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P35689

- ERCC5_MOUSE

UniProt

P35689 - ERCC5_MOUSE

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Protein

DNA repair protein complementing XP-G cells homolog

Gene
Ercc5, Ercc-5, Xpg
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too By similarity.

Cofactori

Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi30 – 301Magnesium 1 By similarity
Metal bindingi77 – 771Magnesium 1 By similarity
Metal bindingi788 – 7881Magnesium 1 By similarity
Metal bindingi790 – 7901Magnesium 1 By similarity
Metal bindingi809 – 8091Magnesium 2 By similarity
Metal bindingi811 – 8111Magnesium 2 By similarity
Metal bindingi860 – 8601Magnesium 2 By similarity

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. single-stranded DNA binding Source: InterPro

GO - Biological processi

  1. determination of adult lifespan Source: MGI
  2. DNA repair Source: MGI
  3. multicellular organism growth Source: MGI
  4. nucleotide-excision repair Source: MGI
  5. response to UV Source: MGI
  6. UV protection Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein complementing XP-G cells homolog (EC:3.1.-.-)
Alternative name(s):
DNA excision repair protein ERCC-5
Xeroderma pigmentosum group G-complementing protein homolog
Gene namesi
Name:Ercc5
Synonyms:Ercc-5, Xpg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:103582. Ercc5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11701170DNA repair protein complementing XP-G cells homologPRO_0000154032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81N6-acetyllysine By similarity
Modified residuei384 – 3841Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP35689.

PTM databases

PhosphoSiteiP35689.

Expressioni

Gene expression databases

GenevestigatoriP35689.

Interactioni

Subunit structurei

Interacts with PCNA By similarity.

Structurei

3D structure databases

ProteinModelPortaliP35689.
SMRiP35689. Positions 2-127, 733-998.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9595N-domainAdd
BLAST
Regioni752 – 882131I-domainAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1049 – 106517Nuclear localization signal Reviewed predictionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0258.
HOGENOMiHOG000131367.
HOVERGENiHBG051501.
InParanoidiP35689.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00066. XRODRMPGMNTG.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF88723. SSF88723. 2 hits.
TIGRFAMsiTIGR00600. rad2. 1 hit.
PROSITEiPS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35689-1 [UniParc]FASTAAdd to Basket

« Hide

MGVQGLWKLL ECSGHRVSPE ALEGKVLAVD ISIWLNQALK GVRDSHGNVI     50
ENAHLLTLFH RLCKLLFFRI RPIFVFDGDA PLLKKQTLAK RRQRKDSASI 100
DSRKTTEKLL KTFLKRQALK TAFRSSRHEA PPSLTQVQRQ DDIYVLPPLP 150
EEEKHSSEEE DEKQWQARMD QKQALQEEFF HNPQAIDIES EDFSSLPPEV 200
KHEILTDMKE FTKRRRTLFE AMPEESNDFS QYQLKGLLKK NYLNQHIENV 250
QKEMNQQHSG QIQRQYQDEG GFLKEVESRR VVSEDTSHYI LIKGIQGKKV 300
MDVDSESLPS SSNVHSVSSN LKSSPHEKVK PEREPEAAPP SPRTLLAIQA 350
AMLGSSSEDE PESREGRQSK ERNSGATADA GSISPRTCAA IQKALDDDND 400
EKVSGSSDDL AEKMLLGSGL EQEEHADETA ERGGGVPFDT APLTPSVTEV 450
KECVTSGSSA NGQTDSAHSF TTASHRCDTP KETVSLARAV KEASQISSEC 500
EVEGRPAALS PAFIGTPSSH VSGVLSEREP TLAPPTTRTH SDQGIDIHPE 550
DPELQNGLYP LETKCNSSRL SSDDETEGGQ NPAPKACSTV HVPAEAMSNL 600
ENALPSNAEE RGDFQETIQL REVPEAAARE LISAPKPMGP MEMESEESES 650
DGSFIEVQSV VSNSELQTES SEASTHLSEK DAEEPRETLE EGTSRDTECL 700
LQDSSDIEAM EGHREADIDA EDMPNEWQDI NLEELDALES NLLAEQNSLK 750
AQKQQQDRIA ASVTGQMFLE SQELLRLFGV PYIQAPMEAE AQCAMLDLTD 800
QTSGTITDDS DIWLFGARHV YKNFFNKNKF VEYYQYVDFY SQLGLDRNKL 850
INLAYLLGSD YTEGIPTVGC VTAMEILNEF PGRGLDPLLK FSEWWHEAQN 900
NKKVAENPYD TKVKKKLRKL QLTPGFPNPA VADAYLRPVV DDSRGSFLWG 950
KPDVDKISTF CQRYFGWNRM KTDESLYPVL KHLNAHQTQL RIDSFFRLAQ 1000
QEKQDAKLIK SHRLNRAVTC ILRKEREEKA PELTKVTEAL DDAKGKTQKR 1050
ELPYKKETSV PKRRRPSGNG GFLGDPYCSE SPQESSCEDG EGSSVMSARQ 1100
RSAAESSKIS CSDVPDLVRD PPHGRQGCVS TSSSSEDDED KAKTVLVTAR 1150
PVFGKKKLKL KSMKRRKKKT 1170
Length:1,170
Mass (Da):130,715
Last modified:October 3, 2012 - v4
Checksum:iB4B9F93ACEBC3729
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti388 – 3881C → R in BAA03813. 1 Publication
Sequence conflicti419 – 4191G → R in BAA03813. 1 Publication
Sequence conflicti419 – 4191G → R in AAA91039. 1 Publication
Sequence conflicti419 – 4191G → R in AAB17885. 1 Publication
Sequence conflicti462 – 4621G → E in BAA03813. 1 Publication
Sequence conflicti462 – 4621G → E in AAA91039. 1 Publication
Sequence conflicti462 – 4621G → E in AAB17885. 1 Publication
Sequence conflicti488 – 4881R → S in BAA03813. 1 Publication
Sequence conflicti688 – 6881T → I in BAA03813. 1 Publication
Sequence conflicti799 – 7991T → S in BAA03813. 1 Publication
Sequence conflicti799 – 7991T → S in AAA91039. 1 Publication
Sequence conflicti799 – 7991T → S in AAB17885. 1 Publication
Sequence conflicti958 – 9592ST → RE in BAA03813. 1 Publication
Sequence conflicti958 – 9592ST → RE in AAA91039. 1 Publication
Sequence conflicti958 – 9592ST → RE in AAB17885. 1 Publication
Sequence conflicti1015 – 10151N → S in BAA03813. 1 Publication
Sequence conflicti1021 – 10211I → M in BAA03813. 1 Publication
Sequence conflicti1110 – 11101S → G in BAA03813. 1 Publication
Sequence conflicti1110 – 11101S → G in AAA91039. 1 Publication
Sequence conflicti1110 – 11101S → G in AAB17885. 1 Publication
Sequence conflicti1121 – 11211P → S in BAA03813. 1 Publication
Sequence conflicti1138 – 11381D → G in BAA03813. 1 Publication
Sequence conflicti1138 – 11381D → G in AAA91039. 1 Publication
Sequence conflicti1138 – 11381D → G in AAB17885. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16306 mRNA. Translation: BAA03813.1.
U40796 mRNA. Translation: AAA91039.1.
U40795
, U39892, U39893, U39894, U39896, U40073, U40431, U40432, U40668, U40669, U40670, U40792, U40793, U40794 Genomic DNA. Translation: AAB17885.1.
AC123800 Genomic DNA. No translation available.
CCDSiCCDS35553.1.
PIRiA57650.
UniGeneiMm.2213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16306 mRNA. Translation: BAA03813.1 .
U40796 mRNA. Translation: AAA91039.1 .
U40795
, U39892 , U39893 , U39894 , U39896 , U40073 , U40431 , U40432 , U40668 , U40669 , U40670 , U40792 , U40793 , U40794 Genomic DNA. Translation: AAB17885.1 .
AC123800 Genomic DNA. No translation available.
CCDSi CCDS35553.1.
PIRi A57650.
UniGenei Mm.2213.

3D structure databases

ProteinModelPortali P35689.
SMRi P35689. Positions 2-127, 733-998.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P35689.

Proteomic databases

PRIDEi P35689.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:103582. Ercc5.

Phylogenomic databases

eggNOGi COG0258.
HOGENOMi HOG000131367.
HOVERGENi HBG051501.
InParanoidi P35689.

Miscellaneous databases

PROi P35689.
SOURCEi Search...

Gene expression databases

Genevestigatori P35689.

Family and domain databases

Gene3Di 3.40.50.1010. 2 hits.
InterProi IPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view ]
Pfami PF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view ]
PRINTSi PR00066. XRODRMPGMNTG.
SMARTi SM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view ]
SUPFAMi SSF47807. SSF47807. 1 hit.
SSF88723. SSF88723. 2 hits.
TIGRFAMsi TIGR00600. rad2. 1 hit.
PROSITEi PS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An ERCC5 gene with homology to yeast RAD2 is involved in group G Xeroderma pigmentosum."
    Shiomi T., Harada Y.-N., Saito T., Shiomi N., Okuno Y., Yamaizumi M.
    Mutat. Res. 314:167-175(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complementary DNA sequence and chromosomal localization of xpg, the mouse counterpart of human repair gene XPG/ERCC5."
    Harada Y.N., Matsuda Y., Shiomi N., Shiomi T.
    Genomics 28:59-65(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10.
    Tissue: Liver.
  3. "Molecular cloning and structural analysis of the functional mouse genomic XPG gene."
    Ludwig D.L., Mudgett J.S., Park M.S., Perez-Castro A.V., Macinnes M.A.
    Mamm. Genome 7:644-649(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: DBA/2.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiERCC5_MOUSE
AccessioniPrimary (citable) accession number: P35689
Secondary accession number(s): Q61528, Q64248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 122 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi