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P35749

- MYH11_HUMAN

UniProt

P35749 - MYH11_HUMAN

Protein

Myosin-11

Gene

MYH11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 3 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Muscle contraction.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi178 – 1858ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: Ensembl
    3. protein binding Source: IntAct
    4. structural constituent of muscle Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. cardiac muscle fiber development Source: UniProtKB
    3. elastic fiber assembly Source: UniProtKB
    4. muscle contraction Source: Reactome
    5. skeletal muscle myosin thick filament assembly Source: UniProtKB
    6. smooth muscle contraction Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_19277. Sema4D induced cell migration and growth-cone collapse.
    REACT_20558. Smooth Muscle Contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-11
    Alternative name(s):
    Myosin heavy chain 11
    Myosin heavy chain, smooth muscle isoform
    SMMHC
    Gene namesi
    Name:MYH11
    Synonyms:KIAA0866
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:7569. MYH11.

    Subcellular locationi

    Melanosome 1 Publication
    Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. melanosome Source: UniProtKB-SubCell
    3. muscle myosin complex Source: ProtInc
    4. myosin filament Source: UniProtKB-KW
    5. smooth muscle contractile fiber Source: Ensembl
    6. stress fiber Source: Ensembl

    Keywords - Cellular componenti

    Thick filament

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
    Aortic aneurysm, familial thoracic 4 (AAT4) [MIM:132900]: A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1241 – 126424Missing in AAT4.
    VAR_031734Add
    BLAST
    Natural varianti1758 – 17581R → Q in AAT4. 1 Publication
    VAR_031735

    Keywords - Diseasei

    Aortic aneurysm, Disease mutation, Proto-oncogene

    Organism-specific databases

    MIMi132900. phenotype.
    Orphaneti98829. Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22).
    229. Familial aortic dissection.
    91387. Familial thoracic aortic aneurysm and aortic dissection.
    PharmGKBiPA31367.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19721972Myosin-11PRO_0000123424Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81PhosphoserineBy similarity
    Modified residuei129 – 1291N6,N6,N6-trimethyllysineSequence Analysis
    Modified residuei1954 – 19541Phosphoserine1 Publication

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiP35749.
    PaxDbiP35749.
    PRIDEiP35749.

    PTM databases

    PhosphoSiteiP35749.

    Expressioni

    Tissue specificityi

    Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.1 Publication

    Gene expression databases

    ArrayExpressiP35749.
    BgeeiP35749.
    CleanExiHS_MYH11.
    GenevestigatoriP35749.

    Organism-specific databases

    HPAiCAB002302.
    HPA014539.
    HPA015310.

    Interactioni

    Subunit structurei

    Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MYL12BO149502EBI-1052928,EBI-1642165

    Protein-protein interaction databases

    BioGridi110714. 20 interactions.
    DIPiDIP-47268N.
    IntActiP35749. 9 interactions.
    MINTiMINT-2802946.
    STRINGi9606.ENSP00000379616.

    Structurei

    3D structure databases

    ProteinModelPortaliP35749.
    SMRiP35749. Positions 7-904.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 783699Myosin motorAdd
    BLAST
    Domaini786 – 81530IQPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni661 – 68323Actin-bindingBy similarityAdd
    BLAST
    Regioni762 – 77615Actin-bindingBy similarityAdd
    BLAST
    Regioni1935 – 197238C-terminalAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili844 – 19341091Sequence AnalysisAdd
    BLAST

    Domaini

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000173958.
    HOVERGENiHBG004704.
    KOiK10352.
    OMAiQAKQDVE.
    OrthoDBiEOG71CFK3.
    PhylomeDBiP35749.
    TreeFamiTF333601.

    Family and domain databases

    Gene3Di4.10.270.10. 1 hit.
    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR008989. Myosin_S1_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50084. SSF50084. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P35749-1) [UniParc]FASTAAdd to Basket

    Also known as: SM-A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI     50
    KEEKGDEVVV ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS 100
    VLHNLRERYF SGLIYTYSGL FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM 150
    PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS 200
    SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS RFGKFIRINF 250
    DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYMIAG AKEKMRSDLL 300
    LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMAIMGFSE EEQLSILKVV 350
    SSVLQLGNIV FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR 400
    IKVGRDVVQK AQTKEQADFA VEALAKATYE RLFRWILTRV NKALDKTHRQ 450
    GASFLGILDI AGFEIFEVNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ 500
    REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW FPKATDKSFV 550
    EKLCTEQGSH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN 600
    DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF 650
    RTVGQLYKEQ LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR 700
    CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LAANAIPKGF MDGKQACILM 750
    IKALELDPNL YRIGQSKIFF RTGVLAHLEE ERDLKITDVI MAFQAMCRGY 800
    LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK VKPLLQVTRQ 850
    EEEMQAKEDE LQKTKERQQK AENELKELEQ KHSQLTEEKN LLQEQLQAET 900
    ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ 950
    QMLDLEEQLE EEEAARQKLQ LEKVTAEAKI KKLEDEILVM DDQNNKLSKE 1000
    RKLLEERISD LTTNLAEEEE KAKNLTKLKN KHESMISELE VRLKKEEKSR 1050
    QELEKLKRKL EGDASDFHEQ IADLQAQIAE LKMQLAKKEE ELQAALARLD 1100
    DEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ KRDLGEELEA 1150
    LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK 1200
    HAQAVEELTE QLEQFKRAKA NLDKNKQTLE KENADLAGEL RVLGQAKQEV 1250
    EHKKKKLEAQ VQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLNEAE 1300
    GKAIKLAKDV ASLSSQLQDT QELLQEETRQ KLNVSTKLRQ LEEERNSLQD 1350
    QLDEEMEAKQ NLERHISTLN IQLSDSKKKL QDFASTVEAL EEGKKRFQKE 1400
    IENLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR QLVSNLEKKQ 1450
    RKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE 1500
    ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE 1550
    LEDELQATED AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE 1600
    YETELEDERK QRALAAAAKK KLEGDLKDLE LQADSAIKGR EEAIKQLRKL 1650
    QAQMKDFQRE LEDARASRDE IFATAKENEK KAKSLEADLM QLQEDLAAAE 1700
    RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ LEEELEEEQG 1750
    NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK 1800
    LHEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK 1850
    LKEILLQVED ERKMAEQYKE QAEKGNARVK QLKRQLEEAE EESQRINANR 1900
    RKLQRELDEA TESNEAMGRE VNALKSKLRR GNETSFVPSR RSGGRRVIEN 1950
    ADGSEEETDT RDADFNGTKA SE 1972
    Length:1,972
    Mass (Da):227,339
    Last modified:April 27, 2001 - v3
    Checksum:i67665BB2AECE1277
    GO
    Isoform 2 (identifier: P35749-2) [UniParc]FASTAAdd to Basket

    Also known as: SM-B1

    The sequence of this isoform differs from the canonical sequence as follows:
         211-211: T → TQGPSFAY

    Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.

    Show »
    Length:1,979
    Mass (Da):228,090
    Checksum:i9B70CDC6279DC694
    GO
    Isoform 3 (identifier: P35749-3) [UniParc]FASTAAdd to Basket

    Also known as: SM-B2

    The sequence of this isoform differs from the canonical sequence as follows:
         211-211: T → TQGPSFAY
         1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

    Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.

    Show »
    Length:1,945
    Mass (Da):224,328
    Checksum:i0FA4E1636B68B8AC
    GO
    Isoform 4 (identifier: P35749-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

    Note: No experimental confirmation available.

    Show »
    Length:1,938
    Mass (Da):223,577
    Checksum:i61D4A502A155BEC0
    GO

    Sequence cautioni

    The sequence BAA74889.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti887 – 8893EEK → NSE in D10667. (PubMed:7684189)Curated
    Sequence conflicti1558 – 15581T → S in D10667. (PubMed:7684189)Curated
    Sequence conflicti1610 – 16112KQ → NE in D10667. (PubMed:7684189)Curated
    Sequence conflicti1786 – 17861A → S in CAA49154. 1 PublicationCurated
    Sequence conflicti1958 – 19581T → L in D10667. (PubMed:7684189)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1104 – 11041A → T.
    Corresponds to variant rs34263860 [ dbSNP | Ensembl ].
    VAR_050205
    Natural varianti1234 – 12341A → T.
    Corresponds to variant rs16967494 [ dbSNP | Ensembl ].
    VAR_030239
    Natural varianti1241 – 126424Missing in AAT4.
    VAR_031734Add
    BLAST
    Natural varianti1289 – 12891V → A.
    Corresponds to variant rs16967510 [ dbSNP | Ensembl ].
    VAR_030240
    Natural varianti1310 – 13101V → M.
    Corresponds to variant rs7196804 [ dbSNP | Ensembl ].
    VAR_030241
    Natural varianti1508 – 15081M → V.
    Corresponds to variant rs35176378 [ dbSNP | Ensembl ].
    VAR_050206
    Natural varianti1758 – 17581R → Q in AAT4. 1 Publication
    VAR_031735

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei211 – 2111T → TQGPSFAY in isoform 2 and isoform 3. 2 PublicationsVSP_043017
    Alternative sequencei1930 – 197243RGNET…TKASE → GPPPQETSQ in isoform 3 and isoform 4. 2 PublicationsVSP_043018Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY520816 mRNA. Translation: AAS98910.1.
    AY520817 mRNA. Translation: AAS98911.1.
    AF001548 Genomic DNA. Translation: AAC31665.1.
    U91323 Genomic DNA. Translation: AAC35212.1.
    AB020673 mRNA. Translation: BAA74889.2. Different initiation.
    GU143399 Genomic DNA. Translation: ACZ58373.1.
    GU143400 Genomic DNA. Translation: ACZ58374.1.
    AC024120 Genomic DNA. No translation available.
    AC026401 Genomic DNA. No translation available.
    AC130651 Genomic DNA. No translation available.
    CH471226 Genomic DNA. Translation: EAW53924.1.
    CH471226 Genomic DNA. Translation: EAW53926.1.
    BC101677 mRNA. Translation: AAI01678.1.
    BC104906 mRNA. Translation: AAI04907.1.
    BC143364 mRNA. Translation: AAI43365.1.
    D10667 mRNA. No translation available.
    X69292 mRNA. Translation: CAA49154.1.
    CCDSiCCDS10565.1. [P35749-1]
    CCDS10566.1. [P35749-4]
    CCDS45423.1. [P35749-2]
    CCDS45424.1. [P35749-3]
    RefSeqiNP_001035202.1. NM_001040113.1. [P35749-3]
    NP_001035203.1. NM_001040114.1. [P35749-2]
    NP_002465.1. NM_002474.2. [P35749-1]
    NP_074035.1. NM_022844.2. [P35749-4]
    UniGeneiHs.460109.

    Genome annotation databases

    EnsembliENST00000300036; ENSP00000300036; ENSG00000133392. [P35749-1]
    ENST00000396324; ENSP00000379616; ENSG00000133392. [P35749-2]
    ENST00000452625; ENSP00000407821; ENSG00000133392. [P35749-3]
    ENST00000576790; ENSP00000458731; ENSG00000133392. [P35749-4]
    GeneIDi4629.
    KEGGihsa:4629.
    UCSCiuc002ddv.3. human. [P35749-3]
    uc002ddw.3. human. [P35749-4]
    uc002ddx.3. human. [P35749-2]
    uc002ddy.3. human. [P35749-1]

    Polymorphism databases

    DMDMi13432177.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY520816 mRNA. Translation: AAS98910.1 .
    AY520817 mRNA. Translation: AAS98911.1 .
    AF001548 Genomic DNA. Translation: AAC31665.1 .
    U91323 Genomic DNA. Translation: AAC35212.1 .
    AB020673 mRNA. Translation: BAA74889.2 . Different initiation.
    GU143399 Genomic DNA. Translation: ACZ58373.1 .
    GU143400 Genomic DNA. Translation: ACZ58374.1 .
    AC024120 Genomic DNA. No translation available.
    AC026401 Genomic DNA. No translation available.
    AC130651 Genomic DNA. No translation available.
    CH471226 Genomic DNA. Translation: EAW53924.1 .
    CH471226 Genomic DNA. Translation: EAW53926.1 .
    BC101677 mRNA. Translation: AAI01678.1 .
    BC104906 mRNA. Translation: AAI04907.1 .
    BC143364 mRNA. Translation: AAI43365.1 .
    D10667 mRNA. No translation available.
    X69292 mRNA. Translation: CAA49154.1 .
    CCDSi CCDS10565.1. [P35749-1 ]
    CCDS10566.1. [P35749-4 ]
    CCDS45423.1. [P35749-2 ]
    CCDS45424.1. [P35749-3 ]
    RefSeqi NP_001035202.1. NM_001040113.1. [P35749-3 ]
    NP_001035203.1. NM_001040114.1. [P35749-2 ]
    NP_002465.1. NM_002474.2. [P35749-1 ]
    NP_074035.1. NM_022844.2. [P35749-4 ]
    UniGenei Hs.460109.

    3D structure databases

    ProteinModelPortali P35749.
    SMRi P35749. Positions 7-904.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110714. 20 interactions.
    DIPi DIP-47268N.
    IntActi P35749. 9 interactions.
    MINTi MINT-2802946.
    STRINGi 9606.ENSP00000379616.

    PTM databases

    PhosphoSitei P35749.

    Polymorphism databases

    DMDMi 13432177.

    Proteomic databases

    MaxQBi P35749.
    PaxDbi P35749.
    PRIDEi P35749.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300036 ; ENSP00000300036 ; ENSG00000133392 . [P35749-1 ]
    ENST00000396324 ; ENSP00000379616 ; ENSG00000133392 . [P35749-2 ]
    ENST00000452625 ; ENSP00000407821 ; ENSG00000133392 . [P35749-3 ]
    ENST00000576790 ; ENSP00000458731 ; ENSG00000133392 . [P35749-4 ]
    GeneIDi 4629.
    KEGGi hsa:4629.
    UCSCi uc002ddv.3. human. [P35749-3 ]
    uc002ddw.3. human. [P35749-4 ]
    uc002ddx.3. human. [P35749-2 ]
    uc002ddy.3. human. [P35749-1 ]

    Organism-specific databases

    CTDi 4629.
    GeneCardsi GC16M015704.
    GeneReviewsi MYH11.
    HGNCi HGNC:7569. MYH11.
    HPAi CAB002302.
    HPA014539.
    HPA015310.
    MIMi 132900. phenotype.
    160745. gene.
    neXtProti NX_P35749.
    Orphaneti 98829. Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22).
    229. Familial aortic dissection.
    91387. Familial thoracic aortic aneurysm and aortic dissection.
    PharmGKBi PA31367.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000173958.
    HOVERGENi HBG004704.
    KOi K10352.
    OMAi QAKQDVE.
    OrthoDBi EOG71CFK3.
    PhylomeDBi P35749.
    TreeFami TF333601.

    Enzyme and pathway databases

    Reactomei REACT_19277. Sema4D induced cell migration and growth-cone collapse.
    REACT_20558. Smooth Muscle Contraction.

    Miscellaneous databases

    ChiTaRSi MYH11. human.
    GeneWikii MYH11.
    GenomeRNAii 4629.
    NextBioi 17818.
    PROi P35749.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35749.
    Bgeei P35749.
    CleanExi HS_MYH11.
    Genevestigatori P35749.

    Family and domain databases

    Gene3Di 4.10.270.10. 1 hit.
    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR008989. Myosin_S1_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50084. SSF50084. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "(+)Insert smooth muscle myosin heavy chain (SM-B) isoform expression in human tissues."
      Leguillette R., Gil F.R., Zitouni N., Lajoie-Kadoch S., Sobieszek A., Lauzon A.M.
      Am. J. Physiol. 289:C1277-C1285(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. Nagase T., Kikuno R., Yamakawa H., Ohara O.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. NHLBI resequencing and genotyping service (RS&G)
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Colon.
    9. "Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12."
      Matsuoka R., Yoshida M.C., Furutani Y., Imamura S., Kanda N., Yanagisawa M., Masaki T., Takao A.
      Am. J. Med. Genet. 46:61-67(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 885-1972 (ISOFORM 1/2).
    10. Okajima K.
      Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1093-1972 (ISOFORM 1/2).
      Tissue: Hippocampus.
    11. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    12. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1954, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus."
      Zhu L., Vranckx R., Khau Van Kien P., Lalande A., Boisset N., Mathieu F., Wegman M., Glancy L., Gasc J.-M., Brunotte F., Bruneval P., Wolf J.-E., Michel J.-B., Jeunemaitre X.
      Nat. Genet. 38:343-349(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS AAT4 1241-ARG--LEU-1264 DEL AND GLN-1758.

    Entry informationi

    Entry nameiMYH11_HUMAN
    AccessioniPrimary (citable) accession number: P35749
    Secondary accession number(s): D2JYH7
    , O00396, O94944, P78422, Q3MIV8, Q3MNF0, Q3MNF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 157 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3