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Protein

Venom allergen 2

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 2
Alternative name(s):
Allergen Sol i II
Venom allergen II
Allergen: Sol i 2
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3482. Sol i 2.0101.
631. Sol i 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 PublicationsAdd
BLAST
Chaini20 – 138119Venom allergen 2PRO_0000022646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 571 Publication
Disulfide bondi41 – 41Interchain1 Publication
Disulfide bondi81 ↔ 941 Publication
Disulfide bondi101 ↔ 1221 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Structurei

Secondary structure

1
138
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 3717Combined sources
Helixi48 – 503Combined sources
Helixi52 – 6110Combined sources
Turni62 – 654Combined sources
Helixi70 – 8415Combined sources
Helixi88 – 10518Combined sources
Beta strandi108 – 1103Combined sources
Helixi112 – 12514Combined sources
Helixi128 – 1314Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YGUX-ray2.60A/B/C/D/E/F/G/H20-138[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ant venom allergen 2/4 family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd12800. Sol_i_2. 1 hit.
InterProiIPR020181. Ant_venom_allergen_Sol_i_2/4.
[Graphical view]
ProDomiPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFVLATCL LGFAQIIYAD NKELKIIRKD VAECLRTLPK CGNQPDDPLA
60 70 80 90 100
RVDVWHCAMA KRGVYDNPDP AVIKERSMKM CTKIITDPAN VENCKKVASR
110 120 130
CVDRETQGPK SNRQKAVNII GCALRAGVAE TTVLARKK
Length:138
Mass (Da):15,289
Last modified:June 1, 1994 - v1
Checksum:iDA30E1E41041EE75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09560 mRNA. No translation available.
PIRiS32389. A37330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09560 mRNA. No translation available.
PIRiS32389. A37330.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YGUX-ray2.60A/B/C/D/E/F/G/H20-138[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3482. Sol i 2.0101.
631. Sol i 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd12800. Sol_i_2. 1 hit.
InterProiIPR020181. Ant_venom_allergen_Sol_i_2/4.
[Graphical view]
ProDomiPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiVA2_SOLIN
AccessioniPrimary (citable) accession number: P35775
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.