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P35742 (HN_NDVJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemagglutinin-neuraminidase

EC=3.2.1.18
Gene names
Name:HN
OrganismNewcastle disease virus (strain Iba/85) (NDV)
Taxonomic identifier11183 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 571571Hemagglutinin-neuraminidase
PRO_0000142613

Regions

Topological domain1 – 2626Intravirion Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 571524Virion surface Potential

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...); by host Potential
Glycosylation3411N-linked (GlcNAc...); by host Potential
Glycosylation4811N-linked (GlcNAc...); by host Potential
Glycosylation5081N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P35742 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 3560C140B04FB515

FASTA57162,995
        10         20         30         40         50         60 
MDRAVSRVVL ENEEREAKNT WRFVFRIAVL LLIVMTLAIS AAALVYSMGA STPRDLASIS 

        70         80         90        100        110        120 
TAISKMEDKI TSSLSSNQDV VDRIYKQVAL ESPLALLNTE SIIMNAITSL SYQINGAANN 

       130        140        150        160        170        180 
SGCGAPVHDP DYIGGIGKEL IVDDTSDVTS FYPSAYQEHL NFIPAPTTGS GCTRIPSFDM 

       190        200        210        220        230        240 
SATHYCYTHN VILSGCRDHS HSHQYLALGV LRTSATGKVF FSTLRSINLD DTQNRKSCSV 

       250        260        270        280        290        300 
SATPLGCDML CSKVTETEEE DYKSVTPTSM VHGRFRFDGQ YHEKDSDRTT LFKDWVANYP 

       310        320        330        340        350        360 
GVGGGSFIDD RVWFPIYGGL KPNSPSDIAQ EGKYVIYKRY NNTFPDKQDY QIRMAKSSYK 

       370        380        390        400        410        420 
PGRFGGKRVQ QAILSIKVST SLGEDPVLTV PPNTITLMGA EGRVLTVGTS HFLYQRGSSY 

       430        440        450        460        470        480 
FSPALLYPMT VYQQTATLHS PYTFNAFTRP GSVPCQASAR CPNSCITGVY TDPYPLVFHR 

       490        500        510        520        530        540 
NHTLRGVFGT MLDDEQARLN PVSAVFDNIS RSRVTRVSSS STKAAYTTST CFKVVKTSKA 

       550        560        570 
YCLSIAEISN TLFGEFRIVP LLVEILKDDR V 

« Hide

References

[1]"Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24717 Genomic RNA. Translation: AAA46667.1.
PIRD36829.

3D structure databases

ProteinModelPortalP35742.
SMRP35742. Positions 124-569.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_NDVJ
AccessionPrimary (citable) accession number: P35742
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries