Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35731 (FABG_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Gene names
Name:OAR1
Ordered Locus Names:YKL055C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in biosynthesis of fatty acids in mitochondria By similarity. Ref.4

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Mitochondrion Ref.5.

Miscellaneous

Present with 1760 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2782783-oxoacyl-[acyl-carrier-protein] reductase
PRO_0000054872

Regions

Nucleotide binding8 – 3225NAD or NADP By similarity

Sites

Active site1981Proton acceptor By similarity
Binding site1831Substrate By similarity

Secondary structure

................................................. 278
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35731 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 62FC3BC347D3E933

FASTA27831,184
        10         20         30         40         50         60 
MHYLPVAIVT GATRGIGKAI CQKLFQKGLS CIILGSTKES IERTAIDRGQ LQSGLSYQRQ 

        70         80         90        100        110        120 
CAIAIDFKKW PHWLDYESYD GIEYFKDRPP LKQKYSTLFD PCNKWSNNER RYYVNLLINC 

       130        140        150        160        170        180 
AGLTQESLSV RTTASQIQDI MNVNFMSPVT MTNICIKYMM KSQRRWPELS GQSARPTIVN 

       190        200        210        220        230        240 
ISSILHSGKM KVPGTSVYSA SKAALSRFTE VLAAEMEPRN IRCFTISPGL VKGTDMIQNL 

       250        260        270 
PVEAKEMLER TIGASGTSAP AEIAEEVWSL YSRTALET 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins."
Rasmussen S.W.
Yeast 10:S63-S68(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae."
Schneider R., Brors B., Buerger F., Camrath S., Weiss H.
Curr. Genet. 32:384-388(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75781 Genomic DNA. Translation: CAA53417.1.
Z28055 Genomic DNA. Translation: CAA81892.1.
BK006944 Genomic DNA. Translation: DAA09102.1.
PIRS37877.
RefSeqNP_012868.1. NM_001179621.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4FD3X-ray2.60A/B/C/D/E/F1-278[»]
4FDAX-ray2.10A1-273[»]
4HBGX-ray2.27A1-278[»]
ProteinModelPortalP35731.
SMRP35731. Positions 1-274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34078. 142 interactions.
DIPDIP-5403N.
MINTMINT-478684.
STRING4932.YKL055C.

Proteomic databases

MaxQBP35731.
PaxDbP35731.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL055C; YKL055C; YKL055C.
GeneID853810.
KEGGsce:YKL055C.

Organism-specific databases

CYGDYKL055c.
SGDS000001538. OAR1.

Phylogenomic databases

eggNOGCOG1028.
KOK00540.
OMAEASKLMT.
OrthoDBEOG7NPG46.

Enzyme and pathway databases

BioCycMetaCyc:YKL055C-MONOMER.
YEAST:YKL055C-MONOMER.
UniPathwayUPA00094.

Gene expression databases

GenevestigatorP35731.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974975.
PROP35731.

Entry information

Entry nameFABG_YEAST
AccessionPrimary (citable) accession number: P35731
Secondary accession number(s): D6VXN2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways