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P35775 (VA2_SOLIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Venom allergen 2
Alternative name(s):
Allergen Sol i II
Venom allergen II
Allergen=Sol i 2
OrganismSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifier13686 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer; disulfide-linked. Ref.4

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Allergenic properties

Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant.

Sequence similarities

Belongs to the ant venom allergen 2/4 family.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.2 Ref.3
Chain20 – 138119Venom allergen 2
PRO_0000022646

Amino acid modifications

Disulfide bond34 ↔ 57 Ref.4
Disulfide bond41Interchain Ref.4
Disulfide bond81 ↔ 94 Ref.4
Disulfide bond101 ↔ 122 Ref.4

Secondary structure

.................. 138
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35775 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: DA30E1E41041EE75

FASTA13815,289
        10         20         30         40         50         60 
MKSFVLATCL LGFAQIIYAD NKELKIIRKD VAECLRTLPK CGNQPDDPLA RVDVWHCAMA 

        70         80         90        100        110        120 
KRGVYDNPDP AVIKERSMKM CTKIITDPAN VENCKKVASR CVDRETQGPK SNRQKAVNII 

       130 
GCALRAGVAE TTVLARKK 

« Hide

References

[1]"Nucleotide sequence of cDNA encoding the fire ant venom protein Sol i II."
Schmidt M., Walker R.B., Hoffman D.R., McConnell T.J.
FEBS Lett. 319:138-140(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.
[2]"Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported fire ant venom allergens Sol i II, Sol i III, and Sol i IV."
Hoffman D.R.
J. Allergy Clin. Immunol. 91:71-78(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-138.
Tissue: Venom.
[3]"Allergens in Hymenoptera venom. XXII. Comparison of venoms from two species of imported fire ants, Solenopsis invicta and richteri."
Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.
J. Allergy Clin. Immunol. 85:988-996(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-87.
Tissue: Venom.
[4]"Crystal structure of Sol I 2: a major allergen from fire ant venom."
Borer A.S., Wassmann P., Schmidt M., Hoffman D.R., Zhou J.J., Wright C., Schirmer T., Markovic-Housley Z.
J. Mol. Biol. 415:635-648(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 20-138, SUBUNIT, DISULFIDE BONDS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L09560 mRNA. No translation available.
PIRA37330. S32389.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YGUX-ray2.60A/B/C/D/E/F/G/H20-138[»]
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3482. Sol i 2.0101.
631. Sol i 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR020181. Ant_venom_allergen_Sol_i_2/4.
[Graphical view]
ProDomPD031252. Ant_venom_allergen_Sol_i_2/4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameVA2_SOLIN
AccessionPrimary (citable) accession number: P35775
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Allergens

Nomenclature of allergens and list of entries