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Protein

Protein SFK1

Gene

SFK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May control the production of phosphatidylinositol 4-phosphate (PI4P) by the STT4 PI 4-kinase. Mediates proper localization of STT4 to the plasma membrane.1 Publication

GO - Biological processi

  • actin cytoskeleton organization Source: SGD
  • inositol lipid-mediated signaling Source: SGD
  • lipid metabolic process Source: UniProtKB-KW
  • vacuole organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-31852-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SFK1
Alternative name(s):
Suppressor of four kinase protein 1
Gene namesi
Name:SFK1
Ordered Locus Names:YKL051W
ORF Names:YKL303
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL051W.
SGDiS000001534. SFK1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 62ExtracellularSequence analysisAdd BLAST30
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 130CytoplasmicSequence analysisAdd BLAST47
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 160ExtracellularSequence analysis9
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 231CytoplasmicSequence analysisAdd BLAST50
Transmembranei232 – 253HelicalSequence analysisAdd BLAST22
Topological domaini254 – 263ExtracellularSequence analysis10
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 353CytoplasmicSequence analysisAdd BLAST69

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lysosome Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002031791 – 353Protein SFK1Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35735.
PRIDEiP35735.

PTM databases

iPTMnetiP35735.

Interactioni

Protein-protein interaction databases

BioGridi34082. 61 interactors.
DIPiDIP-5309N.
IntActiP35735. 45 interactors.
MINTiMINT-527571.

Structurei

3D structure databases

ProteinModelPortaliP35735.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SFK1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246654.
InParanoidiP35735.
OMAiLMPPYYT.
OrthoDBiEOG092C56Z0.

Family and domain databases

InterProiIPR019402. Frag1/DRAM/Sfk1.
[Graphical view]
PfamiPF10277. Frag1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQFKSPGNW LFIVPWIAFI PWYGMLIAML ICWASQGHPI YWFMHSEQFP
60 70 80 90 100
VYISDIGATN LRPLFISCAG WQGLGYVITV ALEFFQRSGY LPFQLKKKDP
110 120 130 140 150
SISDSTSYAE KLHSGKYLMP PYYTKDERNL IFAAFVLGSI GELALLFSSI
160 170 180 190 200
FSTALYHRVH IAMVSVFVVF MFLSTCCLIA EYFLMGRHYA SVHPLASPHF
210 220 230 240 250
NPQSSEKSFN QDYNTVDELP WYKWKGHVWN KFTISATLKV IWLTLAVVWA
260 270 280 290 300
ICFGAINDRS KSACFEWLLA FWFGIIFMIL SADFYLGGRY RQSRYFNHVE
310 320 330 340 350
SFSGYYKYDK ALGLYHSEDV LPSDDNAGVI ATETASSNIY NNSSSNESIQ

VVV
Length:353
Mass (Da):40,463
Last modified:June 1, 1994 - v1
Checksum:iBB66ED73F1181331
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53425.1.
Z28051 Genomic DNA. Translation: CAA81886.1.
BK006944 Genomic DNA. Translation: DAA09106.1.
PIRiS37873.
RefSeqiNP_012873.1. NM_001179617.1.

Genome annotation databases

EnsemblFungiiYKL051W; YKL051W; YKL051W.
GeneIDi853815.
KEGGisce:YKL051W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53425.1.
Z28051 Genomic DNA. Translation: CAA81886.1.
BK006944 Genomic DNA. Translation: DAA09106.1.
PIRiS37873.
RefSeqiNP_012873.1. NM_001179617.1.

3D structure databases

ProteinModelPortaliP35735.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34082. 61 interactors.
DIPiDIP-5309N.
IntActiP35735. 45 interactors.
MINTiMINT-527571.

PTM databases

iPTMnetiP35735.

Proteomic databases

MaxQBiP35735.
PRIDEiP35735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL051W; YKL051W; YKL051W.
GeneIDi853815.
KEGGisce:YKL051W.

Organism-specific databases

EuPathDBiFungiDB:YKL051W.
SGDiS000001534. SFK1.

Phylogenomic databases

HOGENOMiHOG000246654.
InParanoidiP35735.
OMAiLMPPYYT.
OrthoDBiEOG092C56Z0.

Enzyme and pathway databases

BioCyciYEAST:G3O-31852-MONOMER.

Miscellaneous databases

PROiP35735.

Family and domain databases

InterProiIPR019402. Frag1/DRAM/Sfk1.
[Graphical view]
PfamiPF10277. Frag1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFK1_YEAST
AccessioniPrimary (citable) accession number: P35735
Secondary accession number(s): D6VXN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.