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P35747

- ALBU_HORSE

UniProt

P35747 - ALBU_HORSE

Protein

Serum albumin

Gene

ALB

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271CopperBy similarity
    Metal bindingi91 – 911ZincBy similarity
    Metal bindingi123 – 1231ZincBy similarity
    Metal bindingi270 – 2701ZincBy similarity
    Metal bindingi272 – 2721ZincBy similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. drug binding Source: UniProtKB
    3. fatty acid binding Source: UniProtKB
    4. metal ion binding Source: UniProtKB-KW
    5. pyridoxal phosphate binding Source: UniProtKB
    6. toxic substance binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to starvation Source: UniProtKB
    2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
    3. maintenance of mitochondrion location Source: UniProtKB
    4. negative regulation of apoptotic process Source: UniProtKB
    5. transport Source: InterPro

    Keywords - Ligandi

    Copper, Lipid-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serum albumin
    Alternative name(s):
    Allergen: Equ c 3
    Gene namesi
    Name:ALB
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro
    2. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3302. Equ c 3.0101.
    335. Equ c 3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Propeptidei19 – 224By similarityPRO_0000001065
    Chaini25 – 607583Serum albuminPRO_0000001066Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi77 ↔ 86
    Modified residuei82 – 821PhosphoserineBy similarity
    Disulfide bondi99 ↔ 115
    Disulfide bondi114 ↔ 125
    Disulfide bondi147 ↔ 192
    Disulfide bondi191 ↔ 200
    Disulfide bondi223 ↔ 269
    Disulfide bondi268 ↔ 276
    Disulfide bondi288 ↔ 302
    Disulfide bondi301 ↔ 312
    Disulfide bondi339 ↔ 384
    Disulfide bondi383 ↔ 392
    Disulfide bondi415 ↔ 461
    Modified residuei442 – 4421PhosphoserineBy similarity
    Modified residuei443 – 4431PhosphothreonineBy similarity
    Modified residuei445 – 4451PhosphothreonineBy similarity
    Disulfide bondi460 ↔ 471
    Disulfide bondi484 ↔ 500
    Disulfide bondi499 ↔ 510
    Disulfide bondi537 ↔ 582
    Disulfide bondi581 ↔ 590
    Modified residuei587 – 5871N6-succinyllysineBy similarity

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

    Proteomic databases

    PRIDEiP35747.

    Expressioni

    Tissue specificityi

    Plasma.

    Interactioni

    Protein-protein interaction databases

    STRINGi9796.ENSECAP00000009171.

    Structurei

    Secondary structure

    1
    607
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 293
    Helixi30 – 389
    Helixi40 – 5415
    Beta strandi55 – 584
    Helixi60 – 7920
    Turni84 – 874
    Helixi90 – 989
    Helixi104 – 1074
    Helixi109 – 1168
    Helixi121 – 1299
    Helixi143 – 15210
    Helixi154 – 16815
    Helixi174 – 19118
    Beta strandi192 – 1965
    Helixi197 – 22933
    Helixi231 – 24515
    Helixi251 – 26919
    Helixi273 – 28917
    Helixi291 – 2933
    Helixi298 – 3025
    Helixi306 – 31510
    Helixi329 – 3324
    Helixi338 – 3447
    Helixi346 – 35914
    Helixi366 – 38520
    Beta strandi386 – 3883
    Helixi389 – 3935
    Helixi394 – 3996
    Helixi400 – 43738
    Helixi443 – 46018
    Helixi465 – 48925
    Helixi494 – 5018
    Helixi504 – 5063
    Helixi507 – 5137
    Beta strandi518 – 5203
    Helixi527 – 5304
    Helixi534 – 5385
    Helixi541 – 55818
    Helixi564 – 58219
    Beta strandi584 – 5863
    Helixi587 – 60519

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3V08X-ray2.45A25-607[»]
    4F5TX-ray2.32A25-607[»]
    4F5UX-ray2.04A25-607[»]
    4J2VX-ray2.12A25-607[»]
    4OT2X-ray2.42A25-607[»]
    ProteinModelPortaliP35747.
    SMRiP35747. Positions 27-606.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 209191Albumin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini210 – 402193Albumin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini403 – 600198Albumin 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
    Contains 3 albumin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG45992.
    HOGENOMiHOG000293137.
    HOVERGENiHBG004207.
    InParanoidiP35747.
    KOiK16141.

    Family and domain databases

    InterProiIPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view]
    PfamiPF00273. Serum_albumin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSiPR00802. SERUMALBUMIN.
    SMARTiSM00103. ALBUMIN. 3 hits.
    [Graphical view]
    SUPFAMiSSF48552. SSF48552. 3 hits.
    PROSITEiPS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35747-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWVTFVSLL FLFSSAYSRG VLRRDTHKSE IAHRFNDLGE KHFKGLVLVA    50
    FSQYLQQCPF EDHVKLVNEV TEFAKKCAAD ESAENCDKSL HTLFGDKLCT 100
    VATLRATYGE LADCCEKQEP ERNECFLTHK DDHPNLPKLK PEPDAQCAAF 150
    QEDPDKFLGK YLYEVARRHP YFYGPELLFH AEEYKADFTE CCPADDKLAC 200
    LIPKLDALKE RILLSSAKER LKCSSFQNFG ERAVKAWSVA RLSQKFPKAD 250
    FAEVSKIVTD LTKVHKECCH GDLLECADDR ADLAKYICEH QDSISGKLKA 300
    CCDKPLLQKS HCIAEVKEDD LPSDLPALAA DFAEDKEICK HYKDAKDVFL 350
    GTFLYEYSRR HPDYSVSLLL RIAKTYEATL EKCCAEADPP ACYRTVFDQF 400
    TPLVEEPKSL VKKNCDLFEE VGEYDFQNAL IVRYTKKAPQ VSTPTLVEIG 450
    RTLGKVGSRC CKLPESERLP CSENHLALAL NRLCVLHEKT PVSEKITKCC 500
    TDSLAERRPC FSALELDEGY VPKEFKAETF TFHADICTLP EDEKQIKKQS 550
    ALAELVKHKP KATKEQLKTV LGNFSAFVAK CCGREDKEAC FAEEGPKLVA 600
    SSQLALA 607
    Length:607
    Mass (Da):68,599
    Last modified:June 1, 1994 - v1
    Checksum:i256F6E830A1B90C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74045 mRNA. Translation: CAA52194.1.
    PIRiS34053. ABHOS.
    RefSeqiNP_001075972.1. NM_001082503.1.
    UniGeneiEca.1455.

    Genome annotation databases

    GeneIDi100034206.
    KEGGiecb:100034206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74045 mRNA. Translation: CAA52194.1 .
    PIRi S34053. ABHOS.
    RefSeqi NP_001075972.1. NM_001082503.1.
    UniGenei Eca.1455.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3V08 X-ray 2.45 A 25-607 [» ]
    4F5T X-ray 2.32 A 25-607 [» ]
    4F5U X-ray 2.04 A 25-607 [» ]
    4J2V X-ray 2.12 A 25-607 [» ]
    4OT2 X-ray 2.42 A 25-607 [» ]
    ProteinModelPortali P35747.
    SMRi P35747. Positions 27-606.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9796.ENSECAP00000009171.

    Protein family/group databases

    Allergomei 3302. Equ c 3.0101.
    335. Equ c 3.

    Proteomic databases

    PRIDEi P35747.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100034206.
    KEGGi ecb:100034206.

    Organism-specific databases

    CTDi 213.

    Phylogenomic databases

    eggNOGi NOG45992.
    HOGENOMi HOG000293137.
    HOVERGENi HBG004207.
    InParanoidi P35747.
    KOi K16141.

    Family and domain databases

    InterProi IPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view ]
    Pfami PF00273. Serum_albumin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSi PR00802. SERUMALBUMIN.
    SMARTi SM00103. ALBUMIN. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48552. SSF48552. 3 hits.
    PROSITEi PS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "X-ray and primary structure of horse serum albumin (Equus caballus) at 0.27-nm resolution."
      Ho J.X., Holowachuk E.W., Norton E.J., Twigg P.D., Carter D.C.
      Eur. J. Biochem. 215:205-212(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
      Tissue: Liver.

    Entry informationi

    Entry nameiALBU_HORSE
    AccessioniPrimary (citable) accession number: P35747
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3