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P35695 (BLO7_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase OXA-7

EC=3.5.2.6
Gene names
Name:bla
Synonyms:oxa7
Encoded onPlasmid pMG202
OrganismEscherichia coli
Taxonomic identifier562 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termPlasmid
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 266246Beta-lactamase OXA-7
PRO_0000017029

Sites

Active site681Acyl-ester intermediate By similarity
Binding site2051Substrate By similarity

Amino acid modifications

Modified residue711N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P35695 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: 77531E35389DB866

FASTA26629,461
        10         20         30         40         50         60 
MKTFAAYVIT ACLSSTALAS SITENTFWNK EFSAEAVNGV FVLCKSSSKL ACATNNLARA 

        70         80         90        100        110        120 
SKEYLPASTF KIPNAIIGLE TGVIKNEHQI FKWDGKPRAM KQWERDLSLR GAIQVSAVPV 

       130        140        150        160        170        180 
FQQIAREVGE VRMQKYLKKF SYGNQNISGG IDKFWLEGQL RISAVNQVEF LESLFLNKLS 

       190        200        210        220        230        240 
ASKENQLIVK EALVTEAPEY LVHSKTGFSG VGTESNPGVA WWVGWVEKGA EVYFFAFNMD 

       250        260 
IDNENKLPLR KSIPTKIMAS EGIIGG 

« Hide

References

[1]"Molecular characterization of the OXA-7 beta-lactamase gene."
Scoulica E., Aransay A., Tselentis Y.
Antimicrob. Agents Chemother. 39:1379-1382(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 7181.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75562 Genomic DNA. Translation: CAA53242.1.
PIRS38503.
S38671.

3D structure databases

ProteinModelPortalP35695.
SMRP35695. Positions 20-266.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1255135.

Proteomic databases

PRIDEP35695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLO7_ECOLX
AccessionPrimary (citable) accession number: P35695
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families