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P35777

- VA4_SOLIN

UniProt

P35777 - VA4_SOLIN

Protein

Venom allergen 4

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Venom allergen 4
    Alternative name(s):
    Allergen Sol i IV
    Venom allergen IV
    Allergen: Sol i 4
    OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
    Taxonomic identifieri13686 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3484. Sol i 4.0101.
    633. Sol i 4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19192 PublicationsAdd
    BLAST
    Chaini20 – 137118Venom allergen 4PRO_0000022648Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ant venom allergen 2/4 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR020181. Ant_venom_allergen_Sol_i_2/4.
    [Graphical view]
    ProDomiPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35777-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTFVLVSCL LVFTQIIYAL DIKEISIMNR ILEKCIRTVP KRENDPINPL    50
    RNVNVWYCAF TKRGIFTPKG VNTKQYINYC EKTAISPADI KLCKKIASKC 100
    VKKVYDRPGP IIERSKNLLS CVLKKGLLEL TVYGKKK 137
    Length:137
    Mass (Da):15,728
    Last modified:June 20, 2001 - v2
    Checksum:i2F6E50BA26C57E89
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti136 – 1372KK → N AA sequence (PubMed:8423273)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421R → H.
    Natural varianti51 – 511R → K in Sol i 4.02.
    Natural varianti56 – 561W → I.
    Natural varianti56 – 561W → L in Sol i 4.02.
    Natural varianti84 – 841A → I in Sol i 4.02.
    Natural varianti111 – 1111I → V.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF103805 mRNA. Translation: AAC97369.1.
    AF103806 mRNA. Translation: AAC97370.1.
    PIRiB44582. C37330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF103805 mRNA. Translation: AAC97369.1 .
    AF103806 mRNA. Translation: AAC97370.1 .
    PIRi B44582. C37330.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3484. Sol i 4.0101.
    633. Sol i 4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR020181. Ant_venom_allergen_Sol_i_2/4.
    [Graphical view ]
    ProDomi PD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Schmidt M., Gridley B., Sakell R.H., Hoffman D.R.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV."
      Hoffman D.R.
      J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-137.
      Tissue: Venom.
    3. "Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri."
      Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.
      J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-50.
      Tissue: Venom.

    Entry informationi

    Entry nameiVA4_SOLIN
    AccessioniPrimary (citable) accession number: P35777
    Secondary accession number(s): Q9UB98, Q9UB99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3