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P35663

- CYLC1_HUMAN

UniProt

P35663 - CYLC1_HUMAN

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Protein

Cylicin-1

Gene

CYLC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: InterPro
  2. structural molecule activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cylicin-1
Alternative name(s):
Cylicin I
Multiple-band polypeptide I
Gene namesi
Name:CYLC1
Synonyms:CYL, CYL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:2582. CYLC1.

Subcellular locationi

Cytoplasmcytoskeletonperinuclear thecacalyx
Note: Sperm head cytoskeletal structure.

GO - Cellular componenti

  1. acrosomal matrix Source: MGI
  2. cytoskeleton Source: UniProtKB-KW
  3. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 651651Cylicin-1PRO_0000079753Add
BLAST

Proteomic databases

PaxDbiP35663.
PRIDEiP35663.

PTM databases

PhosphoSiteiP35663.

Expressioni

Tissue specificityi

Testis.

Developmental stagei

Specific to late spermatogenesis.

Gene expression databases

BgeeiP35663.
CleanExiHS_CYLC1.
GenevestigatoriP35663.

Organism-specific databases

HPAiHPA000696.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331556.

Structurei

3D structure databases

ProteinModelPortaliP35663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati278 – 305281Add
BLAST
Repeati306 – 342372Add
BLAST
Repeati343 – 379373Add
BLAST
Repeati380 – 417384Add
BLAST
Repeati418 – 453365Add
BLAST
Repeati454 – 491386Add
BLAST
Repeati492 – 531407Add
BLAST
Repeati532 – 553228Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni532 – 553228 X approximate tandem repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi601 – 65151Pro-richAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG116362.
GeneTreeiENSGT00730000111075.
HOGENOMiHOG000112130.
HOVERGENiHBG081397.
InParanoidiP35663.
OMAiSHENEQS.
OrthoDBiEOG7XH6RP.
PhylomeDBiP35663.
TreeFamiTF337809.

Family and domain databases

InterProiIPR026189. CYLC.
IPR029354. Cylicin_N.
[Graphical view]
PANTHERiPTHR16742. PTHR16742. 1 hit.
PfamiPF15241. Cylicin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35663-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR
60 70 80 90 100
PLKSQITVTR HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF
110 120 130 140 150
RHLYTSKTHL KKAEYKKSKD EKGGTPLKKD SKKKGGSYAT NPESKQIVEE
160 170 180 190 200
KTKRQNEADK TPLKSSHENE QSKKSKSSSE TNPESQNSKT VSKNCSQKDK
210 220 230 240 250
KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE NSLNVDFLML
260 270 280 290 300
VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES
310 320 330 340 350
EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD
360 370 380 390 400
KKKLKKDDKK KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA
410 420 430 440 450
KKITFSTDSE SELESKESQK DEKKDKKDSK TDNKKSVKND EESTDADSEP
460 470 480 490 500
KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN AESTEMESDL ELKKDKKHSK
510 520 530 540 550
EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG SDTESEESLY
560 570 580 590 600
KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV
610 620 630 640 650
PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL

L
Length:651
Mass (Da):74,242
Last modified:October 11, 2005 - v2
Checksum:iEF63B156ADE67B85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541S → G in CAA80457. (PubMed:8354692)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti399 – 3991D → H.
Corresponds to variant rs12008888 [ dbSNP | Ensembl ].
VAR_050937

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL627233 Genomic DNA. Translation: CAI40037.1.
BC126461 mRNA. Translation: AAI26462.1.
Z22780 mRNA. Translation: CAA80457.1.
CCDSiCCDS35341.1.
PIRiB40713.
RefSeqiNP_066941.1. NM_021118.2.
UniGeneiHs.444230.

Genome annotation databases

EnsembliENST00000329312; ENSP00000331556; ENSG00000183035.
GeneIDi1538.
KEGGihsa:1538.
UCSCiuc004eeh.2. human.

Polymorphism databases

DMDMi77416856.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL627233 Genomic DNA. Translation: CAI40037.1 .
BC126461 mRNA. Translation: AAI26462.1 .
Z22780 mRNA. Translation: CAA80457.1 .
CCDSi CCDS35341.1.
PIRi B40713.
RefSeqi NP_066941.1. NM_021118.2.
UniGenei Hs.444230.

3D structure databases

ProteinModelPortali P35663.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331556.

PTM databases

PhosphoSitei P35663.

Polymorphism databases

DMDMi 77416856.

Proteomic databases

PaxDbi P35663.
PRIDEi P35663.

Protocols and materials databases

DNASUi 1538.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329312 ; ENSP00000331556 ; ENSG00000183035 .
GeneIDi 1538.
KEGGi hsa:1538.
UCSCi uc004eeh.2. human.

Organism-specific databases

CTDi 1538.
GeneCardsi GC0XP083116.
HGNCi HGNC:2582. CYLC1.
HPAi HPA000696.
MIMi 300768. gene.
neXtProti NX_P35663.
PharmGKBi PA27082.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG116362.
GeneTreei ENSGT00730000111075.
HOGENOMi HOG000112130.
HOVERGENi HBG081397.
InParanoidi P35663.
OMAi SHENEQS.
OrthoDBi EOG7XH6RP.
PhylomeDBi P35663.
TreeFami TF337809.

Miscellaneous databases

GenomeRNAii 1538.
NextBioi 6361.
PROi P35663.
SOURCEi Search...

Gene expression databases

Bgeei P35663.
CleanExi HS_CYLC1.
Genevestigatori P35663.

Family and domain databases

InterProi IPR026189. CYLC.
IPR029354. Cylicin_N.
[Graphical view ]
PANTHERi PTHR16742. PTHR16742. 1 hit.
Pfami PF15241. Cylicin_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton."
    Hess H., Heid H., Franke W.W.
    J. Cell Biol. 122:1043-1052(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-651.
    Tissue: Testis.

Entry informationi

Entry nameiCYLC1_HUMAN
AccessioniPrimary (citable) accession number: P35663
Secondary accession number(s): A0AVQ8, Q5JQQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3