P35711 (SOX5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-5

Gene names

Name:

SOX5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	763 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 HMG box DNA-binding domain.
Sequence caution	The sequence AAB49537.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage development Inferred from electronic annotation. Source: Compara cell fate commitment Inferred from electronic annotation. Source: Compara cellular response to transforming growth factor beta stimulus Inferred from direct assay PubMed 21401405. Source: UniProtKB central nervous system neuron differentiation Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of cartilage development Inferred from direct assay PubMed 21401405. Source: UniProtKB positive regulation of chondrocyte differentiation Inferred from direct assay PubMed 21401405. Source: UniProtKB positive regulation of mesenchymal stem cell differentiation Inferred from direct assay PubMed 21401405. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of timing of neuron differentiation Inferred from electronic annotation. Source: Compara transcription from RNA polymerase II promoter Traceable author statement Ref.5. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding transcription factor activity Traceable author statement Ref.5. Source: ProtInc transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SHOX	O15266	2	EBI-3505701,EBI-3505698

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35711-1)

Also known as: L-SOX5A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35711-2)

Also known as: L-SOX5B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Isoform 3 (identifier: P35711-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.
     387-388: SK → MH

Note: No experimental confirmation available.

Isoform 4 (identifier: P35711-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     388-495: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: P35711-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MLTDPDLPQEFER → MSV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 763	763	Transcription factor SOX-5		PRO_0000048726
Regions
	DNA binding	556 – 624	69	HMG box
	Coiled coil	193 – 274	82	Potential
	Coiled coil	448 – 515	68	Potential
Amino acid modifications
	Modified residue	108	1	Phosphothreonine By similarity
	Modified residue	414	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 386	386	Missing in isoform 3.		VSP_007262
	Alternative sequence	1 – 13	13	Missing in isoform 2 and isoform 4.		VSP_007261
	Alternative sequence	1 – 13	13	MLTDP…QEFER → MSV in isoform 5.		VSP_045997
	Alternative sequence	387 – 388	2	SK → MH in isoform 3.		VSP_007263
	Alternative sequence	388 – 495	108	Missing in isoform 4.		VSP_007264
	Natural variant	362	1	Q → P in a patient with amyotrophic lateral sclerosis. Ref.8		VAR_065754
Experimental info
	Sequence conflict	276	1	P → L in BAH14086. Ref.2
	Sequence conflict	295	1	Q → H in BAB85048. Ref.2
	Sequence conflict	513	1	N → S in BAB85048. Ref.2
	Sequence conflict	514	1	E → Q in AAB49537. Ref.5
	Sequence conflict	545	1	E → G in BAB85048. Ref.2
	Sequence conflict	754	1	S → N in BAC05353. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (L-SOX5A) [UniParc]. Last modified April 23, 2003. Version 3. Checksum: 02B5B13429A59CAA	FASTA	763	84,026
	10 20 30 40 50 60 MLTDPDLPQE FERMSSKRPA SPYGEADGEV AMVTSRQKVE EEESDGLPAF HLPLHVSFPN 70 80 90 100 110 120 KPHSEEFQPV SLLTQETCGH RTPTSQHNTM EVDGNKVMSS FAPHNSSTSP QKAEEGGRQS 130 140 150 160 170 180 GESLSSTALG TPERRKGSLA DVVDTLKQRK MEELIKNEPE ETPSIEKLLS KDWKDKLLAM 190 200 210 220 230 240 GSGNFGEIKG TPESLAEKER QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL 250 260 270 280 290 300 AKQQQEQIAR QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL 310 320 330 340 350 360 PPGFSYKAGC SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ LYAAQLAAMQ VSPGGKLPGI 370 380 390 400 410 420 PQGNLGAAVS PTSIHTDKST NSPPPKSKDE VAQPLNLSAK PKTSDGKSPT SPTSPHMPAL 430 440 450 460 470 480 RINSGAGPLK ASVPAALASP SARVSTIGYL NDHDAVTKAI QEARQMKEQL RREQQVLDGK 490 500 510 520 530 540 VAVVNSLGLN NCRTEKEKTT LESLTQQLAV KQNEEGKFSH AMMDFNLSGD SDGSAGVSES 550 560 570 580 590 600 RIYRESRGRG SNEPHIKRPM NAFMVWAKDE RRKILQAFPD MHNSNISKIL GSRWKAMTNL 610 620 630 640 650 660 EKQPYYEEQA RLSKQHLEKY PDYKYKPRPK RTCLVDGKKL RIGEYKAIMR NRRQEMRQYF 670 680 690 700 710 720 NVGQQAQIPI ATAGVVYPGA IAMAGMPSPH LPSEHSSVSS SPEPGMPVIQ STYGVKGEEP 730 740 750 760 HIKEEIQAED INGEIYDEYD EEEDDPDVDY GSDSENHIAG QAN
	Isoform 2 (L-SOX5B) [UniParc]. Checksum: F8152F0BD72E6734	FASTA	750	82,453
	10 20 30 40 50 60 MSSKRPASPY GEADGEVAMV TSRQKVEEEE SDGLPAFHLP LHVSFPNKPH SEEFQPVSLL 70 80 90 100 110 120 TQETCGHRTP TSQHNTMEVD GNKVMSSFAP HNSSTSPQKA EEGGRQSGES LSSTALGTPE 130 140 150 160 170 180 RRKGSLADVV DTLKQRKMEE LIKNEPEETP SIEKLLSKDW KDKLLAMGSG NFGEIKGTPE 190 200 210 220 230 240 SLAEKERQLM GMINQLTSLR EQLLAAHDEQ KKLAASQIEK QRQQMELAKQ QQEQIARQQQ 250 260 270 280 290 300 QLLQQQHKIN LLQQQIQVQG QLPPLMIPVF PPDQRTLAAA AQQGFLLPPG FSYKAGCSDP 310 320 330 340 350 360 YPVQLIPTTM AAAAAATPGL GPLQLQQLYA AQLAAMQVSP GGKLPGIPQG NLGAAVSPTS 370 380 390 400 410 420 IHTDKSTNSP PPKSKDEVAQ PLNLSAKPKT SDGKSPTSPT SPHMPALRIN SGAGPLKASV 430 440 450 460 470 480 PAALASPSAR VSTIGYLNDH DAVTKAIQEA RQMKEQLRRE QQVLDGKVAV VNSLGLNNCR 490 500 510 520 530 540 TEKEKTTLES LTQQLAVKQN EEGKFSHAMM DFNLSGDSDG SAGVSESRIY RESRGRGSNE 550 560 570 580 590 600 PHIKRPMNAF MVWAKDERRK ILQAFPDMHN SNISKILGSR WKAMTNLEKQ PYYEEQARLS 610 620 630 640 650 660 KQHLEKYPDY KYKPRPKRTC LVDGKKLRIG EYKAIMRNRR QEMRQYFNVG QQAQIPIATA 670 680 690 700 710 720 GVVYPGAIAM AGMPSPHLPS EHSSVSSSPE PGMPVIQSTY GVKGEEPHIK EEIQAEDING 730 740 750 EIYDEYDEEE DDPDVDYGSD SENHIAGQAN
	Isoform 3 [UniParc]. Checksum: A4B74A55C2E44E9A	FASTA	377	41,990
	10 20 30 40 50 60 MHDEVAQPLN LSAKPKTSDG KSPTSPTSPH MPALRINSGA GPLKASVPAA LASPSARVST 70 80 90 100 110 120 IGYLNDHDAV TKAIQEARQM KEQLRREQQV LDGKVAVVNS LGLNNCRTEK EKTTLESLTQ 130 140 150 160 170 180 QLAVKQNEEG KFSHAMMDFN LSGDSDGSAG VSESRIYRES RGRGSNEPHI KRPMNAFMVW 190 200 210 220 230 240 AKDERRKILQ AFPDMHNSNI SKILGSRWKA MTNLEKQPYY EEQARLSKQH LEKYPDYKYK 250 260 270 280 290 300 PRPKRTCLVD GKKLRIGEYK AIMRNRRQEM RQYFNVGQQA QIPIATAGVV YPGAIAMAGM 310 320 330 340 350 360 PSPHLPSEHS SVSSSPEPGM PVIQSTYGVK GEEPHIKEEI QAEDINGEIY DEYDEEEDDP 370 DVDYGSDSEN HIAGQAN
	Isoform 4 [UniParc]. Checksum: 1F142CAF87059BAA	FASTA	642	71,044
	10 20 30 40 50 60 MSSKRPASPY GEADGEVAMV TSRQKVEEEE SDGLPAFHLP LHVSFPNKPH SEEFQPVSLL 70 80 90 100 110 120 TQETCGHRTP TSQHNTMEVD GNKVMSSFAP HNSSTSPQKA EEGGRQSGES LSSTALGTPE 130 140 150 160 170 180 RRKGSLADVV DTLKQRKMEE LIKNEPEETP SIEKLLSKDW KDKLLAMGSG NFGEIKGTPE 190 200 210 220 230 240 SLAEKERQLM GMINQLTSLR EQLLAAHDEQ KKLAASQIEK QRQQMELAKQ QQEQIARQQQ 250 260 270 280 290 300 QLLQQQHKIN LLQQQIQVQG QLPPLMIPVF PPDQRTLAAA AQQGFLLPPG FSYKAGCSDP 310 320 330 340 350 360 YPVQLIPTTM AAAAAATPGL GPLQLQQLYA AQLAAMQVSP GGKLPGIPQG NLGAAVSPTS 370 380 390 400 410 420 IHTDKSTNSP PPKSKEKTTL ESLTQQLAVK QNEEGKFSHA MMDFNLSGDS DGSAGVSESR 430 440 450 460 470 480 IYRESRGRGS NEPHIKRPMN AFMVWAKDER RKILQAFPDM HNSNISKILG SRWKAMTNLE 490 500 510 520 530 540 KQPYYEEQAR LSKQHLEKYP DYKYKPRPKR TCLVDGKKLR IGEYKAIMRN RRQEMRQYFN 550 560 570 580 590 600 VGQQAQIPIA TAGVVYPGAI AMAGMPSPHL PSEHSSVSSS PEPGMPVIQS TYGVKGEEPH 610 620 630 640 IKEEIQAEDI NGEIYDEYDE EEDDPDVDYG SDSENHIAGQ AN
	Isoform 5 [UniParc]. Checksum: 57F018BA2D8B901E	FASTA	753	82,770
	10 20 30 40 50 60 MSVMSSKRPA SPYGEADGEV AMVTSRQKVE EEESDGLPAF HLPLHVSFPN KPHSEEFQPV 70 80 90 100 110 120 SLLTQETCGH RTPTSQHNTM EVDGNKVMSS FAPHNSSTSP QKAEEGGRQS GESLSSTALG 130 140 150 160 170 180 TPERRKGSLA DVVDTLKQRK MEELIKNEPE ETPSIEKLLS KDWKDKLLAM GSGNFGEIKG 190 200 210 220 230 240 TPESLAEKER QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL AKQQQEQIAR 250 260 270 280 290 300 QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL PPGFSYKAGC 310 320 330 340 350 360 SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ LYAAQLAAMQ VSPGGKLPGI PQGNLGAAVS 370 380 390 400 410 420 PTSIHTDKST NSPPPKSKDE VAQPLNLSAK PKTSDGKSPT SPTSPHMPAL RINSGAGPLK 430 440 450 460 470 480 ASVPAALASP SARVSTIGYL NDHDAVTKAI QEARQMKEQL RREQQVLDGK VAVVNSLGLN 490 500 510 520 530 540 NCRTEKEKTT LESLTQQLAV KQNEEGKFSH AMMDFNLSGD SDGSAGVSES RIYRESRGRG 550 560 570 580 590 600 SNEPHIKRPM NAFMVWAKDE RRKILQAFPD MHNSNISKIL GSRWKAMTNL EKQPYYEEQA 610 620 630 640 650 660 RLSKQHLEKY PDYKYKPRPK RTCLVDGKKL RIGEYKAIMR NRRQEMRQYF NVGQQAQIPI 670 680 690 700 710 720 ATAGVVYPGA IAMAGMPSPH LPSEHSSVSS SPEPGMPVIQ STYGVKGEEP HIKEEIQAED 730 740 750 INGEIYDEYD EEEDDPDVDY GSDSENHIAG QAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the human long form of Sox5 (L-SOX5) gene." Ikeda T., Zhang J., Chano T., Mabuchi A., Fukuda A., Kawaguchi H., Nakamura K., Ikegawa S. Gene 298:59-68(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5). Tissue: Liver, Testis and Trachea.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 388-763 (ISOFORM 3). Tissue: Brain.
[5]	"Cloning and characterization of SOX5, a new member of the human SOX gene family." Wunderle V.M., Critcher R., Ashworth A., Goodfellow P.N. Genomics 36:354-358(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 389-763. Tissue: Testis.
[6]	"A conserved family of genes related to the testis determining gene, SRY." Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A. Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 567-620. Tissue: Fetal heart and Heart.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis." Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A. Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PRO-362.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB081588 mRNA. Translation: BAC16233.1. AB081589 mRNA. Translation: BAC16234.1. AB081590 Genomic DNA. Translation: BAC16235.1. AB081591 Genomic DNA. Translation: BAC16236.1. AK074317 mRNA. Translation: BAB85048.1. AK098610 mRNA. Translation: BAC05353.1. AK303970 mRNA. Translation: BAH14086.1. AC087244 Genomic DNA. No translation available. AC087260 Genomic DNA. No translation available. AC087319 Genomic DNA. No translation available. AC092864 Genomic DNA. No translation available. BC029220 mRNA. Translation: AAH29220.2. BC035227 mRNA. Translation: AAH35227.1. BC047665 mRNA. Translation: AAH47665.2. BC060773 mRNA. Translation: AAH60773.1. S83308 mRNA. Translation: AAB49537.1. Different initiation. X65662 mRNA. Translation: CAA46613.1.
IPI	IPI00166143. IPI00171247. IPI00216317. IPI00221270. IPI01010805.
PIR	S22939.
RefSeq	NP_001248343.1. NM_001261414.1. NP_001248344.1. NM_001261415.1. NP_008871.3. NM_006940.4. NP_694534.1. NM_152989.3. NP_821078.1. NM_178010.2.
UniGene	Hs.657542.
3D structure databases
ProteinModelPortal	P35711.
ModBase	Search...
Protein-protein interaction databases
IntAct	P35711. 8 interactions.
MINT	MINT-1198407.
PTM databases
PhosphoSite	P35711.
Polymorphism databases
DMDM	30179883.
Proteomic databases
PaxDb	P35711.
PRIDE	P35711.
Protocols and materials databases
DNASU	6660.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309359; ENSP00000308927; ENSG00000134532. ENST00000381381; ENSP00000370788; ENSG00000134532. ENST00000396007; ENSP00000379328; ENSG00000134532. ENST00000451604; ENSP00000398273; ENSG00000134532. ENST00000541536; ENSP00000441973; ENSG00000134532. ENST00000545921; ENSP00000443520; ENSG00000134532. ENST00000546136; ENSP00000437487; ENSG00000134532.
GeneID	6660.
KEGG	hsa:6660.
UCSC	uc001rfv.3. human. uc001rfw.3. human. uc001rfy.3. human.
Organism-specific databases
CTD	6660.
GeneCards	GC12M023585.
HGNC	HGNC:11201. SOX5.
MIM	604975. gene.
neXtProt	NX_P35711.
PharmGKB	PA36038.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253815.
HOVERGEN	HBG003915.
InParanoid	P35711.
KO	K09269.
OMA	PSEHSSM.
OrthoDB	EOG42BX84.
PhylomeDB	P35711.
Gene expression databases
ArrayExpress	P35711.
Bgee	P35711.
Genevestigator	P35711.
GermOnline	ENSG00000134532. Homo sapiens.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SOX5. human.
GenomeRNAi	6660.
NextBio	25963.
SOURCE	Search...

Entry information

Entry name

SOX5_HUMAN

Accession

Primary (citable) accession number: P35711
Secondary accession number(s): B7Z8V0 , F5H5B0, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	April 23, 2003
Last modified:	May 1, 2013
This is version 123 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.