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Protein

Venom allergen 3

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 3
Alternative name(s):
Allergen Sol i III
Cysteine-rich venom protein
Short name:
CRVP
Venom allergen III
Allergen: Sol i 3
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3483 Sol i 3.0101
632 Sol i 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000000629323 – 234Venom allergen 3Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 411 Publication
Disulfide bondi31 ↔ 1251 Publication
Disulfide bondi52 ↔ 1181 Publication
Disulfide bondi198 ↔ 2161 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 33Combined sources5
Helixi39 – 42Combined sources4
Helixi62 – 80Combined sources19
Helixi105 – 115Combined sources11
Beta strandi129 – 131Combined sources3
Beta strandi134 – 142Combined sources9
Helixi150 – 158Combined sources9
Helixi159 – 163Combined sources5
Helixi166 – 168Combined sources3
Beta strandi169 – 171Combined sources3
Helixi176 – 188Combined sources13
Beta strandi195 – 204Combined sources10
Beta strandi210 – 220Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VZNX-ray3.05A/B23-234[»]
ProteinModelPortaliP35778
SMRiP35778
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35778

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 218SCPAdd BLAST150

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK19919
OMAiMQWNESI

Family and domain databases

Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR034763 P14a_insect
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PIRSFiPIRSF038921 P14a, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELIVSILWL AITAENLANT LATNYCNLQS CKRNNAIHTM CQYTSPTPGP
60 70 80 90 100
MCLEYSNVGF TDAEKDAIVN KHNELRQRVA SGKEMRGTNG PQPPAVKMPN
110 120 130 140 150
LTWDPELATI AQRWANQCTF EHDACRNVER FAVGQNIAAT SSSGKNKSTP
160 170 180 190 200
NEMILLWYNE VKDFDNRWIS SFPSDDNILM KVGHYTQIVW AKTTKIGCGR
210 220 230
IMFKEPDNWT KHYLVCNYGP AGNVLGAPIY EIKK
Length:234
Mass (Da):26,351
Last modified:June 20, 2001 - v2
Checksum:i539F510B59941D83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183G → E AA sequence (PubMed:8423273).Curated1
Sequence conflicti194T → S AA sequence (PubMed:8423273).Curated1
Sequence conflicti199G → A AA sequence (PubMed:8423273).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012919 mRNA Translation: AAB65434.1
PIRiC44582 B37330
RefSeqiNP_001291520.1, NM_001304591.1

Genome annotation databases

EnsemblMetazoaiXM_011166905.1; XP_011165207.1; LOC105199703
GeneIDi105199703
KEGGisoc:105199703

Similar proteinsi

Entry informationi

Entry nameiVA3_SOLIN
AccessioniPrimary (citable) accession number: P35778
Secondary accession number(s): O16135, Q9TWZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 20, 2001
Last modified: March 28, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
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Main funding by: National Institutes of Health