Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35663

- CYLC1_HUMAN

UniProt

P35663 - CYLC1_HUMAN

Protein

Cylicin-1

Gene

CYLC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (11 Oct 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

    GO - Molecular functioni

    1. structural constituent of cytoskeleton Source: InterPro
    2. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. spermatogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cylicin-1
    Alternative name(s):
    Cylicin I
    Multiple-band polypeptide I
    Gene namesi
    Name:CYLC1
    Synonyms:CYL, CYL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:2582. CYLC1.

    Subcellular locationi

    Cytoplasmcytoskeletonperinuclear thecacalyx
    Note: Sperm head cytoskeletal structure.

    GO - Cellular componenti

    1. acrosomal matrix Source: MGI
    2. cytoskeletal calyx Source: UniProtKB-SubCell
    3. nucleus Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27082.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 651651Cylicin-1PRO_0000079753Add
    BLAST

    Proteomic databases

    PaxDbiP35663.
    PRIDEiP35663.

    PTM databases

    PhosphoSiteiP35663.

    Expressioni

    Tissue specificityi

    Testis.

    Developmental stagei

    Specific to late spermatogenesis.

    Gene expression databases

    BgeeiP35663.
    CleanExiHS_CYLC1.
    GenevestigatoriP35663.

    Organism-specific databases

    HPAiHPA000696.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331556.

    Structurei

    3D structure databases

    ProteinModelPortaliP35663.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati278 – 305281Add
    BLAST
    Repeati306 – 342372Add
    BLAST
    Repeati343 – 379373Add
    BLAST
    Repeati380 – 417384Add
    BLAST
    Repeati418 – 453365Add
    BLAST
    Repeati454 – 491386Add
    BLAST
    Repeati492 – 531407Add
    BLAST
    Repeati532 – 553228Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni532 – 553228 X approximate tandem repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi601 – 65151Pro-richAdd
    BLAST

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG116362.
    HOGENOMiHOG000112130.
    HOVERGENiHBG081397.
    InParanoidiP35663.
    OMAiSHENEQS.
    OrthoDBiEOG7XH6RP.
    PhylomeDBiP35663.
    TreeFamiTF337809.

    Family and domain databases

    InterProiIPR026189. CYLC.
    IPR029354. Cylicin_N.
    [Graphical view]
    PANTHERiPTHR16742. PTHR16742. 1 hit.
    PfamiPF15241. Cylicin_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35663-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR    50
    PLKSQITVTR HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF 100
    RHLYTSKTHL KKAEYKKSKD EKGGTPLKKD SKKKGGSYAT NPESKQIVEE 150
    KTKRQNEADK TPLKSSHENE QSKKSKSSSE TNPESQNSKT VSKNCSQKDK 200
    KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE NSLNVDFLML 250
    VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES 300
    EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD 350
    KKKLKKDDKK KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA 400
    KKITFSTDSE SELESKESQK DEKKDKKDSK TDNKKSVKND EESTDADSEP 450
    KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN AESTEMESDL ELKKDKKHSK 500
    EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG SDTESEESLY 550
    KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV 600
    PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL 650
    L 651
    Length:651
    Mass (Da):74,242
    Last modified:October 11, 2005 - v2
    Checksum:iEF63B156ADE67B85
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541S → G in CAA80457. (PubMed:8354692)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti399 – 3991D → H.
    Corresponds to variant rs12008888 [ dbSNP | Ensembl ].
    VAR_050937

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL627233 Genomic DNA. Translation: CAI40037.1.
    BC126461 mRNA. Translation: AAI26462.1.
    Z22780 mRNA. Translation: CAA80457.1.
    CCDSiCCDS35341.1.
    PIRiB40713.
    RefSeqiNP_066941.1. NM_021118.2.
    UniGeneiHs.444230.

    Genome annotation databases

    EnsembliENST00000329312; ENSP00000331556; ENSG00000183035.
    GeneIDi1538.
    KEGGihsa:1538.
    UCSCiuc004eeh.2. human.

    Polymorphism databases

    DMDMi77416856.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL627233 Genomic DNA. Translation: CAI40037.1 .
    BC126461 mRNA. Translation: AAI26462.1 .
    Z22780 mRNA. Translation: CAA80457.1 .
    CCDSi CCDS35341.1.
    PIRi B40713.
    RefSeqi NP_066941.1. NM_021118.2.
    UniGenei Hs.444230.

    3D structure databases

    ProteinModelPortali P35663.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331556.

    PTM databases

    PhosphoSitei P35663.

    Polymorphism databases

    DMDMi 77416856.

    Proteomic databases

    PaxDbi P35663.
    PRIDEi P35663.

    Protocols and materials databases

    DNASUi 1538.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329312 ; ENSP00000331556 ; ENSG00000183035 .
    GeneIDi 1538.
    KEGGi hsa:1538.
    UCSCi uc004eeh.2. human.

    Organism-specific databases

    CTDi 1538.
    GeneCardsi GC0XP083116.
    HGNCi HGNC:2582. CYLC1.
    HPAi HPA000696.
    MIMi 300768. gene.
    neXtProti NX_P35663.
    PharmGKBi PA27082.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116362.
    HOGENOMi HOG000112130.
    HOVERGENi HBG081397.
    InParanoidi P35663.
    OMAi SHENEQS.
    OrthoDBi EOG7XH6RP.
    PhylomeDBi P35663.
    TreeFami TF337809.

    Miscellaneous databases

    GenomeRNAii 1538.
    NextBioi 6361.
    PROi P35663.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35663.
    CleanExi HS_CYLC1.
    Genevestigatori P35663.

    Family and domain databases

    InterProi IPR026189. CYLC.
    IPR029354. Cylicin_N.
    [Graphical view ]
    PANTHERi PTHR16742. PTHR16742. 1 hit.
    Pfami PF15241. Cylicin_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton."
      Hess H., Heid H., Franke W.W.
      J. Cell Biol. 122:1043-1052(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-651.
      Tissue: Testis.

    Entry informationi

    Entry nameiCYLC1_HUMAN
    AccessioniPrimary (citable) accession number: P35663
    Secondary accession number(s): A0AVQ8, Q5JQQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3