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P35789

- ZNF93_HUMAN

UniProt

P35789 - ZNF93_HUMAN

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Protein
Zinc finger protein 93
Gene
ZNF93, ZNF505
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degenerate
Add
BLAST
Zinc fingeri173 – 19523C2H2-type 2
Add
BLAST
Zinc fingeri201 – 22323C2H2-type 3
Add
BLAST
Zinc fingeri229 – 25123C2H2-type 4
Add
BLAST
Zinc fingeri257 – 27923C2H2-type 5
Add
BLAST
Zinc fingeri285 – 30723C2H2-type 6
Add
BLAST
Zinc fingeri313 – 33523C2H2-type 7
Add
BLAST
Zinc fingeri341 – 36323C2H2-type 8
Add
BLAST
Zinc fingeri369 – 39123C2H2-type 9
Add
BLAST
Zinc fingeri397 – 41923C2H2-type 10
Add
BLAST
Zinc fingeri425 – 44723C2H2-type 11
Add
BLAST
Zinc fingeri453 – 47523C2H2-type 12
Add
BLAST
Zinc fingeri481 – 50323C2H2-type 13
Add
BLAST
Zinc fingeri509 – 53123C2H2-type 14
Add
BLAST
Zinc fingeri537 – 55923C2H2-type 15
Add
BLAST
Zinc fingeri565 – 58723C2H2-type 16
Add
BLAST
Zinc fingeri593 – 61523C2H2-type 17
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 93
Alternative name(s):
Zinc finger protein 505
Zinc finger protein HTF34
Gene namesi
Name:ZNF93
Synonyms:ZNF505
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13169. ZNF93.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Zinc finger protein 93
PRO_0000047402Add
BLAST

Proteomic databases

PRIDEiP35789.

PTM databases

PhosphoSiteiP35789.

Expressioni

Developmental stagei

Expressed early during embryonic development.

Gene expression databases

ArrayExpressiP35789.
BgeeiP35789.
CleanExiHS_ZNF93.
GenevestigatoriP35789.

Interactioni

Protein-protein interaction databases

BioGridi123631. 1 interaction.
STRINGi9606.ENSP00000342002.

Structurei

3D structure databases

ProteinModelPortaliP35789.
SMRiP35789. Positions 143-620.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRAB
Add
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP35789.
KOiK09228.
OMAiNAFCFSS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP35789.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P35789-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP    50
DLIAHLEQGK KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL 100
RRYEKRGHGN LQLIKRCESV DECKVHTGGY NGLNQCSTTT QSKVFQCDKY 150
GKVFHKFSNS NRHNIRHTEK KPFKCIECGK AFNQFSTLIT HKKIHTGEKP 200
YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA SSTLSKHEII 250
HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL 300
TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF 350
IASSTLSRHE FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE 400
ECGKAFKYSS TLSSHKRSHT GEKPYKCEEC GKAFVASSTL SKHEIIHTGK 450
KPYKCEECGK AFNQSSSLTK HKKIHTGEKP YKCEECGKAF NQSSSLTKHK 500
KIHTGEKPYK CEECGKAFNQ SSTLIKHKKI HTREKPYKCE ECGKAFHLST 550
HLTTHKILHT GEKPYRCREC GKAFNHSATL SSHKKIHSGE KPYECDKCGK 600
AFISPSSLSR HEIIHTGEKP 620
Length:620
Mass (Da):70,971
Last modified:January 10, 2006 - v4
Checksum:i722A49B2EA82801A
GO
Isoform 2 (identifier: P35789-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-418: Missing.

Note: No experimental confirmation available.

Show »
Length:592
Mass (Da):67,799
Checksum:i6718FB94ED926F46
GO
Isoform 3 (identifier: P35789-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-582: Missing.

Note: No experimental confirmation available.

Show »
Length:536
Mass (Da):61,323
Checksum:iD9515EAF8AE19FD1
GO

Sequence cautioni

The sequence BAB14093.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti93 – 931D → Y.1 Publication
Corresponds to variant rs12151060 [ dbSNP | Ensembl ].
VAR_052768

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei391 – 41828Missing in isoform 2.
VSP_016988Add
BLAST
Alternative sequencei499 – 58284Missing in isoform 3.
VSP_016989Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751S → SGP in AAA83548. 1 Publication
Sequence conflicti89 – 891Q → H in AAA83548. 1 Publication
Sequence conflicti119 – 1191S → R in AAA83548. 1 Publication
Sequence conflicti136 – 1361C → S in AAA83548. 1 Publication
Sequence conflicti153 – 1531V → D in AAA83548. 1 Publication
Sequence conflicti337 – 3371G → E in BAC04764. 1 Publication
Sequence conflicti597 – 5971K → E in BAC04764. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022550 mRNA. Translation: BAB14093.1. Different initiation.
AK096342 mRNA. Translation: BAC04764.1.
AC007204 Genomic DNA. Translation: AAD22981.1. Sequence problems.
AC011477 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84866.1.
BC136718 mRNA. Translation: AAI36719.1.
BC136719 mRNA. Translation: AAI36720.1.
M61873 Genomic DNA. Translation: AAA83548.1.
CCDSiCCDS32973.1. [P35789-1]
PIRiH39384.
RefSeqiNP_112495.2. NM_031218.3. [P35789-1]
UniGeneiHs.301059.
Hs.723768.

Genome annotation databases

EnsembliENST00000343769; ENSP00000342002; ENSG00000184635. [P35789-1]
GeneIDi81931.
KEGGihsa:81931.
UCSCiuc002non.3. human. [P35789-1]

Polymorphism databases

DMDMi85681872.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022550 mRNA. Translation: BAB14093.1 . Different initiation.
AK096342 mRNA. Translation: BAC04764.1 .
AC007204 Genomic DNA. Translation: AAD22981.1 . Sequence problems.
AC011477 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84866.1 .
BC136718 mRNA. Translation: AAI36719.1 .
BC136719 mRNA. Translation: AAI36720.1 .
M61873 Genomic DNA. Translation: AAA83548.1 .
CCDSi CCDS32973.1. [P35789-1 ]
PIRi H39384.
RefSeqi NP_112495.2. NM_031218.3. [P35789-1 ]
UniGenei Hs.301059.
Hs.723768.

3D structure databases

ProteinModelPortali P35789.
SMRi P35789. Positions 143-620.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123631. 1 interaction.
STRINGi 9606.ENSP00000342002.

PTM databases

PhosphoSitei P35789.

Polymorphism databases

DMDMi 85681872.

Proteomic databases

PRIDEi P35789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343769 ; ENSP00000342002 ; ENSG00000184635 . [P35789-1 ]
GeneIDi 81931.
KEGGi hsa:81931.
UCSCi uc002non.3. human. [P35789-1 ]

Organism-specific databases

CTDi 81931.
GeneCardsi GC19P020012.
HGNCi HGNC:13169. ZNF93.
MIMi 603975. gene.
neXtProti NX_P35789.
PharmGKBi PA37741.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P35789.
KOi K09228.
OMAi NAFCFSS.
OrthoDBi EOG7KSX7Q.
PhylomeDBi P35789.
TreeFami TF342117.

Miscellaneous databases

ChiTaRSi ZNF93. human.
GenomeRNAii 81931.
NextBioi 72275.
PROi P35789.
SOURCEi Search...

Gene expression databases

ArrayExpressi P35789.
Bgeei P35789.
CleanExi HS_ZNF93.
Genevestigatori P35789.

Family and domain databases

Gene3Di 3.30.160.60. 17 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-620 (ISOFORM 3), VARIANT TYR-93.
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.
  5. "The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
    Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-195.

Entry informationi

Entry nameiZNF93_HUMAN
AccessioniPrimary (citable) accession number: P35789
Secondary accession number(s): A6NMY2
, B9EGT2, Q8N8Q4, Q9H9X5, Q9Y2N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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