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Protein

Protein DEK

Gene

DEK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in chromatin organization.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi337 – 35115Add
BLAST
DNA bindingi367 – 3715

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • histone binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • positive regulation of gene expression, epigenetic Source: Reactome
  • regulation of double-strand break repair Source: MGI
  • regulation of double-strand break repair via nonhomologous end joining Source: Ensembl
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • signal transduction Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc
  • viral genome replication Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-5250924. B-WICH complex positively regulates rRNA expression.
SIGNORiP35659.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DEK
Gene namesi
Name:DEK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:2768. DEK.

Subcellular locationi

GO - Cellular componenti

  • contractile fiber Source: Ensembl
  • nucleoplasm Source: Reactome
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MalaCardsiDEK.
Orphaneti402014. 'Acute myeloid leukemia with t(6;9)(p23;q34)'.
PharmGKBiPA27251.

Polymorphism and mutation databases

BioMutaiDEK.
DMDMi544150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 375374Protein DEKPRO_0000079858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources1 Publication
Modified residuei13 – 131PhosphothreonineCombined sources
Modified residuei15 – 151PhosphothreonineBy similarity
Modified residuei19 – 191PhosphoserineCombined sources
Modified residuei32 – 321Phosphoserine; by CK2Combined sources1 Publication
Modified residuei51 – 511PhosphoserineCombined sources
Modified residuei72 – 721PhosphoserineCombined sources
Modified residuei121 – 1211PhosphoserineCombined sources
Modified residuei122 – 1221PhosphoserineCombined sources
Modified residuei159 – 1591Phosphoserine; by CK21 Publication
Modified residuei199 – 1991Phosphothreonine; by CK21 Publication
Modified residuei201 – 2011Phosphoserine; by CK21 Publication
Modified residuei204 – 2041Phosphoserine; by CK21 Publication
Modified residuei210 – 2101PhosphoserineCombined sources
Modified residuei227 – 2271PhosphoserineCombined sources
Modified residuei230 – 2301PhosphoserineCombined sources
Modified residuei231 – 2311PhosphoserineCombined sources
Modified residuei232 – 2321PhosphoserineCombined sources
Modified residuei243 – 2431Phosphoserine; by CK21 Publication
Modified residuei244 – 2441Phosphoserine; by CK21 Publication
Modified residuei251 – 2511Phosphoserine; by CK21 Publication
Modified residuei287 – 2871Phosphoserine; by CK21 Publication
Modified residuei288 – 2881Phosphoserine; by CK21 Publication
Modified residuei289 – 2891Phosphothreonine; by CK21 Publication
Modified residuei290 – 2901Phosphothreonine; by CK21 Publication
Modified residuei296 – 2961Phosphoserine; by CK21 Publication
Modified residuei301 – 3011Phosphoserine; by CK2Combined sources1 Publication
Modified residuei303 – 3031Phosphoserine; by CK2Combined sources1 Publication
Modified residuei306 – 3061Phosphoserine; by CK2Combined sources1 Publication
Modified residuei307 – 3071Phosphoserine; by CK2Combined sources1 Publication

Post-translational modificationi

Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP35659.
MaxQBiP35659.
PaxDbiP35659.
PeptideAtlasiP35659.
PRIDEiP35659.

PTM databases

iPTMnetiP35659.
PhosphoSiteiP35659.
SwissPalmiP35659.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at relatively high levels.

Gene expression databases

BgeeiENSG00000124795.
CleanExiHS_DEK.
ExpressionAtlasiP35659. baseline and differential.
GenevisibleiP35659. HS.

Organism-specific databases

HPAiCAB015226.
HPA054505.
HPA057799.

Interactioni

Subunit structurei

Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.3 Publications

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113643. 53 interactions.
IntActiP35659. 18 interactions.
MINTiMINT-2802925.
STRINGi9606.ENSP00000380414.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni88 – 903Combined sources
Helixi92 – 998Combined sources
Helixi103 – 11210Combined sources
Beta strandi114 – 1163Combined sources
Helixi121 – 1288Combined sources
Helixi140 – 16223Combined sources
Turni163 – 1653Combined sources
Helixi172 – 18110Combined sources
Turni182 – 1843Combined sources
Helixi322 – 33312Combined sources
Helixi338 – 3403Combined sources
Helixi343 – 35311Combined sources
Beta strandi355 – 3573Combined sources
Helixi361 – 37515Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q1VNMR-A309-375[»]
2JX3NMR-A78-208[»]
ProteinModelPortaliP35659.
SMRiP35659. Positions 78-187, 309-375.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35659.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 18335SAPAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi205 – 22117Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 4920Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi228 – 2369Asp/Glu-rich (acidic)
Compositional biasi241 – 25414Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi300 – 31011Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 1 SAP domain.Curated

Phylogenomic databases

eggNOGiKOG2266. Eukaryota.
ENOG410XTJA. LUCA.
GeneTreeiENSGT00390000017282.
HOGENOMiHOG000059552.
HOVERGENiHBG004944.
InParanoidiP35659.
KOiK17046.
OMAiXPLPKSK.
OrthoDBiEOG091G0UKX.
PhylomeDBiP35659.
TreeFamiTF324696.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR014876. DEK_C.
IPR009057. Homeodomain-like.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF08766. DEK_C. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35659-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK
60 70 80 90 100
SLIVEGKREK KKVERLTMQV SSLQREPFTI AQGKGQKLCE IERIHFFLSK
110 120 130 140 150
KKTDELRNLH KLLYNRPGTV SSLKKNVGQF SGFPFEKGSV QYKKKEEMLK
160 170 180 190 200
KFRNAMLKSI CEVLDLERSG VNSELVKRIL NFLMHPKPSG KPLPKSKKTC
210 220 230 240 250
SKGSKKERNS SGMARKAKRT KCPEILSDES SSDEDEKKNK EESSDDEDKE
260 270 280 290 300
SEEEPPKKTA KREKPKQKAT SKSKKSVKSA NVKKADSSTT KKNQNSSKKE
310 320 330 340 350
SESEDSSDDE PLIKKLKKPP TDEELKETIK KLLASANLEE VTMKQICKKV
360 370
YENYPTYDLT ERKDFIKTTV KELIS
Length:375
Mass (Da):42,674
Last modified:June 1, 1994 - v1
Checksum:iC07D22B37B719A23
GO
Isoform 2 (identifier: P35659-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-82: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):38,705
Checksum:i7BA02406C674EDD4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401V → A.
Corresponds to variant rs17336208 [ dbSNP | Ensembl ].
VAR_050949

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei49 – 8234Missing in isoform 2. 1 PublicationVSP_042951Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64229 mRNA. Translation: CAA45536.1.
AK297749 mRNA. Translation: BAG60099.1.
AK312616 mRNA. Translation: BAG35503.1.
AL031774 Genomic DNA. Translation: CAI20082.2.
CH471087 Genomic DNA. Translation: EAW55402.1.
BC035259 mRNA. Translation: AAH35259.1.
CCDSiCCDS34344.1. [P35659-1]
CCDS47382.1. [P35659-2]
PIRiS26059.
RefSeqiNP_001128181.1. NM_001134709.1. [P35659-2]
NP_003463.1. NM_003472.3. [P35659-1]
UniGeneiHs.484813.

Genome annotation databases

EnsembliENST00000244776; ENSP00000244776; ENSG00000124795. [P35659-2]
ENST00000397239; ENSP00000380414; ENSG00000124795. [P35659-1]
GeneIDi7913.
KEGGihsa:7913.
UCSCiuc003ncr.2. human. [P35659-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64229 mRNA. Translation: CAA45536.1.
AK297749 mRNA. Translation: BAG60099.1.
AK312616 mRNA. Translation: BAG35503.1.
AL031774 Genomic DNA. Translation: CAI20082.2.
CH471087 Genomic DNA. Translation: EAW55402.1.
BC035259 mRNA. Translation: AAH35259.1.
CCDSiCCDS34344.1. [P35659-1]
CCDS47382.1. [P35659-2]
PIRiS26059.
RefSeqiNP_001128181.1. NM_001134709.1. [P35659-2]
NP_003463.1. NM_003472.3. [P35659-1]
UniGeneiHs.484813.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q1VNMR-A309-375[»]
2JX3NMR-A78-208[»]
ProteinModelPortaliP35659.
SMRiP35659. Positions 78-187, 309-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113643. 53 interactions.
IntActiP35659. 18 interactions.
MINTiMINT-2802925.
STRINGi9606.ENSP00000380414.

PTM databases

iPTMnetiP35659.
PhosphoSiteiP35659.
SwissPalmiP35659.

Polymorphism and mutation databases

BioMutaiDEK.
DMDMi544150.

Proteomic databases

EPDiP35659.
MaxQBiP35659.
PaxDbiP35659.
PeptideAtlasiP35659.
PRIDEiP35659.

Protocols and materials databases

DNASUi7913.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244776; ENSP00000244776; ENSG00000124795. [P35659-2]
ENST00000397239; ENSP00000380414; ENSG00000124795. [P35659-1]
GeneIDi7913.
KEGGihsa:7913.
UCSCiuc003ncr.2. human. [P35659-1]

Organism-specific databases

CTDi7913.
GeneCardsiDEK.
HGNCiHGNC:2768. DEK.
HPAiCAB015226.
HPA054505.
HPA057799.
MalaCardsiDEK.
MIMi125264. gene.
neXtProtiNX_P35659.
Orphaneti402014. 'Acute myeloid leukemia with t(6;9)(p23;q34)'.
PharmGKBiPA27251.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2266. Eukaryota.
ENOG410XTJA. LUCA.
GeneTreeiENSGT00390000017282.
HOGENOMiHOG000059552.
HOVERGENiHBG004944.
InParanoidiP35659.
KOiK17046.
OMAiXPLPKSK.
OrthoDBiEOG091G0UKX.
PhylomeDBiP35659.
TreeFamiTF324696.

Enzyme and pathway databases

ReactomeiR-HSA-5250924. B-WICH complex positively regulates rRNA expression.
SIGNORiP35659.

Miscellaneous databases

ChiTaRSiDEK. human.
EvolutionaryTraceiP35659.
GeneWikiiDEK_(gene).
GenomeRNAii7913.
PROiP35659.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124795.
CleanExiHS_DEK.
ExpressionAtlasiP35659. baseline and differential.
GenevisibleiP35659. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR014876. DEK_C.
IPR009057. Homeodomain-like.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF08766. DEK_C. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEK_HUMAN
AccessioniPrimary (citable) accession number: P35659
Secondary accession number(s): B2R6K6
, B4DN37, Q5TGV4, Q5TGV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.