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P35663 (CYLC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cylicin-1
Alternative name(s):
Cylicin I
Multiple-band polypeptide I
Gene names
Name:CYLC1
Synonyms:CYL, CYL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length651 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

Subcellular location

Cytoplasmcytoskeletonperinuclear thecacalyx. Note: Sperm head cytoskeletal structure.

Tissue specificity

Testis.

Developmental stage

Specific to late spermatogenesis.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityPolymorphism
   DomainRepeat
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

spermatogenesis

Non-traceable author statement Ref.3. Source: UniProtKB

   Cellular_componentacrosomal matrix

Inferred from direct assay Ref.3. Source: MGI

cytoskeletal calyx

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural constituent of cytoskeleton

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Non-traceable author statement Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 651651Cylicin-1
PRO_0000079753

Regions

Repeat278 – 305281
Repeat306 – 342372
Repeat343 – 379373
Repeat380 – 417384
Repeat418 – 453365
Repeat454 – 491386
Repeat492 – 531407
Repeat532 – 553228
Region532 – 553228 X approximate tandem repeats
Compositional bias601 – 65151Pro-rich

Natural variations

Natural variant3991D → H.
Corresponds to variant rs12008888 [ dbSNP | Ensembl ].
VAR_050937

Experimental info

Sequence conflict541S → G in CAA80457. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P35663 [UniParc].

Last modified October 11, 2005. Version 2.
Checksum: EF63B156ADE67B85

FASTA65174,242
        10         20         30         40         50         60 
MSLPRLLKVN IRTYDNSIPI SESSRKSWNQ KHFALTFPKP LQRGTNDKSR PLKSQITVTR 

        70         80         90        100        110        120 
HDKRKLEEGQ KPAHKWIRHS FRKILQWPPI YTAAREQTPF RHLYTSKTHL KKAEYKKSKD 

       130        140        150        160        170        180 
EKGGTPLKKD SKKKGGSYAT NPESKQIVEE KTKRQNEADK TPLKSSHENE QSKKSKSSSE 

       190        200        210        220        230        240 
TNPESQNSKT VSKNCSQKDK KDSKNSKKTN TEFLHTKNNP KKDLKRSKTS NDPISEICSE 

       250        260        270        280        290        300 
NSLNVDFLML VGQSDDESIN FDAWLRNYSQ NNSKNYSLKY TKYTKKDTKK NAKKSSDAES 

       310        320        330        340        350        360 
EDSKDAKKDS KKVKKNVKKD DKKKDVKKDT ESTDAESGDS KDERKDTKKD KKKLKKDDKK 

       370        380        390        400        410        420 
KDTKKYPEST DTESGDAKDA RNDSRNLKKA SKNDDKKKDA KKITFSTDSE SELESKESQK 

       430        440        450        460        470        480 
DEKKDKKDSK TDNKKSVKND EESTDADSEP KGDSKKGKKD EKKGKKDSKK DDKKKDAKKN 

       490        500        510        520        530        540 
AESTEMESDL ELKKDKKHSK EKKGSKKDIK KDARKDTEST DAEFDESSKT GFKTSTKIKG 

       550        560        570        580        590        600 
SDTESEESLY KPGAKKKIDE SDGTSANSKM EGLESKRGFR MSSKKTTFNE KGEKASTGRV 

       610        620        630        640        650 
PPSREKPPLP ACEPSLPSPK VRRLCWCKMP PPPPKPRYAP LPEAPWIHKL L 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton."
Hess H., Heid H., Franke W.W.
J. Cell Biol. 122:1043-1052(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-651.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL627233 Genomic DNA. Translation: CAI40037.1.
BC126461 mRNA. Translation: AAI26462.1.
Z22780 mRNA. Translation: CAA80457.1.
PIRB40713.
RefSeqNP_066941.1. NM_021118.2.
UniGeneHs.444230.

3D structure databases

ProteinModelPortalP35663.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000331556.

PTM databases

PhosphoSiteP35663.

Polymorphism databases

DMDM77416856.

Proteomic databases

PaxDbP35663.
PRIDEP35663.

Protocols and materials databases

DNASU1538.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329312; ENSP00000331556; ENSG00000183035.
GeneID1538.
KEGGhsa:1538.
UCSCuc004eeh.2. human.

Organism-specific databases

CTD1538.
GeneCardsGC0XP083116.
HGNCHGNC:2582. CYLC1.
HPAHPA000696.
MIM300768. gene.
neXtProtNX_P35663.
PharmGKBPA27082.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG116362.
HOGENOMHOG000112130.
HOVERGENHBG081397.
InParanoidP35663.
OMASHENEQS.
OrthoDBEOG7XH6RP.
PhylomeDBP35663.
TreeFamTF337809.

Gene expression databases

BgeeP35663.
CleanExHS_CYLC1.
GenevestigatorP35663.

Family and domain databases

InterProIPR026189. CYLC.
[Graphical view]
PANTHERPTHR16742. PTHR16742. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi1538.
NextBio6361.
PROP35663.
SOURCESearch...

Entry information

Entry nameCYLC1_HUMAN
AccessionPrimary (citable) accession number: P35663
Secondary accession number(s): A0AVQ8, Q5JQQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM