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P35741

- HN_NDVH3

UniProt

P35741 - HN_NDVH3

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Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Newcastle disease virus (strain Her/33) (NDV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Her/33) (NDV)
Taxonomic identifieri11187 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Intravirion Reviewed prediction
Add
BLAST
Transmembranei27 – 4721Helical; Reviewed prediction
Add
BLAST
Topological domaini48 – 571524Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Hemagglutinin-neuraminidase
PRO_0000142610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi481 – 4811N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi508 – 5081N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP35741.
SMRiP35741. Positions 124-571.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P35741-1 [UniParc]FASTAAdd to Basket

« Hide

MDRAVSRVAL ENEEREAKNT WRFVFRIAIL LLIVITLAIS AAALVYSMEA    50
STPGDLVGIP TVISRAEEKI TSALSSNQDV VDRIYKQVAL ESPLALLNTE 100
SVIMNAITSL SYQINGAANN SGCGAPVHDP DYIGGIGKEL IVDDASDVTS 150
FYPSAFQEHL NFIPAPTTGS GCTRIPSFDI SATHYCYTHN VILSGCRDHS 200
HSHQYLALGV LRTSATGRVF FSTLRSINLD DNQNRKSCSV SATPLGCDML 250
CSKITETEEE DYSSVTPTSM VHGRLGFDGQ YHEKDLDVIT LFKDWVANYP 300
GVGGGSFIDN RVWFPVYGGL KPNSPSDTVQ EGRYVIYKRY NDTCPDEQDY 350
QIRMAKSSYK PGRFGGKRVQ QAILSIKVST SLGEDPVLTI PPNTVTLMGA 400
EGRVLTVGTS HFLYQRGSSY FSPALLYPMT VNNKTATLHS PYTFNAFTRP 450
GSVPCQASAR CPNSCVTGVY TDPYPLIFHR NHTLRGVFGT MLDDGQARLN 500
PVSAVFDNIS RSRITRVSSS RTKAAYTTST CFKVVKTNKT YVLSIAEISN 550
TLFGEFRIVP LLVEILKNDG V 571
Length:571
Mass (Da):62,610
Last modified:June 1, 1994 - v1
Checksum:i60EBC6A508C6A1BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24714 Genomic RNA. Translation: AAA46664.1.
PIRiA36829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24714 Genomic RNA. Translation: AAA46664.1 .
PIRi A36829.

3D structure databases

ProteinModelPortali P35741.
SMRi P35741. Positions 124-571.
ModBasei Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
    Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
    Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_NDVH3
AccessioniPrimary (citable) accession number: P35741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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