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Protein

3-oxoacyl-[acyl-carrier-protein] reductase

Gene

OAR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in biosynthesis of fatty acids in mitochondria.By similarity1 Publication

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183SubstrateBy similarity1
Active sitei198Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 32NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: SGD
  • fatty acid biosynthetic process Source: UniProtKB-UniPathway
  • fatty acid metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:YKL055C-MONOMER.
YEAST:YKL055C-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Gene namesi
Name:OAR1
Ordered Locus Names:YKL055C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL055C.
SGDiS000001538. OAR1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548721 – 2783-oxoacyl-[acyl-carrier-protein] reductaseAdd BLAST278

Proteomic databases

MaxQBiP35731.
PRIDEiP35731.
TopDownProteomicsiP35731.

Interactioni

Protein-protein interaction databases

BioGridi34078. 143 interactors.
DIPiDIP-5403N.
IntActiP35731. 1 interactor.
MINTiMINT-478684.

Structurei

Secondary structure

1278
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 11Combined sources10
Helixi15 – 26Combined sources12
Beta strandi30 – 37Combined sources8
Helixi38 – 42Combined sources5
Helixi49 – 52Combined sources4
Beta strandi60 – 64Combined sources5
Helixi67 – 69Combined sources3
Helixi72 – 75Combined sources4
Beta strandi79 – 84Combined sources6
Beta strandi86 – 88Combined sources3
Beta strandi91 – 97Combined sources7
Helixi100 – 105Combined sources6
Beta strandi108 – 119Combined sources12
Helixi129 – 131Combined sources3
Helixi134 – 144Combined sources11
Helixi146 – 165Combined sources20
Helixi167 – 171Combined sources5
Beta strandi172 – 174Combined sources3
Beta strandi177 – 181Combined sources5
Helixi184 – 186Combined sources3
Beta strandi187 – 189Combined sources3
Helixi196 – 216Combined sources21
Helixi217 – 219Combined sources3
Beta strandi222 – 226Combined sources5
Helixi246 – 251Combined sources6
Helixi260 – 272Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FD3X-ray2.60A/B/C/D/E/F1-278[»]
4FDAX-ray2.10A1-273[»]
4HBGX-ray2.27A1-278[»]
ProteinModelPortaliP35731.
SMRiP35731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP35731.
KOiK00059.
OMAiCTQIANL.
OrthoDBiEOG092C332N.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 4 hits.
PfamiPF00106. adh_short. 2 hits.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHYLPVAIVT GATRGIGKAI CQKLFQKGLS CIILGSTKES IERTAIDRGQ
60 70 80 90 100
LQSGLSYQRQ CAIAIDFKKW PHWLDYESYD GIEYFKDRPP LKQKYSTLFD
110 120 130 140 150
PCNKWSNNER RYYVNLLINC AGLTQESLSV RTTASQIQDI MNVNFMSPVT
160 170 180 190 200
MTNICIKYMM KSQRRWPELS GQSARPTIVN ISSILHSGKM KVPGTSVYSA
210 220 230 240 250
SKAALSRFTE VLAAEMEPRN IRCFTISPGL VKGTDMIQNL PVEAKEMLER
260 270
TIGASGTSAP AEIAEEVWSL YSRTALET
Length:278
Mass (Da):31,184
Last modified:June 1, 1994 - v1
Checksum:i62FC3BC347D3E933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53417.1.
Z28055 Genomic DNA. Translation: CAA81892.1.
BK006944 Genomic DNA. Translation: DAA09102.1.
PIRiS37877.
RefSeqiNP_012868.1. NM_001179621.2.

Genome annotation databases

EnsemblFungiiYKL055C; YKL055C; YKL055C.
GeneIDi853810.
KEGGisce:YKL055C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53417.1.
Z28055 Genomic DNA. Translation: CAA81892.1.
BK006944 Genomic DNA. Translation: DAA09102.1.
PIRiS37877.
RefSeqiNP_012868.1. NM_001179621.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FD3X-ray2.60A/B/C/D/E/F1-278[»]
4FDAX-ray2.10A1-273[»]
4HBGX-ray2.27A1-278[»]
ProteinModelPortaliP35731.
SMRiP35731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34078. 143 interactors.
DIPiDIP-5403N.
IntActiP35731. 1 interactor.
MINTiMINT-478684.

Proteomic databases

MaxQBiP35731.
PRIDEiP35731.
TopDownProteomicsiP35731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL055C; YKL055C; YKL055C.
GeneIDi853810.
KEGGisce:YKL055C.

Organism-specific databases

EuPathDBiFungiDB:YKL055C.
SGDiS000001538. OAR1.

Phylogenomic databases

InParanoidiP35731.
KOiK00059.
OMAiCTQIANL.
OrthoDBiEOG092C332N.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciMetaCyc:YKL055C-MONOMER.
YEAST:YKL055C-MONOMER.

Miscellaneous databases

PROiP35731.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 4 hits.
PfamiPF00106. adh_short. 2 hits.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABG_YEAST
AccessioniPrimary (citable) accession number: P35731
Secondary accession number(s): D6VXN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1760 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.