Reviewed, UniProtKB/Swiss-Prot P35661 (GST27_SCHMA)

Names and origin

Protein names	Recommended name:     Glutathione S-transferase class-mu 26 kDa isozyme       Short name=GST 26     EC=2.5.1.18 Alternative name(s):     Sm26/2 antigen
Organism	Schistosoma mansoni (Blood fluke)
Taxonomic identifier	6183 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the GST superfamily. Mu family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Glutathione S-transferase class-mu 26 kDa isozyme		PRO_0000185811
Regions
	Domain	1 – 83	83	GST N-terminal
	Domain	85 – 203	119	GST C-terminal
Sites
	Active site	7	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35661-1 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: D8D3EE9028B36185	FASTA	218	25,411
	10 20 30 40 50 60 MAPKLGYWKI KGLVQPTRLL LEYLGERYEE RLYDRNDGDV WRNEKFKLGL DFPNLPYYID 70 80 90 100 110 120 GDVKLTQSMA ILRYIADKHN MLGGCPKERA EISMLEGAIL DIRYGVSRIA YNKEFETLKV 130 140 150 160 170 180 DFLNQLPGML KMFEDRLSHN TYLNGDKVTH PDFMLYDALD VVLYMDPKCL DNFPKLISFK 190 200 210 QRIENLPPIK NYLNSNRYIK WPLQGWSATF GGGDAPPK

References

[1]	"Another 26-kilodalton glutathione S-transferase of Schistosoma mansoni." Wright M.D., Harrison R.A., Melder A.M., Newport G.R., Mitchell G.F. Mol. Biochem. Parasitol. 49:177-179(1991) [PubMed: 1775156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M73624 mRNA. No translation available.
PIR	A45556.
3D structure databases
HSSP	HSSP built from PDB template 1GTA based on UniProtKB P08515.
SMR	P35661. Positions 2-218.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.18. 1460.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GST27_SCHMA

Accession

Primary (citable) accession number: P35661

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	March 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)