Reviewed,
UniProtKB/Swiss-Prot P35716 (SOX11_HUMAN)
Last modified
June 16, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transcription factor SOX-11 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 441 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probably important in the developing nervous system. May also have a role in tissue modeling during development. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Expressed mainly in the nervous system. Ref.1 |
| Sequence similarities | Contains 1 HMG box DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Differentiation Neurogenesis Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | DNA-binding |
| Molecular function | Developmental protein |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Ref.1Traceable author statement. Source: ProtInc regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from direct assay. Source: HPA nucleolusInferred from direct assay. Source: HPA |
| Molecular function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 441 | 441 | Transcription factor SOX-11 | PRO_0000048750 | |||||
Regions | |||||||||
| DNA binding | 49 – 117 | 69 | HMG box | ||||||
| Compositional bias | 144 – 148 | 5 | Poly-Gly | ||||||
| Compositional bias | 207 – 214 | 8 | Poly-Gly | ||||||
| Compositional bias | 223 – 233 | 11 | Poly-Asp | ||||||
| Compositional bias | 338 – 354 | 17 | Poly-Ser | ||||||
Amino acid modifications | |||||||||
| Modified residue | 206 | 1 | Phosphoserine Ref.5 | ||||||
| Modified residue | 278 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| U23752 mRNA. Translation: AAB08518.1. AB028641 mRNA. Translation: BAA88122.1. AC108025 Genomic DNA. Translation: AAX88930.1. X73038 Genomic DNA. Translation: CAA51519.1. | |
| IPI | IPI00020435. |
| PIR | G01758. S34118. |
| RefSeq | NP_003099.1. |
| UniGene | Hs.432638 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GT0 based on UniProtKB P48432. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P35716. |
Proteomic databases | |
| PRIDE | P35716. |
Genome annotation databases | |
| Ensembl | ENSG00000176887. Homo sapiens. [Contig view] |
| GeneID | 6664. |
| KEGG | hsa:6664. |
Organism-specific databases | |
| GeneCards | GC02P005783. |
| H-InvDB | HIX0029774. |
| HGNC | HGNC:11191. SOX11. |
| HPA | CAB009378. HPA000536. |
| MIM | 600898. gene. |
| PharmGKB | PA36028. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P35716. |
| HOVERGEN | P35716. |
| OMA | P35716. SNLPREA. |
Gene expression databases | |
| ArrayExpress | P35716. |
| Bgee | P35716. |
| CleanEx | HS_SOX11. |
| GermOnline | ENSG00000176887. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000910. HMG_HMG1/HMG2. IPR017386. SOX-12/11/4a. [Graphical view] |
| Gene3D | G3DSA:1.10.30.10. HMG-box. 1 hit. |
| Pfam | PF00505. HMG_box. 1 hit. [Graphical view] |
| PIRSF | PIRSF038098. SOX-12/11/4a. 1 hit. |
| SMART | SM00398. HMG. 1 hit. [Graphical view] |
| PROSITE | PS50118. HMG_BOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 25981. |
| SOURCE | Search... |
Entry information
| Entry name | SOX11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P35716 Secondary accession number(s): Q4ZFV8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


