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P35747

- ALBU_HORSE

UniProt

P35747 - ALBU_HORSE

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Protein

Serum albumin

Gene

ALB

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271CopperBy similarity
Metal bindingi91 – 911ZincBy similarity
Metal bindingi123 – 1231ZincBy similarity
Metal bindingi270 – 2701ZincBy similarity
Metal bindingi272 – 2721ZincBy similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. drug binding Source: UniProtKB
  3. fatty acid binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. pyridoxal phosphate binding Source: UniProtKB
  6. toxic substance binding Source: UniProtKB

GO - Biological processi

  1. cellular response to starvation Source: UniProtKB
  2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
  3. maintenance of mitochondrion location Source: UniProtKB
  4. negative regulation of apoptotic process Source: UniProtKB
  5. transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
Allergen: Equ c 3
Gene namesi
Name:ALB
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3302. Equ c 3.0101.
335. Equ c 3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 224By similarityPRO_0000001065
Chaini25 – 607583Serum albuminPRO_0000001066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi77 ↔ 86
Modified residuei82 – 821PhosphoserineBy similarity
Disulfide bondi99 ↔ 115
Disulfide bondi114 ↔ 125
Disulfide bondi147 ↔ 192
Disulfide bondi191 ↔ 200
Disulfide bondi223 ↔ 269
Disulfide bondi268 ↔ 276
Disulfide bondi288 ↔ 302
Disulfide bondi301 ↔ 312
Disulfide bondi339 ↔ 384
Disulfide bondi383 ↔ 392
Disulfide bondi415 ↔ 461
Modified residuei442 – 4421PhosphoserineBy similarity
Modified residuei443 – 4431PhosphothreonineBy similarity
Modified residuei445 – 4451PhosphothreonineBy similarity
Disulfide bondi460 ↔ 471
Disulfide bondi484 ↔ 500
Disulfide bondi499 ↔ 510
Disulfide bondi537 ↔ 582
Disulfide bondi581 ↔ 590
Modified residuei587 – 5871N6-succinyllysineBy similarity

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP35747.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000009171.

Structurei

Secondary structure

1
607
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 293Combined sources
Helixi30 – 389Combined sources
Helixi40 – 5415Combined sources
Beta strandi55 – 584Combined sources
Helixi60 – 7920Combined sources
Turni84 – 874Combined sources
Helixi90 – 989Combined sources
Helixi104 – 1074Combined sources
Helixi109 – 1168Combined sources
Helixi121 – 1299Combined sources
Helixi143 – 15210Combined sources
Helixi154 – 16815Combined sources
Helixi174 – 19118Combined sources
Beta strandi192 – 1965Combined sources
Helixi197 – 22933Combined sources
Helixi231 – 24515Combined sources
Helixi251 – 26919Combined sources
Helixi273 – 28917Combined sources
Helixi291 – 2933Combined sources
Helixi298 – 3025Combined sources
Helixi306 – 31510Combined sources
Helixi329 – 3324Combined sources
Helixi338 – 3447Combined sources
Helixi346 – 35914Combined sources
Helixi366 – 38520Combined sources
Beta strandi386 – 3883Combined sources
Helixi389 – 3935Combined sources
Helixi394 – 3996Combined sources
Helixi400 – 43738Combined sources
Helixi443 – 46018Combined sources
Helixi465 – 48925Combined sources
Helixi494 – 5018Combined sources
Helixi504 – 5063Combined sources
Helixi507 – 5137Combined sources
Beta strandi518 – 5203Combined sources
Helixi527 – 5304Combined sources
Helixi534 – 5385Combined sources
Helixi541 – 55818Combined sources
Helixi564 – 58219Combined sources
Beta strandi584 – 5863Combined sources
Helixi587 – 60519Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V08X-ray2.45A25-607[»]
4F5TX-ray2.32A25-607[»]
4F5UX-ray2.04A25-607[»]
4J2VX-ray2.12A25-607[»]
4OT2X-ray2.42A25-607[»]
ProteinModelPortaliP35747.
SMRiP35747. Positions 27-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 209191Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini210 – 402193Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini403 – 600198Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG45992.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP35747.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35747-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKWVTFVSLL FLFSSAYSRG VLRRDTHKSE IAHRFNDLGE KHFKGLVLVA
60 70 80 90 100
FSQYLQQCPF EDHVKLVNEV TEFAKKCAAD ESAENCDKSL HTLFGDKLCT
110 120 130 140 150
VATLRATYGE LADCCEKQEP ERNECFLTHK DDHPNLPKLK PEPDAQCAAF
160 170 180 190 200
QEDPDKFLGK YLYEVARRHP YFYGPELLFH AEEYKADFTE CCPADDKLAC
210 220 230 240 250
LIPKLDALKE RILLSSAKER LKCSSFQNFG ERAVKAWSVA RLSQKFPKAD
260 270 280 290 300
FAEVSKIVTD LTKVHKECCH GDLLECADDR ADLAKYICEH QDSISGKLKA
310 320 330 340 350
CCDKPLLQKS HCIAEVKEDD LPSDLPALAA DFAEDKEICK HYKDAKDVFL
360 370 380 390 400
GTFLYEYSRR HPDYSVSLLL RIAKTYEATL EKCCAEADPP ACYRTVFDQF
410 420 430 440 450
TPLVEEPKSL VKKNCDLFEE VGEYDFQNAL IVRYTKKAPQ VSTPTLVEIG
460 470 480 490 500
RTLGKVGSRC CKLPESERLP CSENHLALAL NRLCVLHEKT PVSEKITKCC
510 520 530 540 550
TDSLAERRPC FSALELDEGY VPKEFKAETF TFHADICTLP EDEKQIKKQS
560 570 580 590 600
ALAELVKHKP KATKEQLKTV LGNFSAFVAK CCGREDKEAC FAEEGPKLVA

SSQLALA
Length:607
Mass (Da):68,599
Last modified:June 1, 1994 - v1
Checksum:i256F6E830A1B90C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74045 mRNA. Translation: CAA52194.1.
PIRiS34053. ABHOS.
RefSeqiNP_001075972.1. NM_001082503.1.
UniGeneiEca.1455.

Genome annotation databases

GeneIDi100034206.
KEGGiecb:100034206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74045 mRNA. Translation: CAA52194.1 .
PIRi S34053. ABHOS.
RefSeqi NP_001075972.1. NM_001082503.1.
UniGenei Eca.1455.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3V08 X-ray 2.45 A 25-607 [» ]
4F5T X-ray 2.32 A 25-607 [» ]
4F5U X-ray 2.04 A 25-607 [» ]
4J2V X-ray 2.12 A 25-607 [» ]
4OT2 X-ray 2.42 A 25-607 [» ]
ProteinModelPortali P35747.
SMRi P35747. Positions 27-606.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000009171.

Protein family/group databases

Allergomei 3302. Equ c 3.0101.
335. Equ c 3.

Proteomic databases

PRIDEi P35747.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100034206.
KEGGi ecb:100034206.

Organism-specific databases

CTDi 213.

Phylogenomic databases

eggNOGi NOG45992.
HOGENOMi HOG000293137.
HOVERGENi HBG004207.
InParanoidi P35747.
KOi K16141.

Family and domain databases

InterProi IPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view ]
Pfami PF00273. Serum_albumin. 3 hits.
[Graphical view ]
PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSi PR00802. SERUMALBUMIN.
SMARTi SM00103. ALBUMIN. 3 hits.
[Graphical view ]
SUPFAMi SSF48552. SSF48552. 3 hits.
PROSITEi PS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "X-ray and primary structure of horse serum albumin (Equus caballus) at 0.27-nm resolution."
    Ho J.X., Holowachuk E.W., Norton E.J., Twigg P.D., Carter D.C.
    Eur. J. Biochem. 215:205-212(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
    Tissue: Liver.

Entry informationi

Entry nameiALBU_HORSE
AccessioniPrimary (citable) accession number: P35747
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3