P35777 (VA4_SOLIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Venom allergen 4 Alternative name(s): Allergen Sol i IV Venom allergen IV Allergen=Sol i 4
Organism	Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifier	13686 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Formicidae › Myrmicinae › Solenopsidini › Solenopsis

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Monomer.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Allergenic properties	Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.
Sequence similarities	Belongs to the ant venom allergen 2/4 family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.2 Ref.3
	Chain	20 – 137	118	Venom allergen 4		PRO_0000022648
Natural variations
	Natural variant	42	1	R → H.
	Natural variant	51	1	R → K in Sol i 4.02.
	Natural variant	56	1	W → I.
	Natural variant	56	1	W → L in Sol i 4.02.
	Natural variant	84	1	A → I in Sol i 4.02.
	Natural variant	111	1	I → V.
Experimental info
	Sequence conflict	136 – 137	2	KK → N AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P35777 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: 2F6E50BA26C57E89	FASTA	137	15,728
	10 20 30 40 50 60 MKTFVLVSCL LVFTQIIYAL DIKEISIMNR ILEKCIRTVP KRENDPINPL RNVNVWYCAF 70 80 90 100 110 120 TKRGIFTPKG VNTKQYINYC EKTAISPADI KLCKKIASKC VKKVYDRPGP IIERSKNLLS 130 CVLKKGLLEL TVYGKKK

References

[1]	Schmidt M., Gridley B., Sakell R.H., Hoffman D.R. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV." Hoffman D.R. J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-137. Tissue: Venom.
[3]	"Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri." Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M. J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-50. Tissue: Venom.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF103805 mRNA. Translation: AAC97369.1. AF103806 mRNA. Translation: AAC97370.1.
PIR	C37330. B44582.
3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	3484. Sol i 4.0101. 633. Sol i 4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR020181. Ant_venom_allergen_Sol_i_2/4. [Graphical view]
ProDom	PD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

VA4_SOLIN

Accession

Primary (citable) accession number: P35777
Secondary accession number(s): Q9UB98, Q9UB99

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 20, 2001
Last modified:	April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)