Reviewed, UniProtKB/Swiss-Prot P35716 (SOX11_HUMAN)

Names and origin

Protein names

Recommended name:
    Transcription factor SOX-11

Gene names

Name:

SOX11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probably important in the developing nervous system. May also have a role in tissue modeling during development.
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed mainly in the nervous system. Ref.1
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Ref.1 Traceable author statement. Source: ProtInc regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Transcription factor SOX-11		PRO_0000048750
Regions
	DNA binding	49 – 117	69	HMG box
	Compositional bias	144 – 148	5	Poly-Gly
	Compositional bias	207 – 214	8	Poly-Gly
	Compositional bias	223 – 233	11	Poly-Asp
	Compositional bias	338 – 354	17	Poly-Ser
Amino acid modifications
	Modified residue	206	1	Phosphoserine Ref.5
	Modified residue	278	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35716-1 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 50567A654F503C63	FASTA	441	46,679
	10 20 30 40 50 60 MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS 70 80 90 100 110 120 KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP 130 140 150 160 170 180 RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA 190 200 210 220 230 240 GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK 250 260 270 280 290 300 QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG 310 320 330 340 350 360 ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD 370 380 390 400 410 420 LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE 430 440 LSEMIAGDWL EANFSDLVFT Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human SOX11 gene: cloning, chromosomal assignment and tissue expression." Jay P., Goze C., Marsollier C., Taviaux S., Hardelin J.-P., Koopman P., Berta P. Genomics 29:541-545(1995) [PubMed: 8666406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region." Azuma T., Ao S., Saito Y., Yano K., Seki N., Wakao H., Masuho Y., Muramatsu M. DNA Res. 6:357-360(1999) [PubMed: 10574465] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Neuroepithelium.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Partial cloning of SOX-11 and SOX-12, two new human SOX genes." Goze C., Poulat F., Berta P. Nucleic Acids Res. 21:2943-2943(1993) [PubMed: 8332506] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U23752 mRNA. Translation: AAB08518.1. AB028641 mRNA. Translation: BAA88122.1. AC108025 Genomic DNA. Translation: AAX88930.1. X73038 Genomic DNA. Translation: CAA51519.1.
IPI	IPI00020435.
PIR	G01758. S34118.
RefSeq	NP_003099.1.
UniGene	Hs.432638
3D structure databases
HSSP	HSSP built from PDB template 1GT0 based on UniProtKB P48432.
ModBase	Search...
PTM databases
PhosphoSite	P35716.
Proteomic databases
PRIDE	P35716.
Genome annotation databases
Ensembl	ENSG00000176887. Homo sapiens. [Contig view]
GeneID	6664.
KEGG	hsa:6664.
Organism-specific databases
GeneCards	GC02P005783.
H-InvDB	HIX0029774.
HGNC	HGNC:11191. SOX11.
HPA	CAB009378. HPA000536.
MIM	600898. gene.
PharmGKB	PA36028.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P35716.
HOVERGEN	P35716.
OMA	P35716. SNLPREA.
Gene expression databases
ArrayExpress	P35716.
Bgee	P35716.
CleanEx	HS_SOX11.
GermOnline	ENSG00000176887. Homo sapiens.
Family and domain databases
InterPro	IPR000910. HMG_HMG1/HMG2. IPR017386. SOX-12/11/4a. [Graphical view]
Gene3D	G3DSA:1.10.30.10. HMG-box. 1 hit.
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
PIRSF	PIRSF038098. SOX-12/11/4a. 1 hit.
SMART	SM00398. HMG. 1 hit. [Graphical view]
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	25981.
SOURCE	Search...

Entry information

Entry name

SOX11_HUMAN

Accession

Primary (citable) accession number: P35716
Secondary accession number(s): Q4ZFV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)