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P35775

- VA2_SOLIN

UniProt

P35775 - VA2_SOLIN

Protein

Venom allergen 2

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Venom allergen 2
    Alternative name(s):
    Allergen Sol i II
    Venom allergen II
    Allergen: Sol i 2
    OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
    Taxonomic identifieri13686 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3482. Sol i 2.0101.
    631. Sol i 2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19192 PublicationsAdd
    BLAST
    Chaini20 – 138119Venom allergen 2PRO_0000022646Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 571 Publication
    Disulfide bondi41 – 41Interchain1 Publication
    Disulfide bondi81 ↔ 941 Publication
    Disulfide bondi101 ↔ 1221 Publication

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    Structurei

    Secondary structure

    1
    138
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi21 – 3717
    Helixi48 – 503
    Helixi52 – 6110
    Turni62 – 654
    Helixi70 – 8415
    Helixi88 – 10518
    Beta strandi108 – 1103
    Helixi112 – 12514
    Helixi128 – 1314

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YGUX-ray2.60A/B/C/D/E/F/G/H20-138[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ant venom allergen 2/4 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR020181. Ant_venom_allergen_Sol_i_2/4.
    [Graphical view]
    ProDomiPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35775-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSFVLATCL LGFAQIIYAD NKELKIIRKD VAECLRTLPK CGNQPDDPLA    50
    RVDVWHCAMA KRGVYDNPDP AVIKERSMKM CTKIITDPAN VENCKKVASR 100
    CVDRETQGPK SNRQKAVNII GCALRAGVAE TTVLARKK 138
    Length:138
    Mass (Da):15,289
    Last modified:June 1, 1994 - v1
    Checksum:iDA30E1E41041EE75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09560 mRNA. No translation available.
    PIRiS32389. A37330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09560 mRNA. No translation available.
    PIRi S32389. A37330.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YGU X-ray 2.60 A/B/C/D/E/F/G/H 20-138 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3482. Sol i 2.0101.
    631. Sol i 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR020181. Ant_venom_allergen_Sol_i_2/4.
    [Graphical view ]
    ProDomi PD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of cDNA encoding the fire ant venom protein Sol i II."
      Schmidt M., Walker R.B., Hoffman D.R., McConnell T.J.
      FEBS Lett. 319:138-140(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom gland.
    2. "Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV."
      Hoffman D.R.
      J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-138.
      Tissue: Venom.
    3. "Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri."
      Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.
      J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-87.
      Tissue: Venom.
    4. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 20-138, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiVA2_SOLIN
    AccessioniPrimary (citable) accession number: P35775
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3