Reviewed,
UniProtKB/Swiss-Prot P35660 (DDL_ANACE)
Last modified
June 16, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: D-alanine--D-alanine ligase EC=6.3.2.4 Alternative name(s): D-alanylalanine synthetase D-Ala-D-Ala ligase | ||
| Gene names |
| ||
| Organism | Anaplasma centrale | ||
| Taxonomic identifier | 769 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma |
Protein attributes
| Sequence length | 205 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cell wall formation. HAMAP MF_00047 |
| Catalytic activity | ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP MF_00047 |
| Cofactor | Binds 2 magnesium or manganese ions per subunit By similarity. |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00047 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the D-alanine--D-alanine ligase family. Contains 1 ATP-grasp domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Manganese Nucleotide-binding |
| Molecular function | Ligase |
| Gene Ontology (GO) | |
| Biological process | cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic processInferred from electronic annotation. Source: HAMAP regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cell wall Inferred from electronic annotation. Source: InterPro cytoplasmInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-D-alanine ligase activityInferred from electronic annotation. Source: HAMAP magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – ›205 | ›205 | D-alanine--D-alanine ligase HAMAP MF_00047 | PRO_0000177778 | |||||
Regions | |||||||||
| Domain | 111 – ›205 | ›95 | ATP-grasp | ||||||
| Nucleotide binding | 139 – 190 | 52 | ATP By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 205 | 1 | |||||||
Sequences
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References
| [1] | "Sequence of a putative glutathione synthetase II gene and flanking regions from Anaplasma centrale." Peters J.M., Dalrymple B.P., Jorgensen W.K. Biochem. Biophys. Res. Commun. 182:1040-1046(1992) [PubMed: 1540152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| M80425 Genomic DNA. Translation: AAA22065.1. | |
| PIR | PQ0272. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IOW based on UniProtKB P07862. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 6.3.2.4. 292244. |
Family and domain databases | |
| HAMAP | MF_00047. [Tree] |
| InterPro | IPR011761. ATP-grasp. IPR013815. ATP_grasp_subdomain_1. IPR000291. D-Ala_lig_Van_CS. IPR011127. Dala_Dala_lig_N. IPR013817. Pre-ATP_grasp. [Graphical view] |
| Gene3D | G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| Pfam | PF01820. Dala_Dala_lig_N. 1 hit. [Graphical view] |
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS00843. DALA_DALA_LIGASE_1. 1 hit. PS00844. DALA_DALA_LIGASE_2. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DDL_ANACE | ||||||||
| Accession | Primary (citable) accession number: P35660 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


