Reviewed,
UniProtKB/Swiss-Prot P35731 (FABG_YEAST)
Last modified
November 3, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 3-oxoacyl-[acyl-carrier-protein] reductase EC=1.1.1.100 Alternative name(s): 3-ketoacyl-acyl carrier protein reductase | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 278 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in biosynthesis of fatty acids in mitochondria By similarity. |
| Catalytic activity | (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH. |
| Pathway | |
| Subcellular location | |
| Miscellaneous | Present with 1760 molecules/cell in log phase SD medium. Ref.5 |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Lipid synthesis |
| Cellular component | Mitochondrion |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aerobic respiration Ref.3 Inferred from mutant phenotype. Source: SGD fatty acid biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrion Ref.3 Inferred from mutant phenotype. Source: SGD |
| Molecular function | 3-oxoacyl-[acyl-carrier-protein] reductase activity Ref.3 Inferred from direct assay. Source: SGD protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 278 | 278 | 3-oxoacyl-[acyl-carrier-protein] reductase | PRO_0000054872 | |||||
Regions | |||||||||
| Nucleotide binding | 8 – 32 | 25 | NAD or NADP By similarity | ||||||
Sites | |||||||||
| Active site | 198 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 183 | 1 | Substrate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins." Rasmussen S.W. Yeast 10:S63-S68(1994) [PubMed: 8091862] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [2] | "Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. Mewes H.-W.Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | "Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae." Schneider R., Brors B., Buerger F., Camrath S., Weiss H. Curr. Genet. 32:384-388(1997) [PubMed: 9388293] [Abstract] Cited for: FUNCTION. |
| [4] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [5] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X75781 Genomic DNA. Translation: CAA53417.1. Z28055 Genomic DNA. Translation: CAA81892.1. | |
| PIR | S37877. |
| RefSeq | NP_012868.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:5403N. |
| IntAct | P35731. 2 interactions. |
| STRING | P35731. |
Genome annotation databases | |
| Ensembl | YKL055C; YKL055C; YKL055C; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 853810. |
| GenomeReviews | Gene locus YKL055C in contig Y13137_GR. |
| KEGG | sce:YKL055C. |
| NMPDR | fig|4932.3.peg.3853. |
Organism-specific databases | |
| CYGD | YKL055c. |
| SGD | S000001538. OAR1. |
Phylogenomic databases | |
| HOGENOM | P35731. |
| OMA | EMLERTI. |
Gene expression databases | |
| ArrayExpress | P35731. |
| Genevestigator | P35731. |
| GermOnline | YKL055C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 974975. |
Entry information
| Entry name | FABG_YEAST | ||||||||
| Accession | Primary (citable) accession number: P35731 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XI Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names |

Clusters with


