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P35749 - MYH11_HUMAN

UniProt

P35749 - MYH11_HUMAN

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Protein

Myosin-11

Gene

MYH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi178 – 1858ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: Ensembl
  3. structural constituent of muscle Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: Reactome
  2. cardiac muscle fiber development Source: UniProtKB
  3. elastic fiber assembly Source: UniProtKB
  4. muscle contraction Source: Reactome
  5. skeletal muscle myosin thick filament assembly Source: UniProtKB
  6. smooth muscle contraction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_19277. Sema4D induced cell migration and growth-cone collapse.
REACT_20558. Smooth Muscle Contraction.
REACT_228063. EPHA-mediated growth cone collapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-11
Alternative name(s):
Myosin heavy chain 11
Myosin heavy chain, smooth muscle isoform
SMMHC
Gene namesi
Name:MYH11
Synonyms:KIAA0866
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 16, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:7569. MYH11.

Subcellular locationi

Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular vesicular exosome Source: UniProtKB
  3. melanosome Source: UniProtKB-SubCell
  4. muscle myosin complex Source: ProtInc
  5. myosin filament Source: UniProtKB-KW
  6. smooth muscle contractile fiber Source: Ensembl
  7. stress fiber Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Thick filament

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.

Aortic aneurysm, familial thoracic 41 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

See also OMIM:132900
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1241 – 126424Missing in AAT4. 1 Publication
VAR_031734Add
BLAST
Natural varianti1758 – 17581R → Q in AAT4. 1 Publication
VAR_031735

Keywords - Diseasei

Aortic aneurysm, Disease mutation, Proto-oncogene

Organism-specific databases

MIMi132900. phenotype.
Orphaneti98829. Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22).
229. Familial aortic dissection.
91387. Familial thoracic aortic aneurysm and aortic dissection.
PharmGKBiPA31367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19721972Myosin-11PRO_0000123424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei129 – 1291N6,N6,N6-trimethyllysineSequence Analysis
Modified residuei1954 – 19541Phosphoserine1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP35749.
PaxDbiP35749.
PRIDEiP35749.

PTM databases

PhosphoSiteiP35749.

Expressioni

Tissue specificityi

Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.1 Publication

Gene expression databases

BgeeiP35749.
CleanExiHS_MYH11.
ExpressionAtlasiP35749. baseline and differential.
GenevestigatoriP35749.

Organism-specific databases

HPAiCAB002302.
HPA014539.
HPA015310.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Binary interactionsi

WithEntry#Exp.IntActNotes
MYL12BO149502EBI-1052928,EBI-1642165

Protein-protein interaction databases

BioGridi110714. 24 interactions.
DIPiDIP-47268N.
IntActiP35749. 9 interactions.
MINTiMINT-2802946.
STRINGi9606.ENSP00000379616.

Structurei

3D structure databases

ProteinModelPortaliP35749.
SMRiP35749. Positions 7-904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 783699Myosin motorAdd
BLAST
Domaini786 – 81530IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni661 – 68323Actin-bindingBy similarityAdd
BLAST
Regioni762 – 77615Actin-bindingBy similarityAdd
BLAST
Regioni1935 – 197238C-terminalAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili844 – 19341091Sequence AnalysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated
Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP35749.
KOiK10352.
OMAiCHLVGIN.
OrthoDBiEOG71CFK3.
PhylomeDBiP35749.
TreeFamiTF333601.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR008989. Myosin_S1_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF50084. SSF50084. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P35749-1) [UniParc]FASTAAdd to Basket

Also known as: SM-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI 
        60         70         80         90        100
KEEKGDEVVV ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS 
       110        120        130        140        150
VLHNLRERYF SGLIYTYSGL FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM 
       160        170        180        190        200
PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS 
       210        220        230        240        250
SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS RFGKFIRINF 
       260        270        280        290        300
DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYMIAG AKEKMRSDLL 
       310        320        330        340        350
LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMAIMGFSE EEQLSILKVV 
       360        370        380        390        400
SSVLQLGNIV FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR 
       410        420        430        440        450
IKVGRDVVQK AQTKEQADFA VEALAKATYE RLFRWILTRV NKALDKTHRQ 
       460        470        480        490        500
GASFLGILDI AGFEIFEVNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ 
       510        520        530        540        550
REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW FPKATDKSFV 
       560        570        580        590        600
EKLCTEQGSH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN 
       610        620        630        640        650
DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF 
       660        670        680        690        700
RTVGQLYKEQ LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR 
       710        720        730        740        750
CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LAANAIPKGF MDGKQACILM 
       760        770        780        790        800
IKALELDPNL YRIGQSKIFF RTGVLAHLEE ERDLKITDVI MAFQAMCRGY 
       810        820        830        840        850
LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK VKPLLQVTRQ 
       860        870        880        890        900
EEEMQAKEDE LQKTKERQQK AENELKELEQ KHSQLTEEKN LLQEQLQAET 
       910        920        930        940        950
ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ 
       960        970        980        990       1000
QMLDLEEQLE EEEAARQKLQ LEKVTAEAKI KKLEDEILVM DDQNNKLSKE 
      1010       1020       1030       1040       1050
RKLLEERISD LTTNLAEEEE KAKNLTKLKN KHESMISELE VRLKKEEKSR 
      1060       1070       1080       1090       1100
QELEKLKRKL EGDASDFHEQ IADLQAQIAE LKMQLAKKEE ELQAALARLD 
      1110       1120       1130       1140       1150
DEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ KRDLGEELEA 
      1160       1170       1180       1190       1200
LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK 
      1210       1220       1230       1240       1250
HAQAVEELTE QLEQFKRAKA NLDKNKQTLE KENADLAGEL RVLGQAKQEV 
      1260       1270       1280       1290       1300
EHKKKKLEAQ VQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLNEAE 
      1310       1320       1330       1340       1350
GKAIKLAKDV ASLSSQLQDT QELLQEETRQ KLNVSTKLRQ LEEERNSLQD 
      1360       1370       1380       1390       1400
QLDEEMEAKQ NLERHISTLN IQLSDSKKKL QDFASTVEAL EEGKKRFQKE 
      1410       1420       1430       1440       1450
IENLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR QLVSNLEKKQ 
      1460       1470       1480       1490       1500
RKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE 
      1510       1520       1530       1540       1550
ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE 
      1560       1570       1580       1590       1600
LEDELQATED AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE 
      1610       1620       1630       1640       1650
YETELEDERK QRALAAAAKK KLEGDLKDLE LQADSAIKGR EEAIKQLRKL 
      1660       1670       1680       1690       1700
QAQMKDFQRE LEDARASRDE IFATAKENEK KAKSLEADLM QLQEDLAAAE 
      1710       1720       1730       1740       1750
RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ LEEELEEEQG 
      1760       1770       1780       1790       1800
NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK 
      1810       1820       1830       1840       1850
LHEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK 
      1860       1870       1880       1890       1900
LKEILLQVED ERKMAEQYKE QAEKGNARVK QLKRQLEEAE EESQRINANR 
      1910       1920       1930       1940       1950
RKLQRELDEA TESNEAMGRE VNALKSKLRR GNETSFVPSR RSGGRRVIEN 
      1960       1970 
ADGSEEETDT RDADFNGTKA SE
Length:1,972
Mass (Da):227,339
Last modified:April 27, 2001 - v3
Checksum:i67665BB2AECE1277
GO
Isoform 2 (identifier: P35749-2) [UniParc]FASTAAdd to Basket

Also known as: SM-B1

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.

Show »
Length:1,979
Mass (Da):228,090
Checksum:i9B70CDC6279DC694
GO
Isoform 3 (identifier: P35749-3) [UniParc]FASTAAdd to Basket

Also known as: SM-B2

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.

Show »
Length:1,945
Mass (Da):224,328
Checksum:i0FA4E1636B68B8AC
GO
Isoform 4 (identifier: P35749-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: No experimental confirmation available.

Show »
Length:1,938
Mass (Da):223,577
Checksum:i61D4A502A155BEC0
GO

Sequence cautioni

The sequence BAA74889.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti887 – 8893EEK → NSE in D10667. (PubMed:7684189)Curated
Sequence conflicti1558 – 15581T → S in D10667. (PubMed:7684189)Curated
Sequence conflicti1610 – 16112KQ → NE in D10667. (PubMed:7684189)Curated
Sequence conflicti1786 – 17861A → S in CAA49154. 1 PublicationCurated
Sequence conflicti1958 – 19581T → L in D10667. (PubMed:7684189)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1104 – 11041A → T.
Corresponds to variant rs34263860 [ dbSNP | Ensembl ].		VAR_050205
Natural varianti1234 – 12341A → T.
Corresponds to variant rs16967494 [ dbSNP | Ensembl ].		VAR_030239
Natural varianti1241 – 126424Missing in AAT4. 1 Publication
VAR_031734Add
BLAST
Natural varianti1289 – 12891V → A.
Corresponds to variant rs16967510 [ dbSNP | Ensembl ].		VAR_030240
Natural varianti1310 – 13101V → M.
Corresponds to variant rs7196804 [ dbSNP | Ensembl ].		VAR_030241
Natural varianti1508 – 15081M → V.
Corresponds to variant rs35176378 [ dbSNP | Ensembl ].		VAR_050206
Natural varianti1758 – 17581R → Q in AAT4. 1 Publication
VAR_031735

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei211 – 2111T → TQGPSFAY in isoform 2 and isoform 3. 2 PublicationsVSP_043017
Alternative sequencei1930 – 197243RGNET…TKASE → GPPPQETSQ in isoform 3 and isoform 4. 2 PublicationsVSP_043018Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY520816 mRNA. Translation: AAS98910.1.
AY520817 mRNA. Translation: AAS98911.1.
AF001548 Genomic DNA. Translation: AAC31665.1.
U91323 Genomic DNA. Translation: AAC35212.1.
AB020673 mRNA. Translation: BAA74889.2. Different initiation.
GU143399 Genomic DNA. Translation: ACZ58373.1.
GU143400 Genomic DNA. Translation: ACZ58374.1.
AC024120 Genomic DNA. No translation available.
AC026401 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
CH471226 Genomic DNA. Translation: EAW53924.1.
CH471226 Genomic DNA. Translation: EAW53926.1.
BC101677 mRNA. Translation: AAI01678.1.
BC104906 mRNA. Translation: AAI04907.1.
BC143364 mRNA. Translation: AAI43365.1.
D10667 mRNA. No translation available.
X69292 mRNA. Translation: CAA49154.1.
CCDSiCCDS10565.1. [P35749-1]
CCDS10566.1. [P35749-4]
CCDS45423.1. [P35749-2]
CCDS45424.1. [P35749-3]
RefSeqiNP_001035202.1. NM_001040113.1. [P35749-3]
NP_001035203.1. NM_001040114.1. [P35749-2]
NP_002465.1. NM_002474.2. [P35749-1]
NP_074035.1. NM_022844.2. [P35749-4]
UniGeneiHs.460109.

Genome annotation databases

EnsembliENST00000300036; ENSP00000300036; ENSG00000133392. [P35749-1]
ENST00000396324; ENSP00000379616; ENSG00000133392. [P35749-2]
ENST00000452625; ENSP00000407821; ENSG00000133392. [P35749-3]
ENST00000576790; ENSP00000458731; ENSG00000133392. [P35749-4]
ENST00000612165; ENSP00000478092; ENSG00000276480. [P35749-3]
ENST00000616422; ENSP00000478816; ENSG00000276480. [P35749-4]
ENST00000621545; ENSP00000478109; ENSG00000276480. [P35749-2]
GeneIDi4629.
KEGGihsa:4629.
UCSCiuc002ddv.3. human. [P35749-3]
uc002ddw.3. human. [P35749-4]
uc002ddx.3. human. [P35749-2]
uc002ddy.3. human. [P35749-1]

Polymorphism databases

DMDMi13432177.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY520816 mRNA. Translation: AAS98910.1.
AY520817 mRNA. Translation: AAS98911.1.
AF001548 Genomic DNA. Translation: AAC31665.1.
U91323 Genomic DNA. Translation: AAC35212.1.
AB020673 mRNA. Translation: BAA74889.2. Different initiation.
GU143399 Genomic DNA. Translation: ACZ58373.1.
GU143400 Genomic DNA. Translation: ACZ58374.1.
AC024120 Genomic DNA. No translation available.
AC026401 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
CH471226 Genomic DNA. Translation: EAW53924.1.
CH471226 Genomic DNA. Translation: EAW53926.1.
BC101677 mRNA. Translation: AAI01678.1.
BC104906 mRNA. Translation: AAI04907.1.
BC143364 mRNA. Translation: AAI43365.1.
D10667 mRNA. No translation available.
X69292 mRNA. Translation: CAA49154.1.
CCDSiCCDS10565.1. [P35749-1]
CCDS10566.1. [P35749-4]
CCDS45423.1. [P35749-2]
CCDS45424.1. [P35749-3]
RefSeqiNP_001035202.1. NM_001040113.1. [P35749-3]
NP_001035203.1. NM_001040114.1. [P35749-2]
NP_002465.1. NM_002474.2. [P35749-1]
NP_074035.1. NM_022844.2. [P35749-4]
UniGeneiHs.460109.

3D structure databases

ProteinModelPortaliP35749.
SMRiP35749. Positions 7-904.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110714. 24 interactions.
DIPiDIP-47268N.
IntActiP35749. 9 interactions.
MINTiMINT-2802946.
STRINGi9606.ENSP00000379616.

PTM databases

PhosphoSiteiP35749.

Polymorphism databases

DMDMi13432177.

Proteomic databases

MaxQBiP35749.
PaxDbiP35749.
PRIDEiP35749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300036; ENSP00000300036; ENSG00000133392. [P35749-1]
ENST00000396324; ENSP00000379616; ENSG00000133392. [P35749-2]
ENST00000452625; ENSP00000407821; ENSG00000133392. [P35749-3]
ENST00000576790; ENSP00000458731; ENSG00000133392. [P35749-4]
ENST00000612165; ENSP00000478092; ENSG00000276480. [P35749-3]
ENST00000616422; ENSP00000478816; ENSG00000276480. [P35749-4]
ENST00000621545; ENSP00000478109; ENSG00000276480. [P35749-2]
GeneIDi4629.
KEGGihsa:4629.
UCSCiuc002ddv.3. human. [P35749-3]
uc002ddw.3. human. [P35749-4]
uc002ddx.3. human. [P35749-2]
uc002ddy.3. human. [P35749-1]

Organism-specific databases

CTDi4629.
GeneCardsiGC16M015704.
GeneReviewsiMYH11.
HGNCiHGNC:7569. MYH11.
HPAiCAB002302.
HPA014539.
HPA015310.
MIMi132900. phenotype.
160745. gene.
neXtProtiNX_P35749.
Orphaneti98829. Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22).
229. Familial aortic dissection.
91387. Familial thoracic aortic aneurysm and aortic dissection.
PharmGKBiPA31367.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP35749.
KOiK10352.
OMAiCHLVGIN.
OrthoDBiEOG71CFK3.
PhylomeDBiP35749.
TreeFamiTF333601.

Enzyme and pathway databases

ReactomeiREACT_19277. Sema4D induced cell migration and growth-cone collapse.
REACT_20558. Smooth Muscle Contraction.
REACT_228063. EPHA-mediated growth cone collapse.

Miscellaneous databases

ChiTaRSiMYH11. human.
GeneWikiiMYH11.
GenomeRNAii4629.
NextBioi17818.
PROiP35749.
SOURCEiSearch...

Gene expression databases

BgeeiP35749.
CleanExiHS_MYH11.
ExpressionAtlasiP35749. baseline and differential.
GenevestigatoriP35749.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR008989. Myosin_S1_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF50084. SSF50084. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
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Publicationsi

« Hide 'large scale' publications
  1. "(+)Insert smooth muscle myosin heavy chain (SM-B) isoform expression in human tissues."
    Leguillette R., Gil F.R., Zitouni N., Lajoie-Kadoch S., Sobieszek A., Lauzon A.M.
    Am. J. Physiol. 289:C1277-C1285(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Nagase T., Kikuno R., Yamakawa H., Ohara O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. NHLBI resequencing and genotyping service (RS&G)
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Colon.
  9. "Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12."
    Matsuoka R., Yoshida M.C., Furutani Y., Imamura S., Kanda N., Yanagisawa M., Masaki T., Takao A.
    Am. J. Med. Genet. 46:61-67(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 885-1972 (ISOFORM 1/2).
  10. Okajima K.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1093-1972 (ISOFORM 1/2).
    Tissue: Hippocampus.
  11. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  12. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1954, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus."
    Zhu L., Vranckx R., Khau Van Kien P., Lalande A., Boisset N., Mathieu F., Wegman M., Glancy L., Gasc J.-M., Brunotte F., Bruneval P., Wolf J.-E., Michel J.-B., Jeunemaitre X.
    Nat. Genet. 38:343-349(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS AAT4 1241-ARG--LEU-1264 DEL AND GLN-1758.
+Additional computationally mapped references.

Entry informationi

Entry nameiMYH11_HUMAN
AccessioniPrimary (citable) accession number: P35749
Secondary accession number(s): D2JYH7
, O00396, O94944, P78422, Q3MIV8, Q3MNF0, Q3MNF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: January 7, 2015
This is version 160 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.