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P35716 (SOX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-11
Gene names
Name:SOX11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably important in the developing nervous system. May also have a role in tissue modeling during development.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed mainly in the nervous system. Ref.1

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcardiac ventricle formation

Inferred from sequence or structural similarity. Source: UniProtKB

closure of optic fissure

Inferred from sequence or structural similarity. Source: UniProtKB

cornea development in camera-type eye

Inferred from sequence or structural similarity. Source: UniProtKB

embryonic digestive tract morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

embryonic skeletal system morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

eyelid development in camera-type eye

Inferred from sequence or structural similarity. Source: UniProtKB

glial cell development

Inferred from sequence or structural similarity. Source: UniProtKB

glial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

hard palate development

Inferred from sequence or structural similarity. Source: UniProtKB

kidney development

Inferred from electronic annotation. Source: Ensembl

lens morphogenesis in camera-type eye

Inferred from sequence or structural similarity. Source: UniProtKB

limb bud formation

Inferred from sequence or structural similarity. Source: UniProtKB

lung morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell death

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of gene expression

Inferred from mutant phenotype PubMed 19808959. Source: UniProtKB

negative regulation of glial cell proliferation

Inferred from mutant phenotype PubMed 19808959. Source: UniProtKB

negative regulation of lymphocyte proliferation

Inferred from mutant phenotype PubMed 20624318. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19808959. Source: UniProtKB

negative regulation of transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

neural crest cell development

Inferred from sequence or structural similarity. Source: UniProtKB

neural tube formation

Inferred from sequence or structural similarity. Source: UniProtKB

neuroepithelial cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

neuron differentiation

Inferred from expression pattern Ref.2. Source: UniProtKB

noradrenergic neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

oligodendrocyte development

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of BMP signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gene expression

Inferred from mutant phenotype PubMed 19808959. Source: UniProtKB

positive regulation of hippo signaling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of hormone secretion

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of lens epithelial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of neurogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of neuron differentiation

Inferred from mutant phenotype PubMed 19808959. Source: UniProtKB

positive regulation of ossification

Inferred from mutant phenotype PubMed 20626275. Source: UniProtKB

positive regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 20626275. Source: UniProtKB

positive regulation of stem cell proliferation

Inferred from mutant phenotype PubMed 20626275. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 21124928. Source: UniProtKB

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of transforming growth factor beta receptor signaling pathway

Inferred from expression pattern PubMed 20624318. Source: UniProtKB

signal transduction involved in cell cycle checkpoint

Inferred from expression pattern PubMed 20624318. Source: UniProtKB

skeletal muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Inferred from sequence or structural similarity. Source: UniProtKB

soft palate development

Inferred from sequence or structural similarity. Source: UniProtKB

somite development

Inferred from sequence or structural similarity. Source: UniProtKB

spinal cord development

Inferred from sequence or structural similarity. Source: UniProtKB

sympathetic nervous system development

Inferred from sequence or structural similarity. Source: UniProtKB

translation

Inferred from direct assay PubMed 10606637. Source: GOC

ventricular septum morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 17934069. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 17934069. Source: UniProtKB

   Molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from sequence or structural similarity. Source: UniProtKB

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 21124928. Source: UniProtKB

RNA polymerase II transcription coactivator activity

Inferred from sequence or structural similarity. Source: UniProtKB

enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 19808959. Source: UniProtKB

nucleic acid binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

translation factor activity, nucleic acid binding

Inferred from direct assay PubMed 10606637. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 441441Transcription factor SOX-11
PRO_0000048750

Regions

DNA binding49 – 11769HMG box
Compositional bias144 – 1485Poly-Gly
Compositional bias207 – 2148Poly-Gly
Compositional bias223 – 23311Poly-Asp
Compositional bias338 – 35417Poly-Ser

Amino acid modifications

Modified residue2061Phosphoserine Ref.5

Sequences

Sequence LengthMass (Da)Tools
P35716 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 50567A654F503C63

FASTA44146,679
        10         20         30         40         50         60 
MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS 

        70         80         90        100        110        120 
KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP 

       130        140        150        160        170        180 
RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA 

       190        200        210        220        230        240 
GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK 

       250        260        270        280        290        300 
QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG 

       310        320        330        340        350        360 
ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD 

       370        380        390        400        410        420 
LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE 

       430        440 
LSEMIAGDWL EANFSDLVFT Y 

« Hide

References

« Hide 'large scale' references
[1]"The human SOX11 gene: cloning, chromosomal assignment and tissue expression."
Jay P., Goze C., Marsollier C., Taviaux S., Hardelin J.-P., Koopman P., Berta P.
Genomics 29:541-545(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region."
Azuma T., Ao S., Saito Y., Yano K., Seki N., Wakao H., Masuho Y., Muramatsu M.
DNA Res. 6:357-360(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Neuroepithelium.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Partial cloning of SOX-11 and SOX-12, two new human SOX genes."
Goze C., Poulat F., Berta P.
Nucleic Acids Res. 21:2943-2943(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U23752 mRNA. Translation: AAB08518.1.
AB028641 mRNA. Translation: BAA88122.1.
AC108025 Genomic DNA. Translation: AAX88930.1.
X73038 Genomic DNA. Translation: CAA51519.1.
PIRG01758.
S34118.
RefSeqNP_003099.1. NM_003108.3.
UniGeneHs.432638.

3D structure databases

ProteinModelPortalP35716.
SMRP35716. Positions 47-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000322568.

PTM databases

PhosphoSiteP35716.

Polymorphism databases

DMDM1351142.

Proteomic databases

PaxDbP35716.
PRIDEP35716.

Protocols and materials databases

DNASU6664.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322002; ENSP00000322568; ENSG00000176887.
GeneID6664.
KEGGhsa:6664.
UCSCuc002qyj.3. human.

Organism-specific databases

CTD6664.
GeneCardsGC02P005842.
HGNCHGNC:11191. SOX11.
HPACAB009378.
CAB056152.
HPA000536.
MIM600898. gene.
neXtProtNX_P35716.
PharmGKBPA36028.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG130659.
HOGENOMHOG000231874.
HOVERGENHBG005040.
InParanoidP35716.
KOK09268.
OMATEEGEFM.
OrthoDBEOG7TMZVP.
PhylomeDBP35716.
TreeFamTF351735.

Gene expression databases

ArrayExpressP35716.
BgeeP35716.
CleanExHS_SOX11.
GenevestigatorP35716.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR017386. SOX-12/11/4a.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFPIRSF038098. SOX-12/11/4a. 1 hit.
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSOX11. human.
GeneWikiSOX11.
GenomeRNAi6664.
NextBio25981.
PROP35716.
SOURCESearch...

Entry information

Entry nameSOX11_HUMAN
AccessionPrimary (citable) accession number: P35716
Secondary accession number(s): Q4ZFV8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM