P35745 (ACYP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acylphosphatase-2
EC=3.6.1.7

Alternative name(s):
Acylphosphatase, muscle type isozyme
Acylphosphate phosphohydrolase 2

Gene names

Name:	Acyp2
Synonyms:	Acyp

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	acylphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 97	96	Acylphosphatase-2		PRO_0000158546
Regions
	Domain	7 – 97	91	Acylphosphatase-like
Sites
	Active site	22	1	Potential
	Active site	40	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine

Sequences

	Sequence		Length	Mass (Da)
	P35745 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 12947520EF12F4BB	FASTA	97	10,863
	10 20 30 40 50 60 MAEPLKSVDY EVFGTVQGVC FRMYTEGEAK KRGLVGWVKN TSKGTVTGQV QGPEEKVNSM 70 80 90 KSWLSKVGSP SSRIDRADFS NEKTISKLEY SNFSIRY

References

[1]	"Rat muscle acylphosphatase: purification, amino sequence, and immunological characterization." Berti A., Tremori E., Pazzagli L., Degl'Innocenti D., Camici G., Cappugi G., Manoa G., Ramponi G. J. Protein Chem. 10:91-102(1991) [PubMed: 1647162] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-97. Tissue: Skeletal muscle.
[2]	Lubec G., Kang S.U. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 44-56, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
IPI	IPI00968497.
PIR	A61427.
UniGene	Rn.22481.
3D structure databases
ProteinModelPortal	P35745.
SMR	P35745. Positions 2-97.
ModBase	Search...
Protein-protein interaction databases
STRING	P35745.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	1561007. Acyp2.
Phylogenomic databases
HOVERGEN	HBG050454.
PhylomeDB	P35745.
Gene expression databases
Genevestigator	P35745.
Family and domain databases
InterPro	IPR020456. Acylphosphatase. IPR001792. Acylphosphatase-like. IPR017968. Acylphosphatase_CS. [Graphical view]
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
PRINTS	PR00112. ACYLPHPHTASE.
SUPFAM	SSF54975. Acylphosphatase. 1 hit.
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACYP2_RAT

Accession

Primary (citable) accession number: P35745

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	January 23, 2007
Last modified:	September 21, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program