Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35716

- SOX11_HUMAN

UniProt

P35716 - SOX11_HUMAN

Protein

Transcription factor SOX-11

Gene

SOX11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probably important in the developing nervous system. May also have a role in tissue modeling during development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi49 – 11769HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. enhancer sequence-specific DNA binding Source: UniProtKB
    2. nucleic acid binding transcription factor activity Source: UniProtKB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB
    4. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
    5. RNA polymerase II transcription coactivator activity Source: UniProtKB
    6. transcription regulatory region sequence-specific DNA binding Source: UniProtKB
    7. translation factor activity, nucleic acid binding Source: UniProtKB

    GO - Biological processi

    1. cardiac ventricle formation Source: UniProtKB
    2. closure of optic fissure Source: UniProtKB
    3. cornea development in camera-type eye Source: UniProtKB
    4. embryonic digestive tract morphogenesis Source: UniProtKB
    5. embryonic skeletal system morphogenesis Source: UniProtKB
    6. eyelid development in camera-type eye Source: UniProtKB
    7. glial cell development Source: UniProtKB
    8. glial cell proliferation Source: UniProtKB
    9. hard palate development Source: UniProtKB
    10. kidney development Source: Ensembl
    11. lens morphogenesis in camera-type eye Source: UniProtKB
    12. limb bud formation Source: UniProtKB
    13. lung morphogenesis Source: UniProtKB
    14. negative regulation of cell death Source: UniProtKB
    15. negative regulation of gene expression Source: UniProtKB
    16. negative regulation of glial cell proliferation Source: UniProtKB
    17. negative regulation of lymphocyte proliferation Source: UniProtKB
    18. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    19. negative regulation of transcription regulatory region DNA binding Source: UniProtKB
    20. neural crest cell development Source: UniProtKB
    21. neural tube formation Source: UniProtKB
    22. neuroepithelial cell differentiation Source: UniProtKB
    23. neuron differentiation Source: UniProtKB
    24. noradrenergic neuron differentiation Source: UniProtKB
    25. oligodendrocyte development Source: Ensembl
    26. outflow tract morphogenesis Source: UniProtKB
    27. positive regulation of BMP signaling pathway Source: UniProtKB
    28. positive regulation of cell proliferation Source: UniProtKB
    29. positive regulation of gene expression Source: UniProtKB
    30. positive regulation of hippo signaling Source: UniProtKB
    31. positive regulation of hormone secretion Source: UniProtKB
    32. positive regulation of lens epithelial cell proliferation Source: UniProtKB
    33. positive regulation of neurogenesis Source: UniProtKB
    34. positive regulation of neuron differentiation Source: UniProtKB
    35. positive regulation of ossification Source: UniProtKB
    36. positive regulation of osteoblast differentiation Source: UniProtKB
    37. positive regulation of stem cell proliferation Source: UniProtKB
    38. positive regulation of transcription, DNA-templated Source: UniProtKB
    39. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    40. regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
    41. signal transduction involved in cell cycle checkpoint Source: UniProtKB
    42. skeletal muscle cell differentiation Source: Ensembl
    43. skeletal system development Source: UniProtKB
    44. soft palate development Source: UniProtKB
    45. somite development Source: UniProtKB
    46. spinal cord development Source: UniProtKB
    47. sympathetic nervous system development Source: UniProtKB
    48. translation Source: GOC
    49. ventricular septum morphogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-11
    Gene namesi
    Name:SOX11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11191. SOX11.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36028.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Transcription factor SOX-11PRO_0000048750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei206 – 2061Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP35716.
    PaxDbiP35716.
    PRIDEiP35716.

    PTM databases

    PhosphoSiteiP35716.

    Expressioni

    Tissue specificityi

    Expressed mainly in the nervous system.1 Publication

    Gene expression databases

    ArrayExpressiP35716.
    BgeeiP35716.
    CleanExiHS_SOX11.
    GenevestigatoriP35716.

    Organism-specific databases

    HPAiCAB009378.
    CAB056152.
    HPA000536.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000322568.

    Structurei

    3D structure databases

    ProteinModelPortaliP35716.
    SMRiP35716. Positions 47-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi144 – 1485Poly-Gly
    Compositional biasi207 – 2148Poly-Gly
    Compositional biasi223 – 23311Poly-AspAdd
    BLAST
    Compositional biasi338 – 35417Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG130659.
    HOGENOMiHOG000231874.
    HOVERGENiHBG005040.
    InParanoidiP35716.
    KOiK09268.
    OMAiMSREATD.
    OrthoDBiEOG7TMZVP.
    PhylomeDBiP35716.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR029551. SOX-11.
    IPR017386. SOX-12/11/4a.
    [Graphical view]
    PANTHERiPTHR10270:SF113. PTHR10270:SF113. 1 hit.
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35716-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK    50
    RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR 100
    EAERLRLKHM ADYPDYKYRP RKKPKMDPSA KPSASQSPEK SAAGGGGGSA 150
    GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA GAGKAAQSGD YGGAGDDYVL 200
    GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK QEPDEEDEEP 250
    PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG 300
    ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS 350
    SGSSGEDADD LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD 400
    SFSEGSLGSH FEFPDYCTPE LSEMIAGDWL EANFSDLVFT Y 441
    Length:441
    Mass (Da):46,679
    Last modified:February 1, 1996 - v2
    Checksum:i50567A654F503C63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23752 mRNA. Translation: AAB08518.1.
    AB028641 mRNA. Translation: BAA88122.1.
    AC108025 Genomic DNA. Translation: AAX88930.1.
    X73038 Genomic DNA. Translation: CAA51519.1.
    CCDSiCCDS1654.1.
    PIRiG01758.
    S34118.
    RefSeqiNP_003099.1. NM_003108.3.
    UniGeneiHs.432638.

    Genome annotation databases

    EnsembliENST00000322002; ENSP00000322568; ENSG00000176887.
    GeneIDi6664.
    KEGGihsa:6664.
    UCSCiuc002qyj.3. human.

    Polymorphism databases

    DMDMi1351142.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U23752 mRNA. Translation: AAB08518.1 .
    AB028641 mRNA. Translation: BAA88122.1 .
    AC108025 Genomic DNA. Translation: AAX88930.1 .
    X73038 Genomic DNA. Translation: CAA51519.1 .
    CCDSi CCDS1654.1.
    PIRi G01758.
    S34118.
    RefSeqi NP_003099.1. NM_003108.3.
    UniGenei Hs.432638.

    3D structure databases

    ProteinModelPortali P35716.
    SMRi P35716. Positions 47-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000322568.

    PTM databases

    PhosphoSitei P35716.

    Polymorphism databases

    DMDMi 1351142.

    Proteomic databases

    MaxQBi P35716.
    PaxDbi P35716.
    PRIDEi P35716.

    Protocols and materials databases

    DNASUi 6664.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322002 ; ENSP00000322568 ; ENSG00000176887 .
    GeneIDi 6664.
    KEGGi hsa:6664.
    UCSCi uc002qyj.3. human.

    Organism-specific databases

    CTDi 6664.
    GeneCardsi GC02P005842.
    HGNCi HGNC:11191. SOX11.
    HPAi CAB009378.
    CAB056152.
    HPA000536.
    MIMi 600898. gene.
    neXtProti NX_P35716.
    PharmGKBi PA36028.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG130659.
    HOGENOMi HOG000231874.
    HOVERGENi HBG005040.
    InParanoidi P35716.
    KOi K09268.
    OMAi MSREATD.
    OrthoDBi EOG7TMZVP.
    PhylomeDBi P35716.
    TreeFami TF351735.

    Miscellaneous databases

    ChiTaRSi SOX11. human.
    GeneWikii SOX11.
    GenomeRNAii 6664.
    NextBioi 25981.
    PROi P35716.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35716.
    Bgeei P35716.
    CleanExi HS_SOX11.
    Genevestigatori P35716.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR029551. SOX-11.
    IPR017386. SOX-12/11/4a.
    [Graphical view ]
    PANTHERi PTHR10270:SF113. PTHR10270:SF113. 1 hit.
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038098. SOX-12/11/4a. 1 hit.
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human SOX11 gene: cloning, chromosomal assignment and tissue expression."
      Jay P., Goze C., Marsollier C., Taviaux S., Hardelin J.-P., Koopman P., Berta P.
      Genomics 29:541-545(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region."
      Azuma T., Ao S., Saito Y., Yano K., Seki N., Wakao H., Masuho Y., Muramatsu M.
      DNA Res. 6:357-360(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Neuroepithelium.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Partial cloning of SOX-11 and SOX-12, two new human SOX genes."
      Goze C., Poulat F., Berta P.
      Nucleic Acids Res. 21:2943-2943(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiSOX11_HUMAN
    AccessioniPrimary (citable) accession number: P35716
    Secondary accession number(s): Q4ZFV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3