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P35774

- SPIKE_ADE1P

UniProt

P35774 - SPIKE_ADE1P

Protein

Fiber protein

Gene

L5

Organism
Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface.

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. pathogenesis Source: InterPro
    3. viral entry into host cell Source: UniProtKB-KW
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host adhesion receptor, Viral attachment to host cell, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fiber protein
    Short name:
    SPIKE
    Alternative name(s):
    Protein IV
    Gene namesi
    ORF Names:L5
    OrganismiHuman adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))
    Taxonomic identifieri343462 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusHuman mastadenovirus B
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion By similarity. Host nucleus By similarity
    Note: Anchored to the pentons, protrudes from the virion surface.By similarity

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Fiber proteinPRO_0000221794Add
    BLAST

    Expressioni

    Inductioni

    Expressed in the late phase of the viral replicative cycle.

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with host receptor CD46. Interacts (via N-terminal tail region) with pentons By similarity.By similarity

    Structurei

    Secondary structure

    1
    325
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi130 – 1323
    Beta strandi133 – 1353
    Beta strandi151 – 1533
    Beta strandi156 – 16510
    Beta strandi168 – 17710
    Helixi180 – 1834
    Helixi184 – 1874
    Beta strandi189 – 19911
    Turni207 – 2093
    Beta strandi210 – 2123
    Helixi232 – 2354
    Turni239 – 2413
    Helixi247 – 2537
    Beta strandi254 – 2629
    Beta strandi268 – 27912
    Beta strandi283 – 2853
    Beta strandi288 – 29710
    Turni305 – 3073
    Beta strandi316 – 3227

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2O39X-ray2.85A/B129-325[»]
    3EXVX-ray1.45A117-325[»]
    ProteinModelPortaliP35774.
    SMRiP35774. Positions 129-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP35774.

    Family & Domainsi

    Domaini

    The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion.By similarity

    Sequence similaritiesi

    Belongs to the adenoviridae fiber family.Curated

    Family and domain databases

    Gene3Di2.10.25.20. 1 hit.
    2.60.90.10. 1 hit.
    InterProiIPR000931. Adeno_fibre.
    IPR000978. Adeno_fibre_knob.
    IPR000939. Adenobir_fibre_prot_rpt/shaft.
    IPR008982. Adenovirus_pIV-rel_att.
    IPR009013. Attachment_protein_shaft_dom.
    [Graphical view]
    PfamiPF00541. Adeno_knob. 1 hit.
    PF00608. Adeno_shaft. 2 hits.
    [Graphical view]
    PRINTSiPR00307. ADENOVSFIBRE.
    SUPFAMiSSF49835. SSF49835. 1 hit.
    SSF51225. SSF51225. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P35774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKRVRLSDS FNPVYPYEDE STSQHPFINP GFISPNGFTQ SPNGVLTLKC    50
    LTPLTTTGGS LQLKVGGGLT VDDTNGFLKE NISATTPLVK TGHSIGLPLG 100
    AGLGTNENKL CIKLGQGLTF NSNNICIDDN INTLWTGVNP TEANCQIMNS 150
    SESNDCKLIL TLVKTGALVT AFVYVIGVSN NFNMLTTHRN INFTAELFFD 200
    STGNLLTRLS SLKTPLNHKS GQNMATGAIT NAKGFMPSTT AYPFNDNSRE 250
    KENYIYGTCY YTASDRTAFP IDISVMLNRR AINDETSYCI RITWSWNTGD 300
    APEVQTSATT LVTSPFTFYY IREDD 325
    Length:325
    Mass (Da):35,538
    Last modified:June 1, 1994 - v1
    Checksum:i3B3ACCA4CBDB3EFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532578 Genomic DNA. Translation: AAA42490.1.
    PIRiD37476.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532578 Genomic DNA. Translation: AAA42490.1 .
    PIRi D37476.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2O39 X-ray 2.85 A/B 129-325 [» ]
    3EXV X-ray 1.45 A 117-325 [» ]
    ProteinModelPortali P35774.
    SMRi P35774. Positions 129-325.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P35774.

    Family and domain databases

    Gene3Di 2.10.25.20. 1 hit.
    2.60.90.10. 1 hit.
    InterProi IPR000931. Adeno_fibre.
    IPR000978. Adeno_fibre_knob.
    IPR000939. Adenobir_fibre_prot_rpt/shaft.
    IPR008982. Adenovirus_pIV-rel_att.
    IPR009013. Attachment_protein_shaft_dom.
    [Graphical view ]
    Pfami PF00541. Adeno_knob. 1 hit.
    PF00608. Adeno_shaft. 2 hits.
    [Graphical view ]
    PRINTSi PR00307. ADENOVSFIBRE.
    SUPFAMi SSF49835. SSF49835. 1 hit.
    SSF51225. SSF51225. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Hemagglutination properties and nucleotide sequence analysis of the fiber gene of adenovirus genome types 11p and 11a."
      Mei Y.-F., Wadell G.
      Virology 194:453-462(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: REVIEW.

    Entry informationi

    Entry nameiSPIKE_ADE1P
    AccessioniPrimary (citable) accession number: P35774
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.By similarity

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3