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P35695

- BLO7_ECOLX

UniProt

P35695 - BLO7_ECOLX

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Protein
Beta-lactamase OXA-7
Gene
bla, oxa7
Organism
Escherichia coli
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This is an oxacillin-hydrolyzing beta-lactamase.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Acyl-ester intermediate By similarity
Binding sitei205 – 2051Substrate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-7 (EC:3.5.2.6)
Gene namesi
Name:bla
Synonyms:oxa7
Encoded oniPlasmid pMG2020 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarity
Add
BLAST
Chaini21 – 266246Beta-lactamase OXA-7
PRO_0000017029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711N6-carboxylysine By similarity

Proteomic databases

PRIDEiP35695.

Structurei

3D structure databases

ProteinModelPortaliP35695.
SMRiP35695. Positions 20-266.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35695-1 [UniParc]FASTAAdd to Basket

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MKTFAAYVIT ACLSSTALAS SITENTFWNK EFSAEAVNGV FVLCKSSSKL    50
ACATNNLARA SKEYLPASTF KIPNAIIGLE TGVIKNEHQI FKWDGKPRAM 100
KQWERDLSLR GAIQVSAVPV FQQIAREVGE VRMQKYLKKF SYGNQNISGG 150
IDKFWLEGQL RISAVNQVEF LESLFLNKLS ASKENQLIVK EALVTEAPEY 200
LVHSKTGFSG VGTESNPGVA WWVGWVEKGA EVYFFAFNMD IDNENKLPLR 250
KSIPTKIMAS EGIIGG 266
Length:266
Mass (Da):29,461
Last modified:November 1, 1995 - v2
Checksum:i77531E35389DB866
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75562 Genomic DNA. Translation: CAA53242.1.
PIRiS38503.
S38671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75562 Genomic DNA. Translation: CAA53242.1 .
PIRi S38503.
S38671.

3D structure databases

ProteinModelPortali P35695.
SMRi P35695. Positions 20-266.
ModBasei Search...

Chemistry

ChEMBLi CHEMBL1255135.

Proteomic databases

PRIDEi P35695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of the OXA-7 beta-lactamase gene."
    Scoulica E., Aransay A., Tselentis Y.
    Antimicrob. Agents Chemother. 39:1379-1382(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 7181.

Entry informationi

Entry nameiBLO7_ECOLX
AccessioniPrimary (citable) accession number: P35695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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