UniProtKB - P35749 (MYH11_HUMAN)
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Protein
Myosin-11
Gene
MYH11
Organism
Homo sapiens (Human)
Status
Functioni
Muscle contraction.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 178 – 185 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin filament binding Source: InterPro
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- microtubule binding Source: InterPro
- microtubule motor activity Source: InterPro
- structural constituent of muscle Source: UniProtKB
GO - Biological processi
- cardiac muscle fiber development Source: UniProtKB
- elastic fiber assembly Source: UniProtKB
- microtubule-based movement Source: InterPro
- muscle contraction Source: Reactome
- skeletal muscle myosin thick filament assembly Source: UniProtKB
- smooth muscle contraction Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-3928663. EPHA-mediated growth cone collapse. R-HSA-416572. Sema4D induced cell migration and growth-cone collapse. R-HSA-445355. Smooth Muscle Contraction. R-HSA-5625740. RHO GTPases activate PKNs. R-HSA-5625900. RHO GTPases activate CIT. R-HSA-5627117. RHO GTPases Activate ROCKs. R-HSA-5627123. RHO GTPases activate PAKs. |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-11Alternative name(s): Myosin heavy chain 11 Myosin heavy chain, smooth muscle isoform SMMHC |
Gene namesi | Name:MYH11 Synonyms:KIAA0866 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000133392.16. |
HGNCi | HGNC:7569. MYH11. |
MIMi | 160745. gene. |
neXtProti | NX_P35749. |
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
Aortic aneurysm, familial thoracic 4 (AAT4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
See also OMIM:132900Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031734 | 1241 – 1264 | Missing in AAT4. 1 PublicationAdd BLAST | 24 | |
Natural variantiVAR_031735 | 1758 | R → Q in AAT4. 1 PublicationCorresponds to variant dbSNP:rs142546324Ensembl. | 1 |
Keywords - Diseasei
Aortic aneurysm, Disease mutation, Proto-oncogeneOrganism-specific databases
DisGeNETi | 4629. |
GeneReviewsi | MYH11. |
MalaCardsi | MYH11. |
MIMi | 132900. phenotype. |
OpenTargetsi | ENSG00000133392. |
Orphaneti | 98829. 'Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)'. 229. Familial aortic dissection. 91387. Familial thoracic aortic aneurysm and aortic dissection. |
PharmGKBi | PA31367. |
Chemistry databases
DrugBanki | DB04444. Tetrafluoroaluminate Ion. |
Polymorphism and mutation databases
BioMutai | MYH11. |
DMDMi | 13432177. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123424 | 1 – 1972 | Myosin-11Add BLAST | 1972 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Modified residuei | 40 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | N6,N6,N6-trimethyllysineSequence analysis | 1 | |
Modified residuei | 1177 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1684 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1722 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1954 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1958 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1971 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
MaxQBi | P35749. |
PaxDbi | P35749. |
PeptideAtlasi | P35749. |
PRIDEi | P35749. |
PTM databases
iPTMneti | P35749. |
PhosphoSitePlusi | P35749. |
SwissPalmi | P35749. |
Expressioni
Tissue specificityi
Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.1 Publication
Gene expression databases
Bgeei | ENSG00000133392. |
CleanExi | HS_MYH11. |
ExpressionAtlasi | P35749. baseline and differential. |
Genevisiblei | P35749. HS. |
Organism-specific databases
HPAi | CAB002302. HPA014539. HPA015310. |
Interactioni
Subunit structurei
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
MYL12B | O14950 | 2 | EBI-1052928,EBI-1642165 |
GO - Molecular functioni
- actin filament binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- microtubule binding Source: InterPro
Protein-protein interaction databases
BioGridi | 110714. 59 interactors. |
DIPi | DIP-47268N. |
IntActi | P35749. 33 interactors. |
MINTi | P35749. |
STRINGi | 9606.ENSP00000379616. |
Structurei
3D structure databases
ProteinModelPortali | P35749. |
SMRi | P35749. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 81 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 85 – 783 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 699 | |
Domaini | 786 – 815 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 661 – 683 | Actin-bindingBy similarityAdd BLAST | 23 | |
Regioni | 762 – 776 | Actin-bindingBy similarityAdd BLAST | 15 | |
Regioni | 1935 – 1972 | C-terminalAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 844 – 1934 | Sequence analysisAdd BLAST | 1091 |
Domaini
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0161. Eukaryota. COG5022. LUCA. |
GeneTreei | ENSGT00760000118919. |
HOGENOMi | HOG000173958. |
HOVERGENi | HBG004704. |
InParanoidi | P35749. |
KOi | K10352. |
OMAi | TQQYEEK. |
PhylomeDBi | P35749. |
TreeFami | TF333601. |
Family and domain databases
Gene3Di | 2.30.30.360. 1 hit. 3.40.850.10. 3 hits. |
InterProi | View protein in InterPro IPR000048. IQ_motif_EF-hand-BS. IPR036961. Kinesin_motor_dom_sf. IPR001609. Myosin_head_motor_dom. IPR004009. Myosin_N. IPR008989. Myosin_S1_N. IPR002928. Myosin_tail. IPR027417. P-loop_NTPase. |
Pfami | View protein in Pfam PF00063. Myosin_head. 1 hit. PF02736. Myosin_N. 1 hit. PF01576. Myosin_tail_1. 1 hit. |
PRINTSi | PR00193. MYOSINHEAVY. |
SMARTi | View protein in SMART SM00015. IQ. 1 hit. SM00242. MYSc. 1 hit. |
SUPFAMi | SSF50084. SSF50084. 1 hit. SSF52540. SSF52540. 1 hit. |
PROSITEi | View protein in PROSITE PS50096. IQ. 1 hit. PS51456. MYOSIN_MOTOR. 1 hit. PS51844. SH3_LIKE. 1 hit. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P35749-1) [UniParc]FASTAAdd to basket
Also known as: SM-A
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI
60 70 80 90 100
KEEKGDEVVV ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS
110 120 130 140 150
VLHNLRERYF SGLIYTYSGL FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM
160 170 180 190 200
PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS
210 220 230 240 250
SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS RFGKFIRINF
260 270 280 290 300
DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYMIAG AKEKMRSDLL
310 320 330 340 350
LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMAIMGFSE EEQLSILKVV
360 370 380 390 400
SSVLQLGNIV FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR
410 420 430 440 450
IKVGRDVVQK AQTKEQADFA VEALAKATYE RLFRWILTRV NKALDKTHRQ
460 470 480 490 500
GASFLGILDI AGFEIFEVNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ
510 520 530 540 550
REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW FPKATDKSFV
560 570 580 590 600
EKLCTEQGSH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN
610 620 630 640 650
DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF
660 670 680 690 700
RTVGQLYKEQ LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR
710 720 730 740 750
CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LAANAIPKGF MDGKQACILM
760 770 780 790 800
IKALELDPNL YRIGQSKIFF RTGVLAHLEE ERDLKITDVI MAFQAMCRGY
810 820 830 840 850
LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK VKPLLQVTRQ
860 870 880 890 900
EEEMQAKEDE LQKTKERQQK AENELKELEQ KHSQLTEEKN LLQEQLQAET
910 920 930 940 950
ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ
960 970 980 990 1000
QMLDLEEQLE EEEAARQKLQ LEKVTAEAKI KKLEDEILVM DDQNNKLSKE
1010 1020 1030 1040 1050
RKLLEERISD LTTNLAEEEE KAKNLTKLKN KHESMISELE VRLKKEEKSR
1060 1070 1080 1090 1100
QELEKLKRKL EGDASDFHEQ IADLQAQIAE LKMQLAKKEE ELQAALARLD
1110 1120 1130 1140 1150
DEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ KRDLGEELEA
1160 1170 1180 1190 1200
LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK
1210 1220 1230 1240 1250
HAQAVEELTE QLEQFKRAKA NLDKNKQTLE KENADLAGEL RVLGQAKQEV
1260 1270 1280 1290 1300
EHKKKKLEAQ VQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLNEAE
1310 1320 1330 1340 1350
GKAIKLAKDV ASLSSQLQDT QELLQEETRQ KLNVSTKLRQ LEEERNSLQD
1360 1370 1380 1390 1400
QLDEEMEAKQ NLERHISTLN IQLSDSKKKL QDFASTVEAL EEGKKRFQKE
1410 1420 1430 1440 1450
IENLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR QLVSNLEKKQ
1460 1470 1480 1490 1500
RKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550
ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE
1560 1570 1580 1590 1600
LEDELQATED AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE
1610 1620 1630 1640 1650
YETELEDERK QRALAAAAKK KLEGDLKDLE LQADSAIKGR EEAIKQLRKL
1660 1670 1680 1690 1700
QAQMKDFQRE LEDARASRDE IFATAKENEK KAKSLEADLM QLQEDLAAAE
1710 1720 1730 1740 1750
RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ LEEELEEEQG
1760 1770 1780 1790 1800
NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK
1810 1820 1830 1840 1850
LHEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK
1860 1870 1880 1890 1900
LKEILLQVED ERKMAEQYKE QAEKGNARVK QLKRQLEEAE EESQRINANR
1910 1920 1930 1940 1950
RKLQRELDEA TESNEAMGRE VNALKSKLRR GNETSFVPSR RSGGRRVIEN
1960 1970
ADGSEEETDT RDADFNGTKA SE
Isoform 2 (identifier: P35749-2) [UniParc]FASTAAdd to basket
Also known as: SM-B1
The sequence of this isoform differs from the canonical sequence as follows:
211-211: T → TQGPSFAY
Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.
Show »Isoform 3 (identifier: P35749-3) [UniParc]FASTAAdd to basket
Also known as: SM-B2
The sequence of this isoform differs from the canonical sequence as follows:
211-211: T → TQGPSFAY
1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ
Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.
Show »Sequence cautioni
The sequence BAA74889 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 887 – 889 | EEK → NSE in D10667 (PubMed:7684189).Curated | 3 | |
Sequence conflicti | 1558 | T → S in D10667 (PubMed:7684189).Curated | 1 | |
Sequence conflicti | 1610 – 1611 | KQ → NE in D10667 (PubMed:7684189).Curated | 2 | |
Sequence conflicti | 1786 | A → S in CAA49154 (Ref. 10) Curated | 1 | |
Sequence conflicti | 1958 | T → L in D10667 (PubMed:7684189).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050205 | 1104 | A → T. Corresponds to variant dbSNP:rs34263860Ensembl. | 1 | |
Natural variantiVAR_030239 | 1234 | A → T. Corresponds to variant dbSNP:rs16967494Ensembl. | 1 | |
Natural variantiVAR_031734 | 1241 – 1264 | Missing in AAT4. 1 PublicationAdd BLAST | 24 | |
Natural variantiVAR_030240 | 1289 | V → A. Corresponds to variant dbSNP:rs16967510Ensembl. | 1 | |
Natural variantiVAR_030241 | 1310 | V → M. Corresponds to variant dbSNP:rs7196804Ensembl. | 1 | |
Natural variantiVAR_050206 | 1508 | M → V. Corresponds to variant dbSNP:rs35176378Ensembl. | 1 | |
Natural variantiVAR_031735 | 1758 | R → Q in AAT4. 1 PublicationCorresponds to variant dbSNP:rs142546324Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043017 | 211 | T → TQGPSFAY in isoform 2 and isoform 3. 2 Publications | 1 | |
Alternative sequenceiVSP_043018 | 1930 – 1972 | RGNET…TKASE → GPPPQETSQ in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY520816 mRNA. Translation: AAS98910.1. AY520817 mRNA. Translation: AAS98911.1. AF001548 Genomic DNA. Translation: AAC31665.1. U91323 Genomic DNA. Translation: AAC35212.1. AB020673 mRNA. Translation: BAA74889.2. Different initiation. GU143399 Genomic DNA. Translation: ACZ58373.1. GU143400 Genomic DNA. Translation: ACZ58374.1. AC024120 Genomic DNA. No translation available. AC026401 Genomic DNA. No translation available. AC130651 Genomic DNA. No translation available. CH471226 Genomic DNA. Translation: EAW53924.1. CH471226 Genomic DNA. Translation: EAW53926.1. BC101677 mRNA. Translation: AAI01678.1. BC104906 mRNA. Translation: AAI04907.1. BC143364 mRNA. Translation: AAI43365.1. D10667 mRNA. No translation available. X69292 mRNA. Translation: CAA49154.1. |
CCDSi | CCDS10565.1. [P35749-1] CCDS10566.1. [P35749-4] CCDS45423.1. [P35749-2] CCDS45424.1. [P35749-3] |
RefSeqi | NP_001035202.1. NM_001040113.1. [P35749-3] NP_001035203.1. NM_001040114.1. [P35749-2] NP_002465.1. NM_002474.2. [P35749-1] NP_074035.1. NM_022844.2. [P35749-4] XP_016878739.1. XM_017023250.1. [P35749-3] |
UniGenei | Hs.460109. |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangement, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | MYH11_HUMAN | |
Accessioni | P35749Primary (citable) accession number: P35749 Secondary accession number(s): D2JYH7 Q3MNF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | April 27, 2001 | |
Last modified: | March 28, 2018 | |
This is version 190 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |