Reviewed, UniProtKB/Swiss-Prot P35658 (NU214_HUMAN)

Names and origin

Protein names

Recommended name:
    Nuclear pore complex protein Nup214
Alternative name(s):
    Nucleoporin Nup214
    214 kDa nucleoporin
    Protein CAN

Gene names

Name:	NUP214
Synonyms:	CAIN, CAN, KIAA0023

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2090 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
Subunit structure	Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5. Ref.7 Ref.8
Subcellular location	Nucleus › nuclear pore complex. Note: Cytoplasmic filaments.
Tissue specificity	Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
Domain	Contains FG repeats.
Post-translational modification	Probably glycosylated as it reacts with wheat germ agglutinin (WGA).
Involvement in disease	A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET. Defects in NUP214 may be a cause of breast cancer.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Domain	Repeat
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: UniProtKB-KW mRNA transport Inferred from electronic annotation. Source: UniProtKB-KW protein export from nucleus Inferred from mutant phenotype. Source: MGI
Cellular component	cytosol Inferred from Experiment. Source: Reactome nuclear pore Ref.6 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB transporter activity Ref.6 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35658-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35658-2)

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N

Note: No experimental confirmation available.

Isoform 3 (identifier: P35658-3)

The sequence of this isoform differs from the canonical sequence as follows:
     648-648: S → SA

Note: No experimental confirmation available.

Isoform 4 (identifier: P35658-4)

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N
     648-648: S → SA

Isoform 5 (identifier: P35658-5)

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N
     1139-1148: Missing.
     2026-2090: FGSSSNTTSF...SVQGFGGWRS → SLAMSLSPTL...PTDFWFWDPE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2090	2090	Nuclear pore complex protein Nup214		PRO_0000204861
Regions
	Domain	740 – 768	29	Leucine-zipper 1
	Domain	861 – 882	22	Leucine-zipper 2
	Region	481 – 2076	1596	11 X 5 AA approximate repeats
	Region	1409 – 2084	676	18 X 4 AA approximate repeats
	Region	1427 – 2085	659	11 X 3 AA approximate repeats
	Compositional bias	1213 – 2090	878	Pro/Ser/Thr-rich
Sites
	Site	812 – 813	2	Breakpoint
Amino acid modifications
	Modified residue	40	1	Phosphoserine Ref.12
	Modified residue	416	1	Phosphothreonine Ref.14
	Modified residue	430	1	Phosphoserine Ref.9 Ref.15
	Modified residue	433	1	Phosphoserine Ref.15
	Modified residue	434	1	Phosphothreonine Ref.15
	Modified residue	437	1	Phosphothreonine Ref.9 Ref.15
	Modified residue	439	1	Phosphothreonine Ref.15
	Modified residue	646	1	Phosphoserine Ref.14
	Modified residue	651	1	Phosphoserine Ref.14
	Modified residue	657	1	Phosphoserine Ref.14
	Modified residue	666	1	Phosphoserine Ref.14 Ref.15 Ref.13
	Modified residue	670	1	Phosphothreonine Ref.14 Ref.15
	Modified residue	678	1	Phosphoserine Ref.14 Ref.15
	Modified residue	940	1	Phosphoserine Ref.14 Ref.15 Ref.10
	Modified residue	970	1	Phosphoserine Ref.14 Ref.15
	Modified residue	974	1	Phosphoserine Ref.15
	Modified residue	985	1	Phosphoserine Ref.15
	Modified residue	987	1	Phosphothreonine Ref.15
	Modified residue	989	1	Phosphoserine Ref.15
	Modified residue	1081	1	Phosphoserine Ref.14 Ref.10 Ref.11
	Modified residue	1156	1	Phosphothreonine Ref.14
	Modified residue	1181	1	Phosphoserine Ref.14
	Modified residue	1203	1	Phosphothreonine Ref.14
	Modified residue	1312	1	Phosphothreonine Ref.14
	Modified residue	1333	1	Phosphoserine Ref.14
	Modified residue	1356	1	Phosphoserine Ref.14
	Modified residue	1963	1	Phosphoserine Ref.15
Natural variations
	Alternative sequence	590 – 601	12	KFTAA…STPVS → N in isoform 2, isoform 4 and isoform 5.		VSP_034896
	Alternative sequence	648	1	S → SA in isoform 3 and isoform 4.		VSP_034897
	Alternative sequence	1139 – 1148	10	Missing in isoform 5.		VSP_034898
	Alternative sequence	2026 – 2090	65	FGSSS…GGWRS → SLAMSLSPTLKGRLLLMRPK AGGGREQAAPGRKSNESRSL GHLCMERALTSPLKVWEQQQ HHILRHARESECPHFRITVP TDFWFWDPE in isoform 5.		VSP_034899
	Natural variant	424	1	G → A in a breast cancer sample; somatic mutation. Ref.17		VAR_035856
	Natural variant	574	1	P → S: dbSNP rs103612. Ref.1 Ref.5		VAR_045691
	Natural variant	1378	1	P → L in a breast cancer sample; somatic mutation. Ref.17		VAR_035857
	Natural variant	1392	1	A → V in a breast cancer sample; somatic mutation. Ref.17		VAR_035858
Experimental info
	Sequence conflict	149	1	G → A in CAA45535. Ref.1
	Sequence conflict	175	1	A → D in CAA45535. Ref.1
	Sequence conflict	1091 – 1092	2	AA → QL in CAA45535. Ref.1
	Sequence conflict	1872	1	S → N in AAH45620. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: EE6F0F3DE3D522C6	FASTA	2,090	213,620
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEK FTAAATSTPV 610 620 630 640 650 660 SSSQSAPPMS PFSSASKPAA SGPLSHPTPL SAPPSSVPLK SSVLPSPSGR SAQGSSSPVP 670 680 690 700 710 720 SMVQKSPRIT PPAAKPGSPQ AKSLQPAVAE KQGHQWKDSD PVMAGIGEEI AHFQKELEEL 730 740 750 760 770 780 KARTSKACFQ VGTSEEMKML RTESDDLHTF LLEIKETTES LHGDISSLKT TLLEGFAGVE 790 800 810 820 830 840 EAREQNERNR DSGYLHLLYK RPLDPKSEAQ LQEIRRLHQY VKFAVQDVND VLDLEWDQHL 850 860 870 880 890 900 EQKKKQRHLL VPERETLFNT LANNREIINQ QRKRLNHLVD SLQQLRLYKQ TSLWSLSSAV 910 920 930 940 950 960 PSQSSIHSFD SDLESLCNAL LKTTIESHTK SLPKVPAKLS PMKQAQLRNF LAKRKTPPVR 970 980 990 1000 1010 1020 STAPASLSRS AFLSQRYYED LDEVSSTSSV SQSLESEDAR TSCKDDEAVV QAPRHAPVVR 1030 1040 1050 1060 1070 1080 TPSIQPSLLP HAAPFAKSHL VHGSSPGVMG TSVATSASKI IPQGADSTML ATKTVKHGAP 1090 1100 1110 1120 1130 1140 SPSHPISAPQ AAAAAALRRQ MASQAPAVNT LTESTLKNVP QVVNVQELKN NPATPSTAMG 1150 1160 1170 1180 1190 1200 SSVPYSTAKT PHPVLTPVAA NQAKQGSLIN SLKPSGPTPA SGQLSSGDKA SGTAKIETAV 1210 1220 1230 1240 1250 1260 TSTPSASGQF SKPFSFSPSG TGFNFGIITP TPSSNFTAAQ GATPSTKESS QPDAFSSGGG 1270 1280 1290 1300 1310 1320 SKPSYEAIPE SSPPSGITSA SNTTPGEPAA SSSRPVAPSG TALSTTSSKL ETPPSKLGEL 1330 1340 1350 1360 1370 1380 LFPSSLAGET LGSFSGLRVG QADDSTKPTN KASSTSLTST QPTKTSGVPS GFNFTAPPVL 1390 1400 1410 1420 1430 1440 GKHTEPPVTS SATTTSVAPP AATSTSSTAV FGSLPVTSAG SSGVISFGGT SLSAGKTSFS 1450 1460 1470 1480 1490 1500 FGSQQTNSTV PPSAPPPTTA ATPLPTSFPT LSFGSLLSSA TTPSLPMSAG RSTEEATSSA 1510 1520 1530 1540 1550 1560 LPEKPGDSEV SASAASLLEE QQSAQLPQAP PQTSDSVKKE PVLAQPAVSN SGTAASSTSL 1570 1580 1590 1600 1610 1620 VALSAEATPA TTGVPDARTE AVPPASSFSV PGQTAVTAAA ISSAGPVAVE TSSTPIASST 1630 1640 1650 1660 1670 1680 TSIVAPGPSA EAAAFGTVTS GSSVFAQPPA ASSSSAFNQL TNNTATAPSA TPVFGQVAAS 1690 1700 1710 1720 1730 1740 TAPSLFGQQT GSTASTAAAT PQVSSSGFSS PAFGTTAPGV FGQTTFGQAS VFGQSASSAA 1750 1760 1770 1780 1790 1800 SVFSFSQPGF SSVPAFGQPA SSTPTSTSGS VFGAASSTSS SSSFSFGQSS PNTGGGLFGQ 1810 1820 1830 1840 1850 1860 SNAPAFGQSP GFGQGGSVFG GTSAATTTAA TSGFSFCQAS GFGSSNTGSV FGQAASTGGI 1870 1880 1890 1900 1910 1920 VFGQQSSSSS GSVFGSGNTG RGGGFFSGLG GKPSQDAANK NPFSSASGGF GSTATSNTSN 1930 1940 1950 1960 1970 1980 LFGNSGAKTF GGFASSSFGE QKPTGTFSSG GGSVASQGFG FSSPNKTGGF GAAPVFGSPP 1990 2000 2010 2020 2030 2040 TFGGSPGFGG VPAFGSAPAF TSPLGSTGGK VFGEGTAAAS AGGFGFGSSS NTTSFGTLAS 2050 2060 2070 2080 2090 QNAPTFGSLS QQTSGFGTQS SGFSGFGSGT GGFSFGSNNS SVQGFGGWRS
	Isoform 2. Checksum: 159D32101C9DF54A	FASTA	2,079	212,571
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEN SSQSAPPMSP 610 620 630 640 650 660 FSSASKPAAS GPLSHPTPLS APPSSVPLKS SVLPSPSGRS AQGSSSPVPS MVQKSPRITP 670 680 690 700 710 720 PAAKPGSPQA KSLQPAVAEK QGHQWKDSDP VMAGIGEEIA HFQKELEELK ARTSKACFQV 730 740 750 760 770 780 GTSEEMKMLR TESDDLHTFL LEIKETTESL HGDISSLKTT LLEGFAGVEE AREQNERNRD 790 800 810 820 830 840 SGYLHLLYKR PLDPKSEAQL QEIRRLHQYV KFAVQDVNDV LDLEWDQHLE QKKKQRHLLV 850 860 870 880 890 900 PERETLFNTL ANNREIINQQ RKRLNHLVDS LQQLRLYKQT SLWSLSSAVP SQSSIHSFDS 910 920 930 940 950 960 DLESLCNALL KTTIESHTKS LPKVPAKLSP MKQAQLRNFL AKRKTPPVRS TAPASLSRSA 970 980 990 1000 1010 1020 FLSQRYYEDL DEVSSTSSVS QSLESEDART SCKDDEAVVQ APRHAPVVRT PSIQPSLLPH 1030 1040 1050 1060 1070 1080 AAPFAKSHLV HGSSPGVMGT SVATSASKII PQGADSTMLA TKTVKHGAPS PSHPISAPQA 1090 1100 1110 1120 1130 1140 AAAAALRRQM ASQAPAVNTL TESTLKNVPQ VVNVQELKNN PATPSTAMGS SVPYSTAKTP 1150 1160 1170 1180 1190 1200 HPVLTPVAAN QAKQGSLINS LKPSGPTPAS GQLSSGDKAS GTAKIETAVT STPSASGQFS 1210 1220 1230 1240 1250 1260 KPFSFSPSGT GFNFGIITPT PSSNFTAAQG ATPSTKESSQ PDAFSSGGGS KPSYEAIPES 1270 1280 1290 1300 1310 1320 SPPSGITSAS NTTPGEPAAS SSRPVAPSGT ALSTTSSKLE TPPSKLGELL FPSSLAGETL 1330 1340 1350 1360 1370 1380 GSFSGLRVGQ ADDSTKPTNK ASSTSLTSTQ PTKTSGVPSG FNFTAPPVLG KHTEPPVTSS 1390 1400 1410 1420 1430 1440 ATTTSVAPPA ATSTSSTAVF GSLPVTSAGS SGVISFGGTS LSAGKTSFSF GSQQTNSTVP 1450 1460 1470 1480 1490 1500 PSAPPPTTAA TPLPTSFPTL SFGSLLSSAT TPSLPMSAGR STEEATSSAL PEKPGDSEVS 1510 1520 1530 1540 1550 1560 ASAASLLEEQ QSAQLPQAPP QTSDSVKKEP VLAQPAVSNS GTAASSTSLV ALSAEATPAT 1570 1580 1590 1600 1610 1620 TGVPDARTEA VPPASSFSVP GQTAVTAAAI SSAGPVAVET SSTPIASSTT SIVAPGPSAE 1630 1640 1650 1660 1670 1680 AAAFGTVTSG SSVFAQPPAA SSSSAFNQLT NNTATAPSAT PVFGQVAAST APSLFGQQTG 1690 1700 1710 1720 1730 1740 STASTAAATP QVSSSGFSSP AFGTTAPGVF GQTTFGQASV FGQSASSAAS VFSFSQPGFS 1750 1760 1770 1780 1790 1800 SVPAFGQPAS STPTSTSGSV FGAASSTSSS SSFSFGQSSP NTGGGLFGQS NAPAFGQSPG 1810 1820 1830 1840 1850 1860 FGQGGSVFGG TSAATTTAAT SGFSFCQASG FGSSNTGSVF GQAASTGGIV FGQQSSSSSG 1870 1880 1890 1900 1910 1920 SVFGSGNTGR GGGFFSGLGG KPSQDAANKN PFSSASGGFG STATSNTSNL FGNSGAKTFG 1930 1940 1950 1960 1970 1980 GFASSSFGEQ KPTGTFSSGG GSVASQGFGF SSPNKTGGFG AAPVFGSPPT FGGSPGFGGV 1990 2000 2010 2020 2030 2040 PAFGSAPAFT SPLGSTGGKV FGEGTAAASA GGFGFGSSSN TTSFGTLASQ NAPTFGSLSQ 2050 2060 2070 QTSGFGTQSS GFSGFGSGTG GFSFGSNNSS VQGFGGWRS
	Isoform 3. Checksum: 765727236C2B47C8	FASTA	2,091	213,691
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEK FTAAATSTPV 610 620 630 640 650 660 SSSQSAPPMS PFSSASKPAA SGPLSHPTPL SAPPSSVPLK SSVLPSPSAG RSAQGSSSPV 670 680 690 700 710 720 PSMVQKSPRI TPPAAKPGSP QAKSLQPAVA EKQGHQWKDS DPVMAGIGEE IAHFQKELEE 730 740 750 760 770 780 LKARTSKACF QVGTSEEMKM LRTESDDLHT FLLEIKETTE SLHGDISSLK TTLLEGFAGV 790 800 810 820 830 840 EEAREQNERN RDSGYLHLLY KRPLDPKSEA QLQEIRRLHQ YVKFAVQDVN DVLDLEWDQH 850 860 870 880 890 900 LEQKKKQRHL LVPERETLFN TLANNREIIN QQRKRLNHLV DSLQQLRLYK QTSLWSLSSA 910 920 930 940 950 960 VPSQSSIHSF DSDLESLCNA LLKTTIESHT KSLPKVPAKL SPMKQAQLRN FLAKRKTPPV 970 980 990 1000 1010 1020 RSTAPASLSR SAFLSQRYYE DLDEVSSTSS VSQSLESEDA RTSCKDDEAV VQAPRHAPVV 1030 1040 1050 1060 1070 1080 RTPSIQPSLL PHAAPFAKSH LVHGSSPGVM GTSVATSASK IIPQGADSTM LATKTVKHGA 1090 1100 1110 1120 1130 1140 PSPSHPISAP QAAAAAALRR QMASQAPAVN TLTESTLKNV PQVVNVQELK NNPATPSTAM 1150 1160 1170 1180 1190 1200 GSSVPYSTAK TPHPVLTPVA ANQAKQGSLI NSLKPSGPTP ASGQLSSGDK ASGTAKIETA 1210 1220 1230 1240 1250 1260 VTSTPSASGQ FSKPFSFSPS GTGFNFGIIT PTPSSNFTAA QGATPSTKES SQPDAFSSGG 1270 1280 1290 1300 1310 1320 GSKPSYEAIP ESSPPSGITS ASNTTPGEPA ASSSRPVAPS GTALSTTSSK LETPPSKLGE 1330 1340 1350 1360 1370 1380 LLFPSSLAGE TLGSFSGLRV GQADDSTKPT NKASSTSLTS TQPTKTSGVP SGFNFTAPPV 1390 1400 1410 1420 1430 1440 LGKHTEPPVT SSATTTSVAP PAATSTSSTA VFGSLPVTSA GSSGVISFGG TSLSAGKTSF 1450 1460 1470 1480 1490 1500 SFGSQQTNST VPPSAPPPTT AATPLPTSFP TLSFGSLLSS ATTPSLPMSA GRSTEEATSS 1510 1520 1530 1540 1550 1560 ALPEKPGDSE VSASAASLLE EQQSAQLPQA PPQTSDSVKK EPVLAQPAVS NSGTAASSTS 1570 1580 1590 1600 1610 1620 LVALSAEATP ATTGVPDART EAVPPASSFS VPGQTAVTAA AISSAGPVAV ETSSTPIASS 1630 1640 1650 1660 1670 1680 TTSIVAPGPS AEAAAFGTVT SGSSVFAQPP AASSSSAFNQ LTNNTATAPS ATPVFGQVAA 1690 1700 1710 1720 1730 1740 STAPSLFGQQ TGSTASTAAA TPQVSSSGFS SPAFGTTAPG VFGQTTFGQA SVFGQSASSA 1750 1760 1770 1780 1790 1800 ASVFSFSQPG FSSVPAFGQP ASSTPTSTSG SVFGAASSTS SSSSFSFGQS SPNTGGGLFG 1810 1820 1830 1840 1850 1860 QSNAPAFGQS PGFGQGGSVF GGTSAATTTA ATSGFSFCQA SGFGSSNTGS VFGQAASTGG 1870 1880 1890 1900 1910 1920 IVFGQQSSSS SGSVFGSGNT GRGGGFFSGL GGKPSQDAAN KNPFSSASGG FGSTATSNTS 1930 1940 1950 1960 1970 1980 NLFGNSGAKT FGGFASSSFG EQKPTGTFSS GGGSVASQGF GFSSPNKTGG FGAAPVFGSP 1990 2000 2010 2020 2030 2040 PTFGGSPGFG GVPAFGSAPA FTSPLGSTGG KVFGEGTAAA SAGGFGFGSS SNTTSFGTLA 2050 2060 2070 2080 2090 SQNAPTFGSL SQQTSGFGTQ SSGFSGFGSG TGGFSFGSNN SSVQGFGGWR S
	Isoform 4. Checksum: A5ECD51E41D40F1F	FASTA	2,080	212,643
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEN SSQSAPPMSP 610 620 630 640 650 660 FSSASKPAAS GPLSHPTPLS APPSSVPLKS SVLPSPSAGR SAQGSSSPVP SMVQKSPRIT 670 680 690 700 710 720 PPAAKPGSPQ AKSLQPAVAE KQGHQWKDSD PVMAGIGEEI AHFQKELEEL KARTSKACFQ 730 740 750 760 770 780 VGTSEEMKML RTESDDLHTF LLEIKETTES LHGDISSLKT TLLEGFAGVE EAREQNERNR 790 800 810 820 830 840 DSGYLHLLYK RPLDPKSEAQ LQEIRRLHQY VKFAVQDVND VLDLEWDQHL EQKKKQRHLL 850 860 870 880 890 900 VPERETLFNT LANNREIINQ QRKRLNHLVD SLQQLRLYKQ TSLWSLSSAV PSQSSIHSFD 910 920 930 940 950 960 SDLESLCNAL LKTTIESHTK SLPKVPAKLS PMKQAQLRNF LAKRKTPPVR STAPASLSRS 970 980 990 1000 1010 1020 AFLSQRYYED LDEVSSTSSV SQSLESEDAR TSCKDDEAVV QAPRHAPVVR TPSIQPSLLP 1030 1040 1050 1060 1070 1080 HAAPFAKSHL VHGSSPGVMG TSVATSASKI IPQGADSTML ATKTVKHGAP SPSHPISAPQ 1090 1100 1110 1120 1130 1140 AAAAAALRRQ MASQAPAVNT LTESTLKNVP QVVNVQELKN NPATPSTAMG SSVPYSTAKT 1150 1160 1170 1180 1190 1200 PHPVLTPVAA NQAKQGSLIN SLKPSGPTPA SGQLSSGDKA SGTAKIETAV TSTPSASGQF 1210 1220 1230 1240 1250 1260 SKPFSFSPSG TGFNFGIITP TPSSNFTAAQ GATPSTKESS QPDAFSSGGG SKPSYEAIPE 1270 1280 1290 1300 1310 1320 SSPPSGITSA SNTTPGEPAA SSSRPVAPSG TALSTTSSKL ETPPSKLGEL LFPSSLAGET 1330 1340 1350 1360 1370 1380 LGSFSGLRVG QADDSTKPTN KASSTSLTST QPTKTSGVPS GFNFTAPPVL GKHTEPPVTS 1390 1400 1410 1420 1430 1440 SATTTSVAPP AATSTSSTAV FGSLPVTSAG SSGVISFGGT SLSAGKTSFS FGSQQTNSTV 1450 1460 1470 1480 1490 1500 PPSAPPPTTA ATPLPTSFPT LSFGSLLSSA TTPSLPMSAG RSTEEATSSA LPEKPGDSEV 1510 1520 1530 1540 1550 1560 SASAASLLEE QQSAQLPQAP PQTSDSVKKE PVLAQPAVSN SGTAASSTSL VALSAEATPA 1570 1580 1590 1600 1610 1620 TTGVPDARTE AVPPASSFSV PGQTAVTAAA ISSAGPVAVE TSSTPIASST TSIVAPGPSA 1630 1640 1650 1660 1670 1680 EAAAFGTVTS GSSVFAQPPA ASSSSAFNQL TNNTATAPSA TPVFGQVAAS TAPSLFGQQT 1690 1700 1710 1720 1730 1740 GSTASTAAAT PQVSSSGFSS PAFGTTAPGV FGQTTFGQAS VFGQSASSAA SVFSFSQPGF 1750 1760 1770 1780 1790 1800 SSVPAFGQPA SSTPTSTSGS VFGAASSTSS SSSFSFGQSS PNTGGGLFGQ SNAPAFGQSP 1810 1820 1830 1840 1850 1860 GFGQGGSVFG GTSAATTTAA TSGFSFCQAS GFGSSNTGSV FGQAASTGGI VFGQQSSSSS 1870 1880 1890 1900 1910 1920 GSVFGSGNTG RGGGFFSGLG GKPSQDAANK NPFSSASGGF GSTATSNTSN LFGNSGAKTF 1930 1940 1950 1960 1970 1980 GGFASSSFGE QKPTGTFSSG GGSVASQGFG FSSPNKTGGF GAAPVFGSPP TFGGSPGFGG 1990 2000 2010 2020 2030 2040 VPAFGSAPAF TSPLGSTGGK VFGEGTAAAS AGGFGFGSSS NTTSFGTLAS QNAPTFGSLS 2050 2060 2070 2080 QQTSGFGTQS SGFSGFGSGT GGFSFGSNNS SVQGFGGWRS
	Isoform 5. Checksum: 4C67CE62D57E590F	FASTA	2,093	215,401
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEN SSQSAPPMSP 610 620 630 640 650 660 FSSASKPAAS GPLSHPTPLS APPSSVPLKS SVLPSPSGRS AQGSSSPVPS MVQKSPRITP 670 680 690 700 710 720 PAAKPGSPQA KSLQPAVAEK QGHQWKDSDP VMAGIGEEIA HFQKELEELK ARTSKACFQV 730 740 750 760 770 780 GTSEEMKMLR TESDDLHTFL LEIKETTESL HGDISSLKTT LLEGFAGVEE AREQNERNRD 790 800 810 820 830 840 SGYLHLLYKR PLDPKSEAQL QEIRRLHQYV KFAVQDVNDV LDLEWDQHLE QKKKQRHLLV 850 860 870 880 890 900 PERETLFNTL ANNREIINQQ RKRLNHLVDS LQQLRLYKQT SLWSLSSAVP SQSSIHSFDS 910 920 930 940 950 960 DLESLCNALL KTTIESHTKS LPKVPAKLSP MKQAQLRNFL AKRKTPPVRS TAPASLSRSA 970 980 990 1000 1010 1020 FLSQRYYEDL DEVSSTSSVS QSLESEDART SCKDDEAVVQ APRHAPVVRT PSIQPSLLPH 1030 1040 1050 1060 1070 1080 AAPFAKSHLV HGSSPGVMGT SVATSASKII PQGADSTMLA TKTVKHGAPS PSHPISAPQA 1090 1100 1110 1120 1130 1140 AAAAALRRQM ASQAPAVNTL TESTLKNVPQ VVNVQELKNN PATPSTAKTP HPVLTPVAAN 1150 1160 1170 1180 1190 1200 QAKQGSLINS LKPSGPTPAS GQLSSGDKAS GTAKIETAVT STPSASGQFS KPFSFSPSGT 1210 1220 1230 1240 1250 1260 GFNFGIITPT PSSNFTAAQG ATPSTKESSQ PDAFSSGGGS KPSYEAIPES SPPSGITSAS 1270 1280 1290 1300 1310 1320 NTTPGEPAAS SSRPVAPSGT ALSTTSSKLE TPPSKLGELL FPSSLAGETL GSFSGLRVGQ 1330 1340 1350 1360 1370 1380 ADDSTKPTNK ASSTSLTSTQ PTKTSGVPSG FNFTAPPVLG KHTEPPVTSS ATTTSVAPPA 1390 1400 1410 1420 1430 1440 ATSTSSTAVF GSLPVTSAGS SGVISFGGTS LSAGKTSFSF GSQQTNSTVP PSAPPPTTAA 1450 1460 1470 1480 1490 1500 TPLPTSFPTL SFGSLLSSAT TPSLPMSAGR STEEATSSAL PEKPGDSEVS ASAASLLEEQ 1510 1520 1530 1540 1550 1560 QSAQLPQAPP QTSDSVKKEP VLAQPAVSNS GTAASSTSLV ALSAEATPAT TGVPDARTEA 1570 1580 1590 1600 1610 1620 VPPASSFSVP GQTAVTAAAI SSAGPVAVET SSTPIASSTT SIVAPGPSAE AAAFGTVTSG 1630 1640 1650 1660 1670 1680 SSVFAQPPAA SSSSAFNQLT NNTATAPSAT PVFGQVAAST APSLFGQQTG STASTAAATP 1690 1700 1710 1720 1730 1740 QVSSSGFSSP AFGTTAPGVF GQTTFGQASV FGQSASSAAS VFSFSQPGFS SVPAFGQPAS 1750 1760 1770 1780 1790 1800 STPTSTSGSV FGAASSTSSS SSFSFGQSSP NTGGGLFGQS NAPAFGQSPG FGQGGSVFGG 1810 1820 1830 1840 1850 1860 TSAATTTAAT SGFSFCQASG FGSSNTGSVF GQAASTGGIV FGQQSSSSSG SVFGSGNTGR 1870 1880 1890 1900 1910 1920 GGGFFSGLGG KPSQDAANKN PFSSASGGFG STATSNTSNL FGNSGAKTFG GFASSSFGEQ 1930 1940 1950 1960 1970 1980 KPTGTFSSGG GSVASQGFGF SSPNKTGGFG AAPVFGSPPT FGGSPGFGGV PAFGSAPAFT 1990 2000 2010 2020 2030 2040 SPLGSTGGKV FGEGTAAASA GGFGSLAMSL SPTLKGRLLL MRPKAGGGRE QAAPGRKSNE 2050 2060 2070 2080 2090 SRSLGHLCME RALTSPLKVW EQQQHHILRH ARESECPHFR ITVPTDFWFW DPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA." Von Lindern M., Fornerod M., Van Baal S., Jaegle M., De Wit T., Buijs A., Grosveld G. Mol. Cell. Biol. 12:1687-1697(1992) [PubMed: 1549122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-574. Tissue: Testis.
[2]	"Homo sapiens mRNA for KIAA0023 splice variant 1 protein." Nagase T., Kikuno R., Ohara O. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT SER-574. Tissue: Placenta and Testis.
[6]	"The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm." Kraemer D., Wozniak R.W., Blobel G., Radu A. Proc. Natl. Acad. Sci. U.S.A. 91:1519-1523(1994) [PubMed: 8108440] [Abstract] Cited for: CHARACTERIZATION.
[7]	"The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88." Fornerod M., van Deursen J.M., van Baal S., Reynolds A., Davis D., Murti K.G., Fransen J., Grosveld G. EMBO J. 16:807-816(1997) [PubMed: 9049309] [Abstract] Cited for: INTERACTION WITH XPO1.
[8]	"Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins." Brownawell A.M., Macara I.G. J. Cell Biol. 156:53-64(2002) [PubMed: 11777942] [Abstract] Cited for: INTERACTION WITH XPO5.
[9]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430 AND THR-437, MASS SPECTROMETRY. Tissue: Epithelium.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-940 AND SER-1081, MASS SPECTROMETRY. Tissue: Epithelium.
[11]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1081, MASS SPECTROMETRY. Tissue: Epithelium.
[12]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, MASS SPECTROMETRY.
[13]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666, MASS SPECTROMETRY.
[14]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-416; SER-646; SER-651; SER-657; SER-666; THR-670; SER-678; SER-940; SER-970; SER-1081; THR-1156; SER-1181; THR-1203; THR-1312; SER-1333 AND SER-1356, MASS SPECTROMETRY.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430; SER-433; THR-434; THR-437; THR-439; SER-666; THR-670; SER-678; SER-940; SER-970; SER-974; SER-985; THR-987; SER-989 AND SER-1963, MASS SPECTROMETRY.
[16]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[17]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-424; LEU-1378 AND VAL-1392.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBLGenBankDDBJ

X64228 mRNA. Translation: CAA45535.1.
AB159230 mRNA. Translation: BAD07398.1. Different initiation.
D14689 mRNA. Translation: BAA03515.1.
AL157938 Genomic DNA. Translation: CAI41111.1.
BC045620 mRNA. Translation: AAH45620.2.
BC105998 mRNA. Translation: AAI05999.1.

IPI

IPI00183294.
IPI00646361.
IPI00900318.
IPI00900325.
IPI00900331.

PIR

S26058.

RefSeq

NP_005076.3.

UniGene

Hs.654530

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OIT	X-ray	1.65	A	1-434	[»]
3FHC	X-ray	2.80	A	1-405	[»]

SMR

P35658. Positions 1-434.

ModBase

Search...

Protein-protein interaction databases

IntAct

P35658. 2 interactions.

PTM databases

PhosphoSite

P35658.

Proteomic databases

PRIDE

P35658.

Genome annotation databases

Ensembl

ENSG00000126883. Homo sapiens. [Contig view]

GeneID

8021.

KEGG

hsa:8021.

Organism-specific databases

GeneCards

GC09P132990.

H-InvDB

HIX0022356.

HGNC

HGNC:8064. NUP214.

HPA

HPA018404.

MIM

114350. gene.

Orphanet

52688. Myelodysplastic syndromes.
86839. Refractory anemia with excess blasts.

PharmGKB

PA31851.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P35658.

OMA

P35658. HLEQKKK.

Enzyme and pathway databases

Pathway_Interaction_DB

bmppathway. BMP receptor signaling.
smad2_3pathway. Regulation of cytoplasmic and nuclear SMAD2/3 signaling.
nfat_3pathway. Role of Calcineurin-dependent NFAT signaling in lymphocytes.

Reactome

REACT_6185. HIV Infection.

Gene expression databases

ArrayExpress

P35658.

Bgee

P35658.

CleanEx

HS_NUP214.

GermOnline

ENSG00000126883. Homo sapiens.

Family and domain databases

InterPro

IPR015943. WD40/YVTN_repeat-like.
IPR001680. WD40_repeat.
[Graphical view]

Gene3D

G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.

SMART

SM00320. WD40. 2 hits.
[Graphical view]

ProtoNet

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Other Resources

NextBio

30584.

SOURCE

Search...

Entry information

Entry name

NU214_HUMAN

Accession

Primary (citable) accession number: P35658
Secondary accession number(s): A6NFQ0 , Q15010, Q3KQZ0, Q5JUP7, Q75R47, Q86XD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	July 22, 2008
Last modified:	June 16, 2009
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)