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Protein

Serum albumin

Gene

ALB

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27CopperBy similarity1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi270ZincBy similarity1
Metal bindingi272ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
Allergen: Equ c 3
Gene namesi
Name:ALB
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3302 Equ c 3.0101
335 Equ c 3

Chemistry databases

ChEMBLiCHEMBL3751645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000106519 – 24By similarity6
ChainiPRO_000000106625 – 607Serum albuminAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115
Modified residuei107PhosphothreonineBy similarity1
Disulfide bondi114 ↔ 125
Disulfide bondi147 ↔ 192
Disulfide bondi191 ↔ 200
Disulfide bondi223 ↔ 269
Disulfide bondi268 ↔ 276
Disulfide bondi288 ↔ 302
Disulfide bondi301 ↔ 312
Disulfide bondi339 ↔ 384
Disulfide bondi383 ↔ 392
Disulfide bondi415 ↔ 461
Modified residuei442PhosphoserineBy similarity1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei445PhosphothreonineBy similarity1
Disulfide bondi460 ↔ 471
Disulfide bondi484 ↔ 500
Disulfide bondi499 ↔ 510
Modified residuei512PhosphoserineBy similarity1
Disulfide bondi537 ↔ 582
Modified residuei557N6-methyllysineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Disulfide bondi581 ↔ 590
Modified residuei587N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP35747
PeptideAtlasiP35747
PRIDEiP35747

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000009171

Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 29Combined sources3
Helixi30 – 54Combined sources25
Beta strandi55 – 58Combined sources4
Helixi60 – 79Combined sources20
Turni84 – 87Combined sources4
Helixi90 – 98Combined sources9
Helixi104 – 107Combined sources4
Turni109 – 111Combined sources3
Helixi112 – 115Combined sources4
Helixi121 – 128Combined sources8
Helixi143 – 152Combined sources10
Helixi154 – 168Combined sources15
Helixi174 – 191Combined sources18
Beta strandi194 – 196Combined sources3
Helixi197 – 229Combined sources33
Helixi231 – 245Combined sources15
Beta strandi247 – 249Combined sources3
Helixi251 – 269Combined sources19
Helixi273 – 289Combined sources17
Helixi291 – 294Combined sources4
Helixi296 – 298Combined sources3
Helixi299 – 302Combined sources4
Helixi306 – 314Combined sources9
Helixi329 – 332Combined sources4
Helixi338 – 344Combined sources7
Helixi346 – 359Combined sources14
Helixi366 – 384Combined sources19
Beta strandi386 – 388Combined sources3
Helixi389 – 393Combined sources5
Helixi394 – 400Combined sources7
Helixi401 – 421Combined sources21
Helixi423 – 437Combined sources15
Helixi443 – 460Combined sources18
Helixi465 – 467Combined sources3
Helixi468 – 489Combined sources22
Helixi494 – 501Combined sources8
Turni504 – 506Combined sources3
Helixi507 – 513Combined sources7
Beta strandi518 – 520Combined sources3
Helixi527 – 530Combined sources4
Helixi534 – 538Combined sources5
Helixi541 – 558Combined sources18
Helixi564 – 582Combined sources19
Beta strandi584 – 586Combined sources3
Helixi587 – 605Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V08X-ray2.45A25-607[»]
4F5TX-ray2.32A25-607[»]
4F5UX-ray2.04A25-607[»]
4J2VX-ray2.12A25-607[»]
4OT2X-ray2.42A25-607[»]
4ZBQX-ray1.92A25-607[»]
4ZBRX-ray2.19A25-607[»]
5DBYX-ray2.35A25-607[»]
5DQFX-ray2.15A28-607[»]
5HOZX-ray2.15A25-607[»]
5ID9X-ray2.48A25-607[»]
5IIHX-ray2.40A25-607[»]
5IIUX-ray2.30A25-607[»]
5IIXX-ray2.20A25-607[»]
5IJ5X-ray2.55A25-607[»]
5IJEX-ray2.40A25-607[»]
5V0VX-ray2.45A25-607[»]
6CI6X-ray2.80A25-607[»]
ProteinModelPortaliP35747
SMRiP35747
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 209Albumin 1PROSITE-ProRule annotationAdd BLAST191
Domaini210 – 402Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini403 – 600Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP35747
KOiK16141

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFVSLL FLFSSAYSRG VLRRDTHKSE IAHRFNDLGE KHFKGLVLVA
60 70 80 90 100
FSQYLQQCPF EDHVKLVNEV TEFAKKCAAD ESAENCDKSL HTLFGDKLCT
110 120 130 140 150
VATLRATYGE LADCCEKQEP ERNECFLTHK DDHPNLPKLK PEPDAQCAAF
160 170 180 190 200
QEDPDKFLGK YLYEVARRHP YFYGPELLFH AEEYKADFTE CCPADDKLAC
210 220 230 240 250
LIPKLDALKE RILLSSAKER LKCSSFQNFG ERAVKAWSVA RLSQKFPKAD
260 270 280 290 300
FAEVSKIVTD LTKVHKECCH GDLLECADDR ADLAKYICEH QDSISGKLKA
310 320 330 340 350
CCDKPLLQKS HCIAEVKEDD LPSDLPALAA DFAEDKEICK HYKDAKDVFL
360 370 380 390 400
GTFLYEYSRR HPDYSVSLLL RIAKTYEATL EKCCAEADPP ACYRTVFDQF
410 420 430 440 450
TPLVEEPKSL VKKNCDLFEE VGEYDFQNAL IVRYTKKAPQ VSTPTLVEIG
460 470 480 490 500
RTLGKVGSRC CKLPESERLP CSENHLALAL NRLCVLHEKT PVSEKITKCC
510 520 530 540 550
TDSLAERRPC FSALELDEGY VPKEFKAETF TFHADICTLP EDEKQIKKQS
560 570 580 590 600
ALAELVKHKP KATKEQLKTV LGNFSAFVAK CCGREDKEAC FAEEGPKLVA

SSQLALA
Length:607
Mass (Da):68,599
Last modified:June 1, 1994 - v1
Checksum:i256F6E830A1B90C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74045 mRNA Translation: CAA52194.1
PIRiS34053 ABHOS
RefSeqiNP_001075972.1, NM_001082503.1
UniGeneiEca.1455

Genome annotation databases

GeneIDi100034206
KEGGiecb:100034206

Similar proteinsi

Entry informationi

Entry nameiALBU_HORSE
AccessioniPrimary (citable) accession number: P35747
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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