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Protein

Venom allergen 5

Gene
N/A
Organism
Polistes exclamans (Paper wasp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Venom allergen 5
Alternative name(s):
Allergen Pol e V
Antigen 5
Short name:
Ag5
Cysteine-rich venom protein
Short name:
CRVP
Allergen: Pol e 5
OrganismiPolistes exclamans (Paper wasp)
Taxonomic identifieri27506 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3441. Pol e 5.0101.
591. Pol e 5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 226205Venom allergen 5PRO_0000211535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 37By similarity
Disulfide bondi29 ↔ 125By similarity
Disulfide bondi49 ↔ 117By similarity
Disulfide bondi192 ↔ 209By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP35759.
SMRiP35759. Positions 19-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 211143SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIGGLVYLV IVVAIIHSSQ GVDYCKIRCP SGIHTVCQYG ESTKPSKNCA
60 70 80 90 100
GKVIKSVGPT EEEKKLIVSE HNRFRQKVAQ GLETRGNPGP QPAASDMNDL
110 120 130 140 150
VWNDELAHIA QVWASQCQFL VHDKCRNTAK YPVGQNIAYA GGSKLPDVVS
160 170 180 190 200
LIKLWENEVK DFNYNTGITK QNFAKIGHYT QMVWGKTKEI GCGSLKYMEN
210 220
KMQNHYLICN YGPAGNYLGQ LPNTKK
Length:226
Mass (Da):25,122
Last modified:November 30, 2010 - v2
Checksum:i2B64A7586E375039
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281R → K AA sequence (PubMed:8454859).Curated
Sequence conflicti198 – 1981M → I AA sequence (PubMed:8454859).Curated
Sequence conflicti223 – 2231N → Y AA sequence (PubMed:8454859).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY684999 mRNA. Translation: AAT95009.1.
PIRiA37329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY684999 mRNA. Translation: AAT95009.1.
PIRiA37329.

3D structure databases

ProteinModelPortaliP35759.
SMRiP35759. Positions 19-226.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3441. Pol e 5.0101.
591. Pol e 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVA5_POLEX
AccessioniPrimary (citable) accession number: P35759
Secondary accession number(s): Q68KJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 30, 2010
Last modified: October 14, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.