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Protein

Venom allergen 4

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 4
Alternative name(s):
Allergen Sol i IV
Venom allergen IV
Allergen: Sol i 4
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3484. Sol i 4.0101.
633. Sol i 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 PublicationsAdd
BLAST
Chaini20 – 137118Venom allergen 4PRO_0000022648Add
BLAST

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.

Family & Domainsi

Sequence similaritiesi

Belongs to the ant venom allergen 2/4 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR020181. Ant_venom_allergen_Sol_i_2/4.
[Graphical view]
ProDomiPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFVLVSCL LVFTQIIYAL DIKEISIMNR ILEKCIRTVP KRENDPINPL
60 70 80 90 100
RNVNVWYCAF TKRGIFTPKG VNTKQYINYC EKTAISPADI KLCKKIASKC
110 120 130
VKKVYDRPGP IIERSKNLLS CVLKKGLLEL TVYGKKK
Length:137
Mass (Da):15,728
Last modified:June 20, 2001 - v2
Checksum:i2F6E50BA26C57E89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1372KK → N AA sequence (PubMed:8423273).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421R → H.
Natural varianti51 – 511R → K in Sol i 4.02.
Natural varianti56 – 561W → I.
Natural varianti56 – 561W → L in Sol i 4.02.
Natural varianti84 – 841A → I in Sol i 4.02.
Natural varianti111 – 1111I → V.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103805 mRNA. Translation: AAC97369.1.
AF103806 mRNA. Translation: AAC97370.1.
PIRiB44582. C37330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103805 mRNA. Translation: AAC97369.1.
AF103806 mRNA. Translation: AAC97370.1.
PIRiB44582. C37330.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3484. Sol i 4.0101.
633. Sol i 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR020181. Ant_venom_allergen_Sol_i_2/4.
[Graphical view]
ProDomiPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. Schmidt M., Gridley B., Sakell R.H., Hoffman D.R.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV."
    Hoffman D.R.
    J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-137.
    Tissue: Venom.
  3. "Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri."
    Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.
    J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-50.
    Tissue: Venom.

Entry informationi

Entry nameiVA4_SOLIN
AccessioniPrimary (citable) accession number: P35777
Secondary accession number(s): Q9UB98, Q9UB99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 20, 2001
Last modified: January 7, 2015
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.