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Protein

Beta-lactamase OXA-7

Gene

bla

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Acyl-ester intermediatePROSITE-ProRule annotation
Binding sitei205 – 2051SubstrateBy similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-7 (EC:3.5.2.6)
Gene namesi
Name:bla
Synonyms:oxa7
Encoded oniPlasmid pMG2020 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 266246Beta-lactamase OXA-7PRO_0000017029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711N6-carboxylysineBy similarity

Proteomic databases

PRIDEiP35695.

Structurei

3D structure databases

ProteinModelPortaliP35695.
SMRiP35695. Positions 20-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFAAYVIT ACLSSTALAS SITENTFWNK EFSAEAVNGV FVLCKSSSKL
60 70 80 90 100
ACATNNLARA SKEYLPASTF KIPNAIIGLE TGVIKNEHQI FKWDGKPRAM
110 120 130 140 150
KQWERDLSLR GAIQVSAVPV FQQIAREVGE VRMQKYLKKF SYGNQNISGG
160 170 180 190 200
IDKFWLEGQL RISAVNQVEF LESLFLNKLS ASKENQLIVK EALVTEAPEY
210 220 230 240 250
LVHSKTGFSG VGTESNPGVA WWVGWVEKGA EVYFFAFNMD IDNENKLPLR
260
KSIPTKIMAS EGIIGG
Length:266
Mass (Da):29,461
Last modified:November 1, 1995 - v2
Checksum:i77531E35389DB866
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75562 Genomic DNA. Translation: CAA53242.1.
PIRiS38503.
S38671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75562 Genomic DNA. Translation: CAA53242.1.
PIRiS38503.
S38671.

3D structure databases

ProteinModelPortaliP35695.
SMRiP35695. Positions 20-266.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL1255135.

Proteomic databases

PRIDEiP35695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of the OXA-7 beta-lactamase gene."
    Scoulica E., Aransay A., Tselentis Y.
    Antimicrob. Agents Chemother. 39:1379-1382(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 7181.

Entry informationi

Entry nameiBLO7_ECOLX
AccessioniPrimary (citable) accession number: P35695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.