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P35777 (VA4_SOLIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Venom allergen 4
Alternative name(s):
Allergen Sol i IV
Venom allergen IV
Allergen=Sol i 4
OrganismSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifier13686 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Monomer.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Allergenic properties

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Sequence similarities

Belongs to the ant venom allergen 2/4 family.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.2 Ref.3
Chain20 – 137118Venom allergen 4
PRO_0000022648

Natural variations

Natural variant421R → H.
Natural variant511R → K in Sol i 4.02.
Natural variant561W → I.
Natural variant561W → L in Sol i 4.02.
Natural variant841A → I in Sol i 4.02.
Natural variant1111I → V.

Experimental info

Sequence conflict136 – 1372KK → N AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P35777 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 2F6E50BA26C57E89

FASTA13715,728
        10         20         30         40         50         60 
MKTFVLVSCL LVFTQIIYAL DIKEISIMNR ILEKCIRTVP KRENDPINPL RNVNVWYCAF 

        70         80         90        100        110        120 
TKRGIFTPKG VNTKQYINYC EKTAISPADI KLCKKIASKC VKKVYDRPGP IIERSKNLLS 

       130 
CVLKKGLLEL TVYGKKK 

« Hide

References

[1]Schmidt M., Gridley B., Sakell R.H., Hoffman D.R.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV."
Hoffman D.R.
J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-137.
Tissue: Venom.
[3]"Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri."
Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.
J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-50.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF103805 mRNA. Translation: AAC97369.1.
AF103806 mRNA. Translation: AAC97370.1.
PIRC37330. B44582.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3484. Sol i 4.0101.
633. Sol i 4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020181. Ant_venom_allergen_Sol_i_2/4.
[Graphical view]
ProDomPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameVA4_SOLIN
AccessionPrimary (citable) accession number: P35777
Secondary accession number(s): Q9UB98, Q9UB99
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 20, 2001
Last modified: April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries