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P35740

- HN_NDVC

UniProt

P35740 - HN_NDVC

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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Newcastle disease virus (strain Chi/85) (NDV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Chi/85) (NDV)
Taxonomic identifieri11179 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626IntravirionSequence AnalysisAdd
BLAST
Transmembranei27 – 4721HelicalSequence AnalysisAdd
BLAST
Topological domaini48 – 571524Virion surfaceSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Hemagglutinin-neuraminidasePRO_0000142608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi341 – 3411N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi481 – 4811N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi508 – 5081N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP35740.
SMRiP35740. Positions 124-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P35740-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRAVNRVVL ENEEREAKNT WRLVFRIAVL LLMVMTLAIS AAALVYSMGA
60 70 80 90 100
STPRDLAGIS TVISKTEDKV TSLLSSKQDV IDRIYKQVAL ESPLALLNTE
110 120 130 140 150
SIIMNAITSL SYQINGAANN SGCGEPVHDP DYIGGIGKEL IVDDISDVTS
160 170 180 190 200
FYPSAYQEHL NFIPAPTTGS GCTRIPSFDM STTHYCYTHN VILSGCRDHS
210 220 230 240 250
HSHQYLALGV LRTSATGRVF FSTLRSINLD DTQNRKSCSV SATPLGCDML
260 270 280 290 300
CSKVTETEEE DYKSVTPTSM VHGRLGFDGQ YHEKDLDTTV LFKDWVANYP
310 320 330 340 350
GVGGGSFIDD RVWFPVYGGL KPNSPSDTAQ EGKYVIYKRY NNTCPDEQDY
360 370 380 390 400
QIRMAKSSYK PGRFGGKRVQ QAILSIKVST SLGEDPVLTI PPNTITLMGA
410 420 430 440 450
EGRVLTVGTS HFLYQRGSSY FSPALLYPMT VNNKTATLHS PYTFNAFTRP
460 470 480 490 500
GSVPCQASAR CPNSCITGVY TDPYPLIFHR NHTLRGVFGT MLDDEQARLN
510 520 530 540 550
PVSAVFDNIS RSRVTRVSSS STKAAYTTST CFKVVKTNKA YCLSIAEISN
560 570
TLFGEFRIVP LLVEILKDDR V
Length:571
Mass (Da):62,901
Last modified:June 1, 1994 - v1
Checksum:i3110CD668D71EF76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24716 Genomic RNA. Translation: AAA46666.1.
PIRiC36829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24716 Genomic RNA. Translation: AAA46666.1 .
PIRi C36829.

3D structure databases

ProteinModelPortali P35740.
SMRi P35740. Positions 124-569.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."
    Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.
    Virology 169:260-272(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_NDVC
AccessioniPrimary (citable) accession number: P35740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3