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Protein

Venom allergen 4

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 4
Alternative name(s):
Allergen Sol i IV
Venom allergen IV
Allergen: Sol i 4
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3484. Sol i 4.0101.
633. Sol i 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
ChainiPRO_000002264820 – 137Venom allergen 4Add BLAST118

Proteomic databases

PRIDEiP35777.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

SMRiP35777.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ant venom allergen 2/4 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.238.20. 1 hit.
InterProiView protein in InterPro
IPR020181. Ant_venom_allergen_Sol_i_2/4.
IPR006170. PBP_GOBP.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFVLVSCL LVFTQIIYAL DIKEISIMNR ILEKCIRTVP KRENDPINPL
60 70 80 90 100
RNVNVWYCAF TKRGIFTPKG VNTKQYINYC EKTAISPADI KLCKKIASKC
110 120 130
VKKVYDRPGP IIERSKNLLS CVLKKGLLEL TVYGKKK
Length:137
Mass (Da):15,728
Last modified:June 20, 2001 - v2
Checksum:i2F6E50BA26C57E89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136 – 137KK → N AA sequence (PubMed:8423273).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti42R → H. 1
Natural varianti51R → K in Sol i 4.02. 1
Natural varianti56W → I. 1
Natural varianti56W → L in Sol i 4.02. 1
Natural varianti84A → I in Sol i 4.02. 1
Natural varianti111I → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103805 mRNA. Translation: AAC97369.1.
AF103806 mRNA. Translation: AAC97370.1.
PIRiB44582. C37330.

Genome annotation databases

EnsemblMetazoaiXM_011174395.1; XP_011172697.1; LOC105205100.

Similar proteinsi

Entry informationi

Entry nameiVA4_SOLIN
AccessioniPrimary (citable) accession number: P35777
Secondary accession number(s): Q9UB98, Q9UB99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 20, 2001
Last modified: August 30, 2017
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families