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P35778

- VA3_SOLIN

UniProt

P35778 - VA3_SOLIN

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Protein

Venom allergen 3

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 3
Alternative name(s):
Allergen Sol i III
Cysteine-rich venom protein
Short name:
CRVP
Venom allergen III
Allergen: Sol i 3
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3483. Sol i 3.0101.
632. Sol i 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22222 PublicationsAdd
BLAST
Chaini23 – 234212Venom allergen 3PRO_0000006293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 411 Publication
Disulfide bondi31 ↔ 1251 Publication
Disulfide bondi52 ↔ 1181 Publication
Disulfide bondi198 ↔ 2161 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1
234
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 335
Helixi39 – 424
Helixi62 – 8019
Helixi105 – 11511
Beta strandi129 – 1313
Beta strandi134 – 1429
Helixi150 – 1589
Helixi159 – 1635
Helixi166 – 1683
Beta strandi169 – 1713
Helixi176 – 18813
Beta strandi195 – 20410
Beta strandi210 – 22011

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VZNX-ray3.05A/B23-234[»]
ProteinModelPortaliP35778.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35778.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 218150SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35778-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELIVSILWL AITAENLANT LATNYCNLQS CKRNNAIHTM CQYTSPTPGP
60 70 80 90 100
MCLEYSNVGF TDAEKDAIVN KHNELRQRVA SGKEMRGTNG PQPPAVKMPN
110 120 130 140 150
LTWDPELATI AQRWANQCTF EHDACRNVER FAVGQNIAAT SSSGKNKSTP
160 170 180 190 200
NEMILLWYNE VKDFDNRWIS SFPSDDNILM KVGHYTQIVW AKTTKIGCGR
210 220 230
IMFKEPDNWT KHYLVCNYGP AGNVLGAPIY EIKK
Length:234
Mass (Da):26,351
Last modified:June 20, 2001 - v2
Checksum:i539F510B59941D83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831G → E AA sequence (PubMed:8423273)Curated
Sequence conflicti194 – 1941T → S AA sequence (PubMed:8423273)Curated
Sequence conflicti199 – 1991G → A AA sequence (PubMed:8423273)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012919 mRNA. Translation: AAB65434.1.
PIRiC44582. B37330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012919 mRNA. Translation: AAB65434.1 .
PIRi C44582. B37330.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VZN X-ray 3.05 A/B 23-234 [» ]
ProteinModelPortali P35778.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3483. Sol i 3.0101.
632. Sol i 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P35778.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
[Graphical view ]
PRINTSi PR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Hoffman D.R., Farrar D., Schmidt M., McConnell T.J.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-234.
    Tissue: Venom gland.
  3. "Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV."
    Hoffman D.R.
    J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-234.
    Tissue: Venom.
  4. "Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri."
    Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.
    J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-45.
    Tissue: Venom.
  5. "Crystal structure of the major allergen from fire ant venom, Sol i 3."
    Padavattan S., Schmidt M., Hoffman D.R., Markovic-Housley Z.
    J. Mol. Biol. 383:178-185(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 23-234, DISULFIDE BONDS.

Entry informationi

Entry nameiVA3_SOLIN
AccessioniPrimary (citable) accession number: P35778
Secondary accession number(s): O16135, Q9TWZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3