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Protein

Translationally-controlled tumor protein homolog

Gene

TMA19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in protein synthesis. Involved in microtubule stabilization.2 Publications

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
  • cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-31855-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein homolog
Short name:
TCTP
Alternative name(s):
Microtubule and mitochondria-interacting protein 1
Translation machinery-associated protein 19
Gene namesi
Name:TMA19
Synonyms:MMI1
Ordered Locus Names:YKL056C
ORF Names:YKL312
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL056C.
SGDiS000001539. TMA19.

Subcellular locationi

  • Cytoplasmcytoskeleton
  • Mitochondrion

  • Note: After induction of apoptosis or mild oxidative stress, reversibly translocates from the cytoplasm to mitochondria, where it is associated with the outer surface.

GO - Cellular componenti

  • cytosol Source: SGD
  • microtubule Source: UniProtKB-KW
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Translationally-controlled tumor protein homologPRO_0000211311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineCombined sources
Modified residuei15 – 151PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP35691.
TopDownProteomicsiP35691.

2D gel databases

SWISS-2DPAGEP35691.

PTM databases

iPTMnetiP35691.

Interactioni

Subunit structurei

Interacts with the 40S and 60S ribosomal subunits. Interacts with microtubules.1 Publication

Protein-protein interaction databases

BioGridi34077. 77 interactions.
DIPiDIP-2116N.
IntActiP35691. 4 interactions.
MINTiMINT-494272.

Structurei

3D structure databases

ProteinModelPortaliP35691.
SMRiP35691. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 167167TCTPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation
Contains 1 TCTP domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
InParanoidiP35691.
OMAiWKHGLKE.
OrthoDBiEOG092C4YQJ.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35691-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYKDIFSN DELLSDAYDA KLVDDVIYEA DCAMVNVGGD NIDIGANPSA
60 70 80 90 100
EGGDDDVEEG AEMVNNVVHS FRLQQTAFDK KSFLTYIKGY MKAVKAKLQE
110 120 130 140 150
TNPEEVPKFE KGAQTYVKKV IGSFKDWEFF TGESMDPDAM VVMLNYREDG
160
TTPFVAIWKH GIVEEKI
Length:167
Mass (Da):18,741
Last modified:June 1, 1994 - v1
Checksum:iC4407A3B3B77124A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 202DA → AD AA sequence (Ref. 4) Curated
Sequence conflicti70 – 701S → G AA sequence (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53416.1.
Z28056 Genomic DNA. Translation: CAA81893.1.
BK006944 Genomic DNA. Translation: DAA09101.1.
PIRiS37878.
RefSeqiNP_012867.1. NM_001179622.1.

Genome annotation databases

EnsemblFungiiYKL056C; YKL056C; YKL056C.
GeneIDi853809.
KEGGisce:YKL056C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA. Translation: CAA53416.1.
Z28056 Genomic DNA. Translation: CAA81893.1.
BK006944 Genomic DNA. Translation: DAA09101.1.
PIRiS37878.
RefSeqiNP_012867.1. NM_001179622.1.

3D structure databases

ProteinModelPortaliP35691.
SMRiP35691. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34077. 77 interactions.
DIPiDIP-2116N.
IntActiP35691. 4 interactions.
MINTiMINT-494272.

PTM databases

iPTMnetiP35691.

2D gel databases

SWISS-2DPAGEP35691.

Proteomic databases

MaxQBiP35691.
TopDownProteomicsiP35691.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL056C; YKL056C; YKL056C.
GeneIDi853809.
KEGGisce:YKL056C.

Organism-specific databases

EuPathDBiFungiDB:YKL056C.
SGDiS000001539. TMA19.

Phylogenomic databases

GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
InParanoidiP35691.
OMAiWKHGLKE.
OrthoDBiEOG092C4YQJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31855-MONOMER.

Miscellaneous databases

PROiP35691.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCTP_YEAST
AccessioniPrimary (citable) accession number: P35691
Secondary accession number(s): D6VXN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 27800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.