Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35774 (SPIKE_ADE1P) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fiber protein

Short name=SPIKE
Alternative name(s):
Protein IV
Gene names
ORF Names:L5
OrganismHuman adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))
Taxonomic identifier343462 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusHuman adenovirus B
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface.

Subunit structure

Homotrimer. Interacts with host receptor CD46. Interacts (via N-terminal tail region) with pentons By similarity.

Subcellular location

Virion By similarity. Host nucleus By similarity. Note: Anchored to the pentons, protrudes from the virion surface By similarity.

Induction

Expressed in the late phase of the viral replicative cycle.

Domain

The tail region anchors the fiber to penton base capsomers, whereas the shaft, built from several repeated motifs, allows the knob to protrude from the virion By similarity.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell By similarity.

Sequence similarities

Belongs to the adenoviridae fiber family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Fiber protein
PRO_0000221794

Secondary structure

................................... 325
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35774 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 3B3ACCA4CBDB3EFD

FASTA32535,538
        10         20         30         40         50         60 
MTKRVRLSDS FNPVYPYEDE STSQHPFINP GFISPNGFTQ SPNGVLTLKC LTPLTTTGGS 

        70         80         90        100        110        120 
LQLKVGGGLT VDDTNGFLKE NISATTPLVK TGHSIGLPLG AGLGTNENKL CIKLGQGLTF 

       130        140        150        160        170        180 
NSNNICIDDN INTLWTGVNP TEANCQIMNS SESNDCKLIL TLVKTGALVT AFVYVIGVSN 

       190        200        210        220        230        240 
NFNMLTTHRN INFTAELFFD STGNLLTRLS SLKTPLNHKS GQNMATGAIT NAKGFMPSTT 

       250        260        270        280        290        300 
AYPFNDNSRE KENYIYGTCY YTASDRTAFP IDISVMLNRR AINDETSYCI RITWSWNTGD 

       310        320 
APEVQTSATT LVTSPFTFYY IREDD 

« Hide

References

[1]"Hemagglutination properties and nucleotide sequence analysis of the fiber gene of adenovirus genome types 11p and 11a."
Mei Y.-F., Wadell G.
Virology 194:453-462(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Adenovirus receptors."
Zhang Y., Bergelson J.M.
J. Virol. 79:12125-12131(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF532578 Genomic DNA. Translation: AAA42490.1.
PIRD37476.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2O39X-ray2.85A/B129-325[»]
3EXVX-ray1.45A117-325[»]
ProteinModelPortalP35774.
SMRP35774. Positions 129-325.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.10.25.20. 1 hit.
2.60.90.10. 1 hit.
InterProIPR000931. Adeno_fibre.
IPR000978. Adeno_fibre_knob.
IPR000939. Adenobir_fibre_prot_rpt/shaft.
IPR008982. Adenovirus_pIV-rel_att.
IPR009013. Attachment_protein_shaft_dom.
[Graphical view]
PfamPF00541. Adeno_knob. 1 hit.
PF00608. Adeno_shaft. 2 hits.
[Graphical view]
PRINTSPR00307. ADENOVSFIBRE.
SUPFAMSSF49835. SSF49835. 1 hit.
SSF51225. SSF51225. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP35774.

Entry information

Entry nameSPIKE_ADE1P
AccessionPrimary (citable) accession number: P35774
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references