P35658 (NU214_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup214

Alternative name(s):
214 kDa nucleoporin
Nucleoporin Nup214
Protein CAN

Gene names

Name:	NUP214
Synonyms:	CAIN, CAN, KIAA0023

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2090 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
Subunit structure	Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5. Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore. Ref.7 Ref.8 Ref.14
Subcellular location	Nucleus › nuclear pore complex. Note: Cytoplasmic filaments.
Tissue specificity	Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
Domain	Contains FG repeats. Ref.19 Ref.21 The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B. Ref.19 Ref.21
Post-translational modification	Probably glycosylated as it reacts with wheat germ agglutinin (WGA).
Involvement in disease	A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.
Sequence caution	The sequence BAD07398.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Nuclear pore complex Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Domain	Coiled coil Repeat
PTM	Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome cytokine-mediated signaling pathway Traceable author statement. Source: Reactome gene expression Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome mRNA export from nucleus Inferred from electronic annotation. Source: Compara mRNA metabolic process Traceable author statement. Source: Reactome protein export from nucleus Inferred from mutant phenotype PubMed 12191473. Source: MGI protein import into nucleus Inferred from electronic annotation. Source: Compara regulation of cell cycle Inferred from electronic annotation. Source: Compara regulation of glucose transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome nuclear pore Traceable author statement Ref.6. Source: ProtInc nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	nucleocytoplasmic transporter activity Inferred from electronic annotation. Source: Compara transporter activity Traceable author statement Ref.6. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35658-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35658-2)

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N

Note: No experimental confirmation available.

Isoform 3 (identifier: P35658-3)

The sequence of this isoform differs from the canonical sequence as follows:
     648-648: S → SA

Note: No experimental confirmation available.

Isoform 4 (identifier: P35658-4)

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N
     648-648: S → SA

Isoform 5 (identifier: P35658-5)

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N
     1139-1148: Missing.
     2026-2090: FGSSSNTTSF...SVQGFGGWRS → SLAMSLSPTL...PTDFWFWDPE

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2090

2090

Nuclear pore complex protein Nup214

PRO_0000204861

Regions

Repeat

41 – 93

53

Blade 1

Repeat

94 – 150

57

Blade 2

Repeat

151 – 193

43

Blade 3

Repeat

194 – 239

46

Blade 4

Repeat

240 – 303

64

Blade 5

Repeat

304 – 359

56

Blade 6

Repeat

360 – 404

45

Blade 7

Region

41 – 404

364

Seven-bladed beta propeller

Region

481 – 2076

1596

11 X 5 AA approximate repeats

Region

740 – 768

29

Leucine-zipper 1

Region

861 – 882

22

Leucine-zipper 2

Region

1409 – 2084

676

18 X 4 AA approximate repeats

Region

1427 – 2085

659

11 X 3 AA approximate repeats

Coiled coil

680 – 1209

530

Ref.21

Compositional bias

1213 – 2090

878

Pro/Ser/Thr-rich

Sites

Site

812 – 813

2

Breakpoint

Amino acid modifications

Modified residue

430

1

Phosphoserine Ref.10 Ref.13 Ref.15

Modified residue

433

1

Phosphoserine Ref.18

Modified residue

434

1

Phosphothreonine Ref.13 Ref.18

Modified residue

437

1

Phosphothreonine Ref.13 Ref.18

Modified residue

439

1

Phosphothreonine Ref.10 Ref.13

Modified residue

651

1

Phosphoserine Ref.12

Modified residue

657

1

Phosphoserine Ref.16 Ref.18

Modified residue

666

1

Phosphoserine Ref.13

Modified residue

670

1

Phosphothreonine Ref.16 Ref.18

Modified residue

678

1

Phosphoserine Ref.16 Ref.18

Modified residue

940

1

Phosphoserine Ref.12 Ref.16 Ref.18

Modified residue

970

1

Phosphoserine Ref.13

Modified residue

974

1

Phosphoserine Ref.13

Modified residue

989

1

Phosphoserine Ref.15

Modified residue

1023

1

Phosphoserine Ref.13

Modified residue

1045

1

Phosphoserine Ref.16

Modified residue

1081

1

Phosphoserine Ref.16

Modified residue

1134

1

Phosphothreonine Ref.16

Modified residue

1150

1

Phosphothreonine Ref.16

Modified residue

1156

1

Phosphothreonine Ref.16

Modified residue

1181

1

Phosphoserine Ref.12

Modified residue

1312

1

Phosphothreonine Ref.16

Modified residue

1963

1

Phosphoserine Ref.13

Modified residue

1985

1

Phosphoserine Ref.16

Natural variations

Alternative sequence

590 – 601

12

KFTAA…STPVS → N in isoform 2, isoform 4 and isoform 5.

VSP_034896

Alternative sequence

648

1

S → SA in isoform 3 and isoform 4.

VSP_034897

Alternative sequence

1139 – 1148

10

Missing in isoform 5.

VSP_034898

Alternative sequence

2026 – 2090

65

FGSSS…GGWRS → SLAMSLSPTLKGRLLLMRPK AGGGREQAAPGRKSNESRSL GHLCMERALTSPLKVWEQQQ HHILRHARESECPHFRITVP TDFWFWDPE in isoform 5.

VSP_034899

Natural variant

424

1

G → A in a breast cancer sample; somatic mutation. Ref.22

VAR_035856

Natural variant

574

1

P → S. Ref.1 Ref.5
Corresponds to variant rs103612 [ dbSNP | Ensembl ].

VAR_045691

Natural variant

1378

1

P → L in a breast cancer sample; somatic mutation. Ref.22

VAR_035857

Natural variant

1392

1

A → V in a breast cancer sample; somatic mutation. Ref.22

VAR_035858

Natural variant

1592

1

G → A.
Corresponds to variant rs28594669 [ dbSNP | Ensembl ].

VAR_061533

Experimental info

Mutagenesis

353

1

V → A: Reduced binding to DDX19B. Ref.20

Mutagenesis

359

1

D → R: Impairs interaction with DDX19B. Ref.20

Sequence conflict

149

1

G → A in CAA45535. Ref.1

Sequence conflict

175

1

A → D in CAA45535. Ref.1

Sequence conflict

1091 – 1092

2

AA → QL in CAA45535. Ref.1

Sequence conflict

1872

1

S → N in AAH45620. Ref.5

Secondary structure

1

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2090

Helix Strand Turn

Details...

Beta strand

4 – 7

4

Beta strand

11 – 21

11

Beta strand

24 – 26

3

Beta strand

42 – 45

4

Turn

46 – 49

4

Beta strand

50 – 55

6

Beta strand

58 – 63

6

Helix

64 – 67

4

Beta strand

80 – 82

3

Beta strand

87 – 89

3

Beta strand

95 – 100

6

Beta strand

106 – 113

8

Turn

114 – 116

3

Beta strand

117 – 124

8

Helix

125 – 129

5

Beta strand

139 – 143

5

Helix

148 – 150

3

Beta strand

151 – 157

7

Beta strand

164 – 169

6

Beta strand

174 – 189

16

Helix

191 – 193

3

Beta strand

195 – 200

6

Beta strand

207 – 211

5

Beta strand

216 – 219

4

Beta strand

225 – 229

5

Beta strand

237 – 239

3

Beta strand

241 – 250

10

Beta strand

253 – 260

8

Beta strand

265 – 267

3

Beta strand

270 – 275

6

Beta strand

286 – 289

4

Beta strand

299 – 301

3

Beta strand

305 – 310

6

Helix

311 – 313

3

Beta strand

315 – 320

6

Beta strand

323 – 325

3

Beta strand

327 – 331

5

Beta strand

338 – 343

6

Helix

345 – 347

3

Beta strand

357 – 359

3

Beta strand

362 – 368

7

Beta strand

375 – 378

4

Beta strand

381 – 383

3

Beta strand

388 – 393

6

Beta strand

396 – 405

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: EE6F0F3DE3D522C6	FASTA	2,090	213,620
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEK FTAAATSTPV 610 620 630 640 650 660 SSSQSAPPMS PFSSASKPAA SGPLSHPTPL SAPPSSVPLK SSVLPSPSGR SAQGSSSPVP 670 680 690 700 710 720 SMVQKSPRIT PPAAKPGSPQ AKSLQPAVAE KQGHQWKDSD PVMAGIGEEI AHFQKELEEL 730 740 750 760 770 780 KARTSKACFQ VGTSEEMKML RTESDDLHTF LLEIKETTES LHGDISSLKT TLLEGFAGVE 790 800 810 820 830 840 EAREQNERNR DSGYLHLLYK RPLDPKSEAQ LQEIRRLHQY VKFAVQDVND VLDLEWDQHL 850 860 870 880 890 900 EQKKKQRHLL VPERETLFNT LANNREIINQ QRKRLNHLVD SLQQLRLYKQ TSLWSLSSAV 910 920 930 940 950 960 PSQSSIHSFD SDLESLCNAL LKTTIESHTK SLPKVPAKLS PMKQAQLRNF LAKRKTPPVR 970 980 990 1000 1010 1020 STAPASLSRS AFLSQRYYED LDEVSSTSSV SQSLESEDAR TSCKDDEAVV QAPRHAPVVR 1030 1040 1050 1060 1070 1080 TPSIQPSLLP HAAPFAKSHL VHGSSPGVMG TSVATSASKI IPQGADSTML ATKTVKHGAP 1090 1100 1110 1120 1130 1140 SPSHPISAPQ AAAAAALRRQ MASQAPAVNT LTESTLKNVP QVVNVQELKN NPATPSTAMG 1150 1160 1170 1180 1190 1200 SSVPYSTAKT PHPVLTPVAA NQAKQGSLIN SLKPSGPTPA SGQLSSGDKA SGTAKIETAV 1210 1220 1230 1240 1250 1260 TSTPSASGQF SKPFSFSPSG TGFNFGIITP TPSSNFTAAQ GATPSTKESS QPDAFSSGGG 1270 1280 1290 1300 1310 1320 SKPSYEAIPE SSPPSGITSA SNTTPGEPAA SSSRPVAPSG TALSTTSSKL ETPPSKLGEL 1330 1340 1350 1360 1370 1380 LFPSSLAGET LGSFSGLRVG QADDSTKPTN KASSTSLTST QPTKTSGVPS GFNFTAPPVL 1390 1400 1410 1420 1430 1440 GKHTEPPVTS SATTTSVAPP AATSTSSTAV FGSLPVTSAG SSGVISFGGT SLSAGKTSFS 1450 1460 1470 1480 1490 1500 FGSQQTNSTV PPSAPPPTTA ATPLPTSFPT LSFGSLLSSA TTPSLPMSAG RSTEEATSSA 1510 1520 1530 1540 1550 1560 LPEKPGDSEV SASAASLLEE QQSAQLPQAP PQTSDSVKKE PVLAQPAVSN SGTAASSTSL 1570 1580 1590 1600 1610 1620 VALSAEATPA TTGVPDARTE AVPPASSFSV PGQTAVTAAA ISSAGPVAVE TSSTPIASST 1630 1640 1650 1660 1670 1680 TSIVAPGPSA EAAAFGTVTS GSSVFAQPPA ASSSSAFNQL TNNTATAPSA TPVFGQVAAS 1690 1700 1710 1720 1730 1740 TAPSLFGQQT GSTASTAAAT PQVSSSGFSS PAFGTTAPGV FGQTTFGQAS VFGQSASSAA 1750 1760 1770 1780 1790 1800 SVFSFSQPGF SSVPAFGQPA SSTPTSTSGS VFGAASSTSS SSSFSFGQSS PNTGGGLFGQ 1810 1820 1830 1840 1850 1860 SNAPAFGQSP GFGQGGSVFG GTSAATTTAA TSGFSFCQAS GFGSSNTGSV FGQAASTGGI 1870 1880 1890 1900 1910 1920 VFGQQSSSSS GSVFGSGNTG RGGGFFSGLG GKPSQDAANK NPFSSASGGF GSTATSNTSN 1930 1940 1950 1960 1970 1980 LFGNSGAKTF GGFASSSFGE QKPTGTFSSG GGSVASQGFG FSSPNKTGGF GAAPVFGSPP 1990 2000 2010 2020 2030 2040 TFGGSPGFGG VPAFGSAPAF TSPLGSTGGK VFGEGTAAAS AGGFGFGSSS NTTSFGTLAS 2050 2060 2070 2080 2090 QNAPTFGSLS QQTSGFGTQS SGFSGFGSGT GGFSFGSNNS SVQGFGGWRS
	Isoform 2 [UniParc]. Checksum: 159D32101C9DF54A	FASTA	2,079	212,571
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEN SSQSAPPMSP 610 620 630 640 650 660 FSSASKPAAS GPLSHPTPLS APPSSVPLKS SVLPSPSGRS AQGSSSPVPS MVQKSPRITP 670 680 690 700 710 720 PAAKPGSPQA KSLQPAVAEK QGHQWKDSDP VMAGIGEEIA HFQKELEELK ARTSKACFQV 730 740 750 760 770 780 GTSEEMKMLR TESDDLHTFL LEIKETTESL HGDISSLKTT LLEGFAGVEE AREQNERNRD 790 800 810 820 830 840 SGYLHLLYKR PLDPKSEAQL QEIRRLHQYV KFAVQDVNDV LDLEWDQHLE QKKKQRHLLV 850 860 870 880 890 900 PERETLFNTL ANNREIINQQ RKRLNHLVDS LQQLRLYKQT SLWSLSSAVP SQSSIHSFDS 910 920 930 940 950 960 DLESLCNALL KTTIESHTKS LPKVPAKLSP MKQAQLRNFL AKRKTPPVRS TAPASLSRSA 970 980 990 1000 1010 1020 FLSQRYYEDL DEVSSTSSVS QSLESEDART SCKDDEAVVQ APRHAPVVRT PSIQPSLLPH 1030 1040 1050 1060 1070 1080 AAPFAKSHLV HGSSPGVMGT SVATSASKII PQGADSTMLA TKTVKHGAPS PSHPISAPQA 1090 1100 1110 1120 1130 1140 AAAAALRRQM ASQAPAVNTL TESTLKNVPQ VVNVQELKNN PATPSTAMGS SVPYSTAKTP 1150 1160 1170 1180 1190 1200 HPVLTPVAAN QAKQGSLINS LKPSGPTPAS GQLSSGDKAS GTAKIETAVT STPSASGQFS 1210 1220 1230 1240 1250 1260 KPFSFSPSGT GFNFGIITPT PSSNFTAAQG ATPSTKESSQ PDAFSSGGGS KPSYEAIPES 1270 1280 1290 1300 1310 1320 SPPSGITSAS NTTPGEPAAS SSRPVAPSGT ALSTTSSKLE TPPSKLGELL FPSSLAGETL 1330 1340 1350 1360 1370 1380 GSFSGLRVGQ ADDSTKPTNK ASSTSLTSTQ PTKTSGVPSG FNFTAPPVLG KHTEPPVTSS 1390 1400 1410 1420 1430 1440 ATTTSVAPPA ATSTSSTAVF GSLPVTSAGS SGVISFGGTS LSAGKTSFSF GSQQTNSTVP 1450 1460 1470 1480 1490 1500 PSAPPPTTAA TPLPTSFPTL SFGSLLSSAT TPSLPMSAGR STEEATSSAL PEKPGDSEVS 1510 1520 1530 1540 1550 1560 ASAASLLEEQ QSAQLPQAPP QTSDSVKKEP VLAQPAVSNS GTAASSTSLV ALSAEATPAT 1570 1580 1590 1600 1610 1620 TGVPDARTEA VPPASSFSVP GQTAVTAAAI SSAGPVAVET SSTPIASSTT SIVAPGPSAE 1630 1640 1650 1660 1670 1680 AAAFGTVTSG SSVFAQPPAA SSSSAFNQLT NNTATAPSAT PVFGQVAAST APSLFGQQTG 1690 1700 1710 1720 1730 1740 STASTAAATP QVSSSGFSSP AFGTTAPGVF GQTTFGQASV FGQSASSAAS VFSFSQPGFS 1750 1760 1770 1780 1790 1800 SVPAFGQPAS STPTSTSGSV FGAASSTSSS SSFSFGQSSP NTGGGLFGQS NAPAFGQSPG 1810 1820 1830 1840 1850 1860 FGQGGSVFGG TSAATTTAAT SGFSFCQASG FGSSNTGSVF GQAASTGGIV FGQQSSSSSG 1870 1880 1890 1900 1910 1920 SVFGSGNTGR GGGFFSGLGG KPSQDAANKN PFSSASGGFG STATSNTSNL FGNSGAKTFG 1930 1940 1950 1960 1970 1980 GFASSSFGEQ KPTGTFSSGG GSVASQGFGF SSPNKTGGFG AAPVFGSPPT FGGSPGFGGV 1990 2000 2010 2020 2030 2040 PAFGSAPAFT SPLGSTGGKV FGEGTAAASA GGFGFGSSSN TTSFGTLASQ NAPTFGSLSQ 2050 2060 2070 QTSGFGTQSS GFSGFGSGTG GFSFGSNNSS VQGFGGWRS
	Isoform 3 [UniParc]. Checksum: 765727236C2B47C8	FASTA	2,091	213,691
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEK FTAAATSTPV 610 620 630 640 650 660 SSSQSAPPMS PFSSASKPAA SGPLSHPTPL SAPPSSVPLK SSVLPSPSAG RSAQGSSSPV 670 680 690 700 710 720 PSMVQKSPRI TPPAAKPGSP QAKSLQPAVA EKQGHQWKDS DPVMAGIGEE IAHFQKELEE 730 740 750 760 770 780 LKARTSKACF QVGTSEEMKM LRTESDDLHT FLLEIKETTE SLHGDISSLK TTLLEGFAGV 790 800 810 820 830 840 EEAREQNERN RDSGYLHLLY KRPLDPKSEA QLQEIRRLHQ YVKFAVQDVN DVLDLEWDQH 850 860 870 880 890 900 LEQKKKQRHL LVPERETLFN TLANNREIIN QQRKRLNHLV DSLQQLRLYK QTSLWSLSSA 910 920 930 940 950 960 VPSQSSIHSF DSDLESLCNA LLKTTIESHT KSLPKVPAKL SPMKQAQLRN FLAKRKTPPV 970 980 990 1000 1010 1020 RSTAPASLSR SAFLSQRYYE DLDEVSSTSS VSQSLESEDA RTSCKDDEAV VQAPRHAPVV 1030 1040 1050 1060 1070 1080 RTPSIQPSLL PHAAPFAKSH LVHGSSPGVM GTSVATSASK IIPQGADSTM LATKTVKHGA 1090 1100 1110 1120 1130 1140 PSPSHPISAP QAAAAAALRR QMASQAPAVN TLTESTLKNV PQVVNVQELK NNPATPSTAM 1150 1160 1170 1180 1190 1200 GSSVPYSTAK TPHPVLTPVA ANQAKQGSLI NSLKPSGPTP ASGQLSSGDK ASGTAKIETA 1210 1220 1230 1240 1250 1260 VTSTPSASGQ FSKPFSFSPS GTGFNFGIIT PTPSSNFTAA QGATPSTKES SQPDAFSSGG 1270 1280 1290 1300 1310 1320 GSKPSYEAIP ESSPPSGITS ASNTTPGEPA ASSSRPVAPS GTALSTTSSK LETPPSKLGE 1330 1340 1350 1360 1370 1380 LLFPSSLAGE TLGSFSGLRV GQADDSTKPT NKASSTSLTS TQPTKTSGVP SGFNFTAPPV 1390 1400 1410 1420 1430 1440 LGKHTEPPVT SSATTTSVAP PAATSTSSTA VFGSLPVTSA GSSGVISFGG TSLSAGKTSF 1450 1460 1470 1480 1490 1500 SFGSQQTNST VPPSAPPPTT AATPLPTSFP TLSFGSLLSS ATTPSLPMSA GRSTEEATSS 1510 1520 1530 1540 1550 1560 ALPEKPGDSE VSASAASLLE EQQSAQLPQA PPQTSDSVKK EPVLAQPAVS NSGTAASSTS 1570 1580 1590 1600 1610 1620 LVALSAEATP ATTGVPDART EAVPPASSFS VPGQTAVTAA AISSAGPVAV ETSSTPIASS 1630 1640 1650 1660 1670 1680 TTSIVAPGPS AEAAAFGTVT SGSSVFAQPP AASSSSAFNQ LTNNTATAPS ATPVFGQVAA 1690 1700 1710 1720 1730 1740 STAPSLFGQQ TGSTASTAAA TPQVSSSGFS SPAFGTTAPG VFGQTTFGQA SVFGQSASSA 1750 1760 1770 1780 1790 1800 ASVFSFSQPG FSSVPAFGQP ASSTPTSTSG SVFGAASSTS SSSSFSFGQS SPNTGGGLFG 1810 1820 1830 1840 1850 1860 QSNAPAFGQS PGFGQGGSVF GGTSAATTTA ATSGFSFCQA SGFGSSNTGS VFGQAASTGG 1870 1880 1890 1900 1910 1920 IVFGQQSSSS SGSVFGSGNT GRGGGFFSGL GGKPSQDAAN KNPFSSASGG FGSTATSNTS 1930 1940 1950 1960 1970 1980 NLFGNSGAKT FGGFASSSFG EQKPTGTFSS GGGSVASQGF GFSSPNKTGG FGAAPVFGSP 1990 2000 2010 2020 2030 2040 PTFGGSPGFG GVPAFGSAPA FTSPLGSTGG KVFGEGTAAA SAGGFGFGSS SNTTSFGTLA 2050 2060 2070 2080 2090 SQNAPTFGSL SQQTSGFGTQ SSGFSGFGSG TGGFSFGSNN SSVQGFGGWR S
	Isoform 4 [UniParc]. Checksum: A5ECD51E41D40F1F	FASTA	2,080	212,643
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEN SSQSAPPMSP 610 620 630 640 650 660 FSSASKPAAS GPLSHPTPLS APPSSVPLKS SVLPSPSAGR SAQGSSSPVP SMVQKSPRIT 670 680 690 700 710 720 PPAAKPGSPQ AKSLQPAVAE KQGHQWKDSD PVMAGIGEEI AHFQKELEEL KARTSKACFQ 730 740 750 760 770 780 VGTSEEMKML RTESDDLHTF LLEIKETTES LHGDISSLKT TLLEGFAGVE EAREQNERNR 790 800 810 820 830 840 DSGYLHLLYK RPLDPKSEAQ LQEIRRLHQY VKFAVQDVND VLDLEWDQHL EQKKKQRHLL 850 860 870 880 890 900 VPERETLFNT LANNREIINQ QRKRLNHLVD SLQQLRLYKQ TSLWSLSSAV PSQSSIHSFD 910 920 930 940 950 960 SDLESLCNAL LKTTIESHTK SLPKVPAKLS PMKQAQLRNF LAKRKTPPVR STAPASLSRS 970 980 990 1000 1010 1020 AFLSQRYYED LDEVSSTSSV SQSLESEDAR TSCKDDEAVV QAPRHAPVVR TPSIQPSLLP 1030 1040 1050 1060 1070 1080 HAAPFAKSHL VHGSSPGVMG TSVATSASKI IPQGADSTML ATKTVKHGAP SPSHPISAPQ 1090 1100 1110 1120 1130 1140 AAAAAALRRQ MASQAPAVNT LTESTLKNVP QVVNVQELKN NPATPSTAMG SSVPYSTAKT 1150 1160 1170 1180 1190 1200 PHPVLTPVAA NQAKQGSLIN SLKPSGPTPA SGQLSSGDKA SGTAKIETAV TSTPSASGQF 1210 1220 1230 1240 1250 1260 SKPFSFSPSG TGFNFGIITP TPSSNFTAAQ GATPSTKESS QPDAFSSGGG SKPSYEAIPE 1270 1280 1290 1300 1310 1320 SSPPSGITSA SNTTPGEPAA SSSRPVAPSG TALSTTSSKL ETPPSKLGEL LFPSSLAGET 1330 1340 1350 1360 1370 1380 LGSFSGLRVG QADDSTKPTN KASSTSLTST QPTKTSGVPS GFNFTAPPVL GKHTEPPVTS 1390 1400 1410 1420 1430 1440 SATTTSVAPP AATSTSSTAV FGSLPVTSAG SSGVISFGGT SLSAGKTSFS FGSQQTNSTV 1450 1460 1470 1480 1490 1500 PPSAPPPTTA ATPLPTSFPT LSFGSLLSSA TTPSLPMSAG RSTEEATSSA LPEKPGDSEV 1510 1520 1530 1540 1550 1560 SASAASLLEE QQSAQLPQAP PQTSDSVKKE PVLAQPAVSN SGTAASSTSL VALSAEATPA 1570 1580 1590 1600 1610 1620 TTGVPDARTE AVPPASSFSV PGQTAVTAAA ISSAGPVAVE TSSTPIASST TSIVAPGPSA 1630 1640 1650 1660 1670 1680 EAAAFGTVTS GSSVFAQPPA ASSSSAFNQL TNNTATAPSA TPVFGQVAAS TAPSLFGQQT 1690 1700 1710 1720 1730 1740 GSTASTAAAT PQVSSSGFSS PAFGTTAPGV FGQTTFGQAS VFGQSASSAA SVFSFSQPGF 1750 1760 1770 1780 1790 1800 SSVPAFGQPA SSTPTSTSGS VFGAASSTSS SSSFSFGQSS PNTGGGLFGQ SNAPAFGQSP 1810 1820 1830 1840 1850 1860 GFGQGGSVFG GTSAATTTAA TSGFSFCQAS GFGSSNTGSV FGQAASTGGI VFGQQSSSSS 1870 1880 1890 1900 1910 1920 GSVFGSGNTG RGGGFFSGLG GKPSQDAANK NPFSSASGGF GSTATSNTSN LFGNSGAKTF 1930 1940 1950 1960 1970 1980 GGFASSSFGE QKPTGTFSSG GGSVASQGFG FSSPNKTGGF GAAPVFGSPP TFGGSPGFGG 1990 2000 2010 2020 2030 2040 VPAFGSAPAF TSPLGSTGGK VFGEGTAAAS AGGFGFGSSS NTTSFGTLAS QNAPTFGSLS 2050 2060 2070 2080 QQTSGFGTQS SGFSGFGSGT GGFSFGSNNS SVQGFGGWRS
	Isoform 5 [UniParc]. Checksum: 4C67CE62D57E590F	FASTA	2,093	215,401
	10 20 30 40 50 60 MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 70 80 90 100 110 120 IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 130 140 150 160 170 180 AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 190 200 210 220 230 240 ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 250 260 270 280 290 300 VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 310 320 330 340 350 360 RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 370 380 390 400 410 420 LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 430 440 450 460 470 480 SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 490 500 510 520 530 540 VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 550 560 570 580 590 600 PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEN SSQSAPPMSP 610 620 630 640 650 660 FSSASKPAAS GPLSHPTPLS APPSSVPLKS SVLPSPSGRS AQGSSSPVPS MVQKSPRITP 670 680 690 700 710 720 PAAKPGSPQA KSLQPAVAEK QGHQWKDSDP VMAGIGEEIA HFQKELEELK ARTSKACFQV 730 740 750 760 770 780 GTSEEMKMLR TESDDLHTFL LEIKETTESL HGDISSLKTT LLEGFAGVEE AREQNERNRD 790 800 810 820 830 840 SGYLHLLYKR PLDPKSEAQL QEIRRLHQYV KFAVQDVNDV LDLEWDQHLE QKKKQRHLLV 850 860 870 880 890 900 PERETLFNTL ANNREIINQQ RKRLNHLVDS LQQLRLYKQT SLWSLSSAVP SQSSIHSFDS 910 920 930 940 950 960 DLESLCNALL KTTIESHTKS LPKVPAKLSP MKQAQLRNFL AKRKTPPVRS TAPASLSRSA 970 980 990 1000 1010 1020 FLSQRYYEDL DEVSSTSSVS QSLESEDART SCKDDEAVVQ APRHAPVVRT PSIQPSLLPH 1030 1040 1050 1060 1070 1080 AAPFAKSHLV HGSSPGVMGT SVATSASKII PQGADSTMLA TKTVKHGAPS PSHPISAPQA 1090 1100 1110 1120 1130 1140 AAAAALRRQM ASQAPAVNTL TESTLKNVPQ VVNVQELKNN PATPSTAKTP HPVLTPVAAN 1150 1160 1170 1180 1190 1200 QAKQGSLINS LKPSGPTPAS GQLSSGDKAS GTAKIETAVT STPSASGQFS KPFSFSPSGT 1210 1220 1230 1240 1250 1260 GFNFGIITPT PSSNFTAAQG ATPSTKESSQ PDAFSSGGGS KPSYEAIPES SPPSGITSAS 1270 1280 1290 1300 1310 1320 NTTPGEPAAS SSRPVAPSGT ALSTTSSKLE TPPSKLGELL FPSSLAGETL GSFSGLRVGQ 1330 1340 1350 1360 1370 1380 ADDSTKPTNK ASSTSLTSTQ PTKTSGVPSG FNFTAPPVLG KHTEPPVTSS ATTTSVAPPA 1390 1400 1410 1420 1430 1440 ATSTSSTAVF GSLPVTSAGS SGVISFGGTS LSAGKTSFSF GSQQTNSTVP PSAPPPTTAA 1450 1460 1470 1480 1490 1500 TPLPTSFPTL SFGSLLSSAT TPSLPMSAGR STEEATSSAL PEKPGDSEVS ASAASLLEEQ 1510 1520 1530 1540 1550 1560 QSAQLPQAPP QTSDSVKKEP VLAQPAVSNS GTAASSTSLV ALSAEATPAT TGVPDARTEA 1570 1580 1590 1600 1610 1620 VPPASSFSVP GQTAVTAAAI SSAGPVAVET SSTPIASSTT SIVAPGPSAE AAAFGTVTSG 1630 1640 1650 1660 1670 1680 SSVFAQPPAA SSSSAFNQLT NNTATAPSAT PVFGQVAAST APSLFGQQTG STASTAAATP 1690 1700 1710 1720 1730 1740 QVSSSGFSSP AFGTTAPGVF GQTTFGQASV FGQSASSAAS VFSFSQPGFS SVPAFGQPAS 1750 1760 1770 1780 1790 1800 STPTSTSGSV FGAASSTSSS SSFSFGQSSP NTGGGLFGQS NAPAFGQSPG FGQGGSVFGG 1810 1820 1830 1840 1850 1860 TSAATTTAAT SGFSFCQASG FGSSNTGSVF GQAASTGGIV FGQQSSSSSG SVFGSGNTGR 1870 1880 1890 1900 1910 1920 GGGFFSGLGG KPSQDAANKN PFSSASGGFG STATSNTSNL FGNSGAKTFG GFASSSFGEQ 1930 1940 1950 1960 1970 1980 KPTGTFSSGG GSVASQGFGF SSPNKTGGFG AAPVFGSPPT FGGSPGFGGV PAFGSAPAFT 1990 2000 2010 2020 2030 2040 SPLGSTGGKV FGEGTAAASA GGFGSLAMSL SPTLKGRLLL MRPKAGGGRE QAAPGRKSNE 2050 2060 2070 2080 2090 SRSLGHLCME RALTSPLKVW EQQQHHILRH ARESECPHFR ITVPTDFWFW DPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA." Von Lindern M., Fornerod M., Van Baal S., Jaegle M., De Wit T., Buijs A., Grosveld G. Mol. Cell. Biol. 12:1687-1697(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-574. Tissue: Testis.
[2]	"Homo sapiens mRNA for KIAA0023 splice variant 1 protein." Nagase T., Kikuno R., Ohara O. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT SER-574. Tissue: Placenta and Testis.
[6]	"The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm." Kraemer D., Wozniak R.W., Blobel G., Radu A. Proc. Natl. Acad. Sci. U.S.A. 91:1519-1523(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[7]	"The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88." Fornerod M., van Deursen J.M., van Baal S., Reynolds A., Davis D., Murti K.G., Fransen J., Grosveld G. EMBO J. 16:807-816(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH XPO1.
[8]	"Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins." Brownawell A.M., Macara I.G. J. Cell Biol. 156:53-64(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH XPO5.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430 AND THR-439, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-651; SER-940 AND SER-1181, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430; THR-434; THR-437; THR-439; SER-666; SER-970; SER-974; SER-1023 AND SER-1963, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25." Pasdeloup D., Blondel D., Isidro A.L., Rixon F.J. J. Virol. 83:6610-6623(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HHV-1 PROTEIN UL25.
[15]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430 AND SER-989, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[16]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-657; THR-670; SER-678; SER-940; SER-1045; SER-1081; THR-1134; THR-1150; THR-1156; THR-1312 AND SER-1985, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433; THR-434; THR-437; SER-657; THR-670; SER-678 AND SER-940, MASS SPECTROMETRY.
[19]	"Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN." Napetschnig J., Blobel G., Hoelz A. Proc. Natl. Acad. Sci. U.S.A. 104:1783-1788(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 1-434, BETA-PROPELLER DOMAIN.
[20]	"The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner." von Moeller H., Basquin C., Conti E. Nat. Struct. Mol. Biol. 16:247-254(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-405 IN COMPLEX WITH DDX19B, MUTAGENESIS OF VAL-353 AND ASP-359.
[21]	"Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19." Napetschnig J., Kassube S.A., Debler E.W., Wong R.W., Blobel G., Hoelz A. Proc. Natl. Acad. Sci. U.S.A. 106:3089-3094(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 1-450 IN COMPLEX WITH DDX19B, COILED COIL DOMAIN.
[22]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-424; LEU-1378 AND VAL-1392.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X64228 mRNA. Translation: CAA45535.1.
AB159230 mRNA. Translation: BAD07398.1. Different initiation.
D14689 mRNA. Translation: BAA03515.1.
AL157938 Genomic DNA. Translation: CAI41111.1.
BC045620 mRNA. Translation: AAH45620.2.
BC105998 mRNA. Translation: AAI05999.1.

IPI

IPI00183294.
IPI00646361.
IPI00900318.
IPI00900325.
IPI00900331.

PIR

S26058.

RefSeq

NP_005076.3. NM_005085.2.

UniGene

Hs.654530.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OIT	X-ray	1.65	A	1-434	[»]
3FHC	X-ray	2.80	A	1-405	[»]
3FMO	X-ray	2.51	A	1-450	[»]
3FMP	X-ray	3.19	A/C	1-450	[»]

ProteinModelPortal

P35658.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-38367N.

IntAct

P35658. 18 interactions.

MINT

MINT-121482.

STRING

9606.ENSP00000352400.

PTM databases

PhosphoSite

P35658.

Polymorphism databases

DMDM

205831380.

Proteomic databases

PaxDb

P35658.

PRIDE

P35658.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000359428; ENSP00000352400; ENSG00000126883.
ENST00000411637; ENSP00000396576; ENSG00000126883.
ENST00000451030; ENSP00000405014; ENSG00000126883.

GeneID

8021.

KEGG

hsa:8021.

UCSC

uc004caf.1. human.
uc004cag.3. human.
uc004cah.3. human.

Organism-specific databases

CTD

8021.

GeneCards

GC09P134000.

HGNC

HGNC:8064. NUP214.

HPA

HPA018404.

MIM

114350. gene.

neXtProt

NX_P35658.

Orphanet

98277. Acute myeloid leukemia with recurrent genetic anomaly.

PharmGKB

PA31851.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG12793.

HOVERGEN

HBG052683.

KO

K14317.

OMA

FGQSPGF.

OrthoDB

EOG41G33J.

Enzyme and pathway databases

Pathway_Interaction_DB

bmppathway. BMP receptor signaling.
smad2_3pathway. Regulation of cytoplasmic and nuclear SMAD2/3 signaling.
nfat_3pathway. Role of Calcineurin-dependent NFAT signaling in lymphocytes.

Reactome

REACT_111217. Metabolism.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.
REACT_21257. Metabolism of RNA.
REACT_6900. Immune System.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

P35658.

Bgee

P35658.

CleanEx

HS_NUP214.

Genevestigator

P35658.

GermOnline

ENSG00000126883. Homo sapiens.

Family and domain databases

Gene3D

2.130.10.10. 1 hit.

InterPro

IPR026054. Nucleoporin.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
[Graphical view]

PANTHER

PTHR23193. PTHR23193. 1 hit.

SMART

SM00320. WD40. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NUP214. human.

EvolutionaryTrace

P35658.

GenomeRNAi

8021.

NextBio

30584.

SOURCE

Search...

Entry information

Entry name

NU214_HUMAN

Accession

Primary (citable) accession number: P35658
Secondary accession number(s): A6NFQ0 , Q15010, Q3KQZ0, Q5JUP7, Q75R47, Q86XD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 134 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.