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Protein

Ice-structuring protein RD3

Gene
N/A
Organism
Lycodichthys dearborni (Antarctic eelpout) (Rhigophila dearborni)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei9Important for ice-bindingBy similarity1
Sitei14Important for ice-bindingBy similarity1
Sitei18Important for ice-bindingBy similarity1
Sitei44Important for ice-bindingBy similarity1
Sitei79Important for ice-bindingBy similarity1
Sitei84Important for ice-bindingBy similarity1
Sitei88Important for ice-bindingBy similarity1
Sitei114Important for ice-bindingBy similarity1

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antifreeze protein

Names & Taxonomyi

Protein namesi
Recommended name:
Ice-structuring protein RD3
Short name:
ISP RD3
Alternative name(s):
Antifreeze peptide RD3
OrganismiLycodichthys dearborni (Antarctic eelpout) (Rhigophila dearborni)
Taxonomic identifieri8201 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiZoarcalesZoarcidaeLycodinaeLycodichthys

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001551531 – 134Ice-structuring protein RD3Add BLAST134

Expressioni

Tissue specificityi

Detected in blood serum (at protein level).1 Publication

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Turni19 – 21Combined sources3
Beta strandi22 – 25Combined sources4
Beta strandi32 – 34Combined sources3
Helixi37 – 40Combined sources4
Beta strandi45 – 47Combined sources3
Turni57 – 59Combined sources3
Beta strandi60 – 62Combined sources3
Beta strandi71 – 79Combined sources9
Turni89 – 91Combined sources3
Beta strandi93 – 96Combined sources4
Beta strandi103 – 106Combined sources4
Helixi107 – 110Combined sources4
Beta strandi121 – 124Combined sources4
Turni127 – 129Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C89NMR-A1-134[»]
1C8ANMR-A1-134[»]
3NLANMR-A1-73[»]
3RDNNMR-A1-73[»]
ProteinModelPortaliP35753.
SMRiP35753.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35753.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 63AFP-like 1PROSITE-ProRule annotationAdd BLAST60
Domaini74 – 133AFP-like 2PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 70Linker6

Sequence similaritiesi

Belongs to the type-III AFP family.Curated
Contains 2 AFP-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG004240.

Family and domain databases

Gene3Di3.90.1210.10. 2 hits.
InterProiIPR006190. AFP_Neu5c_C.
IPR006013. Antifreeze_III.
IPR013974. SAF.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SMARTiSM00858. SAF. 2 hits.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 2 hits.
PROSITEiPS50844. AFP_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NKASVVANQL IPINTALTLI MMKAEVVTPM GIPAEEIPNL VGMQVNRAVP
60 70 80 90 100
LGTTLMPDMV KNYEDGTTSP GLKSVVANQL IPINTALTLV MMKAEEVSPK
110 120 130
GIPSEEISKL VGMQVNRAVY LDQTLMPDMV KNYE
Length:134
Mass (Da):14,480
Last modified:June 1, 1994 - v1
Checksum:iF7F208BF3E2CAA54
GO

Sequence databases

PIRiS53514.

Cross-referencesi

Sequence databases

PIRiS53514.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C89NMR-A1-134[»]
1C8ANMR-A1-134[»]
3NLANMR-A1-73[»]
3RDNNMR-A1-73[»]
ProteinModelPortaliP35753.
SMRiP35753.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004240.

Miscellaneous databases

EvolutionaryTraceiP35753.

Family and domain databases

Gene3Di3.90.1210.10. 2 hits.
InterProiIPR006190. AFP_Neu5c_C.
IPR006013. Antifreeze_III.
IPR013974. SAF.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SMARTiSM00858. SAF. 2 hits.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 2 hits.
PROSITEiPS50844. AFP_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANP3_LYCDA
AccessioniPrimary (citable) accession number: P35753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.