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Protein

Translationally-controlled tumor protein homolog

Gene

TMA19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in protein synthesis. Involved in microtubule stabilization.2 Publications

Miscellaneous

Present with 27800 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • cellular response to oxidative stress Source: SGD
  • cytoplasmic translation Source: SGD

Keywordsi

Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-31855-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein homolog
Short name:
TCTP
Alternative name(s):
Microtubule and mitochondria-interacting protein 1
Translation machinery-associated protein 19
Gene namesi
Name:TMA19
Synonyms:MMI1
Ordered Locus Names:YKL056C
ORF Names:YKL312
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL056C.
SGDiS000001539. TMA19.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113111 – 167Translationally-controlled tumor protein homologAdd BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35691.
PRIDEiP35691.
TopDownProteomicsiP35691.

2D gel databases

SWISS-2DPAGEiP35691.

PTM databases

iPTMnetiP35691.

Interactioni

Subunit structurei

Interacts with the 40S and 60S ribosomal subunits. Interacts with microtubules.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34077. 203 interactors.
DIPiDIP-2116N.
IntActiP35691. 23 interactors.
MINTiMINT-494272.
STRINGi4932.YKL056C.

Structurei

3D structure databases

ProteinModelPortaliP35691.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 167TCTPPROSITE-ProRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
InParanoidiP35691.
OMAiMVVLLNY.
OrthoDBiEOG092C4YQJ.

Family and domain databases

InterProiView protein in InterPro
IPR011057. Mss4-like.
IPR034737. TCTP.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiView protein in Pfam
PF00838. TCTP. 1 hit.
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiView protein in PROSITE
PS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P35691-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYKDIFSN DELLSDAYDA KLVDDVIYEA DCAMVNVGGD NIDIGANPSA
60 70 80 90 100
EGGDDDVEEG AEMVNNVVHS FRLQQTAFDK KSFLTYIKGY MKAVKAKLQE
110 120 130 140 150
TNPEEVPKFE KGAQTYVKKV IGSFKDWEFF TGESMDPDAM VVMLNYREDG
160
TTPFVAIWKH GIVEEKI
Length:167
Mass (Da):18,741
Last modified:June 1, 1994 - v1
Checksum:iC4407A3B3B77124A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 20DA → AD AA sequence (Ref. 4) Curated2
Sequence conflicti70S → G AA sequence (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53416.1.
Z28056 Genomic DNA. Translation: CAA81893.1.
BK006944 Genomic DNA. Translation: DAA09101.1.
PIRiS37878.
RefSeqiNP_012867.1. NM_001179622.1.

Genome annotation databases

EnsemblFungiiYKL056C; YKL056C; YKL056C.
GeneIDi853809.
KEGGisce:YKL056C.

Similar proteinsi

Entry informationi

Entry nameiTCTP_YEAST
AccessioniPrimary (citable) accession number: P35691
Secondary accession number(s): D6VXN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 27, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names