P35716 (SOX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-11

Gene names

Name:

SOX11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably important in the developing nervous system. May also have a role in tissue modeling during development.
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed mainly in the nervous system. Ref.1
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac ventricle formation Inferred from sequence or structural similarity. Source: UniProtKB closure of optic fissure Inferred from sequence or structural similarity. Source: UniProtKB cornea development in camera-type eye Inferred from sequence or structural similarity. Source: UniProtKB embryonic digestive tract morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB embryonic skeletal system morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB eyelid development in camera-type eye Inferred from sequence or structural similarity. Source: UniProtKB glial cell development Inferred from sequence or structural similarity. Source: UniProtKB glial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB hard palate development Inferred from sequence or structural similarity. Source: UniProtKB kidney development Inferred from electronic annotation. Source: Compara lens morphogenesis in camera-type eye Inferred from sequence or structural similarity. Source: UniProtKB limb bud formation Inferred from sequence or structural similarity. Source: UniProtKB lung morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell death Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of glial cell proliferation Inferred from mutant phenotype PubMed 19808959. Source: UniProtKB negative regulation of lymphocyte proliferation Inferred from mutant phenotype PubMed 20624318. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 19808959. Source: UniProtKB negative regulation of transcription regulatory region DNA binding Inferred from sequence or structural similarity. Source: UniProtKB neural crest cell development Inferred from sequence or structural similarity. Source: UniProtKB neural tube formation Inferred from sequence or structural similarity. Source: UniProtKB neuroepithelial cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB noradrenergic neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB oligodendrocyte development Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of BMP signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of hippo signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of hormone secretion Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of lens epithelial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of neurogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of neuron differentiation Inferred from mutant phenotype PubMed 19808959. Source: UniProtKB positive regulation of ossification Inferred from mutant phenotype PubMed 20626275. Source: UniProtKB positive regulation of osteoblast differentiation Inferred from mutant phenotype PubMed 20626275. Source: UniProtKB positive regulation of stem cell proliferation Inferred from mutant phenotype PubMed 20626275. Source: UniProtKB regulation of transforming growth factor beta receptor signaling pathway Inferred from expression pattern PubMed 20624318. Source: UniProtKB signal transduction involved in cell cycle checkpoint Inferred from expression pattern PubMed 20624318. Source: UniProtKB soft palate development Inferred from sequence or structural similarity. Source: UniProtKB somite development Inferred from sequence or structural similarity. Source: UniProtKB spinal cord development Inferred from sequence or structural similarity. Source: UniProtKB sympathetic nervous system development Inferred from sequence or structural similarity. Source: UniProtKB ventricular septum morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay PubMed 17934069. Source: UniProtKB nucleus Inferred from direct assay PubMed 17934069. Source: UniProtKB
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from sequence or structural similarity. Source: UniProtKB RNA polymerase II core promoter sequence-specific DNA binding Inferred from direct assay PubMed 21124928. Source: UniProtKB RNA polymerase II transcription coactivator activity Inferred from sequence or structural similarity. Source: UniProtKB enhancer sequence-specific DNA binding Inferred from direct assay PubMed 19808959. Source: UniProtKB translation factor activity, nucleic acid binding Inferred from direct assay PubMed 10606637. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Transcription factor SOX-11		PRO_0000048750
Regions
	DNA binding	49 – 117	69	HMG box
	Compositional bias	144 – 148	5	Poly-Gly
	Compositional bias	207 – 214	8	Poly-Gly
	Compositional bias	223 – 233	11	Poly-Asp
	Compositional bias	338 – 354	17	Poly-Ser
Amino acid modifications
	Modified residue	206	1	Phosphoserine Ref.5
	Modified residue	278	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35716 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 50567A654F503C63	FASTA	441	46,679
	10 20 30 40 50 60 MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS 70 80 90 100 110 120 KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP 130 140 150 160 170 180 RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA 190 200 210 220 230 240 GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK 250 260 270 280 290 300 QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG 310 320 330 340 350 360 ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD 370 380 390 400 410 420 LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE 430 440 LSEMIAGDWL EANFSDLVFT Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human SOX11 gene: cloning, chromosomal assignment and tissue expression." Jay P., Goze C., Marsollier C., Taviaux S., Hardelin J.-P., Koopman P., Berta P. Genomics 29:541-545(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region." Azuma T., Ao S., Saito Y., Yano K., Seki N., Wakao H., Masuho Y., Muramatsu M. DNA Res. 6:357-360(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Neuroepithelium.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Partial cloning of SOX-11 and SOX-12, two new human SOX genes." Goze C., Poulat F., Berta P. Nucleic Acids Res. 21:2943-2943(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	U23752 mRNA. Translation: AAB08518.1. AB028641 mRNA. Translation: BAA88122.1. AC108025 Genomic DNA. Translation: AAX88930.1. X73038 Genomic DNA. Translation: CAA51519.1.
IPI	IPI00020435.
PIR	G01758. S34118.
RefSeq	NP_003099.1. NM_003108.3.
UniGene	Hs.432638.
3D structure databases
ProteinModelPortal	P35716.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000322568.
PTM databases
PhosphoSite	P35716.
Polymorphism databases
DMDM	1351142.
Proteomic databases
PaxDb	P35716.
PRIDE	P35716.
Protocols and materials databases
DNASU	6664.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322002; ENSP00000322568; ENSG00000176887.
GeneID	6664.
KEGG	hsa:6664.
UCSC	uc002qyj.3. human.
Organism-specific databases
CTD	6664.
GeneCards	GC02P005834.
HGNC	HGNC:11191. SOX11.
HPA	CAB009378. CAB056152. HPA000536.
MIM	600898. gene.
neXtProt	NX_P35716.
PharmGKB	PA36028.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG130659.
HOGENOM	HOG000231874.
HOVERGEN	HBG005040.
InParanoid	P35716.
KO	K09268.
OMA	TEEGEFM.
OrthoDB	EOG4QVCCX.
Gene expression databases
ArrayExpress	P35716.
Bgee	P35716.
CleanEx	HS_SOX11.
Genevestigator	P35716.
GermOnline	ENSG00000176887. Homo sapiens.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR017386. SOX-12/11/4a. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
PIRSF	PIRSF038098. SOX-12/11/4a. 1 hit.
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SOX11. human.
GenomeRNAi	6664.
NextBio	25981.
SOURCE	Search...

Entry information

Entry name

SOX11_HUMAN

Accession

Primary (citable) accession number: P35716
Secondary accession number(s): Q4ZFV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	February 1, 1996
Last modified:	May 29, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.