]. Checksum: D9515EAF8AE19FD1	FASTA	536	61,323
	10 20 30 40 50 60 MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP DLIAHLEQGK 70 80 90 100 110 120 KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL RRYEKRGHGN LQLIKRCESV 130 140 150 160 170 180 DECKVHTGGY NGLNQCSTTT QSKVFQCDKY GKVFHKFSNS NRHNIRHTEK KPFKCIECGK 190 200 210 220 230 240 AFNQFSTLIT HKKIHTGEKP YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA 250 260 270 280 290 300 SSTLSKHEII HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL 310 320 330 340 350 360 TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF IASSTLSRHE 370 380 390 400 410 420 FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE ECGKAFKYSS TLSSHKRSHT 430 440 450 460 470 480 GEKPYKCEEC GKAFVASSTL SKHEIIHTGK KPYKCEECGK AFNQSSSLTK HKKIHTGEKP 490 500 510 520 530 YKCEECGKAF NQSSSLTKHK KIHSGEKPYE CDKCGKAFIS PSSLSRHEII HTGEKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-620 (ISOFORM 3), VARIANT TYR-93. Tissue: Teratocarcinoma.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Testis.
[5]	"The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins." Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A. Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-195.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022550 mRNA. Translation: BAB14093.1. Different initiation. AK096342 mRNA. Translation: BAC04764.1. AC007204 Genomic DNA. Translation: AAD22981.1. Sequence problems. AC011477 Genomic DNA. No translation available. CH471106 Genomic DNA. Translation: EAW84866.1. BC136718 mRNA. Translation: AAI36719.1. BC136719 mRNA. Translation: AAI36720.1. M61873 Genomic DNA. Translation: AAA83548.1.
IPI	IPI00384789. IPI00396397. IPI00552967.
PIR	H39384.
RefSeq	NP_112495.2. NM_031218.3.
UniGene	Hs.723768.
3D structure databases
ProteinModelPortal	P35789.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000342002.
PTM databases
PhosphoSite	P35789.
Polymorphism databases
DMDM	85681872.
Proteomic databases
PRIDE	P35789.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343769; ENSP00000342002; ENSG00000184635.
GeneID	81931.
KEGG	hsa:81931.
UCSC	uc002non.3. human.
Organism-specific databases
CTD	81931.
GeneCards	GC19P019979.
HGNC	HGNC:13169. ZNF93.
MIM	603975. gene.
neXtProt	NX_P35789.
PharmGKB	PA37741.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	P35789.
KO	K09228.
OMA	IHMGKKH.
Gene expression databases
ArrayExpress	P35789.
Bgee	P35789.
CleanEx	HS_ZNF93.
Genevestigator	P35789.
GermOnline	ENSG00000081665. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 17 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 17 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 16 hits. PS50157. ZINC_FINGER_C2H2_2. 17 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF93. human.
GenomeRNAi	81931.
NextBio	72275.
SOURCE	Search...

Entry information

Entry name

ZNF93_HUMAN

Accession

Primary (citable) accession number: P35789
Secondary accession number(s): A6NMY2 , B9EGT2, Q8N8Q4, Q9H9X5, Q9Y2N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 124 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.