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P35735 (SFK1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SFK1
Alternative name(s):
Suppressor of four kinase protein 1
Gene names
Name:SFK1
Ordered Locus Names:YKL051W
ORF Names:YKL303
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May control the production of phosphatidylinositol 4-phosphate (PI4P) by the STT4 PI 4-kinase. Mediates proper localization of STT4 to the plasma membrane. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.4 Ref.5.

Sequence similarities

Belongs to the SFK1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-26678,EBI-26678
ARF3P409941EBI-26678,EBI-2824
BEM1P293661EBI-26678,EBI-3508
DUR3P334131EBI-26678,EBI-2060312
FLC1Q089671EBI-26678,EBI-36673
FLC2P397191EBI-26678,EBI-20703
FMP45Q076511EBI-26678,EBI-2051056
FTR1P400881EBI-26678,EBI-7138
GPA2P108231EBI-26678,EBI-7382
GPX2P381431EBI-26678,EBI-7863
HNM1P198071EBI-26678,EBI-8409
HSP30P256191EBI-26678,EBI-8563
HXT1P324651EBI-26678,EBI-8759
HXT3P324661EBI-26678,EBI-8770
HXT5P386951EBI-26678,EBI-8778
HXT7P390041EBI-26678,EBI-8790
IST2P382501EBI-26678,EBI-21520
MAM33P405131EBI-26678,EBI-10316
MBF1O144671EBI-26678,EBI-2043025
MEP1P402601EBI-26678,EBI-10714
MEP3P533901EBI-26678,EBI-10729
MID2P360271EBI-26678,EBI-10901
MSC3Q058121EBI-26678,EBI-33150
MUP1P502761EBI-26678,EBI-11624
OSH6Q022011EBI-26678,EBI-12636
PDR12Q027851EBI-26678,EBI-13065
PDR5P333021EBI-26678,EBI-13038
PLM2Q043831EBI-26678,EBI-2079237
PMP2P409751EBI-26678,EBI-2043041
PMP3P872841EBI-26678,EBI-13555
PPZ1P265701EBI-26678,EBI-13807
PST2Q123351EBI-26678,EBI-14064
QDR2P404741EBI-26678,EBI-25203
RFS1P382341EBI-26678,EBI-21445
RIM1P324451EBI-26678,EBI-15206
SDS23P531721EBI-26678,EBI-23782
SLM1P404851EBI-26678,EBI-25172
SNQ2P325681EBI-26678,EBI-17590
SYP1P256231EBI-26678,EBI-21900
TCB3Q036401EBI-26678,EBI-27872
TPO1Q078241EBI-26678,EBI-38106
TPO2P532831EBI-26678,EBI-2044753
TPO3Q064511EBI-26678,EBI-34275
TPO4Q122561EBI-26678,EBI-37213
VHT1P532411EBI-26678,EBI-20297
WSC2P538321EBI-26678,EBI-2055941
YBL029C-AQ3E7561EBI-26678,EBI-2044812
YGL108CP531391EBI-26678,EBI-23908
YGR130CP532781EBI-26678,EBI-23314
YHR146WP388451EBI-26678,EBI-24770
YLR326WQ061701EBI-26678,EBI-35994
YLR413WQ066891EBI-26678,EBI-38659
YOR1P530491EBI-26678,EBI-29324

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Protein SFK1
PRO_0000203179

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Helical; Potential
Topological domain33 – 6230Extracellular Potential
Transmembrane63 – 8321Helical; Potential
Topological domain84 – 13047Cytoplasmic Potential
Transmembrane131 – 15121Helical; Potential
Topological domain152 – 1609Extracellular Potential
Transmembrane161 – 18121Helical; Potential
Topological domain182 – 23150Cytoplasmic Potential
Transmembrane232 – 25322Helical; Potential
Topological domain254 – 26310Extracellular Potential
Transmembrane264 – 28421Helical; Potential
Topological domain285 – 35369Cytoplasmic Potential

Amino acid modifications

Modified residue2081Phosphoserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P35735 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: BB66ED73F1181331

FASTA35340,463
        10         20         30         40         50         60 
MIQFKSPGNW LFIVPWIAFI PWYGMLIAML ICWASQGHPI YWFMHSEQFP VYISDIGATN 

        70         80         90        100        110        120 
LRPLFISCAG WQGLGYVITV ALEFFQRSGY LPFQLKKKDP SISDSTSYAE KLHSGKYLMP 

       130        140        150        160        170        180 
PYYTKDERNL IFAAFVLGSI GELALLFSSI FSTALYHRVH IAMVSVFVVF MFLSTCCLIA 

       190        200        210        220        230        240 
EYFLMGRHYA SVHPLASPHF NPQSSEKSFN QDYNTVDELP WYKWKGHVWN KFTISATLKV 

       250        260        270        280        290        300 
IWLTLAVVWA ICFGAINDRS KSACFEWLLA FWFGIIFMIL SADFYLGGRY RQSRYFNHVE 

       310        320        330        340        350 
SFSGYYKYDK ALGLYHSEDV LPSDDNAGVI ATETASSNIY NNSSSNESIQ VVV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins."
Rasmussen S.W.
Yeast 10:S63-S68(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade."
Audhya A., Emr S.D.
Dev. Cell 2:593-605(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[7]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75781 Genomic DNA. Translation: CAA53425.1.
Z28051 Genomic DNA. Translation: CAA81886.1.
BK006944 Genomic DNA. Translation: DAA09106.1.
PIRS37873.
RefSeqNP_012873.1. NM_001179617.1.

3D structure databases

ProteinModelPortalP35735.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34082. 62 interactions.
DIPDIP-5309N.
IntActP35735. 45 interactions.
MINTMINT-527571.
STRING4932.YKL051W.

Proteomic databases

MaxQBP35735.
PaxDbP35735.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL051W; YKL051W; YKL051W.
GeneID853815.
KEGGsce:YKL051W.

Organism-specific databases

CYGDYKL051w.
SGDS000001534. SFK1.

Phylogenomic databases

eggNOGNOG88024.
HOGENOMHOG000246654.
OMALMPPYYT.
OrthoDBEOG7XPZHD.

Enzyme and pathway databases

BioCycYEAST:G3O-31852-MONOMER.

Gene expression databases

GenevestigatorP35735.

Family and domain databases

InterProIPR019402. Frag1/DRAM/Sfk1.
[Graphical view]
PfamPF10277. Frag1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974987.

Entry information

Entry nameSFK1_YEAST
AccessionPrimary (citable) accession number: P35735
Secondary accession number(s): D6VXN6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families