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P35735

- SFK1_YEAST

UniProt

P35735 - SFK1_YEAST

Protein

Protein SFK1

Gene

SFK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    May control the production of phosphatidylinositol 4-phosphate (PI4P) by the STT4 PI 4-kinase. Mediates proper localization of STT4 to the plasma membrane.1 Publication

    GO - Biological processi

    1. actin cytoskeleton organization Source: SGD
    2. inositol lipid-mediated signaling Source: SGD
    3. lipid metabolic process Source: UniProtKB-KW
    4. vacuole organization Source: SGD

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31852-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SFK1
    Alternative name(s):
    Suppressor of four kinase protein 1
    Gene namesi
    Name:SFK1
    Ordered Locus Names:YKL051W
    ORF Names:YKL303
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL051w.
    SGDiS000001534. SFK1.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353Protein SFK1PRO_0000203179Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei208 – 2081Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP35735.
    PaxDbiP35735.

    Expressioni

    Gene expression databases

    GenevestigatoriP35735.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself1EBI-26678,EBI-26678
    ARF3P409941EBI-26678,EBI-2824
    BEM1P293661EBI-26678,EBI-3508
    DUR3P334131EBI-26678,EBI-2060312
    FLC1Q089671EBI-26678,EBI-36673
    FLC2P397191EBI-26678,EBI-20703
    FMP45Q076511EBI-26678,EBI-2051056
    FTR1P400881EBI-26678,EBI-7138
    GPA2P108231EBI-26678,EBI-7382
    GPX2P381431EBI-26678,EBI-7863
    HNM1P198071EBI-26678,EBI-8409
    HSP30P256191EBI-26678,EBI-8563
    HXT1P324651EBI-26678,EBI-8759
    HXT3P324661EBI-26678,EBI-8770
    HXT5P386951EBI-26678,EBI-8778
    HXT7P390041EBI-26678,EBI-8790
    IST2P382501EBI-26678,EBI-21520
    MAM33P405131EBI-26678,EBI-10316
    MBF1O144671EBI-26678,EBI-2043025
    MEP1P402601EBI-26678,EBI-10714
    MEP3P533901EBI-26678,EBI-10729
    MID2P360271EBI-26678,EBI-10901
    MSC3Q058121EBI-26678,EBI-33150
    MUP1P502761EBI-26678,EBI-11624
    OSH6Q022011EBI-26678,EBI-12636
    PDR12Q027851EBI-26678,EBI-13065
    PDR5P333021EBI-26678,EBI-13038
    PLM2Q043831EBI-26678,EBI-2079237
    PMP2P409751EBI-26678,EBI-2043041
    PMP3P872841EBI-26678,EBI-13555
    PPZ1P265701EBI-26678,EBI-13807
    PST2Q123351EBI-26678,EBI-14064
    QDR2P404741EBI-26678,EBI-25203
    RFS1P382341EBI-26678,EBI-21445
    RIM1P324451EBI-26678,EBI-15206
    SDS23P531721EBI-26678,EBI-23782
    SLM1P404851EBI-26678,EBI-25172
    SNQ2P325681EBI-26678,EBI-17590
    SYP1P256231EBI-26678,EBI-21900
    TCB3Q036401EBI-26678,EBI-27872
    TPO1Q078241EBI-26678,EBI-38106
    TPO2P532831EBI-26678,EBI-2044753
    TPO3Q064511EBI-26678,EBI-34275
    TPO4Q122561EBI-26678,EBI-37213
    VHT1P532411EBI-26678,EBI-20297
    WSC2P538321EBI-26678,EBI-2055941
    YBL029C-AQ3E7561EBI-26678,EBI-2044812
    YGL108CP531391EBI-26678,EBI-23908
    YGR130CP532781EBI-26678,EBI-23314
    YHR146WP388451EBI-26678,EBI-24770
    YLR326WQ061701EBI-26678,EBI-35994
    YLR413WQ066891EBI-26678,EBI-38659
    YOR1P530491EBI-26678,EBI-29324

    Protein-protein interaction databases

    BioGridi34082. 62 interactions.
    DIPiDIP-5309N.
    IntActiP35735. 45 interactions.
    MINTiMINT-527571.
    STRINGi4932.YKL051W.

    Structurei

    3D structure databases

    ProteinModelPortaliP35735.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 6230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini84 – 13047CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini152 – 1609ExtracellularSequence Analysis
    Topological domaini182 – 23150CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 26310ExtracellularSequence Analysis
    Topological domaini285 – 35369CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SFK1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG88024.
    HOGENOMiHOG000246654.
    OMAiLMPPYYT.
    OrthoDBiEOG7XPZHD.

    Family and domain databases

    InterProiIPR019402. Frag1/DRAM/Sfk1.
    [Graphical view]
    PfamiPF10277. Frag1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35735-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQFKSPGNW LFIVPWIAFI PWYGMLIAML ICWASQGHPI YWFMHSEQFP    50
    VYISDIGATN LRPLFISCAG WQGLGYVITV ALEFFQRSGY LPFQLKKKDP 100
    SISDSTSYAE KLHSGKYLMP PYYTKDERNL IFAAFVLGSI GELALLFSSI 150
    FSTALYHRVH IAMVSVFVVF MFLSTCCLIA EYFLMGRHYA SVHPLASPHF 200
    NPQSSEKSFN QDYNTVDELP WYKWKGHVWN KFTISATLKV IWLTLAVVWA 250
    ICFGAINDRS KSACFEWLLA FWFGIIFMIL SADFYLGGRY RQSRYFNHVE 300
    SFSGYYKYDK ALGLYHSEDV LPSDDNAGVI ATETASSNIY NNSSSNESIQ 350
    VVV 353
    Length:353
    Mass (Da):40,463
    Last modified:June 1, 1994 - v1
    Checksum:iBB66ED73F1181331
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75781 Genomic DNA. Translation: CAA53425.1.
    Z28051 Genomic DNA. Translation: CAA81886.1.
    BK006944 Genomic DNA. Translation: DAA09106.1.
    PIRiS37873.
    RefSeqiNP_012873.1. NM_001179617.1.

    Genome annotation databases

    EnsemblFungiiYKL051W; YKL051W; YKL051W.
    GeneIDi853815.
    KEGGisce:YKL051W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75781 Genomic DNA. Translation: CAA53425.1 .
    Z28051 Genomic DNA. Translation: CAA81886.1 .
    BK006944 Genomic DNA. Translation: DAA09106.1 .
    PIRi S37873.
    RefSeqi NP_012873.1. NM_001179617.1.

    3D structure databases

    ProteinModelPortali P35735.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34082. 62 interactions.
    DIPi DIP-5309N.
    IntActi P35735. 45 interactions.
    MINTi MINT-527571.
    STRINGi 4932.YKL051W.

    Proteomic databases

    MaxQBi P35735.
    PaxDbi P35735.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL051W ; YKL051W ; YKL051W .
    GeneIDi 853815.
    KEGGi sce:YKL051W.

    Organism-specific databases

    CYGDi YKL051w.
    SGDi S000001534. SFK1.

    Phylogenomic databases

    eggNOGi NOG88024.
    HOGENOMi HOG000246654.
    OMAi LMPPYYT.
    OrthoDBi EOG7XPZHD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31852-MONOMER.

    Miscellaneous databases

    NextBioi 974987.

    Gene expression databases

    Genevestigatori P35735.

    Family and domain databases

    InterProi IPR019402. Frag1/DRAM/Sfk1.
    [Graphical view ]
    Pfami PF10277. Frag1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins."
      Rasmussen S.W.
      Yeast 10:S63-S68(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade."
      Audhya A., Emr S.D.
      Dev. Cell 2:593-605(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSFK1_YEAST
    AccessioniPrimary (citable) accession number: P35735
    Secondary accession number(s): D6VXN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3