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P35739

- NTRK1_RAT

UniProt

P35739 - NTRK1_RAT

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Protein

High affinity nerve growth factor receptor

Gene

Ntrk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

The pro-survival signaling effect of NTRK1 in neurons requires its endocytosis into signaling early endosomes and its retrograde axonal transport. This is regulated by different proteins including CFL1, RAC1 and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in endosomes By similarity. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. Regulated by NGFR By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei499 – 4991Interaction with SHC1By similarity
Binding sitei547 – 5471ATPPROSITE-ProRule annotation
Active sitei653 – 6531Proton acceptorPROSITE-ProRule annotation
Sitei794 – 7941Interaction with PLCG1By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi519 – 5279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ephrin receptor binding Source: BHF-UCL
  3. kinase binding Source: RGD
  4. nerve growth factor binding Source: UniProtKB
  5. nerve growth factor receptor activity Source: UniProtKB
  6. neurotrophin p75 receptor binding Source: RGD
  7. protein homodimerization activity Source: UniProtKB
  8. protein tyrosine kinase activity Source: MGI
  9. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  1. aging Source: RGD
  2. axon guidance Source: RGD
  3. axonogenesis involved in innervation Source: UniProtKB
  4. B cell differentiation Source: Ensembl
  5. cellular response to growth factor stimulus Source: MGI
  6. cellular response to nerve growth factor stimulus Source: UniProtKB
  7. cellular response to nicotine Source: RGD
  8. circadian rhythm Source: Ensembl
  9. detection of mechanical stimulus involved in sensory perception of pain Source: RGD
  10. detection of temperature stimulus involved in sensory perception of pain Source: RGD
  11. developmental programmed cell death Source: UniProtKB
  12. learning or memory Source: RGD
  13. mechanoreceptor differentiation Source: Ensembl
  14. negative regulation of cell proliferation Source: UniProtKB
  15. negative regulation of neuron apoptotic process Source: UniProtKB
  16. negative regulation of neuron death Source: RGD
  17. nerve growth factor signaling pathway Source: UniProtKB
  18. neurotrophin TRK receptor signaling pathway Source: UniProtKB
  19. olfactory nerve development Source: RGD
  20. peptidyl-tyrosine phosphorylation Source: GOC
  21. positive regulation of angiogenesis Source: Ensembl
  22. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  23. positive regulation of neuron projection development Source: UniProtKB
  24. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  25. positive regulation of programmed cell death Source: UniProtKB
  26. positive regulation of Ras GTPase activity Source: UniProtKB
  27. positive regulation of Ras protein signal transduction Source: UniProtKB
  28. positive regulation of synaptic transmission, glutamatergic Source: RGD
  29. protein autophosphorylation Source: MGI
  30. protein phosphorylation Source: UniProtKB
  31. response to activity Source: RGD
  32. response to axon injury Source: RGD
  33. response to drug Source: RGD
  34. response to electrical stimulus Source: RGD
  35. response to ethanol Source: RGD
  36. response to hydrostatic pressure Source: RGD
  37. response to nicotine Source: RGD
  38. response to nutrient levels Source: RGD
  39. response to radiation Source: RGD
  40. sensory perception of pain Source: RGD
  41. Sertoli cell development Source: RGD
  42. sympathetic nervous system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 5301.
ReactomeiREACT_219269. PLC-gamma1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity nerve growth factor receptor (EC:2.7.10.1)
Alternative name(s):
Neurotrophic tyrosine kinase receptor type 1
Slow nerve growth factor receptor
p140-TrkA
Short name:
Trk-A
Gene namesi
Name:Ntrk1
Synonyms:Trk, Trka
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi620144. Ntrk1.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein
Note: Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes.

GO - Cellular componenti

  1. axon Source: RGD
  2. cell surface Source: MGI
  3. cytoplasmic vesicle Source: RGD
  4. dendrite Source: RGD
  5. early endosome Source: UniProtKB
  6. Golgi membrane Source: Reactome
  7. integral component of plasma membrane Source: UniProtKB
  8. late endosome Source: UniProtKB
  9. neuronal cell body Source: RGD
  10. plasma membrane Source: UniProtKB
  11. protein complex Source: UniProtKB
  12. receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi527 – 5271V → D: Loss of kinase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 799767High affinity nerve growth factor receptorPRO_0000016725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi154 ↔ 193PROSITE-ProRule annotation
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi217 ↔ 267PROSITE-ProRule annotation
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
Modified residuei499 – 4991Phosphotyrosine; by autocatalysisBy similarity
Modified residuei679 – 6791Phosphotyrosine; by autocatalysisBy similarity
Modified residuei683 – 6831Phosphotyrosine; by autocatalysisBy similarity
Modified residuei684 – 6841Phosphotyrosine; by autocatalysisBy similarity
Modified residuei794 – 7941Phosphotyrosine; by autocatalysisBy similarity

Post-translational modificationi

Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-499 mediates interaction and phosphorylation of SHC1.
N-glycosylated.By similarity
Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor By similarity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

PTM databases

PhosphoSiteiP35739.

Expressioni

Tissue specificityi

Isoform Trka-II is primarily expressed in neuronal cells; isoform Trka-I is found in non-neuronal tissues.

Gene expression databases

GenevestigatoriP35739.

Interactioni

Subunit structurei

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Homodimerization is induced by binding of a NGF dimer By similarity. Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner. Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation. Interacts with SQSTM1; bridges NTRK1 to NGFR. Forms a ternary complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (phosphorylated upon activation by NGF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by NGF) with PLCG1; mediates PLCG1 phosphorylation and activation. Interacts (phosphorylated) with SH2B1 and SH2B2. Interacts with GRB2. Interacts with PIK3R1. Interacts with FRS2. Interacts with SORT1; may regulate NTRK1 anterograde axonal transport. Interacts with SH2D1A; regulates NTRK1. Interacts with NRADD. Interacts with RAB7A.By similarity11 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Grb2P629946EBI-976667,EBI-401775

Protein-protein interaction databases

BioGridi248731. 18 interactions.
DIPiDIP-5716N.
IntActiP35739. 2 interactions.
MINTiMINT-191667.

Structurei

3D structure databases

ProteinModelPortaliP35739.
SMRiP35739. Positions 36-385.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 418386ExtracellularSequence AnalysisAdd
BLAST
Topological domaini443 – 799357CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei419 – 44224HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati90 – 11324LRR 1Add
BLAST
Repeati116 – 13722LRR 2Add
BLAST
Domaini148 – 21972LRRCTAdd
BLAST
Domaini196 – 28590Ig-like C2-type 1Add
BLAST
Domaini295 – 36874Ig-like C2-type 2Add
BLAST
Domaini513 – 784272Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni472 – 49322Interaction with SQSTM1Add
BLAST

Domaini

The transmembrane domain mediates interaction with KIDINS220.
The extracellular domain mediates interaction with NGFR.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118818.
HOGENOMiHOG000264255.
HOVERGENiHBG056735.
InParanoidiP35739.
KOiK03176.
OMAiKNVTCWA.
OrthoDBiEOG7GTT32.
PhylomeDBiP35739.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Both isoforms have similar biological properties.

Isoform TrkA-II (identifier: P35739-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRGQRHGQL GWHRPAAGLG GLVTSLMLAC ACAASCRETC CPVGPSGLRC
60 70 80 90 100
TRAGTLNTLR GLRGAGNLTE LYVENQRDLQ RLEFEDLQGL GELRSLTIVK
110 120 130 140 150
SGLRFVAPDA FHFTPRLSHL NLSSNALESL SWKTVQGLSL QDLTLSGNPL
160 170 180 190 200
HCSCALLWLQ RWEQEDLCGV YTQKLQGSGS GDQFLPLGHN NSCGVPSVKI
210 220 230 240 250
QMPNDSVEVG DDVFLQCQVE GQALQQADWI LTELEGTATM KKSGDLPSLG
260 270 280 290 300
LTLVNVTSDL NKKNVTCWAE NDVGRAEVSV QVSVSFPASV HLGKAVEQHH
310 320 330 340 350
WCIPFSVDGQ PAPSLRWFFN GSVLNETSFI FTQFLESALT NETMRHGCLR
360 370 380 390 400
LNQPTHVNNG NYTLLAANPY GQAAASIMAA FMDNPFEFNP EDPIPVSFSP
410 420 430 440 450
VDTNSTSRDP VEKKDETPFG VSVAVGLAVS AALFLSALLL VLNKCGQRSK
460 470 480 490 500
FGINRPAVLA PEDGLAMSLH FMTLGGSSLS PTEGKGSGLQ GHIMENPQYF
510 520 530 540 550
SDTCVHHIKR QDIILKWELG EGAFGKVFLA ECYNLLNDQD KMLVAVKALK
560 570 580 590 600
ETSENARQDF HREAELLTML QHQHIVRFFG VCTEGGPLLM VFEYMRHGDL
610 620 630 640 650
NRFLRSHGPD AKLLAGGEDV APGPLGLGQL LAVASQVAAG MVYLASLHFV
660 670 680 690 700
HRDLATRNCL VGQGLVVKIG DFGMSRDIYS TDYYRVGGRT MLPIRWMPPE
710 720 730 740 750
SILYRKFSTE SDVWSFGVVL WEIFTYGKQP WYQLSNTEAI ECITQGRELE
760 770 780 790
RPRACPPDVY AIMRGCWQRE PQQRLSMKDV HARLQALAQA PPSYLDVLG
Length:799
Mass (Da):87,868
Last modified:June 1, 1994 - v1
Checksum:iD564E8801E8978F8
GO
Isoform TrkA-I (identifier: P35739-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-401: Missing.

Show »
Length:793
Mass (Da):87,252
Checksum:iA4A5D0B76B08655D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei396 – 4016Missing in isoform TrkA-I. CuratedVSP_002900

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M85214 mRNA. Translation: AAA42286.1.
L12225 Genomic DNA. No translation available.
PIRiA41981. TVRTTB.
RefSeqiNP_067600.1. NM_021589.1. [P35739-1]
XP_006232808.1. XM_006232746.2. [P35739-2]
UniGeneiRn.39098.

Genome annotation databases

EnsembliENSRNOT00000018961; ENSRNOP00000018961; ENSRNOG00000013953. [P35739-1]
ENSRNOT00000044046; ENSRNOP00000048885; ENSRNOG00000013953. [P35739-2]
GeneIDi59109.
KEGGirno:59109.
UCSCiRGD:620144. rat. [P35739-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M85214 mRNA. Translation: AAA42286.1 .
L12225 Genomic DNA. No translation available.
PIRi A41981. TVRTTB.
RefSeqi NP_067600.1. NM_021589.1. [P35739-1 ]
XP_006232808.1. XM_006232746.2. [P35739-2 ]
UniGenei Rn.39098.

3D structure databases

ProteinModelPortali P35739.
SMRi P35739. Positions 36-385.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248731. 18 interactions.
DIPi DIP-5716N.
IntActi P35739. 2 interactions.
MINTi MINT-191667.

Chemistry

ChEMBLi CHEMBL4220.

PTM databases

PhosphoSitei P35739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018961 ; ENSRNOP00000018961 ; ENSRNOG00000013953 . [P35739-1 ]
ENSRNOT00000044046 ; ENSRNOP00000048885 ; ENSRNOG00000013953 . [P35739-2 ]
GeneIDi 59109.
KEGGi rno:59109.
UCSCi RGD:620144. rat. [P35739-1 ]

Organism-specific databases

CTDi 4914.
RGDi 620144. Ntrk1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118818.
HOGENOMi HOG000264255.
HOVERGENi HBG056735.
InParanoidi P35739.
KOi K03176.
OMAi KNVTCWA.
OrthoDBi EOG7GTT32.
PhylomeDBi P35739.
TreeFami TF106465.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 5301.
Reactomei REACT_219269. PLC-gamma1 signalling.

Miscellaneous databases

NextBioi 611747.
PROi P35739.

Gene expression databases

Genevestigatori P35739.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
Pfami PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTi SM00409. IG. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor."
    Meakin S.O., Suter U., Drinkwater C.C., Welcher A.A., Shooter E.M.
    Proc. Natl. Acad. Sci. U.S.A. 89:2374-2378(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRKA-II).
  2. "Tissue-specific alternative splicing generates two isoforms of the trkA receptor."
    Barker P.A., Lomen-Hoerth C., Gensch E.M., Meakin S.O., Glass D.J., Shooter E.M.
    J. Biol. Chem. 268:15150-15157(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS TRKA-I AND TRKA-II).
  3. "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses."
    Stephens R.M., Loeb D.M., Copeland T.D., Pawson T., Greene L.A., Kaplan D.R.
    Neuron 12:691-705(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHC1.
  4. "Identification and characterization of novel substrates of Trk receptors in developing neurons."
    Qian X., Riccio A., Zhang Y., Ginty D.D.
    Neuron 21:1017-1029(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLCG1; SHC1; SH2B1 AND SH2B2, MUTAGENESIS OF VAL-527.
  5. "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor."
    Wooten M.W., Seibenhener M.L., Mamidipudi V., Diaz-Meco M.T., Barker P.A., Moscat J.
    J. Biol. Chem. 276:7709-7712(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SQSTM1.
  6. "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors."
    Kong H., Boulter J., Weber J.L., Lai C., Chao M.V.
    J. Neurosci. 21:176-185(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIDINS220.
  7. "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling."
    Geetha T., Wooten M.W.
    J. Biol. Chem. 278:4730-4739(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SQSTM1, SUBCELLULAR LOCATION, DOMAIN.
  8. "A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein."
    Arevalo J.C., Yano H., Teng K.K., Chao M.V.
    EMBO J. 23:2358-2368(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIDINS220, DOMAIN.
  9. "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein."
    Chang M.-S., Arevalo J.C., Chao M.V.
    J. Neurosci. Res. 78:186-192(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NGFR AND KIDINS220, DOMAIN.
  10. "SLAM-associated protein as a potential negative regulator in Trk signaling."
    Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y.
    J. Biol. Chem. 280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, INTERACTION WITH SH2D1A.
  11. "The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA."
    Saxena S., Bucci C., Weis J., Kruttgen A.
    J. Neurosci. 25:10930-10940(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB7A.
  12. "Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth."
    Hisata S., Sakisaka T., Baba T., Yamada T., Aoki K., Matsuda M., Takai Y.
    J. Cell Biol. 178:843-860(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH KIDINS220; MAGI2 AND RAPGEF2, INTERACTION WITH RAPGEF2, SUBCELLULAR LOCATION.
  13. "Neurotrophin receptor homolog-2 regulates nerve growth factor signaling."
    Wong A.W., Willingham M., Xiao J., Kilpatrick T.J., Murray S.S.
    J. Neurochem. 106:1964-1976(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NRADD.
  14. "Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not."
    Nikoletopoulou V., Lickert H., Frade J.M., Rencurel C., Giallonardo P., Zhang L., Bibel M., Barde Y.A.
    Nature 467:59-63(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL DEATH.

Entry informationi

Entry nameiNTRK1_RAT
AccessioniPrimary (citable) accession number: P35739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3