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P35789

- ZNF93_HUMAN

UniProt

P35789 - ZNF93_HUMAN

Protein

Zinc finger protein 93

Gene

ZNF93

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 4 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri509 – 53123C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri537 – 55923C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri565 – 58723C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri593 – 61523C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 93
    Alternative name(s):
    Zinc finger protein 505
    Zinc finger protein HTF34
    Gene namesi
    Name:ZNF93
    Synonyms:ZNF505
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13169. ZNF93.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37741.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 620620Zinc finger protein 93PRO_0000047402Add
    BLAST

    Proteomic databases

    PRIDEiP35789.

    PTM databases

    PhosphoSiteiP35789.

    Expressioni

    Developmental stagei

    Expressed early during embryonic development.

    Gene expression databases

    ArrayExpressiP35789.
    BgeeiP35789.
    CleanExiHS_ZNF93.
    GenevestigatoriP35789.

    Interactioni

    Protein-protein interaction databases

    BioGridi123631. 1 interaction.
    STRINGi9606.ENSP00000342002.

    Structurei

    3D structure databases

    ProteinModelPortaliP35789.
    SMRiP35789. Positions 143-620.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri173 – 19523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri509 – 53123C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri537 – 55923C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri565 – 58723C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri593 – 61523C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP35789.
    KOiK09228.
    OMAiNAFCFSS.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiP35789.
    TreeFamiTF342117.

    Family and domain databases

    Gene3Di3.30.160.60. 17 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 17 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 17 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P35789-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP    50
    DLIAHLEQGK KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL 100
    RRYEKRGHGN LQLIKRCESV DECKVHTGGY NGLNQCSTTT QSKVFQCDKY 150
    GKVFHKFSNS NRHNIRHTEK KPFKCIECGK AFNQFSTLIT HKKIHTGEKP 200
    YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA SSTLSKHEII 250
    HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL 300
    TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF 350
    IASSTLSRHE FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE 400
    ECGKAFKYSS TLSSHKRSHT GEKPYKCEEC GKAFVASSTL SKHEIIHTGK 450
    KPYKCEECGK AFNQSSSLTK HKKIHTGEKP YKCEECGKAF NQSSSLTKHK 500
    KIHTGEKPYK CEECGKAFNQ SSTLIKHKKI HTREKPYKCE ECGKAFHLST 550
    HLTTHKILHT GEKPYRCREC GKAFNHSATL SSHKKIHSGE KPYECDKCGK 600
    AFISPSSLSR HEIIHTGEKP 620
    Length:620
    Mass (Da):70,971
    Last modified:January 10, 2006 - v4
    Checksum:i722A49B2EA82801A
    GO
    Isoform 2 (identifier: P35789-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         391-418: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:592
    Mass (Da):67,799
    Checksum:i6718FB94ED926F46
    GO
    Isoform 3 (identifier: P35789-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         499-582: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:536
    Mass (Da):61,323
    Checksum:iD9515EAF8AE19FD1
    GO

    Sequence cautioni

    The sequence BAB14093.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751S → SGP in AAA83548. (PubMed:2023909)Curated
    Sequence conflicti89 – 891Q → H in AAA83548. (PubMed:2023909)Curated
    Sequence conflicti119 – 1191S → R in AAA83548. (PubMed:2023909)Curated
    Sequence conflicti136 – 1361C → S in AAA83548. (PubMed:2023909)Curated
    Sequence conflicti153 – 1531V → D in AAA83548. (PubMed:2023909)Curated
    Sequence conflicti337 – 3371G → E in BAC04764. (PubMed:14702039)Curated
    Sequence conflicti597 – 5971K → E in BAC04764. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti93 – 931D → Y.1 Publication
    Corresponds to variant rs12151060 [ dbSNP | Ensembl ].
    VAR_052768

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei391 – 41828Missing in isoform 2. 1 PublicationVSP_016988Add
    BLAST
    Alternative sequencei499 – 58284Missing in isoform 3. 1 PublicationVSP_016989Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022550 mRNA. Translation: BAB14093.1. Different initiation.
    AK096342 mRNA. Translation: BAC04764.1.
    AC007204 Genomic DNA. Translation: AAD22981.1. Sequence problems.
    AC011477 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84866.1.
    BC136718 mRNA. Translation: AAI36719.1.
    BC136719 mRNA. Translation: AAI36720.1.
    M61873 Genomic DNA. Translation: AAA83548.1.
    CCDSiCCDS32973.1. [P35789-1]
    PIRiH39384.
    RefSeqiNP_112495.2. NM_031218.3. [P35789-1]
    UniGeneiHs.301059.
    Hs.723768.

    Genome annotation databases

    EnsembliENST00000343769; ENSP00000342002; ENSG00000184635. [P35789-1]
    GeneIDi81931.
    KEGGihsa:81931.
    UCSCiuc002non.3. human. [P35789-1]

    Polymorphism databases

    DMDMi85681872.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022550 mRNA. Translation: BAB14093.1 . Different initiation.
    AK096342 mRNA. Translation: BAC04764.1 .
    AC007204 Genomic DNA. Translation: AAD22981.1 . Sequence problems.
    AC011477 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84866.1 .
    BC136718 mRNA. Translation: AAI36719.1 .
    BC136719 mRNA. Translation: AAI36720.1 .
    M61873 Genomic DNA. Translation: AAA83548.1 .
    CCDSi CCDS32973.1. [P35789-1 ]
    PIRi H39384.
    RefSeqi NP_112495.2. NM_031218.3. [P35789-1 ]
    UniGenei Hs.301059.
    Hs.723768.

    3D structure databases

    ProteinModelPortali P35789.
    SMRi P35789. Positions 143-620.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123631. 1 interaction.
    STRINGi 9606.ENSP00000342002.

    PTM databases

    PhosphoSitei P35789.

    Polymorphism databases

    DMDMi 85681872.

    Proteomic databases

    PRIDEi P35789.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343769 ; ENSP00000342002 ; ENSG00000184635 . [P35789-1 ]
    GeneIDi 81931.
    KEGGi hsa:81931.
    UCSCi uc002non.3. human. [P35789-1 ]

    Organism-specific databases

    CTDi 81931.
    GeneCardsi GC19P020012.
    HGNCi HGNC:13169. ZNF93.
    MIMi 603975. gene.
    neXtProti NX_P35789.
    PharmGKBi PA37741.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P35789.
    KOi K09228.
    OMAi NAFCFSS.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi P35789.
    TreeFami TF342117.

    Miscellaneous databases

    ChiTaRSi ZNF93. human.
    GenomeRNAii 81931.
    NextBioi 72275.
    PROi P35789.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35789.
    Bgeei P35789.
    CleanExi HS_ZNF93.
    Genevestigatori P35789.

    Family and domain databases

    Gene3Di 3.30.160.60. 17 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 17 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 17 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-620 (ISOFORM 3), VARIANT TYR-93.
      Tissue: Teratocarcinoma.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Testis.
    5. "The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
      Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
      Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-195.

    Entry informationi

    Entry nameiZNF93_HUMAN
    AccessioniPrimary (citable) accession number: P35789
    Secondary accession number(s): A6NMY2
    , B9EGT2, Q8N8Q4, Q9H9X5, Q9Y2N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 135 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3