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UniProtKB - P35749 (MYH11_HUMAN)

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Protein

Myosin-11

Gene

MYH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 185ATPSequence analysis8

GO - Molecular functioni

  • actin filament binding Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB-KW
  • motor activity Source: InterPro
  • structural constituent of muscle Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • cardiac muscle fiber development Source: UniProtKB
  • elastic fiber assembly Source: UniProtKB
  • muscle contraction Source: Reactome
  • skeletal muscle myosin thick filament assembly Source: UniProtKB
  • smooth muscle contraction Source: UniProtKB
Complete GO annotation...

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-445355. Smooth Muscle Contraction.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5627123. RHO GTPases activate PAKs.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-11
Alternative name(s):
Myosin heavy chain 11
Myosin heavy chain, smooth muscle isoform
SMMHC
Gene namesi
Name:MYH11
Synonyms:KIAA0866
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7569. MYH11.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • muscle myosin complex Source: ProtInc
  • myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Thick filament

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
Aortic aneurysm, familial thoracic 4 (AAT4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
See also OMIM:132900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0317341241 – 1264Missing in AAT4. 1 PublicationAdd BLAST24
Natural variantiVAR_0317351758R → Q in AAT4. 1 PublicationCorresponds to variant dbSNP:rs142546324Ensembl.1

Keywords - Diseasei

Aortic aneurysm, Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi4629.
MalaCardsiMYH11.
MIMi132900. phenotype.
OpenTargetsiENSG00000133392.
Orphaneti98829. 'Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)'.
229. Familial aortic dissection.
91387. Familial thoracic aortic aneurysm and aortic dissection.
PharmGKBiPA31367.

Chemistry databases

DrugBankiDB04444. Tetrafluoroaluminate Ion.

Polymorphism and mutation databases

BioMutaiMYH11.
DMDMi13432177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234241 – 1972Myosin-11Add BLAST1972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei129N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei1684PhosphoserineBy similarity1
Modified residuei1722PhosphoserineBy similarity1
Modified residuei1954PhosphoserineCombined sources1
Modified residuei1958PhosphothreonineCombined sources1
Modified residuei1971PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP35749.
PaxDbiP35749.
PeptideAtlasiP35749.
PRIDEiP35749.

PTM databases

iPTMnetiP35749.
PhosphoSitePlusiP35749.
SwissPalmiP35749.

Expressioni

Tissue specificityi

Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.1 Publication

Gene expression databases

BgeeiENSG00000133392.
CleanExiHS_MYH11.
ExpressionAtlasiP35749. baseline and differential.
GenevisibleiP35749. HS.

Organism-specific databases

HPAiCAB002302.
HPA014539.
HPA015310.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Binary interactionsi

WithEntry#Exp.IntActNotes
MYL12BO149502EBI-1052928,EBI-1642165

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi110714. 47 interactors.
DIPiDIP-47268N.
IntActiP35749. 31 interactors.
MINTiMINT-2802946.
STRINGi9606.ENSP00000379616.

Structurei

3D structure databases

ProteinModelPortaliP35749.
SMRiP35749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 783Myosin motorAdd BLAST699
Domaini786 – 815IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni661 – 683Actin-bindingBy similarityAdd BLAST23
Regioni762 – 776Actin-bindingBy similarityAdd BLAST15
Regioni1935 – 1972C-terminalAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili844 – 1934Sequence analysisAdd BLAST1091

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP35749.
KOiK10352.
OMAiTQQYEEK.
PhylomeDBiP35749.
TreeFamiTF333601.

Family and domain databases

InterProiView protein in InterPro
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR008989. Myosin_S1_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
PRINTSiPR00193. MYOSINHEAVY.
SMARTiView protein in SMART
SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SUPFAMiSSF50084. SSF50084. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35749-1) [UniParc]FASTAAdd to basket
Also known as: SM-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI 
        60         70         80         90        100
KEEKGDEVVV ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS 
       110        120        130        140        150
VLHNLRERYF SGLIYTYSGL FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM 
       160        170        180        190        200
PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS 
       210        220        230        240        250
SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS RFGKFIRINF 
       260        270        280        290        300
DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYMIAG AKEKMRSDLL 
       310        320        330        340        350
LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMAIMGFSE EEQLSILKVV 
       360        370        380        390        400
SSVLQLGNIV FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR 
       410        420        430        440        450
IKVGRDVVQK AQTKEQADFA VEALAKATYE RLFRWILTRV NKALDKTHRQ 
       460        470        480        490        500
GASFLGILDI AGFEIFEVNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ 
       510        520        530        540        550
REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW FPKATDKSFV 
       560        570        580        590        600
EKLCTEQGSH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN 
       610        620        630        640        650
DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF 
       660        670        680        690        700
RTVGQLYKEQ LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR 
       710        720        730        740        750
CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LAANAIPKGF MDGKQACILM 
       760        770        780        790        800
IKALELDPNL YRIGQSKIFF RTGVLAHLEE ERDLKITDVI MAFQAMCRGY 
       810        820        830        840        850
LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK VKPLLQVTRQ 
       860        870        880        890        900
EEEMQAKEDE LQKTKERQQK AENELKELEQ KHSQLTEEKN LLQEQLQAET 
       910        920        930        940        950
ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ 
       960        970        980        990       1000
QMLDLEEQLE EEEAARQKLQ LEKVTAEAKI KKLEDEILVM DDQNNKLSKE 
      1010       1020       1030       1040       1050
RKLLEERISD LTTNLAEEEE KAKNLTKLKN KHESMISELE VRLKKEEKSR 
      1060       1070       1080       1090       1100
QELEKLKRKL EGDASDFHEQ IADLQAQIAE LKMQLAKKEE ELQAALARLD 
      1110       1120       1130       1140       1150
DEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ KRDLGEELEA 
      1160       1170       1180       1190       1200
LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK 
      1210       1220       1230       1240       1250
HAQAVEELTE QLEQFKRAKA NLDKNKQTLE KENADLAGEL RVLGQAKQEV 
      1260       1270       1280       1290       1300
EHKKKKLEAQ VQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLNEAE 
      1310       1320       1330       1340       1350
GKAIKLAKDV ASLSSQLQDT QELLQEETRQ KLNVSTKLRQ LEEERNSLQD 
      1360       1370       1380       1390       1400
QLDEEMEAKQ NLERHISTLN IQLSDSKKKL QDFASTVEAL EEGKKRFQKE 
      1410       1420       1430       1440       1450
IENLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR QLVSNLEKKQ 
      1460       1470       1480       1490       1500
RKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE 
      1510       1520       1530       1540       1550
ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE 
      1560       1570       1580       1590       1600
LEDELQATED AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE 
      1610       1620       1630       1640       1650
YETELEDERK QRALAAAAKK KLEGDLKDLE LQADSAIKGR EEAIKQLRKL 
      1660       1670       1680       1690       1700
QAQMKDFQRE LEDARASRDE IFATAKENEK KAKSLEADLM QLQEDLAAAE 
      1710       1720       1730       1740       1750
RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ LEEELEEEQG 
      1760       1770       1780       1790       1800
NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK 
      1810       1820       1830       1840       1850
LHEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK 
      1860       1870       1880       1890       1900
LKEILLQVED ERKMAEQYKE QAEKGNARVK QLKRQLEEAE EESQRINANR 
      1910       1920       1930       1940       1950
RKLQRELDEA TESNEAMGRE VNALKSKLRR GNETSFVPSR RSGGRRVIEN 
      1960       1970 
ADGSEEETDT RDADFNGTKA SE
Length:1,972
Mass (Da):227,339
Last modified:April 27, 2001 - v3
Checksum:i67665BB2AECE1277
GO
Isoform 2 (identifier: P35749-2) [UniParc]FASTAAdd to basket
Also known as: SM-B1

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.
Show »
Length:1,979
Mass (Da):228,090
Checksum:i9B70CDC6279DC694
GO
Isoform 3 (identifier: P35749-3) [UniParc]FASTAAdd to basket
Also known as: SM-B2

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.
Show »
Length:1,945
Mass (Da):224,328
Checksum:i0FA4E1636B68B8AC
GO
Isoform 4 (identifier: P35749-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: No experimental confirmation available.
Show »
Length:1,938
Mass (Da):223,577
Checksum:i61D4A502A155BEC0
GO

Sequence cautioni

The sequence BAA74889 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti887 – 889EEK → NSE in D10667 (PubMed:7684189).Curated3
Sequence conflicti1558T → S in D10667 (PubMed:7684189).Curated1
Sequence conflicti1610 – 1611KQ → NE in D10667 (PubMed:7684189).Curated2
Sequence conflicti1786A → S in CAA49154 (Ref. 10) Curated1
Sequence conflicti1958T → L in D10667 (PubMed:7684189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0502051104A → T. Corresponds to variant dbSNP:rs34263860Ensembl.1
Natural variantiVAR_0302391234A → T. Corresponds to variant dbSNP:rs16967494Ensembl.1
Natural variantiVAR_0317341241 – 1264Missing in AAT4. 1 PublicationAdd BLAST24
Natural variantiVAR_0302401289V → A. Corresponds to variant dbSNP:rs16967510Ensembl.1
Natural variantiVAR_0302411310V → M. Corresponds to variant dbSNP:rs7196804Ensembl.1
Natural variantiVAR_0502061508M → V. Corresponds to variant dbSNP:rs35176378Ensembl.1
Natural variantiVAR_0317351758R → Q in AAT4. 1 PublicationCorresponds to variant dbSNP:rs142546324Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043017211T → TQGPSFAY in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_0430181930 – 1972RGNET…TKASE → GPPPQETSQ in isoform 3 and isoform 4. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY520816 mRNA. Translation: AAS98910.1.
AY520817 mRNA. Translation: AAS98911.1.
AF001548 Genomic DNA. Translation: AAC31665.1.
U91323 Genomic DNA. Translation: AAC35212.1.
AB020673 mRNA. Translation: BAA74889.2. Different initiation.
GU143399 Genomic DNA. Translation: ACZ58373.1.
GU143400 Genomic DNA. Translation: ACZ58374.1.
AC024120 Genomic DNA. No translation available.
AC026401 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
CH471226 Genomic DNA. Translation: EAW53924.1.
CH471226 Genomic DNA. Translation: EAW53926.1.
BC101677 mRNA. Translation: AAI01678.1.
BC104906 mRNA. Translation: AAI04907.1.
BC143364 mRNA. Translation: AAI43365.1.
D10667 mRNA. No translation available.
X69292 mRNA. Translation: CAA49154.1.
CCDSiCCDS10565.1. [P35749-1]
CCDS10566.1. [P35749-4]
CCDS45423.1. [P35749-2]
CCDS45424.1. [P35749-3]
RefSeqiNP_001035202.1. NM_001040113.1. [P35749-3]
NP_001035203.1. NM_001040114.1. [P35749-2]
NP_002465.1. NM_002474.2. [P35749-1]
NP_074035.1. NM_022844.2. [P35749-4]
XP_016878739.1. XM_017023250.1. [P35749-3]
UniGeneiHs.460109.

Genome annotation databases

EnsembliENST00000300036; ENSP00000300036; ENSG00000133392. [P35749-1]
ENST00000396324; ENSP00000379616; ENSG00000133392. [P35749-2]
ENST00000452625; ENSP00000407821; ENSG00000133392. [P35749-3]
ENST00000576790; ENSP00000458731; ENSG00000133392. [P35749-4]
ENST00000612165; ENSP00000478092; ENSG00000276480. [P35749-3]
ENST00000616422; ENSP00000478816; ENSG00000276480. [P35749-4]
ENST00000621545; ENSP00000478109; ENSG00000276480. [P35749-2]
ENST00000634050; ENSP00000488461; ENSG00000276480. [P35749-1]
GeneIDi4629.
KEGGihsa:4629.
UCSCiuc002ddv.4. human. [P35749-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMYH11_HUMAN
AccessioniPrimary (citable) accession number: P35749
Secondary accession number(s): D2JYH7
, O00396, O94944, P78422, Q3MIV8, Q3MNF0, Q3MNF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: July 5, 2017
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families