Reviewed, UniProtKB/Swiss-Prot P35744 (ACYP2_CAVPO)

Names and origin

Protein names

Recommended name:
    Acylphosphatase-2
    EC=3.6.1.7
Alternative name(s):
    Acylphosphate phosphohydrolase 2
    Acylphosphatase, muscle type isozyme

Gene names

Name:	ACYP2
Synonyms:	ACYP

Organism

Cavia porcellus (Guinea pig)

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	acylphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 99	98	Acylphosphatase-2		PRO_0000158540
Regions
	Domain	9 – 99	91	Acylphosphatase-like
Sites
	Active site	24	1	Potential
	Active site	42	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P35744-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 1DF22894292E5137	FASTA	99	11,007
	10 20 30 40 50 60 MSAAAQLKSV DYEVFGRVQG VCFRMYTEGE AKKIGVVGWV KNTSKGTVTG QVQGPEEKVN 70 80 90 SMKSWLSKVG SPSSRIDRTN FSNEKSISKL EYSNFSIRY

References

[1]	"Guinea pig acylphosphatase: the amino acid sequence." Manao G., Cappugi G., Modesti A., Stefani M., Marzocchini R., Degl'Innocenti D., Camici G. J. Protein Chem. 7:417-426(1988) [PubMed: 2855598] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99. Tissue: Skeletal muscle.

Cross-references

Sequence databases
PIR	QPGP. A60893.
3D structure databases
HSSP	HSSP built from PDB template 1APS based on UniProtKB P00818.
SMR	P35744. Positions 2-99.
ModBase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000008911; ENSCPOP00000007930; ENSCPOG00000008832; Cavia porcellus. [Genome view]
Phylogenomic databases
HOVERGEN	P35744.
Enzyme and pathway databases
BRENDA	3.6.1.7. 44.
Family and domain databases
InterPro	IPR020456. Acylphosphatase. IPR001792. Acylphosphatase-like. IPR017968. Acylphosphatase_CS. [Graphical view]
PANTHER	PTHR10029. Acylphosphatase. 1 hit.
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
PRINTS	PR00112. ACYLPHPHTASE.
ProDom	PD001884. Acylphosphatase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACYP2_CAVPO

Accession

Primary (citable) accession number: P35744

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	January 23, 2007
Last modified:	July 28, 2009
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)