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P35762

- CD81_MOUSE

UniProt

P35762 - CD81_MOUSE

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Protein
CD81 antigen
Gene
Cd81, Tapa1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: UniProtKB
  2. phosphatidylinositol biosynthetic process Source: UniProtKB
  3. phosphatidylinositol metabolic process Source: UniProtKB
  4. positive regulation of 1-phosphatidylinositol 4-kinase activity Source: UniProtKB
  5. positive regulation of B cell proliferation Source: UniProtKB
  6. positive regulation of cell growth Source: UniProtKB
  7. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  8. protein localization Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD81 antigen
Alternative name(s):
26 kDa cell surface protein TAPA-1
Target of the antiproliferative antibody 1
CD_antigen: CD81
Gene namesi
Name:Cd81
Synonyms:Tapa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1096398. Cd81.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Topological domaini34 – 5724Extracellular Reviewed prediction
Add
BLAST
Transmembranei58 – 7821Helical; Reviewed prediction
Add
BLAST
Topological domaini79 – 8911Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei90 – 11526Helical; Reviewed prediction
Add
BLAST
Topological domaini116 – 20186Extracellular Reviewed prediction
Add
BLAST
Transmembranei202 – 22625Helical; Reviewed prediction
Add
BLAST
Topological domaini227 – 23610Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. immunological synapse Source: Ensembl
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduction in the fecundity of female mice and their eggs have impaired ability to fuse with sperm.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236CD81 antigen
PRO_0000219222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi156 ↔ 190 By similarity
Disulfide bondi157 ↔ 175 By similarity

Post-translational modificationi

Not glycosylated Inferred.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP35762.
PRIDEiP35762.

PTM databases

PhosphoSiteiP35762.

Expressioni

Tissue specificityi

Expressed in oocytes. Highly expressed in granulosa cells.2 Publications

Gene expression databases

CleanExiMM_CD81.
GenevestigatoriP35762.

Interactioni

Subunit structurei

Interacts with CD53 and SCIMP. Interacts directly with IGSF8. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11.2 Publications

Protein-protein interaction databases

IntActiP35762. 3 interactions.
MINTiMINT-4090262.

Structurei

3D structure databases

ProteinModelPortaliP35762.
SMRiP35762. Positions 113-201.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305712.
GeneTreeiENSGT00680000099842.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP35762.
KOiK06508.
OMAiCHQKIDE.
OrthoDBiEOG7K3TMW.
TreeFamiTF352895.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35762-1 [UniParc]FASTAAdd to Basket

« Hide

MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTSLLYLELG    50
NKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI 100
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF 150
HETLNCCGSN ALTTLTTTIL RNSLCPSGGN ILTPLLQQDC HQKIDELFSG 200
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY 236
Length:236
Mass (Da):25,815
Last modified:October 3, 2012 - v2
Checksum:i7BDCB792E7F9FA4E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731S → T in AAB19417. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S45012
, S44957, S44966, S45001, S45008, S45010 Genomic DNA. Translation: AAB19417.1.
AJ251835 Genomic DNA. Translation: CAB94774.1.
AK166521 mRNA. Translation: BAE38825.1.
AK170741 mRNA. Translation: BAE41994.1.
AC015800 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18195.1.
BC011433 mRNA. Translation: AAH11433.1.
X59047 mRNA. No translation available.
CCDSiCCDS22038.1.
PIRiA46472.
RefSeqiNP_598416.1. NM_133655.2.
UniGeneiMm.806.

Genome annotation databases

EnsembliENSMUST00000037941; ENSMUSP00000043768; ENSMUSG00000037706.
GeneIDi12520.
KEGGimmu:12520.
UCSCiuc009kou.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S45012
, S44957 , S44966 , S45001 , S45008 , S45010 Genomic DNA. Translation: AAB19417.1 .
AJ251835 Genomic DNA. Translation: CAB94774.1 .
AK166521 mRNA. Translation: BAE38825.1 .
AK170741 mRNA. Translation: BAE41994.1 .
AC015800 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18195.1 .
BC011433 mRNA. Translation: AAH11433.1 .
X59047 mRNA. No translation available.
CCDSi CCDS22038.1.
PIRi A46472.
RefSeqi NP_598416.1. NM_133655.2.
UniGenei Mm.806.

3D structure databases

ProteinModelPortali P35762.
SMRi P35762. Positions 113-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P35762. 3 interactions.
MINTi MINT-4090262.

PTM databases

PhosphoSitei P35762.

Proteomic databases

PaxDbi P35762.
PRIDEi P35762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037941 ; ENSMUSP00000043768 ; ENSMUSG00000037706 .
GeneIDi 12520.
KEGGi mmu:12520.
UCSCi uc009kou.2. mouse.

Organism-specific databases

CTDi 975.
MGIi MGI:1096398. Cd81.

Phylogenomic databases

eggNOGi NOG305712.
GeneTreei ENSGT00680000099842.
HOGENOMi HOG000230651.
HOVERGENi HBG002324.
InParanoidi P35762.
KOi K06508.
OMAi CHQKIDE.
OrthoDBi EOG7K3TMW.
TreeFami TF352895.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSi CD81. mouse.
NextBioi 281526.
PROi P35762.
SOURCEi Search...

Gene expression databases

CleanExi MM_CD81.
Genevestigatori P35762.

Family and domain databases

Gene3Di 1.10.1450.10. 1 hit.
InterProi IPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and chromosomal localization of the TAPA-1 gene."
    Andria M.L., Hsieh C.L., Oren R., Francke U., Levy S.
    J. Immunol. 147:1030-1036(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse."
    Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K., Reinhardt R., Reik W., Walter J.
    Hum. Mol. Genet. 9:1829-1841(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  7. Duff K., Parsons J.
    Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-236.
    Tissue: Heart.
  8. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 125-144; 149-171 AND 194-201, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  9. "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins."
    Clark K.L., Zeng Z., Langford A.L., Bowen S.M., Todd S.C.
    J. Immunol. 167:5115-5121(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGSF8.
  10. Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  11. "Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes."
    Smith R.A., Young J., Weis J.J., Weis J.H.
    Genes Immun. 7:113-121(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFITM2 AND IFITM3.
  12. Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, FUNCTION IN ACROSOME REACTION.

Entry informationi

Entry nameiCD81_MOUSE
AccessioniPrimary (citable) accession number: P35762
Secondary accession number(s): Q91V78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi