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P35695

- BLO7_ECOLX

UniProt

P35695 - BLO7_ECOLX

Protein

Beta-lactamase OXA-7

Gene

bla

Organism
Escherichia coli
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    • Comment

    Functioni

    This is an oxacillin-hydrolyzing beta-lactamase.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Acyl-ester intermediatePROSITE-ProRule annotation
    Binding sitei205 – 2051SubstrateBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase OXA-7 (EC:3.5.2.6)
    Gene namesi
    Name:bla
    Synonyms:oxa7
    Encoded oniPlasmid pMG2020 Publication
    OrganismiEscherichia coli
    Taxonomic identifieri562 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 266246Beta-lactamase OXA-7PRO_0000017029Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei71 – 711N6-carboxylysineBy similarity

    Proteomic databases

    PRIDEiP35695.

    Structurei

    3D structure databases

    ProteinModelPortaliP35695.
    SMRiP35695. Positions 20-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-D beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35695-1 [UniParc]FASTAAdd to Basket

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    MKTFAAYVIT ACLSSTALAS SITENTFWNK EFSAEAVNGV FVLCKSSSKL    50
    ACATNNLARA SKEYLPASTF KIPNAIIGLE TGVIKNEHQI FKWDGKPRAM 100
    KQWERDLSLR GAIQVSAVPV FQQIAREVGE VRMQKYLKKF SYGNQNISGG 150
    IDKFWLEGQL RISAVNQVEF LESLFLNKLS ASKENQLIVK EALVTEAPEY 200
    LVHSKTGFSG VGTESNPGVA WWVGWVEKGA EVYFFAFNMD IDNENKLPLR 250
    KSIPTKIMAS EGIIGG 266
    Length:266
    Mass (Da):29,461
    Last modified:November 1, 1995 - v2
    Checksum:i77531E35389DB866
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75562 Genomic DNA. Translation: CAA53242.1.
    PIRiS38503.
    S38671.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75562 Genomic DNA. Translation: CAA53242.1 .
    PIRi S38503.
    S38671.

    3D structure databases

    ProteinModelPortali P35695.
    SMRi P35695. Positions 20-266.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL1255135.

    Proteomic databases

    PRIDEi P35695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the OXA-7 beta-lactamase gene."
      Scoulica E., Aransay A., Tselentis Y.
      Antimicrob. Agents Chemother. 39:1379-1382(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 7181.

    Entry informationi

    Entry nameiBLO7_ECOLX
    AccessioniPrimary (citable) accession number: P35695
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3