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P35751

- ANP1_RHIDE

UniProt

P35751 - ANP1_RHIDE

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Protein
Ice-structuring protein RD1
Gene
N/A
Organism
Rhigophila dearborni (Antarctic eelpout) (Lycodichthys dearborni)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei9 – 91Important for ice-binding By similarity
Sitei14 – 141Important for ice-binding By similarity
Sitei18 – 181Important for ice-binding By similarity
Sitei44 – 441Important for ice-binding By similarity

GO - Biological processi

  1. response to freezing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antifreeze protein

Names & Taxonomyi

Protein namesi
Recommended name:
Ice-structuring protein RD1
Short name:
ISP RD1
Alternative name(s):
Antifreeze peptide RD1
OrganismiRhigophila dearborni (Antarctic eelpout) (Lycodichthys dearborni)
Taxonomic identifieri8201 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaPerciformesCottioideiZoarcalesZoarcidaeLycodinaeLycodichthys

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6464Ice-structuring protein RD1
PRO_0000155151Add
BLAST

Expressioni

Tissue specificityi

Detected in blood serum (at protein level).1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96
Helixi19 – 213
Beta strandi22 – 254
Helixi34 – 363
Helixi37 – 404
Beta strandi44 – 474
Helixi57 – 593

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UCSX-ray0.62A1-64[»]
ProteinModelPortaliP35751.
SMRiP35751. Positions 1-64.

Miscellaneous databases

EvolutionaryTraceiP35751.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6360AFP-like
Add
BLAST

Sequence similaritiesi

Belongs to the type-III AFP family.
Contains 1 AFP-like domain.

Phylogenomic databases

HOVERGENiHBG004237.

Family and domain databases

Gene3Di3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR006013. Antifreeze_III.
IPR013974. SAF.
[Graphical view]
PfamiPF08666. SAF. 1 hit.
[Graphical view]
PRINTSiPR00357. ANTIFREEZIII.
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35751-1 [UniParc]FASTAAdd to Basket

« Hide

NKASVVANQL IPINTALTLI MMKAEVVTPM GIPAEEIPKL VGMQVNRAVP   50
LGTTLMPDMV KNYE 64
Length:64
Mass (Da):6,906
Last modified:June 1, 1994 - v1
Checksum:i154C6BE62D913192
GO

Sequence databases

PIRiS53512.

Cross-referencesi

Sequence databases

PIRi S53512.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UCS X-ray 0.62 A 1-64 [» ]
ProteinModelPortali P35751.
SMRi P35751. Positions 1-64.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004237.

Miscellaneous databases

EvolutionaryTracei P35751.

Family and domain databases

Gene3Di 3.90.1210.10. 1 hit.
InterProi IPR006190. AFP_Neu5c_C.
IPR006013. Antifreeze_III.
IPR013974. SAF.
[Graphical view ]
Pfami PF08666. SAF. 1 hit.
[Graphical view ]
PRINTSi PR00357. ANTIFREEZIII.
SUPFAMi SSF51269. SSF51269. 1 hit.
PROSITEi PS50844. AFP_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Antifreeze peptide heterogeneity in an antarctic eel pout includes an unusually large major variant comprised of two 7 kDa type III AFPs linked in tandem."
    Wang X., Devries A.L., Cheng C.-H.C.
    Biochim. Biophys. Acta 1247:163-172(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The refined crystal structure of an eel pout type III antifreeze protein RD1 at 0.62-A resolution reveals structuRAl microheterogeneity of protein and solvation."
    Ko T.-P., Robinson H., Gao Y.-G., Cheng C.H.-C., DeVries A.L., Wang A.H.-J.
    Biophys. J. 84:1228-1237(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (0.62 ANGSTROMS).

Entry informationi

Entry nameiANP1_RHIDE
AccessioniPrimary (citable) accession number: P35751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi