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P35778 (VA3_SOLIN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Venom allergen 3
Alternative name(s):
Allergen Sol i III
Cysteine-rich venom protein
Short name=CRVP
Venom allergen III
Allergen=Sol i 3
OrganismSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifier13686 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Allergenic properties

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.3 Ref.4
Chain23 – 234212Venom allergen 3
PRO_0000006293

Regions

Domain69 – 218150SCP

Amino acid modifications

Disulfide bond26 ↔ 41 Ref.5
Disulfide bond31 ↔ 125 Ref.5
Disulfide bond52 ↔ 118 Ref.5
Disulfide bond198 ↔ 216 Ref.5

Experimental info

Sequence conflict1831G → E AA sequence Ref.3
Sequence conflict1941T → S AA sequence Ref.3
Sequence conflict1991G → A AA sequence Ref.3

Secondary structure

......................... 234
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35778 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 539F510B59941D83

FASTA23426,351
        10         20         30         40         50         60 
MELIVSILWL AITAENLANT LATNYCNLQS CKRNNAIHTM CQYTSPTPGP MCLEYSNVGF 

        70         80         90        100        110        120 
TDAEKDAIVN KHNELRQRVA SGKEMRGTNG PQPPAVKMPN LTWDPELATI AQRWANQCTF 

       130        140        150        160        170        180 
EHDACRNVER FAVGQNIAAT SSSGKNKSTP NEMILLWYNE VKDFDNRWIS SFPSDDNILM 

       190        200        210        220        230 
KVGHYTQIVW AKTTKIGCGR IMFKEPDNWT KHYLVCNYGP AGNVLGAPIY EIKK 

« Hide

References

[1]Hoffman D.R., Farrar D., Schmidt M., McConnell T.J.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.
[2]"Fire ant venom allergy."
Hoffman D.R.
Allergy 50:535-544(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-234.
Tissue: Venom gland.
[3]"Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV."
Hoffman D.R.
J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-234.
Tissue: Venom.
[4]"Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri."
Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.
J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-45.
Tissue: Venom.
[5]"Crystal structure of the major allergen from fire ant venom, Sol i 3."
Padavattan S., Schmidt M., Hoffman D.R., Markovic-Housley Z.
J. Mol. Biol. 383:178-185(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 23-234, DISULFIDE BONDS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF012919 mRNA. Translation: AAB65434.1.
PIRB37330. C44582.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VZNX-ray3.05A/B23-234[»]
ProteinModelPortalP35778.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3483. Sol i 3.0101.
632. Sol i 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
[Graphical view]
PRINTSPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP35778.

Entry information

Entry nameVA3_SOLIN
AccessionPrimary (citable) accession number: P35778
Secondary accession number(s): O16135, Q9TWZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 20, 2001
Last modified: October 16, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Allergens

Nomenclature of allergens and list of entries