SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35774

- SPIKE_ADE1P

UniProt

P35774 - SPIKE_ADE1P

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Fiber protein
Gene
L5
Organism
Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface.

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. pathogenesis Source: InterPro
  3. viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host adhesion receptor, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Fiber protein
Short name:
SPIKE
Alternative name(s):
Protein IV
Gene namesi
ORF Names:L5
OrganismiHuman adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))
Taxonomic identifieri343462 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusHuman adenovirus B
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion By similarity. Host nucleus By similarity
Note: Anchored to the pentons, protrudes from the virion surface By similarity.

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
  2. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Fiber protein
PRO_0000221794Add
BLAST

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homotrimer. Interacts with host receptor CD46. Interacts (via N-terminal tail region) with pentons By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi130 – 1323
Beta strandi133 – 1353
Beta strandi151 – 1533
Beta strandi156 – 16510
Beta strandi168 – 17710
Helixi180 – 1834
Helixi184 – 1874
Beta strandi189 – 19911
Turni207 – 2093
Beta strandi210 – 2123
Helixi232 – 2354
Turni239 – 2413
Helixi247 – 2537
Beta strandi254 – 2629
Beta strandi268 – 27912
Beta strandi283 – 2853
Beta strandi288 – 29710
Turni305 – 3073
Beta strandi316 – 3227

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O39X-ray2.85A/B129-325[»]
3EXVX-ray1.45A117-325[»]
ProteinModelPortaliP35774.
SMRiP35774. Positions 129-325.

Miscellaneous databases

EvolutionaryTraceiP35774.

Family & Domainsi

Domaini

The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion By similarity.

Sequence similaritiesi

Family and domain databases

Gene3Di2.10.25.20. 1 hit.
2.60.90.10. 1 hit.
InterProiIPR000931. Adeno_fibre.
IPR000978. Adeno_fibre_knob.
IPR000939. Adenobir_fibre_prot_rpt/shaft.
IPR008982. Adenovirus_pIV-rel_att.
IPR009013. Attachment_protein_shaft_dom.
[Graphical view]
PfamiPF00541. Adeno_knob. 1 hit.
PF00608. Adeno_shaft. 2 hits.
[Graphical view]
PRINTSiPR00307. ADENOVSFIBRE.
SUPFAMiSSF49835. SSF49835. 1 hit.
SSF51225. SSF51225. 1 hit.

Sequencei

Sequence statusi: Complete.

P35774-1 [UniParc]FASTAAdd to Basket

« Hide

MTKRVRLSDS FNPVYPYEDE STSQHPFINP GFISPNGFTQ SPNGVLTLKC    50
LTPLTTTGGS LQLKVGGGLT VDDTNGFLKE NISATTPLVK TGHSIGLPLG 100
AGLGTNENKL CIKLGQGLTF NSNNICIDDN INTLWTGVNP TEANCQIMNS 150
SESNDCKLIL TLVKTGALVT AFVYVIGVSN NFNMLTTHRN INFTAELFFD 200
STGNLLTRLS SLKTPLNHKS GQNMATGAIT NAKGFMPSTT AYPFNDNSRE 250
KENYIYGTCY YTASDRTAFP IDISVMLNRR AINDETSYCI RITWSWNTGD 300
APEVQTSATT LVTSPFTFYY IREDD 325
Length:325
Mass (Da):35,538
Last modified:June 1, 1994 - v1
Checksum:i3B3ACCA4CBDB3EFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532578 Genomic DNA. Translation: AAA42490.1.
PIRiD37476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532578 Genomic DNA. Translation: AAA42490.1 .
PIRi D37476.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2O39 X-ray 2.85 A/B 129-325 [» ]
3EXV X-ray 1.45 A 117-325 [» ]
ProteinModelPortali P35774.
SMRi P35774. Positions 129-325.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P35774.

Family and domain databases

Gene3Di 2.10.25.20. 1 hit.
2.60.90.10. 1 hit.
InterProi IPR000931. Adeno_fibre.
IPR000978. Adeno_fibre_knob.
IPR000939. Adenobir_fibre_prot_rpt/shaft.
IPR008982. Adenovirus_pIV-rel_att.
IPR009013. Attachment_protein_shaft_dom.
[Graphical view ]
Pfami PF00541. Adeno_knob. 1 hit.
PF00608. Adeno_shaft. 2 hits.
[Graphical view ]
PRINTSi PR00307. ADENOVSFIBRE.
SUPFAMi SSF49835. SSF49835. 1 hit.
SSF51225. SSF51225. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Hemagglutination properties and nucleotide sequence analysis of the fiber gene of adenovirus genome types 11p and 11a."
    Mei Y.-F., Wadell G.
    Virology 194:453-462(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: REVIEW.

Entry informationi

Entry nameiSPIKE_ADE1P
AccessioniPrimary (citable) accession number: P35774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi