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Protein

CD81 antigen

Gene

Cd81

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD81 antigen
Alternative name(s):
26 kDa cell surface protein TAPA-1
Target of the antiproliferative antibody 1
CD_antigen: CD81
Gene namesi
Name:Cd81
Synonyms:Tapa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1096398. Cd81.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 57ExtracellularSequence analysisAdd BLAST24
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 89CytoplasmicSequence analysisAdd BLAST11
Transmembranei90 – 115HelicalSequence analysisAdd BLAST26
Topological domaini116 – 201ExtracellularSequence analysisAdd BLAST86
Transmembranei202 – 226HelicalSequence analysisAdd BLAST25
Topological domaini227 – 236CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduction in the fecundity of female mice and their eggs have impaired ability to fuse with sperm.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192221 – 236CD81 antigenAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi156 ↔ 190By similarity
Disulfide bondi157 ↔ 175By similarity

Post-translational modificationi

Not glycosylated.Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP35762.
PaxDbiP35762.
PeptideAtlasiP35762.
PRIDEiP35762.

PTM databases

iPTMnetiP35762.
PhosphoSitePlusiP35762.
SwissPalmiP35762.

Expressioni

Tissue specificityi

Expressed in oocytes. Highly expressed in granulosa cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000037706.
CleanExiMM_CD81.
ExpressionAtlasiP35762. baseline and differential.
GenevisibleiP35762. MM.

Interactioni

Subunit structurei

Interacts with CD53 and SCIMP. Interacts directly with IGSF8. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198613. 3 interactors.
IntActiP35762. 4 interactors.
MINTiMINT-4090262.
STRINGi10090.ENSMUSP00000043768.

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi116 – 136Combined sources21
Helixi141 – 154Combined sources14
Helixi161 – 170Combined sources10
Helixi172 – 174Combined sources3
Helixi183 – 186Combined sources4
Helixi190 – 197Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3X0FX-ray1.47A/B113-202[»]
ProteinModelPortaliP35762.
SMRiP35762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP35762.
KOiK06508.
OMAiVDDEANN.
OrthoDBiEOG091G0K9H.
TreeFamiTF352895.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTSLLYLELG
60 70 80 90 100
NKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI
110 120 130 140 150
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF
160 170 180 190 200
HETLNCCGSN ALTTLTTTIL RNSLCPSGGN ILTPLLQQDC HQKIDELFSG
210 220 230
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
Length:236
Mass (Da):25,815
Last modified:October 3, 2012 - v2
Checksum:i7BDCB792E7F9FA4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173S → T in AAB19417 (PubMed:1650385).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45012
, S44957, S44966, S45001, S45008, S45010 Genomic DNA. Translation: AAB19417.1.
AJ251835 Genomic DNA. Translation: CAB94774.1.
AK166521 mRNA. Translation: BAE38825.1.
AK170741 mRNA. Translation: BAE41994.1.
AC015800 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18195.1.
BC011433 mRNA. Translation: AAH11433.1.
X59047 mRNA. No translation available.
CCDSiCCDS22038.1.
PIRiA46472.
RefSeqiNP_598416.1. NM_133655.2.
UniGeneiMm.806.

Genome annotation databases

EnsembliENSMUST00000037941; ENSMUSP00000043768; ENSMUSG00000037706.
GeneIDi12520.
KEGGimmu:12520.
UCSCiuc009kou.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45012
, S44957, S44966, S45001, S45008, S45010 Genomic DNA. Translation: AAB19417.1.
AJ251835 Genomic DNA. Translation: CAB94774.1.
AK166521 mRNA. Translation: BAE38825.1.
AK170741 mRNA. Translation: BAE41994.1.
AC015800 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL18195.1.
BC011433 mRNA. Translation: AAH11433.1.
X59047 mRNA. No translation available.
CCDSiCCDS22038.1.
PIRiA46472.
RefSeqiNP_598416.1. NM_133655.2.
UniGeneiMm.806.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3X0FX-ray1.47A/B113-202[»]
ProteinModelPortaliP35762.
SMRiP35762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198613. 3 interactors.
IntActiP35762. 4 interactors.
MINTiMINT-4090262.
STRINGi10090.ENSMUSP00000043768.

PTM databases

iPTMnetiP35762.
PhosphoSitePlusiP35762.
SwissPalmiP35762.

Proteomic databases

EPDiP35762.
PaxDbiP35762.
PeptideAtlasiP35762.
PRIDEiP35762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037941; ENSMUSP00000043768; ENSMUSG00000037706.
GeneIDi12520.
KEGGimmu:12520.
UCSCiuc009kou.2. mouse.

Organism-specific databases

CTDi975.
MGIiMGI:1096398. Cd81.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiP35762.
KOiK06508.
OMAiVDDEANN.
OrthoDBiEOG091G0K9H.
TreeFamiTF352895.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiCd81. mouse.
PROiP35762.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037706.
CleanExiMM_CD81.
ExpressionAtlasiP35762. baseline and differential.
GenevisibleiP35762. MM.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD81_MOUSE
AccessioniPrimary (citable) accession number: P35762
Secondary accession number(s): Q91V78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.