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P35711

- SOX5_HUMAN

UniProt

P35711 - SOX5_HUMAN

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Protein

Transcription factor SOX-5

Gene

SOX5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi556 – 62469HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. cartilage development Source: Ensembl
  2. cell fate commitment Source: Ensembl
  3. cellular response to transforming growth factor beta stimulus Source: UniProtKB
  4. central nervous system neuron differentiation Source: Ensembl
  5. in utero embryonic development Source: Ensembl
  6. negative regulation of transcription, DNA-templated Source: Ensembl
  7. oligodendrocyte differentiation Source: Ensembl
  8. positive regulation of cartilage development Source: UniProtKB
  9. positive regulation of chondrocyte differentiation Source: UniProtKB
  10. positive regulation of mesenchymal stem cell differentiation Source: UniProtKB
  11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. regulation of timing of neuron differentiation Source: Ensembl
  13. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP35711.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-5
Gene namesi
Name:SOX5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:11201. SOX5.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nuclear transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti313884. 12p12.1 microdeletion syndrome.
313892. Developmental and speech delay due to SOX5 deficiency.
PharmGKBiPA36038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Transcription factor SOX-5PRO_0000048726Add
BLAST

Proteomic databases

MaxQBiP35711.
PaxDbiP35711.
PRIDEiP35711.

PTM databases

PhosphoSiteiP35711.

Expressioni

Gene expression databases

BgeeiP35711.
ExpressionAtlasiP35711. baseline and differential.
GenevestigatoriP35711.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SHOXO152662EBI-3505701,EBI-3505698
taxP034103EBI-3505701,EBI-9676218From a different organism.

Protein-protein interaction databases

BioGridi112543. 13 interactions.
IntActiP35711. 13 interactions.
MINTiMINT-1198407.

Structurei

3D structure databases

ProteinModelPortaliP35711.
SMRiP35711. Positions 554-623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili193 – 27482Sequence AnalysisAdd
BLAST
Coiled coili448 – 51568Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG253815.
GeneTreeiENSGT00760000119274.
HOVERGENiHBG003915.
InParanoidiP35711.
KOiK09269.
OMAiPSEHSSM.
OrthoDBiEOG7W153F.
PhylomeDBiP35711.
TreeFamiTF320471.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P35711-1) [UniParc]FASTAAdd to Basket

Also known as: L-SOX5A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTDPDLPQE FERMSSKRPA SPYGEADGEV AMVTSRQKVE EEESDGLPAF
60 70 80 90 100
HLPLHVSFPN KPHSEEFQPV SLLTQETCGH RTPTSQHNTM EVDGNKVMSS
110 120 130 140 150
FAPHNSSTSP QKAEEGGRQS GESLSSTALG TPERRKGSLA DVVDTLKQRK
160 170 180 190 200
MEELIKNEPE ETPSIEKLLS KDWKDKLLAM GSGNFGEIKG TPESLAEKER
210 220 230 240 250
QLMGMINQLT SLREQLLAAH DEQKKLAASQ IEKQRQQMEL AKQQQEQIAR
260 270 280 290 300
QQQQLLQQQH KINLLQQQIQ VQGQLPPLMI PVFPPDQRTL AAAAQQGFLL
310 320 330 340 350
PPGFSYKAGC SDPYPVQLIP TTMAAAAAAT PGLGPLQLQQ LYAAQLAAMQ
360 370 380 390 400
VSPGGKLPGI PQGNLGAAVS PTSIHTDKST NSPPPKSKDE VAQPLNLSAK
410 420 430 440 450
PKTSDGKSPT SPTSPHMPAL RINSGAGPLK ASVPAALASP SARVSTIGYL
460 470 480 490 500
NDHDAVTKAI QEARQMKEQL RREQQVLDGK VAVVNSLGLN NCRTEKEKTT
510 520 530 540 550
LESLTQQLAV KQNEEGKFSH AMMDFNLSGD SDGSAGVSES RIYRESRGRG
560 570 580 590 600
SNEPHIKRPM NAFMVWAKDE RRKILQAFPD MHNSNISKIL GSRWKAMTNL
610 620 630 640 650
EKQPYYEEQA RLSKQHLEKY PDYKYKPRPK RTCLVDGKKL RIGEYKAIMR
660 670 680 690 700
NRRQEMRQYF NVGQQAQIPI ATAGVVYPGA IAMAGMPSPH LPSEHSSVSS
710 720 730 740 750
SPEPGMPVIQ STYGVKGEEP HIKEEIQAED INGEIYDEYD EEEDDPDVDY
760
GSDSENHIAG QAN
Length:763
Mass (Da):84,026
Last modified:April 23, 2003 - v3
Checksum:i02B5B13429A59CAA
GO
Isoform 2 (identifier: P35711-2) [UniParc]FASTAAdd to Basket

Also known as: L-SOX5B

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:750
Mass (Da):82,453
Checksum:iF8152F0BD72E6734
GO
Isoform 3 (identifier: P35711-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.
     387-388: SK → MH

Note: No experimental confirmation available.

Show »
Length:377
Mass (Da):41,990
Checksum:iA4B74A55C2E44E9A
GO
Isoform 4 (identifier: P35711-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     388-495: Missing.

Note: No experimental confirmation available.

Show »
Length:642
Mass (Da):71,044
Checksum:i1F142CAF87059BAA
GO
Isoform 5 (identifier: P35711-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MLTDPDLPQEFER → MSV

Note: No experimental confirmation available.

Show »
Length:753
Mass (Da):82,770
Checksum:i57F018BA2D8B901E
GO

Sequence cautioni

The sequence AAB49537.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti276 – 2761P → L in BAH14086. (PubMed:14702039)Curated
Sequence conflicti295 – 2951Q → H in BAB85048. (PubMed:14702039)Curated
Sequence conflicti513 – 5131N → S in BAB85048. (PubMed:14702039)Curated
Sequence conflicti514 – 5141E → Q in AAB49537. (PubMed:8812465)Curated
Sequence conflicti545 – 5451E → G in BAB85048. (PubMed:14702039)Curated
Sequence conflicti754 – 7541S → N in BAC05353. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti362 – 3621Q → P in a patient with amyotrophic lateral sclerosis. 1 Publication
VAR_065754

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 386386Missing in isoform 3. 2 PublicationsVSP_007262Add
BLAST
Alternative sequencei1 – 1313Missing in isoform 2 and isoform 4. 2 PublicationsVSP_007261Add
BLAST
Alternative sequencei1 – 1313MLTDP…QEFER → MSV in isoform 5. 1 PublicationVSP_045997Add
BLAST
Alternative sequencei387 – 3882SK → MH in isoform 3. 2 PublicationsVSP_007263
Alternative sequencei388 – 495108Missing in isoform 4. 1 PublicationVSP_007264Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081588 mRNA. Translation: BAC16233.1.
AB081589 mRNA. Translation: BAC16234.1.
AB081590 Genomic DNA. Translation: BAC16235.1.
AB081591 Genomic DNA. Translation: BAC16236.1.
AK074317 mRNA. Translation: BAB85048.1.
AK098610 mRNA. Translation: BAC05353.1.
AK303970 mRNA. Translation: BAH14086.1.
AC087244 Genomic DNA. No translation available.
AC087260 Genomic DNA. No translation available.
AC087319 Genomic DNA. No translation available.
AC092864 Genomic DNA. No translation available.
BC029220 mRNA. Translation: AAH29220.2.
BC035227 mRNA. Translation: AAH35227.1.
BC047665 mRNA. Translation: AAH47665.2.
BC060773 mRNA. Translation: AAH60773.1.
S83308 mRNA. Translation: AAB49537.1. Different initiation.
X65662 mRNA. Translation: CAA46613.1.
CCDSiCCDS41761.1. [P35711-3]
CCDS44844.1. [P35711-2]
CCDS58216.1. [P35711-4]
CCDS58217.1. [P35711-5]
CCDS8699.1. [P35711-1]
PIRiS22939.
RefSeqiNP_001248343.1. NM_001261414.1. [P35711-4]
NP_001248344.1. NM_001261415.1. [P35711-5]
NP_008871.3. NM_006940.4. [P35711-1]
NP_694534.1. NM_152989.3. [P35711-2]
NP_821078.1. NM_178010.2. [P35711-3]
XP_006719212.1. XM_006719149.1. [P35711-2]
XP_006719213.1. XM_006719150.1. [P35711-2]
UniGeneiHs.657542.

Genome annotation databases

EnsembliENST00000381381; ENSP00000370788; ENSG00000134532. [P35711-4]
ENST00000396007; ENSP00000379328; ENSG00000134532. [P35711-3]
ENST00000451604; ENSP00000398273; ENSG00000134532. [P35711-1]
ENST00000541536; ENSP00000441973; ENSG00000134532. [P35711-4]
ENST00000545921; ENSP00000443520; ENSG00000134532. [P35711-5]
ENST00000546136; ENSP00000437487; ENSG00000134532. [P35711-2]
GeneIDi6660.
KEGGihsa:6660.
UCSCiuc001rfv.4. human. [P35711-3]
uc001rfw.3. human. [P35711-1]
uc001rfy.4. human. [P35711-4]

Polymorphism databases

DMDMi30179883.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081588 mRNA. Translation: BAC16233.1 .
AB081589 mRNA. Translation: BAC16234.1 .
AB081590 Genomic DNA. Translation: BAC16235.1 .
AB081591 Genomic DNA. Translation: BAC16236.1 .
AK074317 mRNA. Translation: BAB85048.1 .
AK098610 mRNA. Translation: BAC05353.1 .
AK303970 mRNA. Translation: BAH14086.1 .
AC087244 Genomic DNA. No translation available.
AC087260 Genomic DNA. No translation available.
AC087319 Genomic DNA. No translation available.
AC092864 Genomic DNA. No translation available.
BC029220 mRNA. Translation: AAH29220.2 .
BC035227 mRNA. Translation: AAH35227.1 .
BC047665 mRNA. Translation: AAH47665.2 .
BC060773 mRNA. Translation: AAH60773.1 .
S83308 mRNA. Translation: AAB49537.1 . Different initiation.
X65662 mRNA. Translation: CAA46613.1 .
CCDSi CCDS41761.1. [P35711-3 ]
CCDS44844.1. [P35711-2 ]
CCDS58216.1. [P35711-4 ]
CCDS58217.1. [P35711-5 ]
CCDS8699.1. [P35711-1 ]
PIRi S22939.
RefSeqi NP_001248343.1. NM_001261414.1. [P35711-4 ]
NP_001248344.1. NM_001261415.1. [P35711-5 ]
NP_008871.3. NM_006940.4. [P35711-1 ]
NP_694534.1. NM_152989.3. [P35711-2 ]
NP_821078.1. NM_178010.2. [P35711-3 ]
XP_006719212.1. XM_006719149.1. [P35711-2 ]
XP_006719213.1. XM_006719150.1. [P35711-2 ]
UniGenei Hs.657542.

3D structure databases

ProteinModelPortali P35711.
SMRi P35711. Positions 554-623.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112543. 13 interactions.
IntActi P35711. 13 interactions.
MINTi MINT-1198407.

PTM databases

PhosphoSitei P35711.

Polymorphism databases

DMDMi 30179883.

Proteomic databases

MaxQBi P35711.
PaxDbi P35711.
PRIDEi P35711.

Protocols and materials databases

DNASUi 6660.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381381 ; ENSP00000370788 ; ENSG00000134532 . [P35711-4 ]
ENST00000396007 ; ENSP00000379328 ; ENSG00000134532 . [P35711-3 ]
ENST00000451604 ; ENSP00000398273 ; ENSG00000134532 . [P35711-1 ]
ENST00000541536 ; ENSP00000441973 ; ENSG00000134532 . [P35711-4 ]
ENST00000545921 ; ENSP00000443520 ; ENSG00000134532 . [P35711-5 ]
ENST00000546136 ; ENSP00000437487 ; ENSG00000134532 . [P35711-2 ]
GeneIDi 6660.
KEGGi hsa:6660.
UCSCi uc001rfv.4. human. [P35711-3 ]
uc001rfw.3. human. [P35711-1 ]
uc001rfy.4. human. [P35711-4 ]

Organism-specific databases

CTDi 6660.
GeneCardsi GC12M023585.
HGNCi HGNC:11201. SOX5.
MIMi 604975. gene.
neXtProti NX_P35711.
Orphaneti 313884. 12p12.1 microdeletion syndrome.
313892. Developmental and speech delay due to SOX5 deficiency.
PharmGKBi PA36038.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253815.
GeneTreei ENSGT00760000119274.
HOVERGENi HBG003915.
InParanoidi P35711.
KOi K09269.
OMAi PSEHSSM.
OrthoDBi EOG7W153F.
PhylomeDBi P35711.
TreeFami TF320471.

Enzyme and pathway databases

SignaLinki P35711.

Miscellaneous databases

ChiTaRSi SOX5. human.
GeneWikii SOX5.
GenomeRNAii 6660.
NextBioi 25963.
PROi P35711.
SOURCEi Search...

Gene expression databases

Bgeei P35711.
ExpressionAtlasi P35711. baseline and differential.
Genevestigatori P35711.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the human long form of Sox5 (L-SOX5) gene."
    Ikeda T., Zhang J., Chano T., Mabuchi A., Fukuda A., Kawaguchi H., Nakamura K., Ikegawa S.
    Gene 298:59-68(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5).
    Tissue: Liver, Testis and Trachea.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 388-763 (ISOFORM 3).
    Tissue: Brain.
  5. "Cloning and characterization of SOX5, a new member of the human SOX gene family."
    Wunderle V.M., Critcher R., Ashworth A., Goodfellow P.N.
    Genomics 36:354-358(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 389-763.
    Tissue: Testis.
  6. "A conserved family of genes related to the testis determining gene, SRY."
    Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
    Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 567-620.
    Tissue: Fetal heart and Heart.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
    Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A.
    Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PRO-362.

Entry informationi

Entry nameiSOX5_HUMAN
AccessioniPrimary (citable) accession number: P35711
Secondary accession number(s): B7Z8V0
, F5H5B0, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 23, 2003
Last modified: October 29, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3