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Protein

CD81 antigen

Gene

Cd81

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD81 antigen
Alternative name(s):
26 kDa cell surface protein TAPA-1
Target of the antiproliferative antibody 1
CD_antigen: CD81
Gene namesi
Name:Cd81
Synonyms:Tapa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1096398. Cd81.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 5724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Topological domaini79 – 8911CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei90 – 11526HelicalSequence AnalysisAdd
BLAST
Topological domaini116 – 20186ExtracellularSequence AnalysisAdd
BLAST
Transmembranei202 – 22625HelicalSequence AnalysisAdd
BLAST
Topological domaini227 – 23610CytoplasmicSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduction in the fecundity of female mice and their eggs have impaired ability to fuse with sperm.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236CD81 antigenPRO_0000219222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi156 ↔ 190By similarity
Disulfide bondi157 ↔ 175By similarity

Post-translational modificationi

Not glycosylated.Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP35762.
PRIDEiP35762.

PTM databases

PhosphoSiteiP35762.

Expressioni

Tissue specificityi

Expressed in oocytes. Highly expressed in granulosa cells.2 Publications

Gene expression databases

CleanExiMM_CD81.

Interactioni

Subunit structurei

Interacts with CD53 and SCIMP. Interacts directly with IGSF8. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11.2 Publications

Protein-protein interaction databases

BioGridi198613. 3 interactions.
IntActiP35762. 3 interactions.
MINTiMINT-4090262.
STRINGi10090.ENSMUSP00000043768.

Structurei

3D structure databases

ProteinModelPortaliP35762.
SMRiP35762. Positions 113-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305712.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP35762.
KOiK06508.
OMAiVDDEANN.
OrthoDBiEOG7K3TMW.
TreeFamiTF352895.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTSLLYLELG
60 70 80 90 100
NKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI
110 120 130 140 150
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF
160 170 180 190 200
HETLNCCGSN ALTTLTTTIL RNSLCPSGGN ILTPLLQQDC HQKIDELFSG
210 220 230
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
Length:236
Mass (Da):25,815
Last modified:October 3, 2012 - v2
Checksum:i7BDCB792E7F9FA4E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731S → T in AAB19417 (PubMed:1650385).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45012
, S44957, S44966, S45001, S45008, S45010 Genomic DNA. Translation: AAB19417.1.
AJ251835 Genomic DNA. Translation: CAB94774.1.
AK166521 mRNA. Translation: BAE38825.1.
AK170741 mRNA. Translation: BAE41994.1.
AC015800 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18195.1.
BC011433 mRNA. Translation: AAH11433.1.
X59047 mRNA. No translation available.
CCDSiCCDS22038.1.
PIRiA46472.
RefSeqiNP_598416.1. NM_133655.2.
UniGeneiMm.806.

Genome annotation databases

EnsembliENSMUST00000037941; ENSMUSP00000043768; ENSMUSG00000037706.
GeneIDi12520.
KEGGimmu:12520.
UCSCiuc009kou.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45012
, S44957, S44966, S45001, S45008, S45010 Genomic DNA. Translation: AAB19417.1.
AJ251835 Genomic DNA. Translation: CAB94774.1.
AK166521 mRNA. Translation: BAE38825.1.
AK170741 mRNA. Translation: BAE41994.1.
AC015800 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18195.1.
BC011433 mRNA. Translation: AAH11433.1.
X59047 mRNA. No translation available.
CCDSiCCDS22038.1.
PIRiA46472.
RefSeqiNP_598416.1. NM_133655.2.
UniGeneiMm.806.

3D structure databases

ProteinModelPortaliP35762.
SMRiP35762. Positions 113-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198613. 3 interactions.
IntActiP35762. 3 interactions.
MINTiMINT-4090262.
STRINGi10090.ENSMUSP00000043768.

PTM databases

PhosphoSiteiP35762.

Proteomic databases

PaxDbiP35762.
PRIDEiP35762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037941; ENSMUSP00000043768; ENSMUSG00000037706.
GeneIDi12520.
KEGGimmu:12520.
UCSCiuc009kou.2. mouse.

Organism-specific databases

CTDi975.
MGIiMGI:1096398. Cd81.

Phylogenomic databases

eggNOGiNOG305712.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP35762.
KOiK06508.
OMAiVDDEANN.
OrthoDBiEOG7K3TMW.
TreeFamiTF352895.

Enzyme and pathway databases

ReactomeiREACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiCd81. mouse.
NextBioi281526.
PROiP35762.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CD81.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and chromosomal localization of the TAPA-1 gene."
    Andria M.L., Hsieh C.L., Oren R., Francke U., Levy S.
    J. Immunol. 147:1030-1036(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse."
    Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K., Reinhardt R., Reik W., Walter J.
    Hum. Mol. Genet. 9:1829-1841(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  7. Duff K., Parsons J.
    Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-236.
    Tissue: Heart.
  8. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 125-144; 149-171 AND 194-201, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  9. "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins."
    Clark K.L., Zeng Z., Langford A.L., Bowen S.M., Todd S.C.
    J. Immunol. 167:5115-5121(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGSF8.
  10. Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  11. "Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes."
    Smith R.A., Young J., Weis J.J., Weis J.H.
    Genes Immun. 7:113-121(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IFITM2 AND IFITM3.
  12. Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, FUNCTION IN ACROSOME REACTION.

Entry informationi

Entry nameiCD81_MOUSE
AccessioniPrimary (citable) accession number: P35762
Secondary accession number(s): Q91V78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 3, 2012
Last modified: June 24, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.