P35663 (CYLC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cylicin-1

Alternative name(s):
Cylicin I
Multiple-band polypeptide I

Gene names

Name:	CYLC1
Synonyms:	CYL, CYL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	651 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.
Subcellular location	Cytoplasm › cytoskeleton › perinuclear theca › calyx. Note: Sperm head cytoskeletal structure.
Tissue specificity	Testis.
Developmental stage	Specific to late spermatogenesis.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Domain	Repeat
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Non-traceable author statement Ref.3. Source: UniProtKB
Cellular_component	acrosomal matrix Inferred from direct assay Ref.3. Source: MGI cytoskeletal calyx Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Non-traceable author statement. Source: UniProtKB
Molecular_function	structural constituent of cytoskeleton Inferred from electronic annotation. Source: InterPro structural molecule activity Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 651	651	Cylicin-1		PRO_0000079753
Regions
	Repeat	278 – 305	28	1
	Repeat	306 – 342	37	2
	Repeat	343 – 379	37	3
	Repeat	380 – 417	38	4
	Repeat	418 – 453	36	5
	Repeat	454 – 491	38	6
	Repeat	492 – 531	40	7
	Repeat	532 – 553	22	8
	Region	532 – 553	22	8 X approximate tandem repeats
	Compositional bias	601 – 651	51	Pro-rich
Natural variations
	Natural variant	399	1	D → H. Corresponds to variant rs12008888 [ dbSNP | Ensembl ].		VAR_050937
Experimental info
	Sequence conflict	54	1	S → G in CAA80457. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P35663 [UniParc]. Last modified October 11, 2005. Version 2. Checksum: EF63B156ADE67B85	FASTA	651	74,242
	10 20 30 40 50 60 MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR PLKSQITVTR 70 80 90 100 110 120 HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF RHLYTSKTHL KKAEYKKSKD 130 140 150 160 170 180 EKGGTPLKKD SKKKGGSYAT NPESKQIVEE KTKRQNEADK TPLKSSHENE QSKKSKSSSE 190 200 210 220 230 240 TNPESQNSKT VSKNCSQKDK KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE 250 260 270 280 290 300 NSLNVDFLML VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES 310 320 330 340 350 360 EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD KKKLKKDDKK 370 380 390 400 410 420 KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA KKITFSTDSE SELESKESQK 430 440 450 460 470 480 DEKKDKKDSK TDNKKSVKND EESTDADSEP KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN 490 500 510 520 530 540 AESTEMESDL ELKKDKKHSK EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG 550 560 570 580 590 600 SDTESEESLY KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV 610 620 630 640 650 PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton." Hess H., Heid H., Franke W.W. J. Cell Biol. 122:1043-1052(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-651. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL627233 Genomic DNA. Translation: CAI40037.1. BC126461 mRNA. Translation: AAI26462.1. Z22780 mRNA. Translation: CAA80457.1.
IPI	IPI00020039.
PIR	B40713.
RefSeq	NP_066941.1. NM_021118.2.
UniGene	Hs.444230.
3D structure databases
ProteinModelPortal	P35663.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000331556.
PTM databases
PhosphoSite	P35663.
Polymorphism databases
DMDM	77416856.
Proteomic databases
PaxDb	P35663.
PRIDE	P35663.
Protocols and materials databases
DNASU	1538.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329312; ENSP00000331556; ENSG00000183035.
GeneID	1538.
KEGG	hsa:1538.
UCSC	uc004eeh.1. human.
Organism-specific databases
CTD	1538.
GeneCards	GC0XP083116.
HGNC	HGNC:2582. CYLC1.
HPA	HPA000696.
MIM	300768. gene.
neXtProt	NX_P35663.
PharmGKB	PA27082.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG116362.
HOGENOM	HOG000112130.
HOVERGEN	HBG081397.
InParanoid	P35663.
OrthoDB	EOG40VVPZ.
Gene expression databases
Bgee	P35663.
CleanEx	HS_CYLC1.
Genevestigator	P35663.
GermOnline	ENSG00000183035. Homo sapiens.
Family and domain databases
InterPro	IPR026189. CYLC. [Graphical view]
PANTHER	PTHR16742. PTHR16742. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	1538.
NextBio	6361.
SOURCE	Search...

Entry information

Entry name

CYLC1_HUMAN

Accession

Primary (citable) accession number: P35663
Secondary accession number(s): A0AVQ8, Q5JQQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.