P35749 (MYH11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myosin-11

Alternative name(s):
Myosin heavy chain 11
Myosin heavy chain, smooth muscle isoform
SMMHC

Gene names

Name:	MYH11
Synonyms:	KIAA0866

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1972 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Muscle contraction.
Subunit structure	Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
Subcellular location	Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils. Ref.11
Tissue specificity	Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles. Ref.1
Domain	The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
Involvement in disease	A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv16(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11. Aortic aneurysm, familial thoracic 4 (AAT4) [MIM:132900]: A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain.
Sequence caution	The sequence BAA74889.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Thick filament
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Aortic aneurysm Disease mutation Proto-oncogene
Domain	Coiled coil
Ligand	Actin-binding ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Muscle protein Myosin
PTM	Methylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome cardiac muscle fiber development Inferred from mutant phenotype Ref.14. Source: UniProtKB elastic fiber assembly Inferred from mutant phenotype Ref.14. Source: UniProtKB muscle contraction Traceable author statement. Source: Reactome skeletal muscle myosin thick filament assembly Inferred from sequence or structural similarity. Source: UniProtKB smooth muscle contraction Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Traceable author statement. Source: Reactome melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell muscle myosin complex Traceable author statement Ref.9. Source: ProtInc myosin filament Inferred from electronic annotation. Source: UniProtKB-KW smooth muscle contractile fiber Inferred from electronic annotation. Source: Ensembl stress fiber Inferred from electronic annotation. Source: Ensembl
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW motor activity Inferred from electronic annotation. Source: Ensembl structural constituent of muscle Inferred from mutant phenotype Ref.14. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MYL12B	O14950	2	EBI-1052928,EBI-1642165

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35749-1)

Also known as: SM-A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35749-2)

Also known as: SM-B1;

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.

Isoform 3 (identifier: P35749-3)

Also known as: SM-B2;

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.

Isoform 4 (identifier: P35749-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1972	1972	Myosin-11		PRO_0000123424
Regions
	Domain	1 – 785	785	Myosin head-like
	Domain	786 – 815	30	IQ
	Nucleotide binding	178 – 185	8	ATP Potential
	Region	661 – 683	23	Actin-binding By similarity
	Region	762 – 776	15	Actin-binding By similarity
	Region	1935 – 1972	38	C-terminal
	Coiled coil	844 – 1934	1091	Potential
Amino acid modifications
	Modified residue	8	1	Phosphoserine By similarity
	Modified residue	129	1	N6,N6,N6-trimethyllysine Potential
	Modified residue	1954	1	Phosphoserine Ref.12
Natural variations
	Alternative sequence	211	1	T → TQGPSFAY in isoform 2 and isoform 3.		VSP_043017
	Alternative sequence	1930 – 1972	43	RGNET…TKASE → GPPPQETSQ in isoform 3 and isoform 4.		VSP_043018
	Natural variant	1104	1	A → T. Corresponds to variant rs34263860 [ dbSNP | Ensembl ].		VAR_050205
	Natural variant	1234	1	A → T. Corresponds to variant rs16967494 [ dbSNP | Ensembl ].		VAR_030239
	Natural variant	1241 – 1264	24	Missing in AAT4.		VAR_031734
	Natural variant	1289	1	V → A. Corresponds to variant rs16967510 [ dbSNP | Ensembl ].		VAR_030240
	Natural variant	1310	1	V → M. Corresponds to variant rs7196804 [ dbSNP | Ensembl ].		VAR_030241
	Natural variant	1508	1	M → V. Corresponds to variant rs35176378 [ dbSNP | Ensembl ].		VAR_050206
	Natural variant	1758	1	R → Q in AAT4. Ref.14		VAR_031735
Experimental info
	Sequence conflict	887 – 889	3	EEK → NSE in D10667. Ref.9
	Sequence conflict	1558	1	T → S in D10667. Ref.9
	Sequence conflict	1610 – 1611	2	KQ → NE in D10667. Ref.9
	Sequence conflict	1786	1	A → S in CAA49154. Ref.10
	Sequence conflict	1958	1	T → L in D10667. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SM-A) [UniParc]. Last modified April 27, 2001. Version 3. Checksum: 67665BB2AECE1277	FASTA	1,972	227,339
	10 20 30 40 50 60 MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI KEEKGDEVVV 70 80 90 100 110 120 ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLRERYF SGLIYTYSGL 130 140 150 160 170 180 FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM PPHIYAIADT AYRSMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAVVAS SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS 250 260 270 280 290 300 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYMIAG AKEKMRSDLL 310 320 330 340 350 360 LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMAIMGFSE EEQLSILKVV SSVLQLGNIV 370 380 390 400 410 420 FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR IKVGRDVVQK AQTKEQADFA 430 440 450 460 470 480 VEALAKATYE RLFRWILTRV NKALDKTHRQ GASFLGILDI AGFEIFEVNS FEQLCINYTN 490 500 510 520 530 540 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW 550 560 570 580 590 600 FPKATDKSFV EKLCTEQGSH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN 610 620 630 640 650 660 DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF RTVGQLYKEQ 670 680 690 700 710 720 LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR CNGVLEGIRI CRQGFPNRIV 730 740 750 760 770 780 FQEFRQRYEI LAANAIPKGF MDGKQACILM IKALELDPNL YRIGQSKIFF RTGVLAHLEE 790 800 810 820 830 840 ERDLKITDVI MAFQAMCRGY LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK 850 860 870 880 890 900 VKPLLQVTRQ EEEMQAKEDE LQKTKERQQK AENELKELEQ KHSQLTEEKN LLQEQLQAET 910 920 930 940 950 960 ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ QMLDLEEQLE 970 980 990 1000 1010 1020 EEEAARQKLQ LEKVTAEAKI KKLEDEILVM DDQNNKLSKE RKLLEERISD LTTNLAEEEE 1030 1040 1050 1060 1070 1080 KAKNLTKLKN KHESMISELE VRLKKEEKSR QELEKLKRKL EGDASDFHEQ IADLQAQIAE 1090 1100 1110 1120 1130 1140 LKMQLAKKEE ELQAALARLD DEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ 1150 1160 1170 1180 1190 1200 KRDLGEELEA LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK 1210 1220 1230 1240 1250 1260 HAQAVEELTE QLEQFKRAKA NLDKNKQTLE KENADLAGEL RVLGQAKQEV EHKKKKLEAQ 1270 1280 1290 1300 1310 1320 VQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLNEAE GKAIKLAKDV ASLSSQLQDT 1330 1340 1350 1360 1370 1380 QELLQEETRQ KLNVSTKLRQ LEEERNSLQD QLDEEMEAKQ NLERHISTLN IQLSDSKKKL 1390 1400 1410 1420 1430 1440 QDFASTVEAL EEGKKRFQKE IENLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR 1450 1460 1470 1480 1490 1500 QLVSNLEKKQ RKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE 1510 1520 1530 1540 1550 1560 ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE LEDELQATED 1570 1580 1590 1600 1610 1620 AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE YETELEDERK QRALAAAAKK 1630 1640 1650 1660 1670 1680 KLEGDLKDLE LQADSAIKGR EEAIKQLRKL QAQMKDFQRE LEDARASRDE IFATAKENEK 1690 1700 1710 1720 1730 1740 KAKSLEADLM QLQEDLAAAE RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ 1750 1760 1770 1780 1790 1800 LEEELEEEQG NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK 1810 1820 1830 1840 1850 1860 LHEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK LKEILLQVED 1870 1880 1890 1900 1910 1920 ERKMAEQYKE QAEKGNARVK QLKRQLEEAE EESQRINANR RKLQRELDEA TESNEAMGRE 1930 1940 1950 1960 1970 VNALKSKLRR GNETSFVPSR RSGGRRVIEN ADGSEEETDT RDADFNGTKA SE
	Isoform 2 (SM-B1) [UniParc]. Checksum: 9B70CDC6279DC694	FASTA	1,979	228,090
	10 20 30 40 50 60 MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI KEEKGDEVVV 70 80 90 100 110 120 ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLRERYF SGLIYTYSGL 130 140 150 160 170 180 FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM PPHIYAIADT AYRSMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAVVAS SHKGKKDTSI TQGPSFAYGE LEKQLLQANP ILEAFGNAKT 250 260 270 280 290 300 VKNDNSSRFG KFIRINFDVT GYIVGANIET YLLEKSRAIR QARDERTFHI FYYMIAGAKE 310 320 330 340 350 360 KMRSDLLLEG FNNYTFLSNG FVPIPAAQDD EMFQETVEAM AIMGFSEEEQ LSILKVVSSV 370 380 390 400 410 420 LQLGNIVFKK ERNTDQASMP DNTAAQKVCH LMGINVTDFT RSILTPRIKV GRDVVQKAQT 430 440 450 460 470 480 KEQADFAVEA LAKATYERLF RWILTRVNKA LDKTHRQGAS FLGILDIAGF EIFEVNSFEQ 490 500 510 520 530 540 LCINYTNEKL QQLFNHTMFI LEQEEYQREG IEWNFIDFGL DLQPCIELIE RPNNPPGVLA 550 560 570 580 590 600 LLDEECWFPK ATDKSFVEKL CTEQGSHPKF QKPKQLKDKT EFSIIHYAGK VDYNASAWLT 610 620 630 640 650 660 KNMDPLNDNV TSLLNASSDK FVADLWKDVD RIVGLDQMAK MTESSLPSAS KTKKGMFRTV 670 680 690 700 710 720 GQLYKEQLGK LMTTLRNTTP NFVRCIIPNH EKRSGKLDAF LVLEQLRCNG VLEGIRICRQ 730 740 750 760 770 780 GFPNRIVFQE FRQRYEILAA NAIPKGFMDG KQACILMIKA LELDPNLYRI GQSKIFFRTG 790 800 810 820 830 840 VLAHLEEERD LKITDVIMAF QAMCRGYLAR KAFAKRQQQL TAMKVIQRNC AAYLKLRNWQ 850 860 870 880 890 900 WWRLFTKVKP LLQVTRQEEE MQAKEDELQK TKERQQKAEN ELKELEQKHS QLTEEKNLLQ 910 920 930 940 950 960 EQLQAETELY AEAEEMRVRL AAKKQELEEI LHEMEARLEE EEDRGQQLQA ERKKMAQQML 970 980 990 1000 1010 1020 DLEEQLEEEE AARQKLQLEK VTAEAKIKKL EDEILVMDDQ NNKLSKERKL LEERISDLTT 1030 1040 1050 1060 1070 1080 NLAEEEEKAK NLTKLKNKHE SMISELEVRL KKEEKSRQEL EKLKRKLEGD ASDFHEQIAD 1090 1100 1110 1120 1130 1140 LQAQIAELKM QLAKKEEELQ AALARLDDEI AQKNNALKKI RELEGHISDL QEDLDSERAA 1150 1160 1170 1180 1190 1200 RNKAEKQKRD LGEELEALKT ELEDTLDSTA TQQELRAKRE QEVTVLKKAL DEETRSHEAQ 1210 1220 1230 1240 1250 1260 VQEMRQKHAQ AVEELTEQLE QFKRAKANLD KNKQTLEKEN ADLAGELRVL GQAKQEVEHK 1270 1280 1290 1300 1310 1320 KKKLEAQVQE LQSKCSDGER ARAELNDKVH KLQNEVESVT GMLNEAEGKA IKLAKDVASL 1330 1340 1350 1360 1370 1380 SSQLQDTQEL LQEETRQKLN VSTKLRQLEE ERNSLQDQLD EEMEAKQNLE RHISTLNIQL 1390 1400 1410 1420 1430 1440 SDSKKKLQDF ASTVEALEEG KKRFQKEIEN LTQQYEEKAA AYDKLEKTKN RLQQELDDLV 1450 1460 1470 1480 1490 1500 VDLDNQRQLV SNLEKKQRKF DQLLAEEKNI SSKYADERDR AEAEAREKET KALSLARALE 1510 1520 1530 1540 1550 1560 EALEAKEELE RTNKMLKAEM EDLVSSKDDV GKNVHELEKS KRALETQMEE MKTQLEELED 1570 1580 1590 1600 1610 1620 ELQATEDAKL RLEVNMQALK GQFERDLQAR DEQNEEKRRQ LQRQLHEYET ELEDERKQRA 1630 1640 1650 1660 1670 1680 LAAAAKKKLE GDLKDLELQA DSAIKGREEA IKQLRKLQAQ MKDFQRELED ARASRDEIFA 1690 1700 1710 1720 1730 1740 TAKENEKKAK SLEADLMQLQ EDLAAAERAR KQADLEKEEL AEELASSLSG RNALQDEKRR 1750 1760 1770 1780 1790 1800 LEARIAQLEE ELEEEQGNME AMSDRVRKAT QQAEQLSNEL ATERSTAQKN ESARQQLERQ 1810 1820 1830 1840 1850 1860 NKELRSKLHE MEGAVKSKFK STIAALEAKI AQLEEQVEQE AREKQAATKS LKQKDKKLKE 1870 1880 1890 1900 1910 1920 ILLQVEDERK MAEQYKEQAE KGNARVKQLK RQLEEAEEES QRINANRRKL QRELDEATES 1930 1940 1950 1960 1970 NEAMGREVNA LKSKLRRGNE TSFVPSRRSG GRRVIENADG SEEETDTRDA DFNGTKASE
	Isoform 3 (SM-B2) [UniParc]. Checksum: 0FA4E1636B68B8AC	FASTA	1,945	224,328
	10 20 30 40 50 60 MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI KEEKGDEVVV 70 80 90 100 110 120 ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLRERYF SGLIYTYSGL 130 140 150 160 170 180 FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM PPHIYAIADT AYRSMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAVVAS SHKGKKDTSI TQGPSFAYGE LEKQLLQANP ILEAFGNAKT 250 260 270 280 290 300 VKNDNSSRFG KFIRINFDVT GYIVGANIET YLLEKSRAIR QARDERTFHI FYYMIAGAKE 310 320 330 340 350 360 KMRSDLLLEG FNNYTFLSNG FVPIPAAQDD EMFQETVEAM AIMGFSEEEQ LSILKVVSSV 370 380 390 400 410 420 LQLGNIVFKK ERNTDQASMP DNTAAQKVCH LMGINVTDFT RSILTPRIKV GRDVVQKAQT 430 440 450 460 470 480 KEQADFAVEA LAKATYERLF RWILTRVNKA LDKTHRQGAS FLGILDIAGF EIFEVNSFEQ 490 500 510 520 530 540 LCINYTNEKL QQLFNHTMFI LEQEEYQREG IEWNFIDFGL DLQPCIELIE RPNNPPGVLA 550 560 570 580 590 600 LLDEECWFPK ATDKSFVEKL CTEQGSHPKF QKPKQLKDKT EFSIIHYAGK VDYNASAWLT 610 620 630 640 650 660 KNMDPLNDNV TSLLNASSDK FVADLWKDVD RIVGLDQMAK MTESSLPSAS KTKKGMFRTV 670 680 690 700 710 720 GQLYKEQLGK LMTTLRNTTP NFVRCIIPNH EKRSGKLDAF LVLEQLRCNG VLEGIRICRQ 730 740 750 760 770 780 GFPNRIVFQE FRQRYEILAA NAIPKGFMDG KQACILMIKA LELDPNLYRI GQSKIFFRTG 790 800 810 820 830 840 VLAHLEEERD LKITDVIMAF QAMCRGYLAR KAFAKRQQQL TAMKVIQRNC AAYLKLRNWQ 850 860 870 880 890 900 WWRLFTKVKP LLQVTRQEEE MQAKEDELQK TKERQQKAEN ELKELEQKHS QLTEEKNLLQ 910 920 930 940 950 960 EQLQAETELY AEAEEMRVRL AAKKQELEEI LHEMEARLEE EEDRGQQLQA ERKKMAQQML 970 980 990 1000 1010 1020 DLEEQLEEEE AARQKLQLEK VTAEAKIKKL EDEILVMDDQ NNKLSKERKL LEERISDLTT 1030 1040 1050 1060 1070 1080 NLAEEEEKAK NLTKLKNKHE SMISELEVRL KKEEKSRQEL EKLKRKLEGD ASDFHEQIAD 1090 1100 1110 1120 1130 1140 LQAQIAELKM QLAKKEEELQ AALARLDDEI AQKNNALKKI RELEGHISDL QEDLDSERAA 1150 1160 1170 1180 1190 1200 RNKAEKQKRD LGEELEALKT ELEDTLDSTA TQQELRAKRE QEVTVLKKAL DEETRSHEAQ 1210 1220 1230 1240 1250 1260 VQEMRQKHAQ AVEELTEQLE QFKRAKANLD KNKQTLEKEN ADLAGELRVL GQAKQEVEHK 1270 1280 1290 1300 1310 1320 KKKLEAQVQE LQSKCSDGER ARAELNDKVH KLQNEVESVT GMLNEAEGKA IKLAKDVASL 1330 1340 1350 1360 1370 1380 SSQLQDTQEL LQEETRQKLN VSTKLRQLEE ERNSLQDQLD EEMEAKQNLE RHISTLNIQL 1390 1400 1410 1420 1430 1440 SDSKKKLQDF ASTVEALEEG KKRFQKEIEN LTQQYEEKAA AYDKLEKTKN RLQQELDDLV 1450 1460 1470 1480 1490 1500 VDLDNQRQLV SNLEKKQRKF DQLLAEEKNI SSKYADERDR AEAEAREKET KALSLARALE 1510 1520 1530 1540 1550 1560 EALEAKEELE RTNKMLKAEM EDLVSSKDDV GKNVHELEKS KRALETQMEE MKTQLEELED 1570 1580 1590 1600 1610 1620 ELQATEDAKL RLEVNMQALK GQFERDLQAR DEQNEEKRRQ LQRQLHEYET ELEDERKQRA 1630 1640 1650 1660 1670 1680 LAAAAKKKLE GDLKDLELQA DSAIKGREEA IKQLRKLQAQ MKDFQRELED ARASRDEIFA 1690 1700 1710 1720 1730 1740 TAKENEKKAK SLEADLMQLQ EDLAAAERAR KQADLEKEEL AEELASSLSG RNALQDEKRR 1750 1760 1770 1780 1790 1800 LEARIAQLEE ELEEEQGNME AMSDRVRKAT QQAEQLSNEL ATERSTAQKN ESARQQLERQ 1810 1820 1830 1840 1850 1860 NKELRSKLHE MEGAVKSKFK STIAALEAKI AQLEEQVEQE AREKQAATKS LKQKDKKLKE 1870 1880 1890 1900 1910 1920 ILLQVEDERK MAEQYKEQAE KGNARVKQLK RQLEEAEEES QRINANRRKL QRELDEATES 1930 1940 NEAMGREVNA LKSKLRGPPP QETSQ
	Isoform 4 [UniParc]. Checksum: 61D4A502A155BEC0	FASTA	1,938	223,577
	10 20 30 40 50 60 MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI KEEKGDEVVV 70 80 90 100 110 120 ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLRERYF SGLIYTYSGL 130 140 150 160 170 180 FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM PPHIYAIADT AYRSMLQDRE DQSILCTGES 190 200 210 220 230 240 GAGKTENTKK VIQYLAVVAS SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS 250 260 270 280 290 300 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYMIAG AKEKMRSDLL 310 320 330 340 350 360 LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMAIMGFSE EEQLSILKVV SSVLQLGNIV 370 380 390 400 410 420 FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR IKVGRDVVQK AQTKEQADFA 430 440 450 460 470 480 VEALAKATYE RLFRWILTRV NKALDKTHRQ GASFLGILDI AGFEIFEVNS FEQLCINYTN 490 500 510 520 530 540 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW 550 560 570 580 590 600 FPKATDKSFV EKLCTEQGSH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN 610 620 630 640 650 660 DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF RTVGQLYKEQ 670 680 690 700 710 720 LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR CNGVLEGIRI CRQGFPNRIV 730 740 750 760 770 780 FQEFRQRYEI LAANAIPKGF MDGKQACILM IKALELDPNL YRIGQSKIFF RTGVLAHLEE 790 800 810 820 830 840 ERDLKITDVI MAFQAMCRGY LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK 850 860 870 880 890 900 VKPLLQVTRQ EEEMQAKEDE LQKTKERQQK AENELKELEQ KHSQLTEEKN LLQEQLQAET 910 920 930 940 950 960 ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ QMLDLEEQLE 970 980 990 1000 1010 1020 EEEAARQKLQ LEKVTAEAKI KKLEDEILVM DDQNNKLSKE RKLLEERISD LTTNLAEEEE 1030 1040 1050 1060 1070 1080 KAKNLTKLKN KHESMISELE VRLKKEEKSR QELEKLKRKL EGDASDFHEQ IADLQAQIAE 1090 1100 1110 1120 1130 1140 LKMQLAKKEE ELQAALARLD DEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ 1150 1160 1170 1180 1190 1200 KRDLGEELEA LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK 1210 1220 1230 1240 1250 1260 HAQAVEELTE QLEQFKRAKA NLDKNKQTLE KENADLAGEL RVLGQAKQEV EHKKKKLEAQ 1270 1280 1290 1300 1310 1320 VQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLNEAE GKAIKLAKDV ASLSSQLQDT 1330 1340 1350 1360 1370 1380 QELLQEETRQ KLNVSTKLRQ LEEERNSLQD QLDEEMEAKQ NLERHISTLN IQLSDSKKKL 1390 1400 1410 1420 1430 1440 QDFASTVEAL EEGKKRFQKE IENLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR 1450 1460 1470 1480 1490 1500 QLVSNLEKKQ RKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE 1510 1520 1530 1540 1550 1560 ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE LEDELQATED 1570 1580 1590 1600 1610 1620 AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE YETELEDERK QRALAAAAKK 1630 1640 1650 1660 1670 1680 KLEGDLKDLE LQADSAIKGR EEAIKQLRKL QAQMKDFQRE LEDARASRDE IFATAKENEK 1690 1700 1710 1720 1730 1740 KAKSLEADLM QLQEDLAAAE RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ 1750 1760 1770 1780 1790 1800 LEEELEEEQG NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK 1810 1820 1830 1840 1850 1860 LHEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK LKEILLQVED 1870 1880 1890 1900 1910 1920 ERKMAEQYKE QAEKGNARVK QLKRQLEEAE EESQRINANR RKLQRELDEA TESNEAMGRE 1930 VNALKSKLRG PPPQETSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"(+)Insert smooth muscle myosin heavy chain (SM-B) isoform expression in human tissues." Leguillette R., Gil F.R., Zitouni N., Lajoie-Kadoch S., Sobieszek A., Lauzon A.M. Am. J. Physiol. 289:C1277-C1285(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY.
[2]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	Nagase T., Kikuno R., Yamakawa H., Ohara O. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	NHLBI resequencing and genotyping service (RS&G) Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Colon.
[9]	"Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12." Matsuoka R., Yoshida M.C., Furutani Y., Imamura S., Kanda N., Yanagisawa M., Masaki T., Takao A. Am. J. Med. Genet. 46:61-67(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 885-1972 (ISOFORM 1/2).
[10]	Okajima K. Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1093-1972 (ISOFORM 1/2). Tissue: Hippocampus.
[11]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Melanoma.
[12]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1954, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Liver.
[13]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus." Zhu L., Vranckx R., Khau Van Kien P., Lalande A., Boisset N., Mathieu F., Wegman M., Glancy L., Gasc J.-M., Brunotte F., Bruneval P., Wolf J.-E., Michel J.-B., Jeunemaitre X. Nat. Genet. 38:343-349(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS AAT4 1241-ARG--LEU-1264 DEL AND GLN-1758.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY520816 mRNA. Translation: AAS98910.1. AY520817 mRNA. Translation: AAS98911.1. AF001548 Genomic DNA. Translation: AAC31665.1. U91323 Genomic DNA. Translation: AAC35212.1. AB020673 mRNA. Translation: BAA74889.2. Different initiation. GU143399 Genomic DNA. Translation: ACZ58373.1. GU143400 Genomic DNA. Translation: ACZ58374.1. AC024120 Genomic DNA. No translation available. AC026401 Genomic DNA. No translation available. AC130651 Genomic DNA. No translation available. CH471226 Genomic DNA. Translation: EAW53924.1. CH471226 Genomic DNA. Translation: EAW53926.1. BC101677 mRNA. Translation: AAI01678.1. BC104906 mRNA. Translation: AAI04907.1. BC143364 mRNA. Translation: AAI43365.1. D10667 mRNA. No translation available. X69292 mRNA. Translation: CAA49154.1.
RefSeq	NP_001035202.1. NM_001040113.1. NP_001035203.1. NM_001040114.1. NP_002465.1. NM_002474.2. NP_074035.1. NM_022844.2.
UniGene	Hs.460109.
3D structure databases
ProteinModelPortal	P35749.
SMR	P35749. Positions 7-904.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	110714. 16 interactions.
DIP	DIP-47268N.
IntAct	P35749. 8 interactions.
MINT	MINT-2802946.
STRING	9606.ENSP00000379616.
PTM databases
PhosphoSite	P35749.
Polymorphism databases
DMDM	13432177.
Proteomic databases
PaxDb	P35749.
PRIDE	P35749.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300036; ENSP00000300036; ENSG00000133392. [P35749-1] ENST00000396324; ENSP00000379616; ENSG00000133392. [P35749-2] ENST00000452625; ENSP00000407821; ENSG00000133392. [P35749-3] ENST00000576790; ENSP00000458731; ENSG00000133392. [P35749-4]
GeneID	4629.
KEGG	hsa:4629.
UCSC	uc002ddv.3. human. [P35749-3] uc002ddw.3. human. [P35749-4] uc002ddx.3. human. [P35749-2] uc002ddy.3. human. [P35749-1]
Organism-specific databases
CTD	4629.
GeneCards	GC16M015704.
HGNC	HGNC:7569. MYH11.
HPA	CAB002302. HPA014539. HPA015310.
MIM	132900. phenotype. 160745. gene.
neXtProt	NX_P35749.
Orphanet	98829. Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22). 229. Familial aortic dissection. 91387. Familial thoracic aortic aneurysm and aortic dissection.
PharmGKB	PA31367.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5022.
HOGENOM	HOG000173958.
HOVERGEN	HBG004704.
KO	K10352.
OMA	FVDKNFV.
OrthoDB	EOG71CFK3.
PhylomeDB	P35749.
TreeFam	TF333601.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_17044. Muscle contraction.
Gene expression databases
ArrayExpress	P35749.
Bgee	P35749.
CleanEx	HS_MYH11.
Genevestigator	P35749.
Family and domain databases
Gene3D	4.10.270.10. 1 hit.
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR027401. Myosin-like_IQ_dom. IPR001609. Myosin_head_motor_dom. IPR004009. Myosin_N. IPR008989. Myosin_S1_N. IPR002928. Myosin_tail. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00063. Myosin_head. 1 hit. PF02736. Myosin_N. 1 hit. PF01576. Myosin_tail_1. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. [Graphical view]
SUPFAM	SSF50084. SSF50084. 1 hit. SSF52540. SSF52540. 1 hit.
PROSITE	PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MYH11. human.
GeneWiki	MYH11.
GenomeRNAi	4629.
NextBio	17818.
PRO	P35749.
SOURCE	Search...

Entry information

Entry name

MYH11_HUMAN

Accession

Primary (citable) accession number: P35749
Secondary accession number(s): D2JYH7 , O00396, O94944, P78422, Q3MIV8, Q3MNF0, Q3MNF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	April 27, 2001
Last modified:	April 16, 2014
This is version 152 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.