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P35735

- SFK1_YEAST

UniProt

P35735 - SFK1_YEAST

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Protein

Protein SFK1

Gene

SFK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May control the production of phosphatidylinositol 4-phosphate (PI4P) by the STT4 PI 4-kinase. Mediates proper localization of STT4 to the plasma membrane.1 Publication

GO - Biological processi

  1. actin cytoskeleton organization Source: SGD
  2. inositol lipid-mediated signaling Source: SGD
  3. lipid metabolic process Source: UniProtKB-KW
  4. vacuole organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-31852-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SFK1
Alternative name(s):
Suppressor of four kinase protein 1
Gene namesi
Name:SFK1
Ordered Locus Names:YKL051W
ORF Names:YKL303
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL051w.
SGDiS000001534. SFK1.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Protein SFK1PRO_0000203179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei208 – 2081Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35735.
PaxDbiP35735.

Expressioni

Gene expression databases

GenevestigatoriP35735.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-26678,EBI-26678
ARF3P409941EBI-26678,EBI-2824
BEM1P293661EBI-26678,EBI-3508
DUR3P334131EBI-26678,EBI-2060312
FLC1Q089671EBI-26678,EBI-36673
FLC2P397191EBI-26678,EBI-20703
FMP45Q076511EBI-26678,EBI-2051056
FTR1P400881EBI-26678,EBI-7138
GPA2P108231EBI-26678,EBI-7382
GPX2P381431EBI-26678,EBI-7863
HNM1P198071EBI-26678,EBI-8409
HSP30P256191EBI-26678,EBI-8563
HXT1P324651EBI-26678,EBI-8759
HXT3P324661EBI-26678,EBI-8770
HXT5P386951EBI-26678,EBI-8778
HXT7P390041EBI-26678,EBI-8790
IST2P382501EBI-26678,EBI-21520
MAM33P405131EBI-26678,EBI-10316
MBF1O144671EBI-26678,EBI-2043025
MEP1P402601EBI-26678,EBI-10714
MEP3P533901EBI-26678,EBI-10729
MID2P360271EBI-26678,EBI-10901
MSC3Q058121EBI-26678,EBI-33150
MUP1P502761EBI-26678,EBI-11624
OSH6Q022011EBI-26678,EBI-12636
PDR12Q027851EBI-26678,EBI-13065
PDR5P333021EBI-26678,EBI-13038
PLM2Q043831EBI-26678,EBI-2079237
PMP2P409751EBI-26678,EBI-2043041
PMP3P872841EBI-26678,EBI-13555
PPZ1P265701EBI-26678,EBI-13807
PST2Q123351EBI-26678,EBI-14064
QDR2P404741EBI-26678,EBI-25203
RFS1P382341EBI-26678,EBI-21445
RIM1P324451EBI-26678,EBI-15206
SDS23P531721EBI-26678,EBI-23782
SLM1P404851EBI-26678,EBI-25172
SNQ2P325681EBI-26678,EBI-17590
SYP1P256231EBI-26678,EBI-21900
TCB3Q036401EBI-26678,EBI-27872
TPO1Q078241EBI-26678,EBI-38106
TPO2P532831EBI-26678,EBI-2044753
TPO3Q064511EBI-26678,EBI-34275
TPO4Q122561EBI-26678,EBI-37213
VHT1P532411EBI-26678,EBI-20297
WSC2P538321EBI-26678,EBI-2055941
YBL029C-AQ3E7561EBI-26678,EBI-2044812
YGL108CP531391EBI-26678,EBI-23908
YGR130CP532781EBI-26678,EBI-23314
YHR146WP388451EBI-26678,EBI-24770
YLR326WQ061701EBI-26678,EBI-35994
YLR413WQ066891EBI-26678,EBI-38659
YOR1P530491EBI-26678,EBI-29324

Protein-protein interaction databases

BioGridi34082. 62 interactions.
DIPiDIP-5309N.
IntActiP35735. 45 interactions.
MINTiMINT-527571.
STRINGi4932.YKL051W.

Structurei

3D structure databases

ProteinModelPortaliP35735.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini33 – 6230ExtracellularSequence AnalysisAdd
BLAST
Topological domaini84 – 13047CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini152 – 1609ExtracellularSequence Analysis
Topological domaini182 – 23150CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini254 – 26310ExtracellularSequence Analysis
Topological domaini285 – 35369CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25322HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the SFK1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG88024.
HOGENOMiHOG000246654.
InParanoidiP35735.
OMAiLMPPYYT.
OrthoDBiEOG7XPZHD.

Family and domain databases

InterProiIPR019402. Frag1/DRAM/Sfk1.
[Graphical view]
PfamiPF10277. Frag1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35735-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQFKSPGNW LFIVPWIAFI PWYGMLIAML ICWASQGHPI YWFMHSEQFP
60 70 80 90 100
VYISDIGATN LRPLFISCAG WQGLGYVITV ALEFFQRSGY LPFQLKKKDP
110 120 130 140 150
SISDSTSYAE KLHSGKYLMP PYYTKDERNL IFAAFVLGSI GELALLFSSI
160 170 180 190 200
FSTALYHRVH IAMVSVFVVF MFLSTCCLIA EYFLMGRHYA SVHPLASPHF
210 220 230 240 250
NPQSSEKSFN QDYNTVDELP WYKWKGHVWN KFTISATLKV IWLTLAVVWA
260 270 280 290 300
ICFGAINDRS KSACFEWLLA FWFGIIFMIL SADFYLGGRY RQSRYFNHVE
310 320 330 340 350
SFSGYYKYDK ALGLYHSEDV LPSDDNAGVI ATETASSNIY NNSSSNESIQ

VVV
Length:353
Mass (Da):40,463
Last modified:June 1, 1994 - v1
Checksum:iBB66ED73F1181331
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75781 Genomic DNA. Translation: CAA53425.1.
Z28051 Genomic DNA. Translation: CAA81886.1.
BK006944 Genomic DNA. Translation: DAA09106.1.
PIRiS37873.
RefSeqiNP_012873.1. NM_001179617.1.

Genome annotation databases

EnsemblFungiiYKL051W; YKL051W; YKL051W.
GeneIDi853815.
KEGGisce:YKL051W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75781 Genomic DNA. Translation: CAA53425.1 .
Z28051 Genomic DNA. Translation: CAA81886.1 .
BK006944 Genomic DNA. Translation: DAA09106.1 .
PIRi S37873.
RefSeqi NP_012873.1. NM_001179617.1.

3D structure databases

ProteinModelPortali P35735.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34082. 62 interactions.
DIPi DIP-5309N.
IntActi P35735. 45 interactions.
MINTi MINT-527571.
STRINGi 4932.YKL051W.

Proteomic databases

MaxQBi P35735.
PaxDbi P35735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL051W ; YKL051W ; YKL051W .
GeneIDi 853815.
KEGGi sce:YKL051W.

Organism-specific databases

CYGDi YKL051w.
SGDi S000001534. SFK1.

Phylogenomic databases

eggNOGi NOG88024.
HOGENOMi HOG000246654.
InParanoidi P35735.
OMAi LMPPYYT.
OrthoDBi EOG7XPZHD.

Enzyme and pathway databases

BioCyci YEAST:G3O-31852-MONOMER.

Miscellaneous databases

NextBioi 974987.

Gene expression databases

Genevestigatori P35735.

Family and domain databases

InterProi IPR019402. Frag1/DRAM/Sfk1.
[Graphical view ]
Pfami PF10277. Frag1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins."
    Rasmussen S.W.
    Yeast 10:S63-S68(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade."
    Audhya A., Emr S.D.
    Dev. Cell 2:593-605(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSFK1_YEAST
AccessioniPrimary (citable) accession number: P35735
Secondary accession number(s): D6VXN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3