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Protein

Venom allergen 2

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 2
Alternative name(s):
Allergen Sol i II
Venom allergen II
Allergen: Sol i 2
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3482. Sol i 2.0101.
631. Sol i 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 PublicationsAdd
BLAST
Chaini20 – 138119Venom allergen 2PRO_0000022646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 571 Publication
Disulfide bondi41 – 41Interchain1 Publication
Disulfide bondi81 ↔ 941 Publication
Disulfide bondi101 ↔ 1221 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Structurei

Secondary structure

1
138
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 3717Combined sources
Helixi48 – 503Combined sources
Helixi52 – 6110Combined sources
Turni62 – 654Combined sources
Helixi70 – 8415Combined sources
Helixi88 – 10518Combined sources
Beta strandi108 – 1103Combined sources
Helixi112 – 12514Combined sources
Helixi128 – 1314Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YGUX-ray2.60A/B/C/D/E/F/G/H20-138[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ant venom allergen 2/4 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR020181. Ant_venom_allergen_Sol_i_2/4.
[Graphical view]
ProDomiPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFVLATCL LGFAQIIYAD NKELKIIRKD VAECLRTLPK CGNQPDDPLA
60 70 80 90 100
RVDVWHCAMA KRGVYDNPDP AVIKERSMKM CTKIITDPAN VENCKKVASR
110 120 130
CVDRETQGPK SNRQKAVNII GCALRAGVAE TTVLARKK
Length:138
Mass (Da):15,289
Last modified:June 1, 1994 - v1
Checksum:iDA30E1E41041EE75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09560 mRNA. No translation available.
PIRiS32389. A37330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09560 mRNA. No translation available.
PIRiS32389. A37330.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YGUX-ray2.60A/B/C/D/E/F/G/H20-138[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3482. Sol i 2.0101.
631. Sol i 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR020181. Ant_venom_allergen_Sol_i_2/4.
[Graphical view]
ProDomiPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of cDNA encoding the fire ant venom protein Sol i II."
    Schmidt M., Walker R.B., Hoffman D.R., McConnell T.J.
    FEBS Lett. 319:138-140(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. "Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV."
    Hoffman D.R.
    J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-138.
    Tissue: Venom.
  3. "Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri."
    Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.
    J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-87.
    Tissue: Venom.
  4. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 20-138, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiVA2_SOLIN
AccessioniPrimary (citable) accession number: P35775
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 7, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.