Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35762

- CD81_MOUSE

UniProt

P35762 - CD81_MOUSE

Protein

CD81 antigen

Gene

Cd81

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction.1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. activation of MAPK activity Source: UniProtKB
    2. phosphatidylinositol biosynthetic process Source: UniProtKB
    3. phosphatidylinositol metabolic process Source: UniProtKB
    4. positive regulation of 1-phosphatidylinositol 4-kinase activity Source: UniProtKB
    5. positive regulation of B cell proliferation Source: UniProtKB
    6. positive regulation of cell growth Source: UniProtKB
    7. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    8. protein localization Source: UniProtKB
    9. regulation of cell motility Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD81 antigen
    Alternative name(s):
    26 kDa cell surface protein TAPA-1
    Target of the antiproliferative antibody 1
    CD_antigen: CD81
    Gene namesi
    Name:Cd81
    Synonyms:Tapa1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1096398. Cd81.

    Subcellular locationi

    GO - Cellular componenti

    1. immunological synapse Source: Ensembl
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Reduction in the fecundity of female mice and their eggs have impaired ability to fuse with sperm.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236CD81 antigenPRO_0000219222Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi156 ↔ 190By similarity
    Disulfide bondi157 ↔ 175By similarity

    Post-translational modificationi

    Not glycosylated.Curated

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP35762.
    PRIDEiP35762.

    PTM databases

    PhosphoSiteiP35762.

    Expressioni

    Tissue specificityi

    Expressed in oocytes. Highly expressed in granulosa cells.2 Publications

    Gene expression databases

    CleanExiMM_CD81.
    GenevestigatoriP35762.

    Interactioni

    Subunit structurei

    Interacts with CD53 and SCIMP. Interacts directly with IGSF8. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11.2 Publications

    Protein-protein interaction databases

    IntActiP35762. 3 interactions.
    MINTiMINT-4090262.

    Structurei

    3D structure databases

    ProteinModelPortaliP35762.
    SMRiP35762. Positions 113-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 5724ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini79 – 8911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini116 – 20186ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 23610CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11526HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22625HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305712.
    GeneTreeiENSGT00680000099842.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiP35762.
    KOiK06508.
    OMAiCHQKIDE.
    OrthoDBiEOG7K3TMW.
    TreeFamiTF352895.

    Family and domain databases

    Gene3Di1.10.1450.10. 1 hit.
    InterProiIPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35762-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTSLLYLELG    50
    NKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI 100
    LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF 150
    HETLNCCGSN ALTTLTTTIL RNSLCPSGGN ILTPLLQQDC HQKIDELFSG 200
    KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY 236
    Length:236
    Mass (Da):25,815
    Last modified:October 3, 2012 - v2
    Checksum:i7BDCB792E7F9FA4E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731S → T in AAB19417. (PubMed:1650385)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S45012
    , S44957, S44966, S45001, S45008, S45010 Genomic DNA. Translation: AAB19417.1.
    AJ251835 Genomic DNA. Translation: CAB94774.1.
    AK166521 mRNA. Translation: BAE38825.1.
    AK170741 mRNA. Translation: BAE41994.1.
    AC015800 Genomic DNA. No translation available.
    CH466531 Genomic DNA. Translation: EDL18195.1.
    BC011433 mRNA. Translation: AAH11433.1.
    X59047 mRNA. No translation available.
    CCDSiCCDS22038.1.
    PIRiA46472.
    RefSeqiNP_598416.1. NM_133655.2.
    UniGeneiMm.806.

    Genome annotation databases

    EnsembliENSMUST00000037941; ENSMUSP00000043768; ENSMUSG00000037706.
    GeneIDi12520.
    KEGGimmu:12520.
    UCSCiuc009kou.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S45012
    , S44957 , S44966 , S45001 , S45008 , S45010 Genomic DNA. Translation: AAB19417.1 .
    AJ251835 Genomic DNA. Translation: CAB94774.1 .
    AK166521 mRNA. Translation: BAE38825.1 .
    AK170741 mRNA. Translation: BAE41994.1 .
    AC015800 Genomic DNA. No translation available.
    CH466531 Genomic DNA. Translation: EDL18195.1 .
    BC011433 mRNA. Translation: AAH11433.1 .
    X59047 mRNA. No translation available.
    CCDSi CCDS22038.1.
    PIRi A46472.
    RefSeqi NP_598416.1. NM_133655.2.
    UniGenei Mm.806.

    3D structure databases

    ProteinModelPortali P35762.
    SMRi P35762. Positions 113-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P35762. 3 interactions.
    MINTi MINT-4090262.

    PTM databases

    PhosphoSitei P35762.

    Proteomic databases

    PaxDbi P35762.
    PRIDEi P35762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037941 ; ENSMUSP00000043768 ; ENSMUSG00000037706 .
    GeneIDi 12520.
    KEGGi mmu:12520.
    UCSCi uc009kou.2. mouse.

    Organism-specific databases

    CTDi 975.
    MGIi MGI:1096398. Cd81.

    Phylogenomic databases

    eggNOGi NOG305712.
    GeneTreei ENSGT00680000099842.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi P35762.
    KOi K06508.
    OMAi CHQKIDE.
    OrthoDBi EOG7K3TMW.
    TreeFami TF352895.

    Enzyme and pathway databases

    Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    ChiTaRSi CD81. mouse.
    NextBioi 281526.
    PROi P35762.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_CD81.
    Genevestigatori P35762.

    Family and domain databases

    Gene3Di 1.10.1450.10. 1 hit.
    InterProi IPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and chromosomal localization of the TAPA-1 gene."
      Andria M.L., Hsieh C.L., Oren R., Francke U., Levy S.
      J. Immunol. 147:1030-1036(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse."
      Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K., Reinhardt R., Reik W., Walter J.
      Hum. Mol. Genet. 9:1829-1841(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Mammary gland.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    7. Duff K., Parsons J.
      Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-236.
      Tissue: Heart.
    8. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 125-144; 149-171 AND 194-201, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    9. "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins."
      Clark K.L., Zeng Z., Langford A.L., Bowen S.M., Todd S.C.
      J. Immunol. 167:5115-5121(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IGSF8.
    10. Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    11. "Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes."
      Smith R.A., Young J., Weis J.J., Weis J.H.
      Genes Immun. 7:113-121(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IFITM2 AND IFITM3.
    12. Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, FUNCTION IN ACROSOME REACTION.

    Entry informationi

    Entry nameiCD81_MOUSE
    AccessioniPrimary (citable) accession number: P35762
    Secondary accession number(s): Q91V78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3