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Protein

Cylicin-1

Gene

CYLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: InterPro
  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organismal development Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cylicin-1
Alternative name(s):
Cylicin I
Multiple-band polypeptide I
Gene namesi
Name:CYLC1
Synonyms:CYL, CYL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:2582. CYLC1.

Subcellular locationi

GO - Cellular componenti

  • acrosomal matrix Source: MGI
  • cytoskeletal calyx Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27082.

Polymorphism and mutation databases

DMDMi77416856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 651651Cylicin-1PRO_0000079753Add
BLAST

Proteomic databases

PaxDbiP35663.
PRIDEiP35663.

PTM databases

PhosphoSiteiP35663.

Expressioni

Tissue specificityi

Testis.

Developmental stagei

Specific to late spermatogenesis.

Gene expression databases

BgeeiP35663.
CleanExiHS_CYLC1.
ExpressionAtlasiP35663. baseline and differential.
GenevisibleiP35663. HS.

Organism-specific databases

HPAiHPA000696.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331556.

Structurei

3D structure databases

ProteinModelPortaliP35663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati278 – 305281Add
BLAST
Repeati306 – 342372Add
BLAST
Repeati343 – 379373Add
BLAST
Repeati380 – 417384Add
BLAST
Repeati418 – 453365Add
BLAST
Repeati454 – 491386Add
BLAST
Repeati492 – 531407Add
BLAST
Repeati532 – 553228Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni532 – 553228 X approximate tandem repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi601 – 65151Pro-richAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG116362.
GeneTreeiENSGT00730000111075.
HOGENOMiHOG000112130.
HOVERGENiHBG081397.
InParanoidiP35663.
OMAiSHENEQS.
OrthoDBiEOG7XH6RP.
PhylomeDBiP35663.
TreeFamiTF337809.

Family and domain databases

InterProiIPR026189. CYLC.
IPR029354. Cylicin_N.
[Graphical view]
PANTHERiPTHR16742. PTHR16742. 1 hit.
PfamiPF15241. Cylicin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR
60 70 80 90 100
PLKSQITVTR HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF
110 120 130 140 150
RHLYTSKTHL KKAEYKKSKD EKGGTPLKKD SKKKGGSYAT NPESKQIVEE
160 170 180 190 200
KTKRQNEADK TPLKSSHENE QSKKSKSSSE TNPESQNSKT VSKNCSQKDK
210 220 230 240 250
KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE NSLNVDFLML
260 270 280 290 300
VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES
310 320 330 340 350
EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD
360 370 380 390 400
KKKLKKDDKK KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA
410 420 430 440 450
KKITFSTDSE SELESKESQK DEKKDKKDSK TDNKKSVKND EESTDADSEP
460 470 480 490 500
KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN AESTEMESDL ELKKDKKHSK
510 520 530 540 550
EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG SDTESEESLY
560 570 580 590 600
KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV
610 620 630 640 650
PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL

L
Length:651
Mass (Da):74,242
Last modified:October 11, 2005 - v2
Checksum:iEF63B156ADE67B85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541S → G in CAA80457 (PubMed:8354692).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti399 – 3991D → H.
Corresponds to variant rs12008888 [ dbSNP | Ensembl ].
VAR_050937

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627233 Genomic DNA. Translation: CAI40037.1.
BC126461 mRNA. Translation: AAI26462.1.
Z22780 mRNA. Translation: CAA80457.1.
CCDSiCCDS35341.1.
PIRiB40713.
RefSeqiNP_066941.1. NM_021118.2.
UniGeneiHs.444230.

Genome annotation databases

EnsembliENST00000329312; ENSP00000331556; ENSG00000183035.
GeneIDi1538.
KEGGihsa:1538.
UCSCiuc004eeh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627233 Genomic DNA. Translation: CAI40037.1.
BC126461 mRNA. Translation: AAI26462.1.
Z22780 mRNA. Translation: CAA80457.1.
CCDSiCCDS35341.1.
PIRiB40713.
RefSeqiNP_066941.1. NM_021118.2.
UniGeneiHs.444230.

3D structure databases

ProteinModelPortaliP35663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331556.

PTM databases

PhosphoSiteiP35663.

Polymorphism and mutation databases

DMDMi77416856.

Proteomic databases

PaxDbiP35663.
PRIDEiP35663.

Protocols and materials databases

DNASUi1538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329312; ENSP00000331556; ENSG00000183035.
GeneIDi1538.
KEGGihsa:1538.
UCSCiuc004eeh.2. human.

Organism-specific databases

CTDi1538.
GeneCardsiGC0XP083116.
HGNCiHGNC:2582. CYLC1.
HPAiHPA000696.
MIMi300768. gene.
neXtProtiNX_P35663.
PharmGKBiPA27082.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG116362.
GeneTreeiENSGT00730000111075.
HOGENOMiHOG000112130.
HOVERGENiHBG081397.
InParanoidiP35663.
OMAiSHENEQS.
OrthoDBiEOG7XH6RP.
PhylomeDBiP35663.
TreeFamiTF337809.

Miscellaneous databases

GenomeRNAii1538.
NextBioi6361.
PROiP35663.
SOURCEiSearch...

Gene expression databases

BgeeiP35663.
CleanExiHS_CYLC1.
ExpressionAtlasiP35663. baseline and differential.
GenevisibleiP35663. HS.

Family and domain databases

InterProiIPR026189. CYLC.
IPR029354. Cylicin_N.
[Graphical view]
PANTHERiPTHR16742. PTHR16742. 1 hit.
PfamiPF15241. Cylicin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton."
    Hess H., Heid H., Franke W.W.
    J. Cell Biol. 122:1043-1052(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-651.
    Tissue: Testis.

Entry informationi

Entry nameiCYLC1_HUMAN
AccessioniPrimary (citable) accession number: P35663
Secondary accession number(s): A0AVQ8, Q5JQQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.