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Protein

Transcription factor SOX-5

Gene

SOX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi556 – 62469HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP35711.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-5
Gene namesi
Name:SOX5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:11201. SOX5.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti313884. 12p12.1 microdeletion syndrome.
313892. Developmental and speech delay due to SOX5 deficiency.
PharmGKBiPA36038.

Polymorphism and mutation databases

BioMutaiSOX5.
DMDMi30179883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Transcription factor SOX-5PRO_0000048726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine1 Publication
Modified residuei131 – 1311Phosphothreonine1 Publication
Modified residuei370 – 3701Phosphoserine1 Publication
Modified residuei372 – 3721Phosphothreonine1 Publication
Modified residuei414 – 4141Phosphoserine1 Publication
Modified residuei439 – 4391Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35711.
PaxDbiP35711.
PRIDEiP35711.

PTM databases

PhosphoSiteiP35711.

Expressioni

Gene expression databases

BgeeiP35711.
ExpressionAtlasiP35711. baseline and differential.
GenevestigatoriP35711.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-3505701,EBI-10175576
AESQ081173EBI-3505701,EBI-717810
ARID5AC9J1Q03EBI-3505701,EBI-10176351
CBX8Q9HC523EBI-3505701,EBI-712912
CDC23Q9UJX23EBI-3505701,EBI-396137
CRXO431863EBI-3505701,EBI-748171
FAM46BQ96A093EBI-3505701,EBI-752030
KAT5Q929933EBI-3505701,EBI-399080
KIFC3Q9BVG83EBI-3505701,EBI-2125614
LMO1P258003EBI-3505701,EBI-8639312
LMO2P257913EBI-3505701,EBI-739696
MORN3Q6PF183EBI-3505701,EBI-9675802
PRR20CP864793EBI-3505701,EBI-10172814
SHOXO152662EBI-3505701,EBI-3505698
taxP034103EBI-3505701,EBI-9676218From a different organism.
ZNF581Q9P0T43EBI-3505701,EBI-745520

Protein-protein interaction databases

BioGridi112543. 29 interactions.
IntActiP35711. 27 interactions.
MINTiMINT-1198407.

Structurei

3D structure databases

ProteinModelPortaliP35711.
SMRiP35711. Positions 554-623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili193 – 27482Sequence AnalysisAdd
BLAST
Coiled coili448 – 51568Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG253815.
GeneTreeiENSGT00760000119274.
HOGENOMiHOG000056455.
HOVERGENiHBG003915.
InParanoidiP35711.
KOiK09269.
OMAiTQESCGH.
OrthoDBiEOG7W153F.
PhylomeDBiP35711.
TreeFamiTF320471.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35711-1) [UniParc]FASTAAdd to basket

Also known as: L-SOX5A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTDPDLPQE FERMSSKRPA SPYGEADGEV AMVTSRQKVE EEESDGLPAF
60 70 80 90 100
HLPLHVSFPN KPHSEEFQPV SLLTQETCGH RTPTSQHNTM EVDGNKVMSS
110 120 130 140 150
FAPHNSSTSP QKAEEGGRQS GESLSSTALG TPERRKGSLA DVVDTLKQRK
160 170 180 190 200
MEELIKNEPE ETPSIEKLLS KDWKDKLLAM GSGNFGEIKG TPESLAEKER
210 220 230 240 250
QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL AKQQQEQIAR
260 270 280 290 300
QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL
310 320 330 340 350
PPGFSYKAGC SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ LYAAQLAAMQ
360 370 380 390 400
VSPGGKLPGI PQGNLGAAVS PTSIHTDKST NSPPPKSKDE VAQPLNLSAK
410 420 430 440 450
PKTSDGKSPT SPTSPHMPAL RINSGAGPLK ASVPAALASP SARVSTIGYL
460 470 480 490 500
NDHDAVTKAI QEARQMKEQL RREQQVLDGK VAVVNSLGLN NCRTEKEKTT
510 520 530 540 550
LESLTQQLAV KQNEEGKFSH AMMDFNLSGD SDGSAGVSES RIYRESRGRG
560 570 580 590 600
SNEPHIKRPM NAFMVWAKDE RRKILQAFPD MHNSNISKIL GSRWKAMTNL
610 620 630 640 650
EKQPYYEEQA RLSKQHLEKY PDYKYKPRPK RTCLVDGKKL RIGEYKAIMR
660 670 680 690 700
NRRQEMRQYF NVGQQAQIPI ATAGVVYPGA IAMAGMPSPH LPSEHSSVSS
710 720 730 740 750
SPEPGMPVIQ STYGVKGEEP HIKEEIQAED INGEIYDEYD EEEDDPDVDY
760
GSDSENHIAG QAN
Length:763
Mass (Da):84,026
Last modified:April 23, 2003 - v3
Checksum:i02B5B13429A59CAA
GO
Isoform 2 (identifier: P35711-2) [UniParc]FASTAAdd to basket

Also known as: L-SOX5B

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:750
Mass (Da):82,453
Checksum:iF8152F0BD72E6734
GO
Isoform 3 (identifier: P35711-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.
     387-388: SK → MH

Note: No experimental confirmation available.

Show »
Length:377
Mass (Da):41,990
Checksum:iA4B74A55C2E44E9A
GO
Isoform 4 (identifier: P35711-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     388-495: Missing.

Note: No experimental confirmation available.

Show »
Length:642
Mass (Da):71,044
Checksum:i1F142CAF87059BAA
GO
Isoform 5 (identifier: P35711-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MLTDPDLPQEFER → MSV

Note: No experimental confirmation available.

Show »
Length:753
Mass (Da):82,770
Checksum:i57F018BA2D8B901E
GO

Sequence cautioni

The sequence AAB49537.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti276 – 2761P → L in BAH14086 (PubMed:14702039).Curated
Sequence conflicti295 – 2951Q → H in BAB85048 (PubMed:14702039).Curated
Sequence conflicti513 – 5131N → S in BAB85048 (PubMed:14702039).Curated
Sequence conflicti514 – 5141E → Q in AAB49537 (PubMed:8812465).Curated
Sequence conflicti545 – 5451E → G in BAB85048 (PubMed:14702039).Curated
Sequence conflicti754 – 7541S → N in BAC05353 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti362 – 3621Q → P in a patient with amyotrophic lateral sclerosis. 1 Publication
VAR_065754

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 386386Missing in isoform 3. 2 PublicationsVSP_007262Add
BLAST
Alternative sequencei1 – 1313Missing in isoform 2 and isoform 4. 2 PublicationsVSP_007261Add
BLAST
Alternative sequencei1 – 1313MLTDP…QEFER → MSV in isoform 5. 1 PublicationVSP_045997Add
BLAST
Alternative sequencei387 – 3882SK → MH in isoform 3. 2 PublicationsVSP_007263
Alternative sequencei388 – 495108Missing in isoform 4. 1 PublicationVSP_007264Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081588 mRNA. Translation: BAC16233.1.
AB081589 mRNA. Translation: BAC16234.1.
AB081590 Genomic DNA. Translation: BAC16235.1.
AB081591 Genomic DNA. Translation: BAC16236.1.
AK074317 mRNA. Translation: BAB85048.1.
AK098610 mRNA. Translation: BAC05353.1.
AK303970 mRNA. Translation: BAH14086.1.
AC087244 Genomic DNA. No translation available.
AC087260 Genomic DNA. No translation available.
AC087319 Genomic DNA. No translation available.
AC092864 Genomic DNA. No translation available.
BC029220 mRNA. Translation: AAH29220.2.
BC035227 mRNA. Translation: AAH35227.1.
BC047665 mRNA. Translation: AAH47665.2.
BC060773 mRNA. Translation: AAH60773.1.
S83308 mRNA. Translation: AAB49537.1. Different initiation.
X65662 mRNA. Translation: CAA46613.1.
CCDSiCCDS41761.1. [P35711-3]
CCDS44844.1. [P35711-2]
CCDS58216.1. [P35711-4]
CCDS58217.1. [P35711-5]
CCDS8699.1. [P35711-1]
PIRiS22939.
RefSeqiNP_001248343.1. NM_001261414.1. [P35711-4]
NP_001248344.1. NM_001261415.1. [P35711-5]
NP_008871.3. NM_006940.4. [P35711-1]
NP_694534.1. NM_152989.3. [P35711-2]
NP_821078.1. NM_178010.2. [P35711-3]
XP_006719212.1. XM_006719149.2. [P35711-2]
UniGeneiHs.657542.

Genome annotation databases

EnsembliENST00000381381; ENSP00000370788; ENSG00000134532. [P35711-4]
ENST00000396007; ENSP00000379328; ENSG00000134532. [P35711-3]
ENST00000451604; ENSP00000398273; ENSG00000134532. [P35711-1]
ENST00000541536; ENSP00000441973; ENSG00000134532. [P35711-4]
ENST00000545921; ENSP00000443520; ENSG00000134532. [P35711-5]
ENST00000546136; ENSP00000437487; ENSG00000134532. [P35711-2]
GeneIDi6660.
KEGGihsa:6660.
UCSCiuc001rfv.4. human. [P35711-3]
uc001rfw.3. human. [P35711-1]
uc001rfy.4. human. [P35711-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081588 mRNA. Translation: BAC16233.1.
AB081589 mRNA. Translation: BAC16234.1.
AB081590 Genomic DNA. Translation: BAC16235.1.
AB081591 Genomic DNA. Translation: BAC16236.1.
AK074317 mRNA. Translation: BAB85048.1.
AK098610 mRNA. Translation: BAC05353.1.
AK303970 mRNA. Translation: BAH14086.1.
AC087244 Genomic DNA. No translation available.
AC087260 Genomic DNA. No translation available.
AC087319 Genomic DNA. No translation available.
AC092864 Genomic DNA. No translation available.
BC029220 mRNA. Translation: AAH29220.2.
BC035227 mRNA. Translation: AAH35227.1.
BC047665 mRNA. Translation: AAH47665.2.
BC060773 mRNA. Translation: AAH60773.1.
S83308 mRNA. Translation: AAB49537.1. Different initiation.
X65662 mRNA. Translation: CAA46613.1.
CCDSiCCDS41761.1. [P35711-3]
CCDS44844.1. [P35711-2]
CCDS58216.1. [P35711-4]
CCDS58217.1. [P35711-5]
CCDS8699.1. [P35711-1]
PIRiS22939.
RefSeqiNP_001248343.1. NM_001261414.1. [P35711-4]
NP_001248344.1. NM_001261415.1. [P35711-5]
NP_008871.3. NM_006940.4. [P35711-1]
NP_694534.1. NM_152989.3. [P35711-2]
NP_821078.1. NM_178010.2. [P35711-3]
XP_006719212.1. XM_006719149.2. [P35711-2]
UniGeneiHs.657542.

3D structure databases

ProteinModelPortaliP35711.
SMRiP35711. Positions 554-623.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112543. 29 interactions.
IntActiP35711. 27 interactions.
MINTiMINT-1198407.

PTM databases

PhosphoSiteiP35711.

Polymorphism and mutation databases

BioMutaiSOX5.
DMDMi30179883.

Proteomic databases

MaxQBiP35711.
PaxDbiP35711.
PRIDEiP35711.

Protocols and materials databases

DNASUi6660.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381381; ENSP00000370788; ENSG00000134532. [P35711-4]
ENST00000396007; ENSP00000379328; ENSG00000134532. [P35711-3]
ENST00000451604; ENSP00000398273; ENSG00000134532. [P35711-1]
ENST00000541536; ENSP00000441973; ENSG00000134532. [P35711-4]
ENST00000545921; ENSP00000443520; ENSG00000134532. [P35711-5]
ENST00000546136; ENSP00000437487; ENSG00000134532. [P35711-2]
GeneIDi6660.
KEGGihsa:6660.
UCSCiuc001rfv.4. human. [P35711-3]
uc001rfw.3. human. [P35711-1]
uc001rfy.4. human. [P35711-4]

Organism-specific databases

CTDi6660.
GeneCardsiGC12M023585.
HGNCiHGNC:11201. SOX5.
MIMi604975. gene.
neXtProtiNX_P35711.
Orphaneti313884. 12p12.1 microdeletion syndrome.
313892. Developmental and speech delay due to SOX5 deficiency.
PharmGKBiPA36038.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG253815.
GeneTreeiENSGT00760000119274.
HOGENOMiHOG000056455.
HOVERGENiHBG003915.
InParanoidiP35711.
KOiK09269.
OMAiTQESCGH.
OrthoDBiEOG7W153F.
PhylomeDBiP35711.
TreeFamiTF320471.

Enzyme and pathway databases

SignaLinkiP35711.

Miscellaneous databases

ChiTaRSiSOX5. human.
GeneWikiiSOX5.
GenomeRNAii6660.
NextBioi25963.
PROiP35711.
SOURCEiSearch...

Gene expression databases

BgeeiP35711.
ExpressionAtlasiP35711. baseline and differential.
GenevestigatoriP35711.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the human long form of Sox5 (L-SOX5) gene."
    Ikeda T., Zhang J., Chano T., Mabuchi A., Fukuda A., Kawaguchi H., Nakamura K., Ikegawa S.
    Gene 298:59-68(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5).
    Tissue: Liver, Testis and Trachea.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 388-763 (ISOFORM 3).
    Tissue: Brain.
  5. "Cloning and characterization of SOX5, a new member of the human SOX gene family."
    Wunderle V.M., Critcher R., Ashworth A., Goodfellow P.N.
    Genomics 36:354-358(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 389-763.
    Tissue: Testis.
  6. "A conserved family of genes related to the testis determining gene, SRY."
    Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
    Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 567-620.
    Tissue: Fetal heart and Heart.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; THR-131; SER-370; THR-372; SER-414 AND SER-439, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
    Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A.
    Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PRO-362.

Entry informationi

Entry nameiSOX5_HUMAN
AccessioniPrimary (citable) accession number: P35711
Secondary accession number(s): B7Z8V0
, F5H5B0, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 23, 2003
Last modified: April 29, 2015
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.