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Protein

3-oxoacyl-[acyl-carrier-protein] reductase

Gene

OAR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in biosynthesis of fatty acids in mitochondria.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831SubstrateBy similarity
Active sitei198 – 1981Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3225NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: SGD

GO - Biological processi

  1. aerobic respiration Source: SGD
  2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
  3. fatty acid metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:YKL055C-MONOMER.
YEAST:YKL055C-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Gene namesi
Name:OAR1
Ordered Locus Names:YKL055C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL055c.
SGDiS000001538. OAR1.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2782783-oxoacyl-[acyl-carrier-protein] reductasePRO_0000054872Add
BLAST

Proteomic databases

MaxQBiP35731.
PaxDbiP35731.

Expressioni

Gene expression databases

GenevestigatoriP35731.

Interactioni

Protein-protein interaction databases

BioGridi34078. 143 interactions.
DIPiDIP-5403N.
MINTiMINT-478684.
STRINGi4932.YKL055C.

Structurei

Secondary structure

1
278
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1110Combined sources
Helixi15 – 2612Combined sources
Beta strandi30 – 378Combined sources
Helixi38 – 425Combined sources
Helixi49 – 524Combined sources
Beta strandi60 – 645Combined sources
Helixi67 – 693Combined sources
Helixi72 – 754Combined sources
Beta strandi79 – 846Combined sources
Beta strandi86 – 883Combined sources
Beta strandi91 – 977Combined sources
Helixi100 – 1056Combined sources
Beta strandi108 – 11912Combined sources
Helixi129 – 1313Combined sources
Helixi134 – 14411Combined sources
Helixi146 – 16520Combined sources
Helixi167 – 1715Combined sources
Beta strandi172 – 1743Combined sources
Beta strandi177 – 1815Combined sources
Helixi184 – 1863Combined sources
Beta strandi187 – 1893Combined sources
Helixi196 – 21621Combined sources
Helixi217 – 2193Combined sources
Beta strandi222 – 2265Combined sources
Helixi246 – 2516Combined sources
Helixi260 – 27213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FD3X-ray2.60A/B/C/D/E/F1-278[»]
4FDAX-ray2.10A1-273[»]
4HBGX-ray2.27A1-278[»]
ProteinModelPortaliP35731.
SMRiP35731. Positions 1-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
InParanoidiP35731.
KOiK00540.
OMAiEDWASII.
OrthoDBiEOG7NPG46.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35731-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHYLPVAIVT GATRGIGKAI CQKLFQKGLS CIILGSTKES IERTAIDRGQ
60 70 80 90 100
LQSGLSYQRQ CAIAIDFKKW PHWLDYESYD GIEYFKDRPP LKQKYSTLFD
110 120 130 140 150
PCNKWSNNER RYYVNLLINC AGLTQESLSV RTTASQIQDI MNVNFMSPVT
160 170 180 190 200
MTNICIKYMM KSQRRWPELS GQSARPTIVN ISSILHSGKM KVPGTSVYSA
210 220 230 240 250
SKAALSRFTE VLAAEMEPRN IRCFTISPGL VKGTDMIQNL PVEAKEMLER
260 270
TIGASGTSAP AEIAEEVWSL YSRTALET
Length:278
Mass (Da):31,184
Last modified:June 1, 1994 - v1
Checksum:i62FC3BC347D3E933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53417.1.
Z28055 Genomic DNA. Translation: CAA81892.1.
BK006944 Genomic DNA. Translation: DAA09102.1.
PIRiS37877.
RefSeqiNP_012868.1. NM_001179621.2.

Genome annotation databases

EnsemblFungiiYKL055C; YKL055C; YKL055C.
GeneIDi853810.
KEGGisce:YKL055C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53417.1.
Z28055 Genomic DNA. Translation: CAA81892.1.
BK006944 Genomic DNA. Translation: DAA09102.1.
PIRiS37877.
RefSeqiNP_012868.1. NM_001179621.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FD3X-ray2.60A/B/C/D/E/F1-278[»]
4FDAX-ray2.10A1-273[»]
4HBGX-ray2.27A1-278[»]
ProteinModelPortaliP35731.
SMRiP35731. Positions 1-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34078. 143 interactions.
DIPiDIP-5403N.
MINTiMINT-478684.
STRINGi4932.YKL055C.

Proteomic databases

MaxQBiP35731.
PaxDbiP35731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL055C; YKL055C; YKL055C.
GeneIDi853810.
KEGGisce:YKL055C.

Organism-specific databases

CYGDiYKL055c.
SGDiS000001538. OAR1.

Phylogenomic databases

eggNOGiCOG1028.
InParanoidiP35731.
KOiK00540.
OMAiEDWASII.
OrthoDBiEOG7NPG46.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciMetaCyc:YKL055C-MONOMER.
YEAST:YKL055C-MONOMER.

Miscellaneous databases

NextBioi974975.
PROiP35731.

Gene expression databases

GenevestigatoriP35731.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins."
    Rasmussen S.W.
    Yeast 10:S63-S68(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae."
    Schneider R., Brors B., Buerger F., Camrath S., Weiss H.
    Curr. Genet. 32:384-388(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFABG_YEAST
AccessioniPrimary (citable) accession number: P35731
Secondary accession number(s): D6VXN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 7, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1760 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.