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P35747

- ALBU_HORSE

UniProt

P35747 - ALBU_HORSE

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Protein
Serum albumin
Gene
ALB
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Copper By similarity
Metal bindingi91 – 911Zinc By similarity
Metal bindingi123 – 1231Zinc By similarity
Metal bindingi270 – 2701Zinc By similarity
Metal bindingi272 – 2721Zinc By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. drug binding Source: UniProtKB
  3. fatty acid binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. pyridoxal phosphate binding Source: UniProtKB
  6. toxic substance binding Source: UniProtKB

GO - Biological processi

  1. cellular response to starvation Source: UniProtKB
  2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
  3. maintenance of mitochondrion location Source: UniProtKB
  4. negative regulation of apoptotic process Source: UniProtKB
  5. transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
Allergen: Equ c 3
Gene namesi
Name:ALB
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3302. Equ c 3.0101.
335. Equ c 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Propeptidei19 – 224 By similarity
PRO_0000001065
Chaini25 – 607583Serum albumin
PRO_0000001066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi77 ↔ 86
Modified residuei82 – 821Phosphoserine By similarity
Disulfide bondi99 ↔ 115
Disulfide bondi114 ↔ 125
Disulfide bondi147 ↔ 192
Disulfide bondi191 ↔ 200
Disulfide bondi223 ↔ 269
Disulfide bondi268 ↔ 276
Disulfide bondi288 ↔ 302
Disulfide bondi301 ↔ 312
Disulfide bondi339 ↔ 384
Disulfide bondi383 ↔ 392
Disulfide bondi415 ↔ 461
Modified residuei442 – 4421Phosphoserine By similarity
Modified residuei443 – 4431Phosphothreonine By similarity
Modified residuei445 – 4451Phosphothreonine By similarity
Disulfide bondi460 ↔ 471
Disulfide bondi484 ↔ 500
Disulfide bondi499 ↔ 510
Disulfide bondi537 ↔ 582
Disulfide bondi581 ↔ 590
Modified residuei587 – 5871N6-succinyllysine By similarity

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP35747.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000009171.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 293
Helixi30 – 389
Helixi40 – 5415
Beta strandi55 – 584
Helixi60 – 7920
Turni84 – 874
Helixi90 – 989
Helixi104 – 1074
Helixi109 – 1168
Helixi121 – 1299
Helixi143 – 15210
Helixi154 – 16815
Helixi174 – 19118
Beta strandi192 – 1965
Helixi197 – 22933
Helixi231 – 24515
Helixi251 – 26919
Helixi273 – 28917
Helixi291 – 2933
Helixi298 – 3025
Helixi306 – 31510
Helixi329 – 3324
Helixi338 – 3447
Helixi346 – 35914
Helixi366 – 38520
Beta strandi386 – 3883
Helixi389 – 3935
Helixi394 – 3996
Helixi400 – 43738
Helixi443 – 46018
Helixi465 – 48925
Helixi494 – 5018
Helixi504 – 5063
Helixi507 – 5137
Beta strandi518 – 5203
Helixi527 – 5304
Helixi534 – 5385
Helixi541 – 55818
Helixi564 – 58219
Beta strandi584 – 5863
Helixi587 – 60519

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V08X-ray2.45A25-607[»]
4F5TX-ray2.32A25-607[»]
4F5UX-ray2.04A25-607[»]
4J2VX-ray2.12A25-607[»]
4OT2X-ray2.42A25-607[»]
ProteinModelPortaliP35747.
SMRiP35747. Positions 27-606.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 209191Albumin 1
Add
BLAST
Domaini210 – 402193Albumin 2
Add
BLAST
Domaini403 – 600198Albumin 3
Add
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG45992.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP35747.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35747-1 [UniParc]FASTAAdd to Basket

« Hide

MKWVTFVSLL FLFSSAYSRG VLRRDTHKSE IAHRFNDLGE KHFKGLVLVA    50
FSQYLQQCPF EDHVKLVNEV TEFAKKCAAD ESAENCDKSL HTLFGDKLCT 100
VATLRATYGE LADCCEKQEP ERNECFLTHK DDHPNLPKLK PEPDAQCAAF 150
QEDPDKFLGK YLYEVARRHP YFYGPELLFH AEEYKADFTE CCPADDKLAC 200
LIPKLDALKE RILLSSAKER LKCSSFQNFG ERAVKAWSVA RLSQKFPKAD 250
FAEVSKIVTD LTKVHKECCH GDLLECADDR ADLAKYICEH QDSISGKLKA 300
CCDKPLLQKS HCIAEVKEDD LPSDLPALAA DFAEDKEICK HYKDAKDVFL 350
GTFLYEYSRR HPDYSVSLLL RIAKTYEATL EKCCAEADPP ACYRTVFDQF 400
TPLVEEPKSL VKKNCDLFEE VGEYDFQNAL IVRYTKKAPQ VSTPTLVEIG 450
RTLGKVGSRC CKLPESERLP CSENHLALAL NRLCVLHEKT PVSEKITKCC 500
TDSLAERRPC FSALELDEGY VPKEFKAETF TFHADICTLP EDEKQIKKQS 550
ALAELVKHKP KATKEQLKTV LGNFSAFVAK CCGREDKEAC FAEEGPKLVA 600
SSQLALA 607
Length:607
Mass (Da):68,599
Last modified:June 1, 1994 - v1
Checksum:i256F6E830A1B90C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74045 mRNA. Translation: CAA52194.1.
PIRiS34053. ABHOS.
RefSeqiNP_001075972.1. NM_001082503.1.
UniGeneiEca.1455.

Genome annotation databases

GeneIDi100034206.
KEGGiecb:100034206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74045 mRNA. Translation: CAA52194.1 .
PIRi S34053. ABHOS.
RefSeqi NP_001075972.1. NM_001082503.1.
UniGenei Eca.1455.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3V08 X-ray 2.45 A 25-607 [» ]
4F5T X-ray 2.32 A 25-607 [» ]
4F5U X-ray 2.04 A 25-607 [» ]
4J2V X-ray 2.12 A 25-607 [» ]
4OT2 X-ray 2.42 A 25-607 [» ]
ProteinModelPortali P35747.
SMRi P35747. Positions 27-606.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000009171.

Protein family/group databases

Allergomei 3302. Equ c 3.0101.
335. Equ c 3.

Proteomic databases

PRIDEi P35747.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100034206.
KEGGi ecb:100034206.

Organism-specific databases

CTDi 213.

Phylogenomic databases

eggNOGi NOG45992.
HOGENOMi HOG000293137.
HOVERGENi HBG004207.
InParanoidi P35747.
KOi K16141.

Family and domain databases

InterProi IPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view ]
Pfami PF00273. Serum_albumin. 3 hits.
[Graphical view ]
PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSi PR00802. SERUMALBUMIN.
SMARTi SM00103. ALBUMIN. 3 hits.
[Graphical view ]
SUPFAMi SSF48552. SSF48552. 3 hits.
PROSITEi PS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "X-ray and primary structure of horse serum albumin (Equus caballus) at 0.27-nm resolution."
    Ho J.X., Holowachuk E.W., Norton E.J., Twigg P.D., Carter D.C.
    Eur. J. Biochem. 215:205-212(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
    Tissue: Liver.

Entry informationi

Entry nameiALBU_HORSE
AccessioniPrimary (citable) accession number: P35747
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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