P35782 (VA52_VESCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Venom allergen 5.02 Alternative name(s): Allergen Vesp c V.02 Antigen 5-2 Short name=Ag5-2 Cysteine-rich venom protein Short name=CRVP Allergen=Vesp c 5.02
Organism	Vespa crabro (European hornet)
Taxonomic identifier	7445 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Vespidae › Vespinae › Vespa

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the CRISP family. Contains 1 SCP domain.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Venom allergen 5.02		PRO_0000211540
Regions
	Domain	46 – 187	142	SCP
Amino acid modifications
	Disulfide bond	4 ↔ 16		By similarity
	Disulfide bond	8 ↔ 101		By similarity
	Disulfide bond	26 ↔ 94		By similarity
	Disulfide bond	168 ↔ 185		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35782 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: B710E9198413F547	FASTA	202	22,781
	10 20 30 40 50 60 NNYCKIKCRS GIHTLCKYGT STKPNCGKNV VKASGLTKQE NLEILKQHNE FRQKVARGLE 70 80 90 100 110 120 TRGNPGPQPP AKSMNTLVWN DELAQIAQVW ANQCNYGHDN CRNSAKYSVG QNIAEGSTSA 130 140 150 160 170 180 DNFVNVSNMV KMWEDEVKDY QYGSPKNKLN KVGHYTQMVW AKTKEIGCGS EDYIEDGWHR 190 200 HYLVCNYGPA GNVGNEPIYE RK

References

[1]	"Allergens in Hymenoptera venom. XXV: the amino acid sequences of antigen 5 molecules and the structural basis of antigenic cross-reactivity." Hoffman D.R. J. Allergy Clin. Immunol. 92:707-716(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	H44583.
3D structure databases
ProteinModelPortal	P35782.
SMR	P35782. Positions 1-202.
ModBase	Search...
Protein family/group databases
Allergome	673. Vesp c 5. 766. Vesp c 5.0102.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.33.10. 1 hit.
InterPro	IPR001283. Allrgn_V5/Tpx1. IPR018244. Allrgn_V5/Tpx1_CS. IPR014044. CAP_domain. IPR002413. V5_allergen. [Graphical view]
PANTHER	PTHR10334. PTHR10334. 1 hit.
Pfam	PF00188. CAP. 1 hit. [Graphical view]
PRINTS	PR00838. V5ALLERGEN. PR00837. V5TPXLIKE.
SMART	SM00198. SCP. 1 hit. [Graphical view]
SUPFAM	SSF55797. SCP-like_extracellular. 1 hit.
PROSITE	PS01009. CRISP_1. 1 hit. PS01010. CRISP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VA52_VESCR

Accession

Primary (citable) accession number: P35782

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)