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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Newcastle disease virus (strain Chi/85) (NDV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutinin, Hydrolase
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83 Glycoside Hydrolase Family 83

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Chi/85) (NDV)
Taxonomic identifieri11179 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26IntravirionSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 571Virion surfaceSequence analysisAdd BLAST524

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426081 – 571Hemagglutinin-neuraminidaseAdd BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi508N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP35740

Structurei

3D structure databases

ProteinModelPortaliP35740
SMRiP35740
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR016285 Hemagglutn-neuramid
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
PIRSFiPIRSF001072 Hemagglut-neuramid_paramyxoV, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

P35740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAVNRVVL ENEEREAKNT WRLVFRIAVL LLMVMTLAIS AAALVYSMGA
60 70 80 90 100
STPRDLAGIS TVISKTEDKV TSLLSSKQDV IDRIYKQVAL ESPLALLNTE
110 120 130 140 150
SIIMNAITSL SYQINGAANN SGCGEPVHDP DYIGGIGKEL IVDDISDVTS
160 170 180 190 200
FYPSAYQEHL NFIPAPTTGS GCTRIPSFDM STTHYCYTHN VILSGCRDHS
210 220 230 240 250
HSHQYLALGV LRTSATGRVF FSTLRSINLD DTQNRKSCSV SATPLGCDML
260 270 280 290 300
CSKVTETEEE DYKSVTPTSM VHGRLGFDGQ YHEKDLDTTV LFKDWVANYP
310 320 330 340 350
GVGGGSFIDD RVWFPVYGGL KPNSPSDTAQ EGKYVIYKRY NNTCPDEQDY
360 370 380 390 400
QIRMAKSSYK PGRFGGKRVQ QAILSIKVST SLGEDPVLTI PPNTITLMGA
410 420 430 440 450
EGRVLTVGTS HFLYQRGSSY FSPALLYPMT VNNKTATLHS PYTFNAFTRP
460 470 480 490 500
GSVPCQASAR CPNSCITGVY TDPYPLIFHR NHTLRGVFGT MLDDEQARLN
510 520 530 540 550
PVSAVFDNIS RSRVTRVSSS STKAAYTTST CFKVVKTNKA YCLSIAEISN
560 570
TLFGEFRIVP LLVEILKDDR V
Length:571
Mass (Da):62,901
Last modified:June 1, 1994 - v1
Checksum:i3110CD668D71EF76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24716 Genomic RNA Translation: AAA46666.1
PIRiC36829

Similar proteinsi

Entry informationi

Entry nameiHN_NDVC
AccessioniPrimary (citable) accession number: P35740
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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