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P35660 (DDL_ANACE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
OrganismAnaplasma centrale
Taxonomic identifier769 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasma

Protein attributes

Sequence length205 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation.

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›205›205D-alanine--D-alanine ligase
PRO_0000177778

Regions

Domain111 – ›205›95ATP-grasp
Nucleotide binding139 – 19052ATP By similarity

Experimental info

Non-terminal residue2051

Sequences

Sequence LengthMass (Da)Tools
P35660 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 0FC7855DFB10A636

FASTA20521,656
        10         20         30         40         50         60 
MPVGLACNAD DVLSIAVLCG GSSPEREVSL AGGKRIADAL GRLGHRAAVV DLNRESAHQL 

        70         80         90        100        110        120 
LAMAPDLVYN ALHGGQGEDG CASGLLDILG LAYTHSRVAA SSVGMDKVLT KHVLKSLGID 

       130        140        150        160        170        180 
FPEFSVLTKE EVLSAKEVMP YPFVIKPICG GSTIGVHAIF SRSEYLDLSV HADALEGRML 

       190        200 
VEEYIPGQEV HTAVFLGRAI GTMEF 

« Hide

References

[1]"Sequence of a putative glutathione synthetase II gene and flanking regions from Anaplasma centrale."
Peters J.M., Dalrymple B.P., Jorgensen W.K.
Biochem. Biophys. Res. Commun. 182:1040-1046(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80425 Genomic DNA. Translation: AAA22065.1.
PIRPQ0272.

3D structure databases

ProteinModelPortalP35660.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1181.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_ANACE
AccessionPrimary (citable) accession number: P35660
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways