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Protein

Venom allergen 5.01

Gene
N/A
Organism
Vespa crabro (European hornet)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5.01
Alternative name(s):
Allergen Vesp c V.01
Antigen 5-1
Short name:
Ag5-1
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Vesp c 5.01
OrganismiVespa crabro (European hornet)
Taxonomic identifieri7445 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespa

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei673. Vesp c 5.
674. Vesp c 5.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Venom allergen 5.01PRO_0000211539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 16By similarity
Disulfide bondi8 ↔ 101By similarity
Disulfide bondi26 ↔ 94By similarity
Disulfide bondi168 ↔ 185By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP35781.
SMRiP35781. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 187142SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NNYCKIKCRS GIHTLCKYGT STKPNCGKNV VKASGLTKQE NLEILKQHNE
60 70 80 90 100
FRQKVARGLE TRGNPGPQPP AKSMNTLVWN DELAQIAQVW ANQCNYGHDN
110 120 130 140 150
CRNSAKYSVG QNIAEGSTTA DNFGSVSNMV KMWEDEVKDY QYGSPKNKLN
160 170 180 190 200
KVGHYTQMVW AKTKEIGCGS IKYIENGWHR HYLVCNYGPA GNVGNEPIYE

RK
Length:202
Mass (Da):22,722
Last modified:June 1, 1994 - v1
Checksum:iEDEB39905B598997
GO

Sequence databases

PIRiG44583.

Cross-referencesi

Sequence databases

PIRiG44583.

3D structure databases

ProteinModelPortaliP35781.
SMRiP35781. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei673. Vesp c 5.
674. Vesp c 5.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Allergens in Hymenoptera venom. XXV: the amino acid sequences of antigen 5 molecules and the structural basis of antigenic cross-reactivity."
    Hoffman D.R.
    J. Allergy Clin. Immunol. 92:707-716(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiVA51_VESCR
AccessioniPrimary (citable) accession number: P35781
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 14, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.