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P35789 (ZNF93_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 93
Alternative name(s):
Zinc finger protein 505
Zinc finger protein HTF34
Gene names
Name:ZNF93
Synonyms:ZNF505
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Developmental stage

Expressed early during embryonic development.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 17 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAB14093.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35789-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P35789-2)

The sequence of this isoform differs from the canonical sequence as follows:
     391-418: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: P35789-3)

The sequence of this isoform differs from the canonical sequence as follows:
     499-582: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 620620Zinc finger protein 93
PRO_0000047402

Regions

Domain4 – 7572KRAB
Zinc finger145 – 16723C2H2-type 1; degenerate
Zinc finger173 – 19523C2H2-type 2
Zinc finger201 – 22323C2H2-type 3
Zinc finger229 – 25123C2H2-type 4
Zinc finger257 – 27923C2H2-type 5
Zinc finger285 – 30723C2H2-type 6
Zinc finger313 – 33523C2H2-type 7
Zinc finger341 – 36323C2H2-type 8
Zinc finger369 – 39123C2H2-type 9
Zinc finger397 – 41923C2H2-type 10
Zinc finger425 – 44723C2H2-type 11
Zinc finger453 – 47523C2H2-type 12
Zinc finger481 – 50323C2H2-type 13
Zinc finger509 – 53123C2H2-type 14
Zinc finger537 – 55923C2H2-type 15
Zinc finger565 – 58723C2H2-type 16
Zinc finger593 – 61523C2H2-type 17

Natural variations

Alternative sequence391 – 41828Missing in isoform 2.
VSP_016988
Alternative sequence499 – 58284Missing in isoform 3.
VSP_016989
Natural variant931D → Y. Ref.1
Corresponds to variant rs12151060 [ dbSNP | Ensembl ].
VAR_052768

Experimental info

Sequence conflict751S → SGP in AAA83548. Ref.5
Sequence conflict891Q → H in AAA83548. Ref.5
Sequence conflict1191S → R in AAA83548. Ref.5
Sequence conflict1361C → S in AAA83548. Ref.5
Sequence conflict1531V → D in AAA83548. Ref.5
Sequence conflict3371G → E in BAC04764. Ref.1
Sequence conflict5971K → E in BAC04764. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2006. Version 4.
Checksum: 722A49B2EA82801A

FASTA62070,971
        10         20         30         40         50         60 
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP DLIAHLEQGK 

        70         80         90        100        110        120 
KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL RRYEKRGHGN LQLIKRCESV 

       130        140        150        160        170        180 
DECKVHTGGY NGLNQCSTTT QSKVFQCDKY GKVFHKFSNS NRHNIRHTEK KPFKCIECGK 

       190        200        210        220        230        240 
AFNQFSTLIT HKKIHTGEKP YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA 

       250        260        270        280        290        300 
SSTLSKHEII HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL 

       310        320        330        340        350        360 
TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF IASSTLSRHE 

       370        380        390        400        410        420 
FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE ECGKAFKYSS TLSSHKRSHT 

       430        440        450        460        470        480 
GEKPYKCEEC GKAFVASSTL SKHEIIHTGK KPYKCEECGK AFNQSSSLTK HKKIHTGEKP 

       490        500        510        520        530        540 
YKCEECGKAF NQSSSLTKHK KIHTGEKPYK CEECGKAFNQ SSTLIKHKKI HTREKPYKCE 

       550        560        570        580        590        600 
ECGKAFHLST HLTTHKILHT GEKPYRCREC GKAFNHSATL SSHKKIHSGE KPYECDKCGK 

       610        620 
AFISPSSLSR HEIIHTGEKP 

« Hide

Isoform 2 [UniParc].

Checksum: 6718FB94ED926F46
Show »

FASTA59267,799
Isoform 3 [UniParc].

Checksum: D9515EAF8AE19FD1
Show »

FASTA53661,323

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-620 (ISOFORM 3), VARIANT TYR-93.
Tissue: Teratocarcinoma.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Testis.
[5]"The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-195.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK022550 mRNA. Translation: BAB14093.1. Different initiation.
AK096342 mRNA. Translation: BAC04764.1.
AC007204 Genomic DNA. Translation: AAD22981.1. Sequence problems.
AC011477 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84866.1.
BC136718 mRNA. Translation: AAI36719.1.
BC136719 mRNA. Translation: AAI36720.1.
M61873 Genomic DNA. Translation: AAA83548.1.
PIRH39384.
RefSeqNP_112495.2. NM_031218.3.
UniGeneHs.301059.
Hs.723768.

3D structure databases

ProteinModelPortalP35789.
SMRP35789. Positions 1-52, 143-620.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123631. 1 interaction.
STRING9606.ENSP00000342002.

PTM databases

PhosphoSiteP35789.

Polymorphism databases

DMDM85681872.

Proteomic databases

PRIDEP35789.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343769; ENSP00000342002; ENSG00000184635. [P35789-1]
GeneID81931.
KEGGhsa:81931.
UCSCuc002non.3. human. [P35789-1]

Organism-specific databases

CTD81931.
GeneCardsGC19P020012.
HGNCHGNC:13169. ZNF93.
MIM603975. gene.
neXtProtNX_P35789.
PharmGKBPA37741.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidP35789.
KOK09228.
OMANAFCFSS.
OrthoDBEOG7KSX7Q.
PhylomeDBP35789.
TreeFamTF342117.

Gene expression databases

ArrayExpressP35789.
BgeeP35789.
CleanExHS_ZNF93.
GenevestigatorP35789.

Family and domain databases

Gene3D3.30.160.60. 17 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF93. human.
GenomeRNAi81931.
NextBio72275.
PROP35789.
SOURCESearch...

Entry information

Entry nameZNF93_HUMAN
AccessionPrimary (citable) accession number: P35789
Secondary accession number(s): A6NMY2 expand/collapse secondary AC list , B9EGT2, Q8N8Q4, Q9H9X5, Q9Y2N8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 10, 2006
Last modified: April 16, 2014
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM