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Protein

Myosin-11

Gene

MYH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 185ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • motor activity Source: InterPro
  • structural constituent of muscle Source: UniProtKB

GO - Biological processi

  • cardiac muscle fiber development Source: UniProtKB
  • elastic fiber assembly Source: UniProtKB
  • muscle contraction Source: Reactome
  • skeletal muscle myosin thick filament assembly Source: UniProtKB
  • smooth muscle contraction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133392-MONOMER.
ReactomeiR-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-445355. Smooth Muscle Contraction.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5627123. RHO GTPases activate PAKs.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-11
Alternative name(s):
Myosin heavy chain 11
Myosin heavy chain, smooth muscle isoform
SMMHC
Gene namesi
Name:MYH11
Synonyms:KIAA0866
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7569. MYH11.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • melanosome Source: UniProtKB-SubCell
  • muscle myosin complex Source: ProtInc
  • myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Thick filament

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.

Aortic aneurysm, familial thoracic 4 (AAT4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
See also OMIM:132900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0317341241 – 1264Missing in AAT4. 1 PublicationAdd BLAST24
Natural variantiVAR_0317351758R → Q in AAT4. 1 PublicationCorresponds to variant rs142546324dbSNPEnsembl.1

Keywords - Diseasei

Aortic aneurysm, Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi4629.
MalaCardsiMYH11.
MIMi132900. phenotype.
OpenTargetsiENSG00000133392.
ENSG00000276480.
Orphaneti98829. 'Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)'.
229. Familial aortic dissection.
91387. Familial thoracic aortic aneurysm and aortic dissection.
PharmGKBiPA31367.

Polymorphism and mutation databases

BioMutaiMYH11.
DMDMi13432177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234241 – 1972Myosin-11Add BLAST1972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei129N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei1684PhosphoserineBy similarity1
Modified residuei1722PhosphoserineBy similarity1
Modified residuei1954PhosphoserineCombined sources1
Modified residuei1958PhosphothreonineCombined sources1
Modified residuei1971PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP35749.
PaxDbiP35749.
PeptideAtlasiP35749.
PRIDEiP35749.

PTM databases

iPTMnetiP35749.
PhosphoSitePlusiP35749.
SwissPalmiP35749.

Expressioni

Tissue specificityi

Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.1 Publication

Gene expression databases

BgeeiENSG00000133392.
CleanExiHS_MYH11.
ExpressionAtlasiP35749. baseline and differential.
GenevisibleiP35749. HS.

Organism-specific databases

HPAiCAB002302.
HPA014539.
HPA015310.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Binary interactionsi

WithEntry#Exp.IntActNotes
MYL12BO149502EBI-1052928,EBI-1642165

Protein-protein interaction databases

BioGridi110714. 46 interactors.
DIPiDIP-47268N.
IntActiP35749. 31 interactors.
MINTiMINT-2802946.
STRINGi9606.ENSP00000379616.

Structurei

3D structure databases

ProteinModelPortaliP35749.
SMRiP35749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 783Myosin motorAdd BLAST699
Domaini786 – 815IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni661 – 683Actin-bindingBy similarityAdd BLAST23
Regioni762 – 776Actin-bindingBy similarityAdd BLAST15
Regioni1935 – 1972C-terminalAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili844 – 1934Sequence analysisAdd BLAST1091

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP35749.
KOiK10352.
PhylomeDBiP35749.
TreeFamiTF333601.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR008989. Myosin_S1_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF50084. SSF50084. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35749-1) [UniParc]FASTAAdd to basket
Also known as: SM-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI
60 70 80 90 100
KEEKGDEVVV ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS
110 120 130 140 150
VLHNLRERYF SGLIYTYSGL FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM
160 170 180 190 200
PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS
210 220 230 240 250
SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS RFGKFIRINF
260 270 280 290 300
DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYMIAG AKEKMRSDLL
310 320 330 340 350
LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMAIMGFSE EEQLSILKVV
360 370 380 390 400
SSVLQLGNIV FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR
410 420 430 440 450
IKVGRDVVQK AQTKEQADFA VEALAKATYE RLFRWILTRV NKALDKTHRQ
460 470 480 490 500
GASFLGILDI AGFEIFEVNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ
510 520 530 540 550
REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW FPKATDKSFV
560 570 580 590 600
EKLCTEQGSH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN
610 620 630 640 650
DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF
660 670 680 690 700
RTVGQLYKEQ LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR
710 720 730 740 750
CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LAANAIPKGF MDGKQACILM
760 770 780 790 800
IKALELDPNL YRIGQSKIFF RTGVLAHLEE ERDLKITDVI MAFQAMCRGY
810 820 830 840 850
LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK VKPLLQVTRQ
860 870 880 890 900
EEEMQAKEDE LQKTKERQQK AENELKELEQ KHSQLTEEKN LLQEQLQAET
910 920 930 940 950
ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ
960 970 980 990 1000
QMLDLEEQLE EEEAARQKLQ LEKVTAEAKI KKLEDEILVM DDQNNKLSKE
1010 1020 1030 1040 1050
RKLLEERISD LTTNLAEEEE KAKNLTKLKN KHESMISELE VRLKKEEKSR
1060 1070 1080 1090 1100
QELEKLKRKL EGDASDFHEQ IADLQAQIAE LKMQLAKKEE ELQAALARLD
1110 1120 1130 1140 1150
DEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ KRDLGEELEA
1160 1170 1180 1190 1200
LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK
1210 1220 1230 1240 1250
HAQAVEELTE QLEQFKRAKA NLDKNKQTLE KENADLAGEL RVLGQAKQEV
1260 1270 1280 1290 1300
EHKKKKLEAQ VQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLNEAE
1310 1320 1330 1340 1350
GKAIKLAKDV ASLSSQLQDT QELLQEETRQ KLNVSTKLRQ LEEERNSLQD
1360 1370 1380 1390 1400
QLDEEMEAKQ NLERHISTLN IQLSDSKKKL QDFASTVEAL EEGKKRFQKE
1410 1420 1430 1440 1450
IENLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR QLVSNLEKKQ
1460 1470 1480 1490 1500
RKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550
ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE
1560 1570 1580 1590 1600
LEDELQATED AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE
1610 1620 1630 1640 1650
YETELEDERK QRALAAAAKK KLEGDLKDLE LQADSAIKGR EEAIKQLRKL
1660 1670 1680 1690 1700
QAQMKDFQRE LEDARASRDE IFATAKENEK KAKSLEADLM QLQEDLAAAE
1710 1720 1730 1740 1750
RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ LEEELEEEQG
1760 1770 1780 1790 1800
NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK
1810 1820 1830 1840 1850
LHEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK
1860 1870 1880 1890 1900
LKEILLQVED ERKMAEQYKE QAEKGNARVK QLKRQLEEAE EESQRINANR
1910 1920 1930 1940 1950
RKLQRELDEA TESNEAMGRE VNALKSKLRR GNETSFVPSR RSGGRRVIEN
1960 1970
ADGSEEETDT RDADFNGTKA SE
Length:1,972
Mass (Da):227,339
Last modified:April 27, 2001 - v3
Checksum:i67665BB2AECE1277
GO
Isoform 2 (identifier: P35749-2) [UniParc]FASTAAdd to basket
Also known as: SM-B1

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.
Show »
Length:1,979
Mass (Da):228,090
Checksum:i9B70CDC6279DC694
GO
Isoform 3 (identifier: P35749-3) [UniParc]FASTAAdd to basket
Also known as: SM-B2

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.
Show »
Length:1,945
Mass (Da):224,328
Checksum:i0FA4E1636B68B8AC
GO
Isoform 4 (identifier: P35749-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: No experimental confirmation available.
Show »
Length:1,938
Mass (Da):223,577
Checksum:i61D4A502A155BEC0
GO

Sequence cautioni

The sequence BAA74889 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti887 – 889EEK → NSE in D10667 (PubMed:7684189).Curated3
Sequence conflicti1558T → S in D10667 (PubMed:7684189).Curated1
Sequence conflicti1610 – 1611KQ → NE in D10667 (PubMed:7684189).Curated2
Sequence conflicti1786A → S in CAA49154 (Ref. 10) Curated1
Sequence conflicti1958T → L in D10667 (PubMed:7684189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0502051104A → T.Corresponds to variant rs34263860dbSNPEnsembl.1
Natural variantiVAR_0302391234A → T.Corresponds to variant rs16967494dbSNPEnsembl.1
Natural variantiVAR_0317341241 – 1264Missing in AAT4. 1 PublicationAdd BLAST24
Natural variantiVAR_0302401289V → A.Corresponds to variant rs16967510dbSNPEnsembl.1
Natural variantiVAR_0302411310V → M.Corresponds to variant rs7196804dbSNPEnsembl.1
Natural variantiVAR_0502061508M → V.Corresponds to variant rs35176378dbSNPEnsembl.1
Natural variantiVAR_0317351758R → Q in AAT4. 1 PublicationCorresponds to variant rs142546324dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043017211T → TQGPSFAY in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_0430181930 – 1972RGNET…TKASE → GPPPQETSQ in isoform 3 and isoform 4. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY520816 mRNA. Translation: AAS98910.1.
AY520817 mRNA. Translation: AAS98911.1.
AF001548 Genomic DNA. Translation: AAC31665.1.
U91323 Genomic DNA. Translation: AAC35212.1.
AB020673 mRNA. Translation: BAA74889.2. Different initiation.
GU143399 Genomic DNA. Translation: ACZ58373.1.
GU143400 Genomic DNA. Translation: ACZ58374.1.
AC024120 Genomic DNA. No translation available.
AC026401 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
CH471226 Genomic DNA. Translation: EAW53924.1.
CH471226 Genomic DNA. Translation: EAW53926.1.
BC101677 mRNA. Translation: AAI01678.1.
BC104906 mRNA. Translation: AAI04907.1.
BC143364 mRNA. Translation: AAI43365.1.
D10667 mRNA. No translation available.
X69292 mRNA. Translation: CAA49154.1.
CCDSiCCDS10565.1. [P35749-1]
CCDS10566.1. [P35749-4]
CCDS45423.1. [P35749-2]
CCDS45424.1. [P35749-3]
RefSeqiNP_001035202.1. NM_001040113.1. [P35749-3]
NP_001035203.1. NM_001040114.1. [P35749-2]
NP_002465.1. NM_002474.2. [P35749-1]
NP_074035.1. NM_022844.2. [P35749-4]
XP_016878739.1. XM_017023250.1. [P35749-3]
UniGeneiHs.460109.

Genome annotation databases

EnsembliENST00000300036; ENSP00000300036; ENSG00000133392. [P35749-1]
ENST00000396324; ENSP00000379616; ENSG00000133392. [P35749-2]
ENST00000452625; ENSP00000407821; ENSG00000133392. [P35749-3]
ENST00000576790; ENSP00000458731; ENSG00000133392. [P35749-4]
ENST00000612165; ENSP00000478092; ENSG00000276480. [P35749-3]
ENST00000616422; ENSP00000478816; ENSG00000276480. [P35749-4]
ENST00000621545; ENSP00000478109; ENSG00000276480. [P35749-2]
ENST00000634050; ENSP00000488461; ENSG00000276480. [P35749-1]
GeneIDi4629.
KEGGihsa:4629.
UCSCiuc002ddv.4. human. [P35749-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY520816 mRNA. Translation: AAS98910.1.
AY520817 mRNA. Translation: AAS98911.1.
AF001548 Genomic DNA. Translation: AAC31665.1.
U91323 Genomic DNA. Translation: AAC35212.1.
AB020673 mRNA. Translation: BAA74889.2. Different initiation.
GU143399 Genomic DNA. Translation: ACZ58373.1.
GU143400 Genomic DNA. Translation: ACZ58374.1.
AC024120 Genomic DNA. No translation available.
AC026401 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
CH471226 Genomic DNA. Translation: EAW53924.1.
CH471226 Genomic DNA. Translation: EAW53926.1.
BC101677 mRNA. Translation: AAI01678.1.
BC104906 mRNA. Translation: AAI04907.1.
BC143364 mRNA. Translation: AAI43365.1.
D10667 mRNA. No translation available.
X69292 mRNA. Translation: CAA49154.1.
CCDSiCCDS10565.1. [P35749-1]
CCDS10566.1. [P35749-4]
CCDS45423.1. [P35749-2]
CCDS45424.1. [P35749-3]
RefSeqiNP_001035202.1. NM_001040113.1. [P35749-3]
NP_001035203.1. NM_001040114.1. [P35749-2]
NP_002465.1. NM_002474.2. [P35749-1]
NP_074035.1. NM_022844.2. [P35749-4]
XP_016878739.1. XM_017023250.1. [P35749-3]
UniGeneiHs.460109.

3D structure databases

ProteinModelPortaliP35749.
SMRiP35749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110714. 46 interactors.
DIPiDIP-47268N.
IntActiP35749. 31 interactors.
MINTiMINT-2802946.
STRINGi9606.ENSP00000379616.

PTM databases

iPTMnetiP35749.
PhosphoSitePlusiP35749.
SwissPalmiP35749.

Polymorphism and mutation databases

BioMutaiMYH11.
DMDMi13432177.

Proteomic databases

MaxQBiP35749.
PaxDbiP35749.
PeptideAtlasiP35749.
PRIDEiP35749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300036; ENSP00000300036; ENSG00000133392. [P35749-1]
ENST00000396324; ENSP00000379616; ENSG00000133392. [P35749-2]
ENST00000452625; ENSP00000407821; ENSG00000133392. [P35749-3]
ENST00000576790; ENSP00000458731; ENSG00000133392. [P35749-4]
ENST00000612165; ENSP00000478092; ENSG00000276480. [P35749-3]
ENST00000616422; ENSP00000478816; ENSG00000276480. [P35749-4]
ENST00000621545; ENSP00000478109; ENSG00000276480. [P35749-2]
ENST00000634050; ENSP00000488461; ENSG00000276480. [P35749-1]
GeneIDi4629.
KEGGihsa:4629.
UCSCiuc002ddv.4. human. [P35749-1]

Organism-specific databases

CTDi4629.
DisGeNETi4629.
GeneCardsiMYH11.
GeneReviewsiMYH11.
HGNCiHGNC:7569. MYH11.
HPAiCAB002302.
HPA014539.
HPA015310.
MalaCardsiMYH11.
MIMi132900. phenotype.
160745. gene.
neXtProtiNX_P35749.
OpenTargetsiENSG00000133392.
ENSG00000276480.
Orphaneti98829. 'Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)'.
229. Familial aortic dissection.
91387. Familial thoracic aortic aneurysm and aortic dissection.
PharmGKBiPA31367.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP35749.
KOiK10352.
PhylomeDBiP35749.
TreeFamiTF333601.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133392-MONOMER.
ReactomeiR-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-445355. Smooth Muscle Contraction.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5627123. RHO GTPases activate PAKs.

Miscellaneous databases

ChiTaRSiMYH11. human.
GeneWikiiMYH11.
GenomeRNAii4629.
PROiP35749.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133392.
CleanExiHS_MYH11.
ExpressionAtlasiP35749. baseline and differential.
GenevisibleiP35749. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR008989. Myosin_S1_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF50084. SSF50084. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYH11_HUMAN
AccessioniPrimary (citable) accession number: P35749
Secondary accession number(s): D2JYH7
, O00396, O94944, P78422, Q3MIV8, Q3MNF0, Q3MNF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 179 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.