Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35711

- SOX5_HUMAN

UniProt

P35711 - SOX5_HUMAN

Protein

Transcription factor SOX-5

Gene

SOX5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 3 (23 Apr 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi556 – 62469HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc
    3. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. cartilage development Source: Ensembl
    2. cell fate commitment Source: Ensembl
    3. cellular response to transforming growth factor beta stimulus Source: UniProtKB
    4. central nervous system neuron differentiation Source: Ensembl
    5. in utero embryonic development Source: Ensembl
    6. negative regulation of transcription, DNA-templated Source: Ensembl
    7. oligodendrocyte differentiation Source: Ensembl
    8. positive regulation of cartilage development Source: UniProtKB
    9. positive regulation of chondrocyte differentiation Source: UniProtKB
    10. positive regulation of mesenchymal stem cell differentiation Source: UniProtKB
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. regulation of timing of neuron differentiation Source: Ensembl
    13. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP35711.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-5
    Gene namesi
    Name:SOX5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:11201. SOX5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti313884. 12p12.1 microdeletion syndrome.
    313892. Developmental and speech delay due to SOX5 deficiency.
    PharmGKBiPA36038.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763Transcription factor SOX-5PRO_0000048726Add
    BLAST

    Proteomic databases

    MaxQBiP35711.
    PaxDbiP35711.
    PRIDEiP35711.

    PTM databases

    PhosphoSiteiP35711.

    Expressioni

    Gene expression databases

    ArrayExpressiP35711.
    BgeeiP35711.
    GenevestigatoriP35711.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SHOXO152662EBI-3505701,EBI-3505698

    Protein-protein interaction databases

    BioGridi112543. 12 interactions.
    IntActiP35711. 12 interactions.
    MINTiMINT-1198407.

    Structurei

    3D structure databases

    ProteinModelPortaliP35711.
    SMRiP35711. Positions 554-623.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili193 – 27482Sequence AnalysisAdd
    BLAST
    Coiled coili448 – 51568Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG253815.
    HOVERGENiHBG003915.
    InParanoidiP35711.
    KOiK09269.
    OMAiPSEHSSM.
    OrthoDBiEOG7W153F.
    PhylomeDBiP35711.
    TreeFamiTF320471.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P35711-1) [UniParc]FASTAAdd to Basket

    Also known as: L-SOX5A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTDPDLPQE FERMSSKRPA SPYGEADGEV AMVTSRQKVE EEESDGLPAF    50
    HLPLHVSFPN KPHSEEFQPV SLLTQETCGH RTPTSQHNTM EVDGNKVMSS 100
    FAPHNSSTSP QKAEEGGRQS GESLSSTALG TPERRKGSLA DVVDTLKQRK 150
    MEELIKNEPE ETPSIEKLLS KDWKDKLLAM GSGNFGEIKG TPESLAEKER 200
    QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL AKQQQEQIAR 250
    QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL 300
    PPGFSYKAGC SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ LYAAQLAAMQ 350
    VSPGGKLPGI PQGNLGAAVS PTSIHTDKST NSPPPKSKDE VAQPLNLSAK 400
    PKTSDGKSPT SPTSPHMPAL RINSGAGPLK ASVPAALASP SARVSTIGYL 450
    NDHDAVTKAI QEARQMKEQL RREQQVLDGK VAVVNSLGLN NCRTEKEKTT 500
    LESLTQQLAV KQNEEGKFSH AMMDFNLSGD SDGSAGVSES RIYRESRGRG 550
    SNEPHIKRPM NAFMVWAKDE RRKILQAFPD MHNSNISKIL GSRWKAMTNL 600
    EKQPYYEEQA RLSKQHLEKY PDYKYKPRPK RTCLVDGKKL RIGEYKAIMR 650
    NRRQEMRQYF NVGQQAQIPI ATAGVVYPGA IAMAGMPSPH LPSEHSSVSS 700
    SPEPGMPVIQ STYGVKGEEP HIKEEIQAED INGEIYDEYD EEEDDPDVDY 750
    GSDSENHIAG QAN 763
    Length:763
    Mass (Da):84,026
    Last modified:April 23, 2003 - v3
    Checksum:i02B5B13429A59CAA
    GO
    Isoform 2 (identifier: P35711-2) [UniParc]FASTAAdd to Basket

    Also known as: L-SOX5B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: Missing.

    Show »
    Length:750
    Mass (Da):82,453
    Checksum:iF8152F0BD72E6734
    GO
    Isoform 3 (identifier: P35711-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-386: Missing.
         387-388: SK → MH

    Note: No experimental confirmation available.

    Show »
    Length:377
    Mass (Da):41,990
    Checksum:iA4B74A55C2E44E9A
    GO
    Isoform 4 (identifier: P35711-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: Missing.
         388-495: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:642
    Mass (Da):71,044
    Checksum:i1F142CAF87059BAA
    GO
    Isoform 5 (identifier: P35711-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MLTDPDLPQEFER → MSV

    Note: No experimental confirmation available.

    Show »
    Length:753
    Mass (Da):82,770
    Checksum:i57F018BA2D8B901E
    GO

    Sequence cautioni

    The sequence AAB49537.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti276 – 2761P → L in BAH14086. (PubMed:14702039)Curated
    Sequence conflicti295 – 2951Q → H in BAB85048. (PubMed:14702039)Curated
    Sequence conflicti513 – 5131N → S in BAB85048. (PubMed:14702039)Curated
    Sequence conflicti514 – 5141E → Q in AAB49537. (PubMed:8812465)Curated
    Sequence conflicti545 – 5451E → G in BAB85048. (PubMed:14702039)Curated
    Sequence conflicti754 – 7541S → N in BAC05353. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti362 – 3621Q → P in a patient with amyotrophic lateral sclerosis. 1 Publication
    VAR_065754

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 386386Missing in isoform 3. 2 PublicationsVSP_007262Add
    BLAST
    Alternative sequencei1 – 1313Missing in isoform 2 and isoform 4. 2 PublicationsVSP_007261Add
    BLAST
    Alternative sequencei1 – 1313MLTDP…QEFER → MSV in isoform 5. 1 PublicationVSP_045997Add
    BLAST
    Alternative sequencei387 – 3882SK → MH in isoform 3. 2 PublicationsVSP_007263
    Alternative sequencei388 – 495108Missing in isoform 4. 1 PublicationVSP_007264Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB081588 mRNA. Translation: BAC16233.1.
    AB081589 mRNA. Translation: BAC16234.1.
    AB081590 Genomic DNA. Translation: BAC16235.1.
    AB081591 Genomic DNA. Translation: BAC16236.1.
    AK074317 mRNA. Translation: BAB85048.1.
    AK098610 mRNA. Translation: BAC05353.1.
    AK303970 mRNA. Translation: BAH14086.1.
    AC087244 Genomic DNA. No translation available.
    AC087260 Genomic DNA. No translation available.
    AC087319 Genomic DNA. No translation available.
    AC092864 Genomic DNA. No translation available.
    BC029220 mRNA. Translation: AAH29220.2.
    BC035227 mRNA. Translation: AAH35227.1.
    BC047665 mRNA. Translation: AAH47665.2.
    BC060773 mRNA. Translation: AAH60773.1.
    S83308 mRNA. Translation: AAB49537.1. Different initiation.
    X65662 mRNA. Translation: CAA46613.1.
    CCDSiCCDS41761.1. [P35711-3]
    CCDS44844.1. [P35711-2]
    CCDS58216.1. [P35711-4]
    CCDS58217.1. [P35711-5]
    CCDS8699.1. [P35711-1]
    PIRiS22939.
    RefSeqiNP_001248343.1. NM_001261414.1. [P35711-4]
    NP_001248344.1. NM_001261415.1. [P35711-5]
    NP_008871.3. NM_006940.4. [P35711-1]
    NP_694534.1. NM_152989.3. [P35711-2]
    NP_821078.1. NM_178010.2. [P35711-3]
    XP_006719212.1. XM_006719149.1. [P35711-2]
    XP_006719213.1. XM_006719150.1. [P35711-2]
    UniGeneiHs.657542.

    Genome annotation databases

    EnsembliENST00000381381; ENSP00000370788; ENSG00000134532. [P35711-4]
    ENST00000396007; ENSP00000379328; ENSG00000134532. [P35711-3]
    ENST00000451604; ENSP00000398273; ENSG00000134532. [P35711-1]
    ENST00000541536; ENSP00000441973; ENSG00000134532. [P35711-4]
    ENST00000545921; ENSP00000443520; ENSG00000134532. [P35711-5]
    ENST00000546136; ENSP00000437487; ENSG00000134532. [P35711-2]
    GeneIDi6660.
    KEGGihsa:6660.
    UCSCiuc001rfv.4. human. [P35711-3]
    uc001rfw.3. human. [P35711-1]
    uc001rfy.4. human. [P35711-4]

    Polymorphism databases

    DMDMi30179883.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB081588 mRNA. Translation: BAC16233.1 .
    AB081589 mRNA. Translation: BAC16234.1 .
    AB081590 Genomic DNA. Translation: BAC16235.1 .
    AB081591 Genomic DNA. Translation: BAC16236.1 .
    AK074317 mRNA. Translation: BAB85048.1 .
    AK098610 mRNA. Translation: BAC05353.1 .
    AK303970 mRNA. Translation: BAH14086.1 .
    AC087244 Genomic DNA. No translation available.
    AC087260 Genomic DNA. No translation available.
    AC087319 Genomic DNA. No translation available.
    AC092864 Genomic DNA. No translation available.
    BC029220 mRNA. Translation: AAH29220.2 .
    BC035227 mRNA. Translation: AAH35227.1 .
    BC047665 mRNA. Translation: AAH47665.2 .
    BC060773 mRNA. Translation: AAH60773.1 .
    S83308 mRNA. Translation: AAB49537.1 . Different initiation.
    X65662 mRNA. Translation: CAA46613.1 .
    CCDSi CCDS41761.1. [P35711-3 ]
    CCDS44844.1. [P35711-2 ]
    CCDS58216.1. [P35711-4 ]
    CCDS58217.1. [P35711-5 ]
    CCDS8699.1. [P35711-1 ]
    PIRi S22939.
    RefSeqi NP_001248343.1. NM_001261414.1. [P35711-4 ]
    NP_001248344.1. NM_001261415.1. [P35711-5 ]
    NP_008871.3. NM_006940.4. [P35711-1 ]
    NP_694534.1. NM_152989.3. [P35711-2 ]
    NP_821078.1. NM_178010.2. [P35711-3 ]
    XP_006719212.1. XM_006719149.1. [P35711-2 ]
    XP_006719213.1. XM_006719150.1. [P35711-2 ]
    UniGenei Hs.657542.

    3D structure databases

    ProteinModelPortali P35711.
    SMRi P35711. Positions 554-623.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112543. 12 interactions.
    IntActi P35711. 12 interactions.
    MINTi MINT-1198407.

    PTM databases

    PhosphoSitei P35711.

    Polymorphism databases

    DMDMi 30179883.

    Proteomic databases

    MaxQBi P35711.
    PaxDbi P35711.
    PRIDEi P35711.

    Protocols and materials databases

    DNASUi 6660.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381381 ; ENSP00000370788 ; ENSG00000134532 . [P35711-4 ]
    ENST00000396007 ; ENSP00000379328 ; ENSG00000134532 . [P35711-3 ]
    ENST00000451604 ; ENSP00000398273 ; ENSG00000134532 . [P35711-1 ]
    ENST00000541536 ; ENSP00000441973 ; ENSG00000134532 . [P35711-4 ]
    ENST00000545921 ; ENSP00000443520 ; ENSG00000134532 . [P35711-5 ]
    ENST00000546136 ; ENSP00000437487 ; ENSG00000134532 . [P35711-2 ]
    GeneIDi 6660.
    KEGGi hsa:6660.
    UCSCi uc001rfv.4. human. [P35711-3 ]
    uc001rfw.3. human. [P35711-1 ]
    uc001rfy.4. human. [P35711-4 ]

    Organism-specific databases

    CTDi 6660.
    GeneCardsi GC12M023585.
    HGNCi HGNC:11201. SOX5.
    MIMi 604975. gene.
    neXtProti NX_P35711.
    Orphaneti 313884. 12p12.1 microdeletion syndrome.
    313892. Developmental and speech delay due to SOX5 deficiency.
    PharmGKBi PA36038.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253815.
    HOVERGENi HBG003915.
    InParanoidi P35711.
    KOi K09269.
    OMAi PSEHSSM.
    OrthoDBi EOG7W153F.
    PhylomeDBi P35711.
    TreeFami TF320471.

    Enzyme and pathway databases

    SignaLinki P35711.

    Miscellaneous databases

    ChiTaRSi SOX5. human.
    GeneWikii SOX5.
    GenomeRNAii 6660.
    NextBioi 25963.
    PROi P35711.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35711.
    Bgeei P35711.
    Genevestigatori P35711.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the human long form of Sox5 (L-SOX5) gene."
      Ikeda T., Zhang J., Chano T., Mabuchi A., Fukuda A., Kawaguchi H., Nakamura K., Ikegawa S.
      Gene 298:59-68(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5).
      Tissue: Liver, Testis and Trachea.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 388-763 (ISOFORM 3).
      Tissue: Brain.
    5. "Cloning and characterization of SOX5, a new member of the human SOX gene family."
      Wunderle V.M., Critcher R., Ashworth A., Goodfellow P.N.
      Genomics 36:354-358(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 389-763.
      Tissue: Testis.
    6. "A conserved family of genes related to the testis determining gene, SRY."
      Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
      Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 567-620.
      Tissue: Fetal heart and Heart.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
      Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A.
      Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PRO-362.

    Entry informationi

    Entry nameiSOX5_HUMAN
    AccessioniPrimary (citable) accession number: P35711
    Secondary accession number(s): B7Z8V0
    , F5H5B0, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: April 23, 2003
    Last modified: October 1, 2014
    This is version 135 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3