Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35739

- NTRK1_RAT

UniProt

P35739 - NTRK1_RAT

Protein

High affinity nerve growth factor receptor

Gene

Ntrk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Enzyme regulationi

    The pro-survival signaling effect of NTRK1 in neurons requires its endocytosis into signaling early endosomes and its retrograde axonal transport. This is regulated by different proteins including CFL1, RAC1 and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in endosomes By similarity. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. Regulated by NGFR By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei499 – 4991Interaction with SHC1By similarity
    Binding sitei547 – 5471ATPPROSITE-ProRule annotation
    Active sitei653 – 6531Proton acceptorPROSITE-ProRule annotation
    Sitei794 – 7941Interaction with PLCG1By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi519 – 5279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ephrin receptor binding Source: BHF-UCL
    3. nerve growth factor binding Source: UniProtKB
    4. nerve growth factor receptor activity Source: UniProtKB
    5. neurotrophin p75 receptor binding Source: RGD
    6. protein binding Source: UniProtKB
    7. protein homodimerization activity Source: UniProtKB
    8. protein tyrosine kinase activity Source: MGI
    9. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB

    GO - Biological processi

    1. aging Source: RGD
    2. axon guidance Source: RGD
    3. axonogenesis involved in innervation Source: UniProtKB
    4. B cell differentiation Source: Ensembl
    5. cellular response to growth factor stimulus Source: MGI
    6. cellular response to nerve growth factor stimulus Source: UniProtKB
    7. cellular response to nicotine Source: RGD
    8. detection of mechanical stimulus involved in sensory perception of pain Source: RGD
    9. detection of temperature stimulus involved in sensory perception of pain Source: RGD
    10. developmental programmed cell death Source: UniProtKB
    11. learning or memory Source: RGD
    12. mechanoreceptor differentiation Source: Ensembl
    13. negative regulation of cell proliferation Source: UniProtKB
    14. negative regulation of neuron apoptotic process Source: UniProtKB
    15. negative regulation of neuron death Source: RGD
    16. nerve growth factor signaling pathway Source: UniProtKB
    17. neurotrophin TRK receptor signaling pathway Source: UniProtKB
    18. olfactory nerve development Source: RGD
    19. peptidyl-tyrosine phosphorylation Source: GOC
    20. positive regulation of angiogenesis Source: Ensembl
    21. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    22. positive regulation of neuron projection development Source: UniProtKB
    23. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    24. positive regulation of programmed cell death Source: UniProtKB
    25. positive regulation of Ras GTPase activity Source: UniProtKB
    26. positive regulation of Ras protein signal transduction Source: UniProtKB
    27. positive regulation of synaptic transmission, glutamatergic Source: RGD
    28. protein autophosphorylation Source: MGI
    29. protein phosphorylation Source: UniProtKB
    30. response to activity Source: RGD
    31. response to axon injury Source: RGD
    32. response to drug Source: RGD
    33. response to electrical stimulus Source: RGD
    34. response to ethanol Source: RGD
    35. response to hydrostatic pressure Source: RGD
    36. response to nicotine Source: RGD
    37. response to nutrient levels Source: RGD
    38. response to radiation Source: RGD
    39. sensory perception of pain Source: RGD
    40. Sertoli cell development Source: RGD
    41. sympathetic nervous system development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 5301.
    ReactomeiREACT_219269. PLC-gamma1 signalling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity nerve growth factor receptor (EC:2.7.10.1)
    Alternative name(s):
    Neurotrophic tyrosine kinase receptor type 1
    Slow nerve growth factor receptor
    p140-TrkA
    Short name:
    Trk-A
    Gene namesi
    Name:Ntrk1
    Synonyms:Trk, Trka
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi620144. Ntrk1.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein
    Note: Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes.

    GO - Cellular componenti

    1. axon Source: RGD
    2. cell surface Source: MGI
    3. cytoplasmic vesicle Source: RGD
    4. dendrite Source: RGD
    5. early endosome Source: UniProtKB
    6. early endosome membrane Source: UniProtKB-SubCell
    7. Golgi membrane Source: Reactome
    8. integral component of plasma membrane Source: UniProtKB
    9. late endosome Source: UniProtKB
    10. late endosome membrane Source: UniProtKB-SubCell
    11. neuronal cell body Source: RGD
    12. plasma membrane Source: UniProtKB
    13. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi527 – 5271V → D: Loss of kinase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 799767High affinity nerve growth factor receptorPRO_0000016725Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi154 ↔ 193PROSITE-ProRule annotation
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi217 ↔ 267PROSITE-ProRule annotation
    Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
    Modified residuei499 – 4991Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei679 – 6791Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei683 – 6831Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei684 – 6841Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei794 – 7941Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-499 mediates interaction and phosphorylation of SHC1.
    N-glycosylated.By similarity
    Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

    PTM databases

    PhosphoSiteiP35739.

    Expressioni

    Tissue specificityi

    Isoform Trka-II is primarily expressed in neuronal cells; isoform Trka-I is found in non-neuronal tissues.

    Gene expression databases

    GenevestigatoriP35739.

    Interactioni

    Subunit structurei

    Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Homodimerization is induced by binding of a NGF dimer By similarity. Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner. Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation. Interacts with SQSTM1; bridges NTRK1 to NGFR. Forms a ternary complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts (phosphorylated upon activation by NGF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by NGF) with PLCG1; mediates PLCG1 phosphorylation and activation. Interacts (phosphorylated) with SH2B1 and SH2B2. Interacts with GRB2. Interacts with PIK3R1. Interacts with FRS2. Interacts with SORT1; may regulate NTRK1 anterograde axonal transport. Interacts with SH2D1A; regulates NTRK1. Interacts with NRADD. Interacts with RAB7A.By similarity11 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Grb2P629946EBI-976667,EBI-401775

    Protein-protein interaction databases

    BioGridi248731. 18 interactions.
    DIPiDIP-5716N.
    IntActiP35739. 2 interactions.
    MINTiMINT-191667.

    Structurei

    3D structure databases

    ProteinModelPortaliP35739.
    SMRiP35739. Positions 36-385.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 418386ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini443 – 799357CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei419 – 44224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati90 – 11324LRR 1Add
    BLAST
    Repeati116 – 13722LRR 2Add
    BLAST
    Domaini148 – 21972LRRCTAdd
    BLAST
    Domaini196 – 28590Ig-like C2-type 1Add
    BLAST
    Domaini295 – 36874Ig-like C2-type 2Add
    BLAST
    Domaini513 – 784272Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni472 – 49322Interaction with SQSTM1Add
    BLAST

    Domaini

    The transmembrane domain mediates interaction with KIDINS220.
    The extracellular domain mediates interaction with NGFR.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
    Contains 2 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110657.
    HOGENOMiHOG000264255.
    HOVERGENiHBG056735.
    InParanoidiP35739.
    KOiK03176.
    OMAiKNVTCWA.
    OrthoDBiEOG7GTT32.
    PhylomeDBiP35739.
    TreeFamiTF106465.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
    IPR020777. Tyr_kinase_NGF_rcpt.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view]
    PfamiPF13855. LRR_8. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR01939. NTKRECEPTOR.
    PR01940. NTKRECEPTOR1.
    PR00109. TYRKINASE.
    SMARTiSM00409. IG. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Both isoforms have similar biological properties.

    Isoform TrkA-II (identifier: P35739-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRGQRHGQL GWHRPAAGLG GLVTSLMLAC ACAASCRETC CPVGPSGLRC    50
    TRAGTLNTLR GLRGAGNLTE LYVENQRDLQ RLEFEDLQGL GELRSLTIVK 100
    SGLRFVAPDA FHFTPRLSHL NLSSNALESL SWKTVQGLSL QDLTLSGNPL 150
    HCSCALLWLQ RWEQEDLCGV YTQKLQGSGS GDQFLPLGHN NSCGVPSVKI 200
    QMPNDSVEVG DDVFLQCQVE GQALQQADWI LTELEGTATM KKSGDLPSLG 250
    LTLVNVTSDL NKKNVTCWAE NDVGRAEVSV QVSVSFPASV HLGKAVEQHH 300
    WCIPFSVDGQ PAPSLRWFFN GSVLNETSFI FTQFLESALT NETMRHGCLR 350
    LNQPTHVNNG NYTLLAANPY GQAAASIMAA FMDNPFEFNP EDPIPVSFSP 400
    VDTNSTSRDP VEKKDETPFG VSVAVGLAVS AALFLSALLL VLNKCGQRSK 450
    FGINRPAVLA PEDGLAMSLH FMTLGGSSLS PTEGKGSGLQ GHIMENPQYF 500
    SDTCVHHIKR QDIILKWELG EGAFGKVFLA ECYNLLNDQD KMLVAVKALK 550
    ETSENARQDF HREAELLTML QHQHIVRFFG VCTEGGPLLM VFEYMRHGDL 600
    NRFLRSHGPD AKLLAGGEDV APGPLGLGQL LAVASQVAAG MVYLASLHFV 650
    HRDLATRNCL VGQGLVVKIG DFGMSRDIYS TDYYRVGGRT MLPIRWMPPE 700
    SILYRKFSTE SDVWSFGVVL WEIFTYGKQP WYQLSNTEAI ECITQGRELE 750
    RPRACPPDVY AIMRGCWQRE PQQRLSMKDV HARLQALAQA PPSYLDVLG 799
    Length:799
    Mass (Da):87,868
    Last modified:June 1, 1994 - v1
    Checksum:iD564E8801E8978F8
    GO
    Isoform TrkA-I (identifier: P35739-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         396-401: Missing.

    Show »
    Length:793
    Mass (Da):87,252
    Checksum:iA4A5D0B76B08655D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei396 – 4016Missing in isoform TrkA-I. CuratedVSP_002900

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M85214 mRNA. Translation: AAA42286.1.
    L12225 Genomic DNA. No translation available.
    PIRiA41981. TVRTTB.
    RefSeqiNP_067600.1. NM_021589.1. [P35739-1]
    XP_006232808.1. XM_006232746.1. [P35739-2]
    UniGeneiRn.39098.

    Genome annotation databases

    EnsembliENSRNOT00000018961; ENSRNOP00000018961; ENSRNOG00000013953. [P35739-1]
    ENSRNOT00000044046; ENSRNOP00000048885; ENSRNOG00000013953. [P35739-2]
    GeneIDi59109.
    KEGGirno:59109.
    UCSCiRGD:620144. rat. [P35739-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M85214 mRNA. Translation: AAA42286.1 .
    L12225 Genomic DNA. No translation available.
    PIRi A41981. TVRTTB.
    RefSeqi NP_067600.1. NM_021589.1. [P35739-1 ]
    XP_006232808.1. XM_006232746.1. [P35739-2 ]
    UniGenei Rn.39098.

    3D structure databases

    ProteinModelPortali P35739.
    SMRi P35739. Positions 36-385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248731. 18 interactions.
    DIPi DIP-5716N.
    IntActi P35739. 2 interactions.
    MINTi MINT-191667.

    Chemistry

    ChEMBLi CHEMBL4220.

    PTM databases

    PhosphoSitei P35739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018961 ; ENSRNOP00000018961 ; ENSRNOG00000013953 . [P35739-1 ]
    ENSRNOT00000044046 ; ENSRNOP00000048885 ; ENSRNOG00000013953 . [P35739-2 ]
    GeneIDi 59109.
    KEGGi rno:59109.
    UCSCi RGD:620144. rat. [P35739-1 ]

    Organism-specific databases

    CTDi 4914.
    RGDi 620144. Ntrk1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110657.
    HOGENOMi HOG000264255.
    HOVERGENi HBG056735.
    InParanoidi P35739.
    KOi K03176.
    OMAi KNVTCWA.
    OrthoDBi EOG7GTT32.
    PhylomeDBi P35739.
    TreeFami TF106465.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 5301.
    Reactomei REACT_219269. PLC-gamma1 signalling.

    Miscellaneous databases

    NextBioi 611747.
    PROi P35739.

    Gene expression databases

    Genevestigatori P35739.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
    IPR020777. Tyr_kinase_NGF_rcpt.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view ]
    Pfami PF13855. LRR_8. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR01939. NTKRECEPTOR.
    PR01940. NTKRECEPTOR1.
    PR00109. TYRKINASE.
    SMARTi SM00409. IG. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor."
      Meakin S.O., Suter U., Drinkwater C.C., Welcher A.A., Shooter E.M.
      Proc. Natl. Acad. Sci. U.S.A. 89:2374-2378(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRKA-II).
    2. "Tissue-specific alternative splicing generates two isoforms of the trkA receptor."
      Barker P.A., Lomen-Hoerth C., Gensch E.M., Meakin S.O., Glass D.J., Shooter E.M.
      J. Biol. Chem. 268:15150-15157(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS TRKA-I AND TRKA-II).
    3. "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses."
      Stephens R.M., Loeb D.M., Copeland T.D., Pawson T., Greene L.A., Kaplan D.R.
      Neuron 12:691-705(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SHC1.
    4. "Identification and characterization of novel substrates of Trk receptors in developing neurons."
      Qian X., Riccio A., Zhang Y., Ginty D.D.
      Neuron 21:1017-1029(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLCG1; SHC1; SH2B1 AND SH2B2, MUTAGENESIS OF VAL-527.
    5. "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor."
      Wooten M.W., Seibenhener M.L., Mamidipudi V., Diaz-Meco M.T., Barker P.A., Moscat J.
      J. Biol. Chem. 276:7709-7712(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SQSTM1.
    6. "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors."
      Kong H., Boulter J., Weber J.L., Lai C., Chao M.V.
      J. Neurosci. 21:176-185(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIDINS220.
    7. "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling."
      Geetha T., Wooten M.W.
      J. Biol. Chem. 278:4730-4739(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SQSTM1, SUBCELLULAR LOCATION, DOMAIN.
    8. "A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein."
      Arevalo J.C., Yano H., Teng K.K., Chao M.V.
      EMBO J. 23:2358-2368(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIDINS220, DOMAIN.
    9. "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein."
      Chang M.-S., Arevalo J.C., Chao M.V.
      J. Neurosci. Res. 78:186-192(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NGFR AND KIDINS220, DOMAIN.
    10. "SLAM-associated protein as a potential negative regulator in Trk signaling."
      Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y.
      J. Biol. Chem. 280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, INTERACTION WITH SH2D1A.
    11. "The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA."
      Saxena S., Bucci C., Weis J., Kruttgen A.
      J. Neurosci. 25:10930-10940(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAB7A.
    12. "Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth."
      Hisata S., Sakisaka T., Baba T., Yamada T., Aoki K., Matsuda M., Takai Y.
      J. Cell Biol. 178:843-860(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH KIDINS220; MAGI2 AND RAPGEF2, INTERACTION WITH RAPGEF2, SUBCELLULAR LOCATION.
    13. "Neurotrophin receptor homolog-2 regulates nerve growth factor signaling."
      Wong A.W., Willingham M., Xiao J., Kilpatrick T.J., Murray S.S.
      J. Neurochem. 106:1964-1976(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NRADD.
    14. "Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not."
      Nikoletopoulou V., Lickert H., Frade J.M., Rencurel C., Giallonardo P., Zhang L., Bibel M., Barde Y.A.
      Nature 467:59-63(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL DEATH.

    Entry informationi

    Entry nameiNTRK1_RAT
    AccessioniPrimary (citable) accession number: P35739
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 148 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3